Teams coached by Bill Belichick like to take away your biggest strength on offense and try to make you win with your team's weaknesses.
Hilton is the best playmaker on the Colts, and I expect New England to give him plenty of attention in the defensive gameplay. Hilton has also struggled with a groin injury during the week to go along with QB Andrew Luck's shoulder problems.
I think the Patriots will roll in this Deflategate rematch, but do acknowledge that the Colts may be able to sneak some garbage time. Those in PPR leagues should still roll out Hilton, but if you are in a shallower league or have other viable options, you may want to consider rolling with someone else in Week 6.