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Most of the San Francisco 49ers starters will not play in their preseason opener at the Tennessee Titans this Saturday, according to head coach Kyle Shanahan. We already know that running backs Christian McCaffrey (calf), Elijah Mitchell (hamstring) and rookie Isaac Guerendo (hamstring) and rookie first-round wide receiver Ricky Pearsall (shoulder) will not suit up for a team that has been hit hard with injuries early in training camp. Quarterback Brock Purdy, receiver Deebo Samuel and tight end George Kittle probably won't suit up, either. The 49ers aren't unlike most teams early in the preseason in sitting their starters. There's still plenty of time for Sn Fran's offensive weapons to heal up before Week 1 of the regular season, but the offense's efficiency will be worth watching early in the year if most of their starters don't get much time to work together in the last two preseason contests.--Keith Hernandez - RotoBaller
Source: The Athletic - David Lombardi
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