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Here we are folks, Week 6 of the NFL and fantasy football season is upon us. We can't wait for this week's games, and we're going to help you win your matchups with our updated Week 6 fantasy football defense (D/ST) rankings, as of October 15th. Our goal is to help you set those winning lineups, so let's see where key team defenses like the Buccaneers DST, Rams DST, Jaguars DST, Bengals DST, and Eagles DST.
Our defense (DST) fantasy football rankings are put together by Nick Mariano, Brandon Murchison and Andersen Pickard. In addition to our staff rankings, below you will also find a summary of the important fantasy football injury news for this week. There are always key injuries to keep track of, so be sure to check back until kickoff.
You should also bookmark our fantasy football rankings portal and check back regularly for updates. In addition to these D/ST rankings, read our fantasy football articles and analysis - our NFL team discusses lineup sleepers, busts, NFL players to start and sit, waiver wire pickups and so much more. Most importantly, our brand new free mobile app is a must have - download it and configure your notifications. We deliver all the top NFL news, injuries, and fantasy analysis 24x7 with our free push notification alerts!
Be sure to check all of our fantasy football rankings for the 2025 playoffs:- Quarterback fantasy football rankings
- Running back fantasy football rankings
- Wide receiver fantasy football rankings
- Tight end fantasy football rankings
- Kicker fantasy football rankings
- FLEX fantasy football rankings
- Defense (D/ST) fantasy football rankings
- Superflex fantasy football rankings
- IDP fantasy football rankings
- Dynasty fantasy football rankings
Week 6 Defense (D/ST) Fantasy Football News
- Bucs' Defense An Elite Option Against The Steelers
- Rams Defense A Top Option Week 6
- Jaguars Defense Is A Fantastic Streaming Option In Week 6
- Eagles Defense A Recommended Start In Week 6
- Bengals Defense Has Upside Versus Hobbled Saints Offense
- Minkah Fitzpatrick Ruled Out Against Buccaneers
- Jadeveon Clowney, Denzel Ward Ruled Out In Week 6
Week 6 Fantasy Football Defense (D/ST) Rankings
You can also check out our Week 6 Half-PPR rankings and Standard rankings. A big congrats to our very own Nick Mariano who once again finished as a top-10 ranker in 2021 across the entire fantasy football industry!
Last updated on Saturday 10/15 at 2:00 pm ET:
| D/ST Tier |
D/ST Rank |
D/ST Name |
Pos |
| 1 | 1 | San Francisco 49ers | DST |
| 1 | 2 | Tampa Bay Buccaneers | DST |
| 1 | 3 | Los Angeles Rams | DST |
| 2 | 4 | Green Bay Packers | DST |
| 2 | 5 | Baltimore Ravens | DST |
| 2 | 6 | Jacksonville Jaguars | DST |
| 3 | 7 | Dallas Cowboys | DST |
| 3 | 8 | Philadelphia Eagles | DST |
| 3 | 9 | Minnesota Vikings | DST |
| 3 | 10 | New England Patriots | DST |
| 4 | 11 | Los Angeles Chargers | DST |
| 4 | 12 | Cleveland Browns | DST |
| 4 | 13 | Indianapolis Colts | DST |
| 4 | 14 | Chicago Bears | DST |
| 4 | 15 | New Orleans Saints | DST |
| 5 | 16 | Buffalo Bills | DST |
| 5 | 17 | Washington Commanders | DST |
| 5 | 18 | Denver Broncos | DST |
| 5 | 19 | Carolina Panthers | DST |
| 5 | 20 | Cincinnati Bengals | DST |
| 5 | 21 | Miami Dolphins | DST |
| 6 | 22 | Kansas City Chiefs | DST |
| 6 | 23 | New York Jets | DST |
| 6 | 24 | Pittsburgh Steelers | DST |
| 6 | 25 | Seattle Seahawks | DST |
| 6 | 26 | Arizona Cardinals | DST |
| 7 | 27 | New York Giants | DST |
| 7 | 28 | Atlanta Falcons | DST |
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