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Many fantasy managers struggle to know which defenses to target in fantasy football each week, so our NFL team's Week 10 fantasy football defense (D/ST) rankings are here to guide you in setting your optimal lineup.
The Chargers, Bears, and Giants have plus matchups and are ranked in the top 10 in RotoBaller's Week 10 DST rankings. Check out where other defenses, such as the 49ers, Jets, and Chiefs stand in the rankings.
Our Week 10 defense (DST) fantasy football rankings are put together by Nick Mariano, Brandon Murchison, Andersen Pickard, and Scott Engel. In addition to our staff rankings, below you will find a summary of this week's important fantasy football injury news.
Be sure to check all of our fantasy football rankings for the 2025 playoffs:- Quarterback fantasy football rankings
- Running back fantasy football rankings
- Wide receiver fantasy football rankings
- Tight end fantasy football rankings
- Kicker fantasy football rankings
- FLEX fantasy football rankings
- Defense (D/ST) fantasy football rankings
- Superflex fantasy football rankings
- IDP fantasy football rankings
- Dynasty fantasy football rankings
Week 10 Defense (D/ST) Fantasy Football News
- Joey Bosa, Khalil Mack Questionable For Week 10
- Will Anderson Jr. Won't Play In Week 10
- Nick Bosa Questionable To Face Buccaneers
- Marshon Lattimore Won't Make Commanders Debut In Week 10
- The Kansas Chiefs Defense Faces Rookie QB In Week 10
- Vikings DST In Line For Smash Matchup
- The New York Giants Defense A Viable Streamer In Week 10
Week 10 Fantasy Football Defense (D/ST) Rankings
Bookmark our weekly PPR rankings, Half-PPR rankings, Standard rankings.
| D/ST Tier | D/ST Rank | D/ST Name | Position |
| 1 | 1 | Los Angeles Chargers | DST |
| 1 | 2 | Philadelphia Eagles | DST |
| 1 | 3 | Minnesota Vikings | DST |
| 1 | 4 | Kansas City Chiefs | DST |
| 2 | 5 | Chicago Bears | DST |
| 2 | 6 | New York Giants | DST |
| 3 | 7 | Buffalo Bills | DST |
| 3 | 8 | Detroit Lions | DST |
| 3 | 9 | San Francisco 49ers | DST |
| 3 | 10 | Pittsburgh Steelers | DST |
| 4 | 11 | Washington Commanders | DST |
| 4 | 12 | Atlanta Falcons | DST |
| 4 | 13 | New York Jets | DST |
| 4 | 14 | Arizona Cardinals | DST |
| 4 | 15 | Los Angeles Rams | DST |
| 5 | 16 | New England Patriots | DST |
| 5 | 17 | Denver Broncos | DST |
| 5 | 18 | Baltimore Ravens | DST |
| 5 | 19 | Carolina Panthers | DST |
| 5 | 20 | New Orleans Saints | DST |
| 5 | 21 | Houston Texans | DST |
| 6 | 22 | Jacksonville Jaguars | DST |
| 6 | 23 | Tennessee Titans | DST |
| 6 | 24 | Indianapolis Colts | DST |
| 6 | 25 | Miami Dolphins | DST |
| 6 | 26 | Cincinnati Bengals | DST |
| 6 | 27 | Tampa Bay Buccaneers | DST |
| 6 | 28 | Dallas Cowboys | DST |
Week 10 Defense Outlooks for Fantasy Football
New York Giants DST - Fantasy Football Outlook
The New York Giants Defense heads into Week 10 against the Carolina Panthers with a strong pass rush and a top red-zone defense. The Giants lead the NFL with 35 sacks this season, which could create significant pressure on rookie QB Bryce Young, whose Panthers rank 30th in passing yards (176.6 per game) and points scored (16.3 per game).
Despite allowing 142.6 rushing yards per game (29th), the Giants' pass defense remains solid, ranking 9th overall by limiting opponents to 191.6 yards per game through the air.
With Carolina struggling as the league's 30th-ranked offense, the Giants' 5th-ranked red-zone defense (44% TD conversion allowed) has a prime opportunity to stifle scoring chances, making them a viable streaming option for fantasy managers in Munich.
- Danny Boyle
Kanas City Chiefs DST - Fantasy Football Outlook
The Kansas City Chiefs defense will take on the Denver Broncos in Week 10. The Kansas City defense gave up 24 points last week against the Tampa Bay Buccaneers but still managed to rack up two sacks. The Chiefs have collected 17 sacks in eight games this season, but that may be difficult in Week 10.
Broncos quarterback Bo Nix has been sacked 15 times this season, fewer times than Patrick Mahomes has been brought down. Nix has shown his ability as a rusher this season, ranking fifth in rushing yards among quarterbacks. That said, Kansas City has been among the best defenses at stopping the run, and they're aware of Nix's rushing ability.
If the Chiefs continue their run-stopping ways, they should be able to contain the Broncos offense. The Chiefs former first-round pick, George Karlaftis, was a limited participant in Wednesday's practice but practiced fully the rest of the week and does not carry an injury designation heading into the contest.
Karlaftis is a vital piece of the defensive unit, so it's positive news that he has been removed from the injury report. This week, the Kansas City defense is ranked as the fourth-best defense in our RotoBaller rankings, so they are among the best options. Fantasy managers should start them confidently.
- Joshua Costello
Los Angeles Chargers DST - Fantasy Football Outlook
The Los Angeles Chargers defense is projected to be one of the top defensive units in fantasy football for Week 10. The Bolts will take on the Tennessee Titans, who will have quarterback Will Levis returning to the starting lineup. In his five games this season, Levis has thrown five touchdowns and seven interceptions.
The Chargers defense has finished as a top-three fantasy defense in both of the past two weeks, and they have a good chance to end up in or near that tier once again this time around. Start them with confidence as a high-floor and even higher-ceiling DST.
- David A. Marcillo
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