October 12, 2025
Jacksonville Jaguars tight end
Hunter Long enters Week 6 atop the depth chart after
Brenton Strange (quad) was placed on injured reserve. While Long's exact volume is uncertain, he did step up and play 60 percent of the snaps after Strange went down last week, so he should definitely get involved. He also has six catches and a touchdown over his last three games, indicating that
Trevor Lawrence is comfortable throwing him the football. Long ranks as a mid-to-low TE2 with some streaming appeal in deeper leagues. Fortunately for Long, he has upside given his matchup against the Seattle Seahawks, who have surrendered the most receptions and seventh-most fantasy points to tight ends in 2025.
--Andersen PickardSource: RotoBaller
October 12, 2025
Los Angeles Chargers running back
Hassan Haskins is expected to operate as the primary option out of the backfield during Sunday's Week 6 contest against the Miami Dolphins, according to Mike Garafolo of NFL Network. Haskins will take on an expanded role this weekend with both
Omarion Hampton (ankle) and
Najee Harris (Achilles) on injured reserve. Haskins' newfound role at the top of the depth chart isn't necessarily a surprise since he was routinely active as the No. 3 running back when Hampton and Harris were healthy. Now, he'll slide into the lead-back role while
Kimani Vidal offers a change of pace. It's possible that Vidal could carve out a low-end fantasy role, but for now, Haskins is the only Chargers running back worth starting in fantasy football. He ranks as an RB3/flex but could have RB2 upside in a favorable matchup against Miami.
--Andersen PickardSource: Mike Garafolo
October 12, 2025
San Francisco 49ers wide receiver
Kendrick Bourne remains an intriguing fantasy option despite teammate
Jauan Jennings (ankle, rib) returning. The veteran receiver is coming off a career performance in which he caught 10 passes for 142 yards.
Ricky Pearsall (knee) remains sidelined for the Niners, so Bourne should still start and carve out a sizable role alongside Jennings. Also working in Bourne's favor is the quarterback situation.
Brock Purdy (toe) will miss his fourth game, leaving
Mac Jones in line to start. Jones and Bourne have a great rapport from their time together in New England, as well as last week's big game, and should continue to strengthen their connection during Week 6 against the Tampa Bay Buccaneers. While Jennings' return may lower Bourne's ceiling, the veteran receiver is still an intriguing WR3/flex in leagues with at least 12 teams.
--Andersen PickardSource: RotoBaller
October 12, 2025
Los Angeles Chargers running back
Omarion Hampton (ankle) is expected to spend more than the minimum four weeks on injured reserve, according to Mike Garafolo of NFL Network. The injury that the rookie suffered in Week 5 appears to be serious enough that he'll be out through at least Week 10, and perhaps longer. The Chargers have a Week 12 bye, so it wouldn't be surprising to see Los Angeles hold him out until Week 13, giving him an extra week off to rest. Losing both Hampton and
Najee Harris (Achilles) is a major blow for the Chargers, who will turn to
Hassan Haskins and
Kimani Vidal but could also look to make external running back additions.
--Andersen PickardSource: Mike Garafolo
October 12, 2025
New Orleans Saints running back
Alvin Kamara has been a possible mid-season trade target given the direction the organization is going right now. The Los Angeles Chargers are reportedly in the market for a running back with multiple backs going down with injuries. On paper, Kamara makes sense for the Chargers, but the 30-year-old doesn't want to leave New Orleans. Kamara said he wants to stay with the Saints and retire with the organization. It remains to be seen if something will change over the next few weeks, but for now Kamara is resistant to any trades.
--Andy WebbSource: Ian Rapoport
October 12, 2025
Dallas Cowboys wide receiver
CeeDee Lamb (ankle) has already been ruled out ahead of the Week 6 matchup against the Carolina Panthers. This marks the third straight absence for Lamb, but he might not be out too much longer. According to Ian Rapoport, Lamb could return for next week's matchup against the Washington Commanders. This is great news for fantasy managers who only got two solid games out of Lamb before he went down. For now,
George Pickens and
Jake Ferguson figure to be the primary receiving options with
Ryan Flournoy being mixed in as well.
--Andy WebbSource: Ian Rapoport
October 12, 2025
New York Jets running back
Khalil Herbert and wide receiver
Allen Lazard are inactive ahead of the Week 6 matchup against the Denver Broncos. As expected, Lazard is out as he didn't make the trip to England due to personal reasons. His absence won't mean much for this offense given he has four receptions for 24 yards and one touchdown this season.
Arian Smith figures to see a majority of the snaps as the third wideout. As for Herbert, he's a healthy scratch as he's too far down on this depth chart to make a serious impact.
Kene Nwangwu figures to do the kick returning with Herbert out.
