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Welcome back RotoBallers to our Monday Night Football matchups analysis article for the 49ers vs. Vikings. Week 7 is almost in the books, and we'll get the final matchup of the week on Monday Night Football. It's been a fun and crazy week of NFL and fantasy football action filled with big performances, new players emerging, and many injuries around the league. Hopefully, you're on the verge of winning your matchups (or already have).
Now, we get one more game on Monday night to finish it off. Below you will find our matchups analysis for the Monday Night Football game between the San Francisco 49ers vs. Minnesota Vikings. Hopefully, it will be an exciting game that adds to a week filled with plenty of booms, busts, and injuries.
Read our fantasy football breakdowns for these games -- the recommended starts, sits, and matchups we love heading into the Week 7 matchup. Good luck RotoBallers!
Be sure to check all of our fantasy football rankings for the 2025 playoffs:- Quarterback fantasy football rankings
- Running back fantasy football rankings
- Wide receiver fantasy football rankings
- Tight end fantasy football rankings
- Kicker fantasy football rankings
- FLEX fantasy football rankings
- Defense (D/ST) fantasy football rankings
- Superflex fantasy football rankings
- IDP fantasy football rankings
- Dynasty fantasy football rankings
San Francisco 49ers at Minnesota Vikings
Spread: 49ers -6.5
Implied Total: 49ers (25.25) vs. Vikings (18.75)
Pace: 49ers (32nd) vs. Vikings (1st)
49ers Off. DVOA: 69.0% Pass (1st), 13.4% Rush (3rd)
Vikings Off. DVOA: 11.9% Pass (16th), -13.5% Rush (24th)
49ers Def. DVOA: -18.9% Pass (2nd), -4.3% Rush (22nd)
Vikings Def. DVOA: 6.7% Pass (15th), -10.9% Rush (16th)
Matchups We Love
Brandon Aiyuk (WR, SF)
There are lots of question marks for the 49ers this week, including Deebo Samuel. He suffered a shoulder injury and could miss this one. Regardless of whether he's out there or not, Aiyuk, who has been exceeding expectations in difficult matchups, would be a top-15 receiver against the Vikings. He'd move into the top 12 if Samuel is sidelined.
George Kittle (TE, SF)
It was another down day for Kittle, which is understandable against the Browns. With so many injuries to the offensive weapons, he gets a boost and becomes more reliable.
Matchups We Hate
Kirk Cousins (QB, MIN)
A dip in production and success without Justin Jefferson is reasonable, but 181 passing yards and one touchdown against the Bears is concerning. The offense really looked out of sync, and now they host the 49ers. Cousins is best avoided this week.
Other Matchups
49ers RBs
The ambiguous title here is because we don't know what will happen with Christian McCaffrey. Obviously, he's been sidelined with an oblique injury but it's too early to know his status for Monday night. What we do know is Elijah Mitchell and Jordan Mason will serve as his backups, making them the potential starters if he's out. No one can say for certain which of those two will be more valuable and play more snaps, but currently, Mitchell is our favorite given his history with the team. He's a risky flex option if McCaffrey is active with a top-24 upside if he's out. Mason would become an exciting flex option if McCaffrey is inactive.
Brock Purdy (QB, SF)
Purdy finally proved to be human. It only took playing the NFL's best defense, watching one of his two star receivers go down, and losing the best running back in the league to happen. You can't completely overlook how badly he performed, but there's no reason to make a mountain out of a molehill. So long as he has one of those two playmakers back to join Kittle and Aiyuk, he's a fringe top-12 QB against Minnesota.
T.J. Hockenson (TE, MIN)
Hockenson led the team in every receiving category except touchdowns. He's locked in because of his elite target share.
Vikings WRs
Both Jordan Addison and K.J. Osborn had 100% route participation, which is promising. They had an identical target share (17%) and targets per route run (15%) with Addison earning more downfield looks. He remains the more exciting young talent and the one to start. This week against San Francisco, they're both top-36 receivers.
Notable Injuries
Justin Jefferson (hamstring)
Christian McCaffrey (oblique, ribs)
Deebo Samuel (shoulder)
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