X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

MLB DFS Lineup Picks - Early Slate (5/22/21): DraftKings, FanDuel Daily Fantasy Baseball

Jorge Pucks highlights the top FanDuel and DraftKings MLB DFS lineup picks for the "Afternoon" slate on 5/22/21, and a couple of sleepers to consider while building daily rosters.

Hello there, MLB DFS grinders! It's Saturday, and that means we have yet another split slate of MLB games today with seven games in the afternoon and six games on the main evening slate.

While most of our MLB DFS coverage here at RotoBaller is geared towards the main slate, I wanted to give you some of my favorite pitchers and bats for these early games that will help you cash in tournaments and cash game contests. I'll highlight my favorite pitching options here first and then give you some hitters at each price tier to consider as well as my favorite teams to stack up! You can read our DraftKings DFS lineup picks for the main slate and FanDuel DFS lineup picks for the main slate as well.

I'll be providing you with my daily fantasy baseball lineup picks for the FanDuel and DraftKings afternoon slate at 4:05 PM on 5/22/2021. Be sure to also check out all the MLB player news, including late scratches, and the projected and confirmed daily MLB lineups for each DFS slate. You can also check out today's MLB DFS lineup picks for the main slate here, and read more DFS advice and lineup picks for other sports too. Let's get to it!

 

MLB DFS Pitchers

Shane Bieber vs. MIN ($11,500 FD, $11,200 DK)

Bieber is the top arm option on this early-only slate and if Nelson Cruz sits again, that only gives another bump to rostering him. When looking at all of his starts this season, Bieber has recorded at least sevens strikeouts in every game and has managed to record a quality start in eight of his nine starts as well. Minnesota is averaging .234 as a team against right-handed pitchers and has a 23.6% strikeout rate against this handedness so there is some strikeout upside in this matchup for Bieber. Rostering Bieber might be tough to do in tournaments but he would be someone to plug in for your cash game lineup and build around.

Matthew Boyd vs. DET ($8,200 FD, $7,700 DK)

Despite having a 2-4 record, Boyd has gotten off to a strong start this season as he has a 2.45 ERA and is generating a 19.5% strikeout percentage in just 47.2 innings pitched. Boyd is the third-highest priced pitcher on FD but is the sixth-highest priced pitcher over on DK but is in play on both sites in all formats. The Royals are only batting .239 against lefty pitchers this season and while they only have 80 strikeouts in 403 plate appearances, they have only managed to hit seven home runs against lefties which is the second-lowest total in the league.

Others to consider: Lance McCullers Jr. vs. TEX, Sonny Gray vs. MIL

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

MLB DFS "Bats Worth Paying For"

Trey Mancini – 1B/OF, TB @ WSH ($3,900 FD, $5,600 DK)

The hot streak continues for Mancini as he has now recorded a hit in eight straight games while hitting three home runs during that stretch. The Orioles will face off against Jon Lester and several of their batters fare very well against lefties with Trey Mancini leading the charge. He is batting .333 against lefties and leads the team with six home runs off of this handedness. Mancini has a .480+ ISO against both of Lester's fastball and cutters which he throws roughly over 60% of the time against right-handed batters so if he sees one he likes, he could take Lester out of the park.

Jose Ramirez – 3B, WSH @ CHC ($3,700 FD, $5,500 DK)

Ramirez has arguably the most upside at the third base position on this slate as he could double-dong at any given moment and this seems like a game where he could take Maeda yard. Ramirez is batting .264 against righties this season but has also taken them deep 10 times this season. Ramirez has an ISO of .268 against righties and profiles well against Maeda as he has a .349+ XwOBA against all three main pitches that Maeda throws against lefty hitters.

Nick Castellanos – OF, CIN vs. MIL ($4,300 FD, $5,600 DK)

Castellanos is definitely one to consider as he has been swinging a hot bat all season long and has fared very well against left-handed pitching which is what he will get against Brett Anderson. Castellanos is hitting .346 against lefties this season with three home runs and sporting an ISO of .321 against this handedness. He is riding a nine-game hitting streak so there is no reason to not consider him in all formats for this matchup.

 

MLB DFS Values

Ozzie Albies – 2B, ATL vs. PIT ($2,700 FD, $5,200 DK)

Albies is an absolute steal on FD at $2,700 while the DK pricing has him all of the way up in the $5,000 range. Albies is coming off of a strong performance at the plate on Friday night where he recorded two hits in five at-bats while recording a home run and three RBIs. Lefties have an ISO of .193 against Keller this season and Albies profiles extremely well against Keller as he has an ISO of .472+ and an XwOBA of  .364+ against his fastball and cutter which he throws for a combined 70% of the time against lefty batters.

