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FanDuel Picks for Daily Fantasy Football Week 10: DFS Lineup Advice and Sleepers

How good is DeAngelo Williams? Seriously. That man has been on a tear with the starting job, and he has been one of my favorite players to watch and play in fantasy this season. Here are a few other guys I like, as well.

In this article, my FanDuel DFS lineup targets, I will be headlining a few of my top plays on FanDuel for Week 10 of the daily fantasy football season.

These DFS lineup picks can range from the elite tier of players to a few guys that I feel are a bit overpriced on FanDuel. Let's get to it!

Be sure to check all of our fantasy football rankings for the 2025 playoffs:

 

FanDuel DFS Quarterbacks for Week 10

Drew Brees - QB, NO (at WAS, $8,600)

Drew Brees is finally heating up, and he has been dominant over his last couple over starts. In those two games, he has combined for 78.68 fantasy points, and he gets another great matchup against the Redskins this week. The Saints defense tends to give up loads of points to even average offenses, which means the Redskins will likely be able to keep this one somewhat close. The Redskins also have a terrible defense, and this game should feature a ton of points. Brees is one of the best fantasy quarterbacks in the NFL right now, and he can be used in all leagues.

Blake Bortles - QB, JAC (at BAL, $7,800)

Bortles has really hit his stride recently, as he has scored over 20 fantasy points in three of his last four starts. Bortles has great upside because of his usage, as he has thrown the ball over 30 times in seven of his last eight starts, including four with 40+ attempts. He gets a great matchup against the Ravens, who have been one of the worst defenses in the NFL against opposing quarterbacks. Bortles has a strong group of wide receivers, and he has great upside. He has also played extremely well in plus matchups this season, and he can be used in all leagues.

 

FanDuel DFS Running Backs for Week 10

DeAngelo Williams - RB, PIT (vs CLE, $7,600)

Technically, Williams is listed as questionable for this week, but he is fully expected to play. In three starts this season, Williams is averaging 26.8 fantasy points. In those three games, he has 449 total yards and five touchdowns. He gets a great matchup this week against the Browns, who have struggled to stop the run this season. The Steelers will likely lean a bit more on Williams this week, as Ben Roethlisberger is expected to be out for a few weeks. Williams looked great last week, reading blocks well while dominating the Raiders defense. He can be used in all leagues this week.

James Starks - RB, GB (vs DET, $6,000)

Starks is a bit of a risky option, as he splits carries on a team that may choose to throw all game. Starks was recently named the starting running back by Mike McCarthy, which many expected, but it is now confirmed. Starks has good receiving ability, which gives him great upside, as he’ll likely only have 5-15 carries. Detroit has a terrible run defense, which gives Starks a bit more upside. He can be used in GPPs this week.

 

FanDuel DFS Wide Receivers for Week 10

Allen Robinson - WR, JAC (at BAL, $7,500)

Allen Robinson has been playing extremely well recently, recording 25 catches for 377 yards and four touchdowns over his last four games. He gets a great matchup against the Ravens, who have one of the worst secondaries in the NFL this season. Robinson flashed as a rookie last year, and now he is becoming a consistent NFL receiver. He’s an extremely safe option this week, and he makes a great pair with Blake Bortles, if you want to stack a quarterback and wide receiver.

Stefon Diggs - WR, MIN (at OAK, $6,600)

Diggs came back down to Earth last week, as he only caught three passes for 42 yards. Before that, however, he had recorded six or more catches in four consecutive games. He gets a great matchup against the Raiders this week (who are allowing 314.6 passing yards per game) which will give Diggs more than enough opportunities to get back on track. Even with his struggles last week, Diggs is a safe option, and his price tag isn’t all that high. He can be used in all leagues, especially if Bridgewater is cleared to play.

 

FanDuel DFS Tight Ends for Week 10

Rob Gronkowski - TE, NE (at NYG, $8,000)

Gronkowski is coming off an unproductive game, but the Patriots didn’t really need him to beat the Redskins. He gets a more favorable matchup this week against the Giants, who have really struggled to cover the tight end this season. The Gronk has already flashed his tremendous upside, but he has also been consistent in close games. That doesn’t mean the Giants will keep this one close, but they should be able to keep it close enough that the Patriots continue to throw the ball. In that situation, Gronk should dominate.

Austin Seferian-Jenkins - TE, TB (vs DAL, $5,300)

Seferian-Jenkins has to be in one of my least-favorite situations in the NFL. Last week, he was a full participant in practice, and then was ruled out for the game. This week, he has been limited in practice, and he remains questionable. If ASJ suits up, he’ll make a great play--that's a big if, though. Lovie Smith loves benching guys until they are fully healthy, but ASJ has to be close at this point. He’s a mountain of a man with great speed and hands. He has all the potential in the world, and his price is low because of his current injury situation.

 

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