Speaking of that DVOA stat, the Bills are 20th against #2 receivers versus being ranked 3rd best against #1 receivers. Now obviously I'm not saying Odell Beckham Jr. is a bad play, that guy is matchup-proof, but with Victor Cruz ailing again and the Giants being thin at wide receiver, Randle has to step up.
The Bills also have a very strong rushing defense that gets to go against a subpar Giants stable of running backs. Rashad Jennings has done little to instill confidence in him and while Andre Williams has looked better, it's not enough to convince me they'll have success against Buffalo.
The line is still banged up and NYG should attack through the air out of the shotgun formation. Saying should is a risky thing to bank on, but it's true. If the Giants want to win, they'll need Randle. Be there if he turns the opportunity into gold.