Austin Riley – 3B, ATL vs. PIT ($2,800 FD, $4,200 DK)

If you're wanting to get a tad different with your Braves stack, you should look to include Austin Riley in them. He should come in lower owned than the likes of Acuna, Freeman, and Albies but still provides a very good bat against Keller. Riley is hitting .321 against righties this season which leads the Braves in batting average against this handedness and has five home runs against this handedness which is tied for the third-most on the Braves team.

Cedric Mullins – OF, BAL @ WSH ($2,800 FD, $4,500 DK)

While Mullins has been a little cold at the plate over the past couple of games, that should not scare us away from considering him. Mullins has the second-highest batting average on the team against lefties (.311) and leads the team with 13 singles and four doubles against this handedness. While Mullins isn't a big power threat, he is a threat if he gets on the basepaths which is something we like against a pitcher like Lester who has a slow delivery so there could be some stolen base upside with Mullins.

Also Consider: Ryan Mountcastle vs Jon Lester, Eddie Rosario vs. Kenta Maeda 

 

MLB DFS Hitter Stacks

Atlanta Braves vs. Mitch Keller

The Braves are coming off of an epic night at the plate as they scored 20 runs so we might as well go right back to the well and consider them against Mitch Keller. Keller has struggled in eight appearances this season as he has a 7.16 ERA and both sides of the plate are hitting .290+ against him. The Braves have the second-most home runs against right-handed pitchers and as a team is sporting an ISO of .209 against right-handed pitchers so looking at some of their power bats like Acuna, Ozuna, Freeman, Albies, and Riley would be the way to go with this team.

Cincinnati Reds vs. Brett Anderson

When the Reds play at home, they definitely get placed into consideration and with Brett Anderson on the hill for the Brewers, they become a team to really consider stacking. Anderson has a 4.50 ERA in 24 innings pitched this season and has gotten roughed up from both sides of the plate. The Reds do come into this matchup pretty banged up so guys like Castellanos, Winker,  Stephenson, and Suarez would be the guys to focus on from Cincinnati.

Other stacks: Baltimore Orioles vs. Jon Lester, Cleveland Indians vs. Kenta Maeda



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF

REAL-TIME FANTASY NEWS

Pablo López19 mins ago

Pablo Lopez Throws Bullpen On Wednesday
Matt Wallner24 mins ago

Missing From Lineup On Wednesday
Carlos Correa30 mins ago

Out On Wednesday
Max Scherzer34 mins ago

Throws Before Visiting With Doctor
Christopher Suero35 mins ago

Hits Two Home Runs On Tuesday
George Springer37 mins ago

Still Out Against Braves
Spencer Strider44 mins ago

Activated From Injured List, Making Season Debut On Wednesday
Tampa Bay Rays49 mins ago

