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ANALYSIS: Did anyone see what DeAngelo Williams, the 32 year-old "washed up" running back did last week against the Patriots? In case you missed it, DeAngelo went for 132 total yards on 28 touches.
This week it's another Williams RB that could go off against the Pats run defense. Karlos Williams looked very explosive last week, turning six carries into 55 yards and a touchdown. LeSean McCoy is once again expected to play this week, but he's had issues practicing with a hamstring injury and is officially questionable.
The Bills have gone on record saying that they overused McCoy a bit in Week 1, so expect more Karlos Williams to be in the mix and if McCoy were to ever really aggravate the injury Williams would be the lead back.