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2 days agoSan Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) is off the injury report and ready to roll for a Week 18 matchup with the Cardinals in Arizona. Last week at home versus Detroit, Guerendo took just nine carries for 34 yards but snagged all four targets in the passing game for 65 yards. Arizona's defense represents a favorable opportunity for Guerendo to finish his first NFL campaign on a high note -- they have allowed the 10th-most half-PPR points per game (21.9). Last week, they allowed 14.7 points to Kyren Williams of the Los Angeles Rams. With the 49ers having been eliminated from playoff contention weeks ago and playing their final game of 2024, head coach Kyle Shanahan should give Guerendo his classic heavy lead-back usage while assessing Guerendo's role in 2025. This could be especially true with the 49ers injury issues -- backup Joshua Dobbs is starting for an injured Brock Purdy (right elbow), wideout Deebo Samuel Sr. (rib, wrist) is out, and tight end George Kittle (ankle, hamstring) is questionable. Guerendo is a back-end RB1 in Week 18.--Brad Beltz - RotoBaller
Source: Pro Football Reference

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