Duncan Davitt Strikes Out 10 In Latest Start
Justin Thomas52 mins ago

Looking To Shake Off Poor Masters At RBC Heritage
Jordan Lawlar1 hour ago

Goes Deep In Second Straight Game
Braden Montgomery1 hour ago

Goes Deep On Tuesday
Matt Svanson1 hour ago

Promoted To Major Leagues
Xander Schauffele1 hour ago

Still Looking For Year's First Win At RBC Heritage
DJ Herz1 hour ago

Will Undergo Tommy John Surgery
Maverick McNealy2 hours ago

Is An Intriguing Play At RBC Heritage
Shane Lowry2 hours ago

Looks To Shake Off Poor Masters Sunday At RBC Heritage
Tre Jones3 hours ago

Remains Out On Wednesday
Kevin Love3 hours ago

Could Return To Action Wednesday
Pelle Larsson3 hours ago

Iffy For Wednesday
Nikola Jović3 hours ago

Nikola Jovic Listed As Questionable For Wednesday
Alec Burks3 hours ago

Active On Wednesday
Brandon Williams3 hours ago

Questionable For Wednesday
Will Zalatoris3 hours ago

Eyes A Bounce-Back At RBC Heritage
Malik Monk3 hours ago

Unavailable For Play-In Tournament
Dereck Lively II4 hours ago

Returns To Action Wednesday
P.J. Washington4 hours ago

Available Against Kings
Klay Thompson4 hours ago

Good To Go Wednesday
Alan Roden4 hours ago

Connects On First Home Run
Andrew Wiggins4 hours ago

Available For Wednesday's Play-In Action
Tyler Herro4 hours ago

Removed From Injury Report
Bam Adebayo4 hours ago

Available Wednesday
Jarren Duran4 hours ago

Productive In Win Over Rays
Damian Lillard4 hours ago

To Miss Start Of Playoffs
Steven Kwan4 hours ago

Homers In Impressive Showing Against Baltimore
Gary Woodland4 hours ago

Could Add Some Surprise At Hilton Head
Jonathan Aranda4 hours ago

Smacks Third Home Run
Cedric Mullins4 hours ago

Homers In Tuesday’s Loss Against Cleveland
Sam Burns4 hours ago

Hoping For Better Times At RBC Heritage
Sahith Theegala4 hours ago

Still Trying To Put It All Together
Angel Martínez4 hours ago

Angel Martinez Triples, Swipes Bag In Win
Aaron Rai5 hours ago

Might Be That Guy For Hilton Head
Robert MacIntyre5 hours ago

All Or Nothing At RBC Heritage
Tom Hoge5 hours ago

Still Playing Solid Heading To Hilton Head
Nick Dunlap5 hours ago

Continues To Have Rough Stretch
George Lombard Jr.5 hours ago

Posts Third Straight Two-Hit Game
Keegan Bradley5 hours ago

Looks To Move On From Masters Performance
Rhys Hoskins5 hours ago

Launches First Home Run Of The Season
Hao-Yu Lee5 hours ago

Goes Deep, Swipes A Bag
Matt Boldy6 hours ago

Tallies Two Points In Victory
Pavel Buchnevich6 hours ago

Scores Goal, Adds Two Helpers
Brayden Point6 hours ago

Busy In Tuesday's Victory
Jet Greaves6 hours ago

Picks Up Fourth Straight Victory
Anthony Stolarz7 hours ago

Stops 35 Shots On Tuesday
Timo Meier7 hours ago

Tallies Three Points In Victory
Matt Fitzpatrick11 hours ago

A Boom-Or-Bust Option At RBC Heritage
Patrick Cantlay11 hours ago

A Strong Play At RBC Heritage
Jordan Spieth12 hours ago

Targets Another Strong RBC Heritage Showing
Collin Morikawa12 hours ago

Eyeing Victory At RBC Heritage
Max Homa12 hours ago

Breaks Through At The Masters
Tony Finau14 hours ago

A Hard Player To Trust At RBC Heritage
Corey Conners15 hours ago

Looking To Keep Momentum Going At RBC Heritage
Moses Moody16 hours ago

Available Versus Memphis
Dalen Terry16 hours ago

Probable Versus The Heat
Lonzo Ball16 hours ago

Doubtful For Wednesday Night
Anthony Davis16 hours ago

Probable Versus Sacramento
John FitzPatrick17 hours ago

Re-Signs With Green Bay
Cleveland Browns17 hours ago

Julian Okwara Signs With Cleveland
Gabriel Landeskog18 hours ago

Could Be An Option For Playoff Opener
MIN18 hours ago

Jake Middleton Returns From Four-Game Absence
Trae Young18 hours ago

Cleared To Face Orlando
Jared Spurgeon18 hours ago

Available Against Ducks
Josh Giddey18 hours ago

Expected To Play On Wednesday Night
Ilya Samsonov18 hours ago

Returns To Vegas Crease Tuesday
Noah Hanifin18 hours ago

To Be Rested Against Flames
Moses Moody18 hours ago

Added To The Injury Report
Mark Stone18 hours ago

Sits Out Tuesday's Action
Oliver Ekman-Larsson19 hours ago

Expected To Return For Postseason
Owen Power19 hours ago

To Miss Rest Of Regular Season
Viktor Hovland19 hours ago

Remains Volatile Ahead Of RBC Heritage
Stefan Noesen19 hours ago

Returns To Action Tuesday
Claude Giroux19 hours ago

Won't Play On Tuesday
Jake Sanderson19 hours ago

Resting Against Blackhawks
Adam Pelech19 hours ago

Available Tuesday
Nikolaj Ehlers20 hours ago

Considered Week-To-Week
Logan Couture20 hours ago

Announces Retirement
Green Bay Packers21 hours ago

Packers Remain Committed To Trading Jaire Alexander, Have Received Interest
Mark Andrews22 hours ago

Ravens Non-Committal On Mark Andrews' Status With Team
22 hours ago

Giants Holding Private Workouts For Jalen Milroe, Tyler Shough
Carolina Panthers22 hours ago

Panthers Open To Trading Back From No. 8 Overall Pick
Dallas Cowboys22 hours ago

Tyron Smith Calling It A Career
23 hours ago

Omarion Hampton Visits With Bears
Tyreek Hill23 hours ago

Dolphins Not Pursuing A Trade Of Tyreek Hill
23 hours ago

Shedeur Sanders To Hold A Final Private Workout For Giants On Thursday
Green Bay Packers23 hours ago

