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Fantasy Football Injury Updates for Week 3: Justin Herbert, Jordan Love, Cooper Kupp, Joe Mixon, A.J. Brown

Jordan Love - Fantasy Football Rankings, Draft Targets, NFL Injury News

Two games into the NFL season, it already seems like every team in the league is missing somebody notable. Naturally, that will have a trickle-down effect for fantasy managers heading into Week 3.

Injury reports are filled with stars this week, ranging from Green Bay Packers quarterback Jordan Love to Los Angeles Chargers quarterback Justin Herbert to Philadelphia Eagles wide receiver A.J. Brown to Los Angeles Rams receiver Cooper Kupp. Not to mention the players already on IR like San Francisco 49ers running back Christian McCaffrey, Rams receiver Puka Nacua, and Miami Dolphins quarterback Tua Tagovailoa.

With significant updates forthcoming on Sunday, be sure to favorite the fantasy football player news page and download the RotoBaller fantasy football mobile app for free. This is the latest as of Saturday, Sept. 21.

Be sure to check all of our fantasy football rankings for 2025:

 

Jordan Love Injury Update

For a second consecutive week, the Green Bay Packers listed quarterback Jordan Love (knee) as questionable on their official injury report, according to Matt Schniedman of The Athletic.

Backup quarterback Malik Willis did enough in a run-heavy game plan to beat Indianapolis in Week 2, but the Packers aren't showing their cards about Week 3 at Tennessee just yet. Fantasy managers will likely have to check in before Sunday's early games to see if the Utah State product is deemed ready to return.

 

Justin Herbert Injury Update

Ahead of a their Week 3 game at Pittsburgh, Los Angeles Chargers quarterback Justin Herbert (ankle) is listed as questionable, according to Kris Rhim of ESPN.

Herbert told reporters that he was dealing with a high-ankle sprain he suffered last week, which casts doubt about whether he can return just seven days later. If the fifth-year pro can't go, Easton Stick would be the next man up for the Chargers.

 

Cooper Kupp Injury Update

The Los Angeles Rams already have ruled wide receiver Cooper Kupp (ankle) out of Sunday's game against San Francisco, according to the team's official injury report. 

The Rams are in bad shape, and Kupp's absence certainly won't help. With Puka Nacua on IR, the Rams will rely upon a combination of Demarcus Robinson, Tyler Johnson, Tutu Atwell, and Jordan Whittington at wide receiver against one of the top teams in the league.

 

A.J. Brown Injury Update

Philadelphia Eagles wide receiver A.J. Brown (hamstring) has been ruled out of the team's Week 3 visit to New Orleans, according to NFL Network's Tom Pelissero.

As expected, wide receiver DeVonta Smith was Philadelphia's target leader without Brown last week. However, after Smith, Britain Covey was the only Eagles receiver to earn more than one target. Running back Saquon Barkley and tight ends Dallas Goedert and Grant Calcaterra figure to have additional chances as pass catchers.

 

Kenneth Walker III Injury Update

The Seattle Seahawks officially listed running back Kenneth Walker III (oblique) as doubtful for their home date against Miami in Week 3.

Walker didn't play in the overtime win at New England, and the club appears slated to give him at least another week of rest. Zach Charbonnet, once again, will be the first choice out of the Seattle backfield.

 

Joe Mixon Injury Update

Houston Texans running back Joe Mixon (ankle) will go into Sunday's game at Minnesota with a doubtful designation, according to ESPN's Adam Schefter.

The Texans already ruled out backup running back Dameon Pierce (hamstring) against the Vikings. The backfield injuries slot in Cam Akers as the Texans' likely starter.

 

Deebo Samuel Injury Update

San Fransisco 49ers wide receiver Deebo Samuel (calf) will not play Sunday against the Los Angeles Rams, according to the team's official injury report.

Samuel always was a long shot to play after not practicing all week, so the designation was not a surprise. San Fransisco's passing offense will have to go through fellow wide receivers Brandon Aiyuk and Jauan Jennings.

 

George Kittle Injury Update

The San Fransisco 49ers' official injury report listed tight end George Kittle (hamstring) as doubtful for the Week 3 clash with the Los Angeles Rams.

Eric Saubert is likely to start at tight end in place of Kittle, but the 30-year-old has never caught more than 15 passes in a season. Fullback Kyle Juszczyk, who is fifth on the team in targets, could draw some extra attention this week.

 

Jordan Addison Injury Update

Minnesota Vikings wide receiver Jordan Addison (ankle) will miss the Week 3 game against Houston, but the team is hopeful he can return next week, according to Ben Goessling of the (Minneapolis) Star-Tribune. 

Minnesota has been one of the early surprises this season, with quarterback Sam Darnold and wide receiver Jalen Nailor combining for two touchdown connections through two weeks. The Michigan State product played 93% of snaps with Addison out last week, a number that is likely to stay elevated in Week 3.

 

Keenan Allen Injury Update

Chicago Bears wide receiver Keenan Allen (heel) has already been ruled out for the Bears' visit to Indianapolis in Week 3, according to the team's official injury report.

The struggling offense will play a second consecutive game without the veteran receiver, who was the targets leader for rookie quarterback Caleb Williams in Week 1. In the absence of the former Charger, fellow Chicago receiver DJ Moore drew a team-high 10 targets in last week's loss to Houston.

 

Rome Odunze Injury Update

Chicago Bears wide receiver Rome Odunze (knee) lost his injury designation heading into Chicago's Week 3 game at the Indianapolis Colts.

The Bears have managed only one offensive touchdown in eight quarters, with Williams still looking for his first NFL score. However, with Allen set to miss the game, Odunze could very well see an increase in targets against a shaky Colts defense.

 

David Njoku Injury Update

Cleveland Browns tight end David Njoku (ankle) will miss Cleveland's game against the New York Giants, according to Mary Kay Cabot of The Cleveland Plain Dealer.

The eighth-year tight end was replaced by Jordan Akins, who drew only one target in a Week 2 victory at Jacksonville. The Browns figure to lean mostly on receivers Amari Cooper, Elijah Moore, and Jerry Jeudy in the passing game.



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