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There are a ton of key running backs dealing with injuries heading into the second round of the fantasy football playoffs, so fantasy managers should be ready to pivot should things go south for their premier back. It's never been more important to make the right start-or-sit decisions and we're here to help with Week 16 fantasy football running back rankings, as of December 22nd. Our goal is to help you set those winning lineups, so let's see where key running backs like Miles Sanders, Zack Moss, Jerick McKinnon, Zonovan Knight, and Latavius Murray rank, among others.
Our running back fantasy football rankings are put together by Nick Mariano, Brandon Murchison and Andersen Pickard. In addition to our staff rankings, below you will also find a summary of the important fantasy football injury news for this week. There are always key injuries to keep track of, so be sure to check back until kickoff.
You should also bookmark our fantasy football rankings portal and check back regularly for updates. In addition to these RB rankings, read our fantasy football articles and analysis - our NFL team discusses lineup sleepers, busts, NFL players to start and sit, waiver wire pickups and so much more. Most importantly, our brand new free mobile app is a must have - download it and configure your notifications. We deliver all the top NFL news, injuries, and fantasy analysis 24x7 with our free push notification alerts!
Be sure to check all of our fantasy football rankings for the 2025 playoffs:- Quarterback fantasy football rankings
- Running back fantasy football rankings
- Wide receiver fantasy football rankings
- Tight end fantasy football rankings
- Kicker fantasy football rankings
- FLEX fantasy football rankings
- Defense (D/ST) fantasy football rankings
- Superflex fantasy football rankings
- IDP fantasy football rankings
- Dynasty fantasy football rankings
Week 16 Running Backs Fantasy Football News and Injuries
- AJ Dillon Clears Concussion Protocol
- J.K. Dobbins Removed From Injury Report
- Nick Chubb Good To Go For Week 16
- Khalil Herbert Will Play In Week 16
- Jonathan Taylor Going On Injured Reserve
- Zonovan Knight Questionable For Thursday Night
- Jeff Wilson Jr. Hopeful To Play Sunday
- Tests Come Back Negative On Austin Ekeler
- Antonio Gibson Limited In Practice Tuesday
- Kenneth Walker III Misses Another Practice Wednesday
- Tony Jones Jr. Waived By The Seahawks
- DeeJay Dallas Returns To Practice Wednesday
- Aaron Jones Limited Wednesday With Knee Injury
- Latavius Murray Limited Wednesday
Week 16 Fantasy Football Running Back Rankings
You can also check out our Week 16 Half-PPR rankings and Standard rankings. A big congrats to our very own Nick Mariano who once again finished as a top-10 ranker in 2021 across the entire fantasy football industry!
Last updated on Thursday 12/22 at 2:00 pm ET:
| RB Tier |
RB Rank |
Player Name |
Pos. | Overall Rank |
| 1 | 1 | Derrick Henry | RB | 1 |
| 1 | 2 | Christian McCaffrey | RB | 2 |
| 1 | 3 | Austin Ekeler | RB | 5 |
| 1 | 4 | Josh Jacobs | RB | 6 |
| 1 | 5 | Dalvin Cook | RB | 9 |
| 2 | 6 | Saquon Barkley | RB | 10 |
| 2 | 7 | Rhamondre Stevenson | RB | 11 |
| 2 | 8 | Tony Pollard | RB | 13 |
| 2 | 9 | Aaron Jones | RB | 18 |
| 3 | 10 | James Conner | RB | 19 |
| 3 | 11 | Joe Mixon | RB | 21 |
| 3 | 12 | Jerick McKinnon | RB | 23 |
| 3 | 13 | Miles Sanders | RB | 24 |
| 3 | 14 | Najee Harris | RB | 25 |
| 3 | 15 | Alvin Kamara | RB | 26 |
