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Williams has been impressive to start the season, most recently catching five passes for 66 yards and a touchdown against the Los Angeles Rams in Week 4. Although there are obviously better options at the position, some fantasy managers may look at last week and Week 2 against the Jacksonville Jaguars as a reason to start Williams against the San Francisco 49ers. In what is a high-volume passing attack in Arizona, it is hard to predict who will be second and third in line for targets on any given week. Rondale Moore, A.J. Green, Christian Kirk, and Williams have all had their big games, so at this point, it is just a dart throw on who may find the end zone on a weekly basis.
It is worth noting that the two games DeAndre Hopkins had a limited role were the same weeks that Williams had his two best games. Hopkins was targeted just four times in Week 2 when Williams finished with seven receptions for 94 yards and was essentially taken out of the game plan in Week 5 when he was matched up with Jalen Ramsey. Hopkins will likely have a large role in this one to take advantage of the weak 49ers cornerbacks, as Davante Adams did in Week 3 with 13 catches for 132 yards and a score. This coupled with the fact that the San Francisco defense has allowed just 19 total fantasy points to tight ends in four games, Williams is an easy fade in Week 5.
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