18 seconds agoSan Francisco 49ers wide receiver Deebo Samuel Sr. (calf) was unable to practice on Wednesday, according to head coach Kyle Shanahan. Samuel suffered a strained right hamstring in the Week 2 loss to the Minnesota Vikings and hasn't practiced since, also missing the Week 3 loss to the division-rival Los Angeles Rams. The injury was initially expected to keep him out for multiple games, so fantasy managers shouldn't plan on having him for the Week 4 tilt against the New England Patriots, especially with him not practicing on Wednesday. The 28-year-old is a must-start in fantasy lineups on a weekly basis when he's active, but he's probably going to be unavailable for a second straight week. Jauan Jennings should be rostered in all fantasy formats after catching 11 of 12 targets for 175 yards and three touchdowns in the Week 3 win with both Samuel and tight end George Kittle (hamstring) both out.--Keith Hernandez - RotoBaller
Source: San Francisco Chronicle - Eric Branch