| 3 | 16 | Ezekiel Elliott | RB | 29 |
| 3 | 17 | Travis Etienne Jr. | RB | 32 |
| 3 | 18 | Kenneth Walker III | RB | 33 |
| 3 | 19 | Raheem Mostert | RB | 35 |
| 3 | 20 | J.K. Dobbins | RB | 37 |
| 4 | 21 | Isiah Pacheco | RB | 39 |
| 4 | 22 | David Montgomery | RB | 45 |
| 4 | 23 | Latavius Murray | RB | 46 |
| 4 | 24 | Rachaad White | RB | 50 |
| 4 | 25 | D'Andre Swift | RB | 53 |
| 5 | 26 | Brian Robinson Jr. | RB | 55 |
| 5 | 27 | Zack Moss | RB | 56 |
| 5 | 28 | Nick Chubb | RB | 57 |
| 5 | 29 | AJ Dillon | RB | 59 |
| 5 | 30 | Devin Singletary | RB | 62 |
| 5 | 31 | Leonard Fournette | RB | 63 |
| 5 | 32 | Jamaal Williams | RB | 65 |
| 5 | 33 | Cordarrelle Patterson | RB | 69 |
| 5 | 34 | Tyler Allgeier | RB | 74 |
| 5 | 35 | Chuba Hubbard | RB | 78 |
| 6 | 36 | Zonovan Knight | RB | 79 |
| 6 | 37 | Cam Akers | RB | 80 |
| 7 | 38 | Deon Jackson | RB | 82 |
| 7 | 39 | D'Onta Foreman | RB | 87 |
| 7 | 40 | James Cook | RB | 93 |
| 7 | 41 | Kareem Hunt | RB | 106 |
| 7 | 42 | Gus Edwards | RB | 111 |
| 7 | 43 | Michael Carter | RB | 115 |
| 8 | 44 | Antonio Gibson | RB | 117 |
| 8 | 45 | Samaje Perine | RB | 120 |
| 8 | 46 | Jeff Wilson Jr. | RB | 132 |
| 9 | 47 | Jordan Mason | RB | 135 |
| 9 | 48 | Jaylen Warren | RB | 137 |
| 9 | 49 | Royce Freeman | RB | 144 |
| 9 | 50 | Marlon Mack | RB | 154 |
| 10 | 51 | Khalil Herbert | RB | 155 |
| 10 | 52 | Joshua Kelley | RB | 160 |
| 10 | 53 | Damien Harris | RB | 161 |
| 11 | 54 | Kenneth Gainwell | RB | 170 |
| 11 | 55 | Rex Burkhead | RB | 178 |
| 11 | 56 | Travis Homer | RB | 180 |
| 11 | 57 | Alexander Mattison | RB | 186 |
| 11 | 58 | Matt Breida | RB | 190 |
| 11 | 59 | Kyren Williams | RB | 193 |
| 11 | 60 | Dare Ogunbowale | RB | 200 |
| 12 | 61 | JaMycal Hasty | RB | 204 |
| 12 | 62 | Justin Jackson | RB | 207 |
| 12 | 63 | Ameer Abdullah | RB | 210 |
| 12 | 64 | Nyheim Hines | RB | 218 |
| 12 | 65 | Salvon Ahmed | RB | 221 |
| 12 | 66 | Boston Scott | RB | 223 |
| 12 | 67 | Pierre Strong Jr. | RB | 225 |
| 13 | 68 | Kevin Harris | RB | 230 |
| 13 | 69 | Ty Johnson | RB | 231 |
| 13 | 70 | Keaontay Ingram | RB | 233 |
| 13 | 71 | David Johnson | RB | 236 |
| 13 | 72 | Raheem Blackshear | RB | 237 |
| 13 | 73 | Gary Brightwell | RB | 240 |
| 13 | 74 | Hassan Haskins | RB | 241 |
| 13 | 75 | Justice Hill | RB | 243 |
| 13 | 76 | Kyle Juszczyk | RB | 248 |
| 13 | 77 | Isaiah Spiller | RB | 249 |
| 13 | 78 | Zamir White | RB | 250 |
| 13 | 79 | Julius Chestnut | RB | 252 |
| 13 | 80 | Darrynton Evans | RB | 254 |
| 13 | 81 | Kenyan Drake | RB | 255 |
| 13 | 82 | Malcolm Brown | RB | 257 |
| 13 | 83 | Corey Clement | RB | 262 |
| 13 | 84 | Benny Snell Jr. | RB | 263 |
| 13 | 85 | Jordan Wilkins | RB | 264 |
| 13 | 86 | Myles Gaskin | RB | 265 |
| 13 | 87 | Ronald Jones II | RB | 266 |
| 13 | 88 | Trayveon Williams | RB | 267 |
| 14 | 89 | Tony Jones Jr. | RB | 268 |
| 14 | 90 | Alec Ingold | RB | 269 |
| 14 | 91 | Eno Benjamin | RB | 270 |
| 14 | 92 | Avery Williams | RB | 271 |
| 14 | 93 | Trestan Ebner | RB | 272 |
| 14 | 94 | Patrick Ricard | RB | 273 |
| 14 | 95 | Zander Horvath | RB | 274 |
| 14 | 96 | C.J. Ham | RB | 275 |
| 14 | 97 | Snoop Conner | RB | 276 |
| 14 | 98 | Derek Watt | RB | 277 |
| 14 | 99 | Ke'Shawn Vaughn | RB | 278 |
| 14 | 100 | Tyrion Davis-Price | RB | 279 |
| 14 | 101 | Jonathan Williams | RB | 282 |
| 14 | 102 | Malik Davis | RB | 290 |
| 14 | 103 | Jakob Johnson | RB | 291 |
| 14 | 104 | Michael Burton | RB | 294 |
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