Isaiah Simmons Visits With Packers
Courtland Sutton23 hours ago

Contract Talks With Courtland Sutton "Moving In The Right Direction"
Dak Prescott24 hours ago

To Be Limited During Voluntary Workouts
NFL24 hours ago

Travis Hunter Not Interested In Being Limited To One Side Of The Ball
Miami Dolphins24 hours ago

Dolphins, Jalen Ramsey Mutually Agree To Explore Trade Options
Alexander Volkanovski1 day ago

Reclaims Featherweight Title
Diego Lopes1 day ago

Drops Decision At UFC 314
Paddy Pimblett1 day ago

Remains Undefeated In The UFC
Michael Chandler1 day ago

Suffers TKO Loss
Frank Nazar1 day ago

Tallies Two Points In Victory
MMA1 day ago

Patricio Freire Gets Dominated In His UFC Debut
Yair Rodriguez1 day ago

Gets Back In The Win Column
Bryce Mitchell1 day ago

Gets Submitted At UFC 314
Jean Silva1 day ago

Gets Submission Win At UFC 314
Dominick Reyes1 day ago

Wins Third Fight In A Row
New England Patriots2 days ago

Abdul Carter Visiting With New England
2 days ago

Cam Skattebo Lined Up For Final Two Top-30 Visits
Dallas Cowboys2 days ago

Micah Parsons In Dallas For Voluntary Workouts
Chicago Bears2 days ago

Bears Extend Kyler Gordon
Austin Dillon2 days ago

Nabs His First Top-10 Finish Of The 2025 Season At Bristol
Ryan Blaney2 days ago

Bold Strategies Fall Flat, Still Musters A Top-Five Finish At Bristol
Christopher Bell2 days ago

Finishes In The Top 10 After Falling Back Midway At Bristol
Ty Gibbs2 days ago

Earns His First Top-Five Finish Of The 2025 Season At Bristol
Chase Briscoe2 days ago

Quietly Scores First Career Top-Five Finish At Bristol
William Byron2 days ago

Denny Hamlin Cuts Into William Byron's Points Lead
William Byron2 days ago

Makes Best Of His Mediocre Qualifying Run With Sixth-Place Finish
Alex Bowman2 days ago

Despite Engine Failure, Alex Bowman's Improved Speed Looks Promising
NASCAR2 days ago

A.J. Allmendinger Enters Playoff Picture With Surprise Bristol Top-10 Finish
Evan Engram3 days ago

Touts Bo Nix As A "True Weapon"
Arizona Cardinals3 days ago

Calais Campbell Still Feeling "Dominant" At Age 38
Kyle Larson3 days ago

Will Compete For The Win At Bristol
Chase Elliott3 days ago

Is One Of The More Favorable DFS Options Available For Bristol
William Byron3 days ago

Is A Solid DFS Option For Bristol Lineups
Tyler Reddick3 days ago

Could Tyler Reddick Be A Sneaky DFS Option For Bristol?
NASCAR3 days ago

Is Bubba Wallace Worth Rostering For Bristol This Week?
Ross Chastain3 days ago

Could Ross Chastain Be A Worthy DFS Choice For Bristol?
Carson Hocevar3 days ago

Is Carson Hocevar Worth Rostering For Bristol DFS Lineups?
NASCAR3 days ago

Should Fantasy Managers Avoid Rostering A.J. Allmendinger In DFS For Bristol?
Ryan Preece3 days ago

Is Ryan Preece Worth Rostering For Bristol Lineups?
Austin Dillon3 days ago

May Be One Of The Top Value Options For Bristol DFS This Week
Noah Gragson3 days ago

Should DFS Players Consider Noah Gragson For Bristol Lineups?
Riley Herbst3 days ago

Is In Play For Bristol DFS Lineups
Diego Lopes5 days ago

Can Become New UFC Featherweight Champion
Alexander Volkanovski5 days ago

Looks To Reclaim Featherweight Title
Paddy Pimblett5 days ago

Looks To Remain Undefeated In The UFC
Michael Chandler5 days ago

Set For Co-Main Event
MMA5 days ago

Patricio Freire Set For His UFC Debut
Yair Rodriguez5 days ago

Looks To Get Back In The Win Column
Jean Silva5 days ago

A Favorite At UFC 314
Bryce Mitchell5 days ago

Looks To Win Back-To-Back Fights
Dominick Reyes5 days ago

Set To Open Up UFC 314 Main Card
Nikita Krylov5 days ago

Looks For His Fourth Win In A Row