--Andy WebbSource: Zack Rosenblatt
October 12, 2025
Las Vegas Raiders tight end
Brock Bowers (knee) has already been ruled out ahead of the Week 6 matchup against the Tennessee Titans. According to Ian Rapoport, Bowers is unlikely to suit up for next week's matchup versus the Kansas City Chiefs. Bowers has been dealing with a PCL injury that he suffered Week 1. His timetable was revealed as week-to-week, so fantasy managers shouldn't be shocked if Bowers misses a third straight game. His absence means that
Michael Mayer will take over as the primary tight end on this offense. Mayer is worth a stash for tight end needy fantasy managers, but isn't a recommended streaming option in Week 6.
--Andy WebbSource: Ian Rapoport
October 12, 2025
San Francisco 49ers wide receiver
Ricky Pearsall (knee) has already been ruled out ahead of the Week 6 matchup against the Tampa Bay Buccaneers. He'll miss his second straight game due to a lingering knee issue. According to Adam Schefter, Pearsall could make his return to the field for the Week 7 matchup against the Atlanta Falcons. Given the injuries to this offense, Pearsall figures to be a focal point in the receiving game once he's healthy enough to play. Hopefully, fantasy managers will only be without him for one more week. His absence figures to mean more involvement for
Jauan Jennings (rib, ankle) and
Kendrick Bourne.
--Andy WebbSource: Adam Schefter
October 12, 2025
Dallas Cowboys wide receiver
Ryan Flournoy is coming off a fantastic performance in Week 5. Flournoy hauled in six of his nine targets for 114 yards in the win over the New York Jets. The 25-year-old came out of nowhere and posted a career-game last week. The assumption is that the Cowboys are going to keep him involved going forward. This offense remains without their top option in
CeeDee Lamb (ankle) for Week 6. That being said,
George Pickens figures to draw the most attention on defense, which could leave Flournoy in favorable coverage. The lack of prior success does make Flournoy a risky choice. He's more of a flex option in deep leagues because it's unclear if he can duplicate that performance.
--Andy WebbSource: Pro Football Reference
October 12, 2025
Dallas Cowboys running back
Jaydon Blue is set for an increase in playing time Sunday against Carolina after the team previously announced that
Miles Sanders (knee, ankle) would miss the rest of the season following surgery. The elevation, however, will still keep Blue behind starter
Javonte Williams, who is in the midst of a resurgent 2025 season. The rookie was a healthy inactive for the first month of the season, then played 11 snaps in his first game last week against the New York Jets. Although Blue will factor into the Dallas offense, he's not likely to earn enough volume to be playable yet, at least while Williams is healthy.
--Nick PiotrowiczSource: ESPN
October 12, 2025
Washington Commanders wide receiver
Terry McLaurin (quadriceps) could return to the lineup in Week 7, according to Tom Pelissero of NFL Network. The former Ohio State star is slated to miss his third consecutive game on Monday against the Chicago Bears, although it appears next week's game against the Dallas Cowboys could be in play. McLaurin has not yet had a breakout week this season after scoring a new contract, but he finished as PPR WR No. 7 last year and figures to be highly involved once back to full health.
--Nick PiotrowiczSource: NFL Network
October 12, 2025
On a Tampa Bay Buccaneers team hampered by injuries at wide receiver, veteran
Sterling Shepard has seen a rapid increase in fantasy value as his team prepares to play San Francisco in Week 6.
Chris Godwin (leg) and
Mike Evans (hamstring) already have been ruled out for the game, slotting in Shepard as the team's likely second receiver behind
Emeka Egbuka. Shepard has seen at least four targets in every game this season and scored his first touchdown of the year last week. The Niners are mid-tier against fantasy receivers, but Shepard should receive enough volume to be considered a flex option, especially in deeper leagues.
--Nick PiotrowiczSource: Pro Football Reference
October 12, 2025
Ian Rapoport of NFL Network is reporting that Dallas Cowboys cornerback Trevon Diggs (knee) is expected to play when his team takes on the Carolina Panthers on Sunday. The corner was listed as questionable on the final injury report. The Cowboys are also likely to have DaRon Bland (shoulder), who was also listed as questionable on the injury report, giving Dallas its top two corners against Carolina. Dallas is allowing 7.5 net yards per attempt this season, which ranks dead last in the NFL.
--Nick PiotrowiczSource: NFL Network
October 12, 2025
The Dallas Cowboys are likely to have cornerback DaRon Bland (shoulder) active when they take on the Carolina Panthers on Sunday, according to NFL Network's Ian Rapoport. Bland was limited in practice all week. The fourth-year corner missed a pair of games this season with a foot injury and is listed as questionable for Sunday, though it appears he will play. Rapoport also reported that Dallas is likely to have fellow corner Trevon Diggs (knee), giving the Cowboys another option to match against Carolina rookie wide receiver
Tetairoa McMillan.
--Nick PiotrowiczSource: NFL Network
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