X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

DraftKings CFB DFS Lineup Picks: Daily Fantasy College Football (10/22/21)

Mike Marteny's DraftKings daily fantasy college football lineup picks for 10/22/21. His CFB DFS lineup picks and DFS sleepers will help you win big.

We have a pretty busy Friday night as well before Saturday's extravaganza. We have four games tonight in the college football universe. We start early with Middle Tennessee State heading up to Hartford to take on UConn. As night falls, Memphis heads down to the Bounce House to take on the beaten up Central Florida team.

We close off with a couple of games out West. First, we have Colorado State heading over the Logan in what has become an interesting rivalry. We close out with some Pac 12 action with Arizona, still looking for that elusive win, hosting Washington. This is going to be a high-scoring one!

In this article, I will be providing you with my daily fantasy college football lineup picks for DraftKings on 10/22/21 locking at 6 pm eastern. I’ll be providing multiple player suggestions for players at guard and forward, aiming to highlight one option apiece at the high, middle, and lower end of the salary scale. Good luck, RotoBallers.

Featured Promo: Get any DFS Premium Bundle for for 30% off using code NEW! Win more with expert advice from proven winners and exclusive DFS tools. Get instant access to RotoBaller's Lineup Optimizers, Research Stations, daily picks and VIP chat rooms across 10 sports! Go Premium, Win More!

 

DraftKings CFB DFS Quarterbacks

Seth Henigan, Memphis ($9,000)

Henigan only threw 12 passes against Navy, completing eight of them. Those eight completions still netted 215 yards and two touchdowns. He'll need to throw more passes against UCF (maybe), so his upside is tangible. He threw 57 passes in week 6 against Tulsa and had three straight 300+ yard passing games before the Navy game. If nothing else, Henigan proved that he doesn't need a ton of volume to still put up a good total. He's hard to fade in cash games, but there is the chance that Memphis will run for much of the second half if they get up big again.

Chase Cunningham, Middle Tennessee State ($7,100)

Cunningham has thrown for 714 yards and nine touchdowns with only two interceptions in his three games as a starter. The MTSU run game has been kind of a mess this year. They will try to get on track against UConn, but I still see the Blue Raiders using this game to let Cunningham explore the offense a little more. This game will never be in question, but the Blue Raiders may keep him out there for at least three quarters anyway to get him more reps. There is still upside here.

Dylan Morris, Washington ($6,500)

This is still a tough one even though Arizona is winless. For the most part, the defense hasn't been the issue for the Wildcats. Washington has had trouble running the ball and I think they will try to take this chance to get Morris back into his comfort zone. Both Oregon State and UCLA tested him big time in close losses. I expect the Huskies to try and get Morris his confidence back, which could me a larger workload than normal. What he does with it is anyone's guess.

Also consider: Logan Bonner, Utah State ($7,700); Todd Centeio, Colorado State ($7,400); Mikey Keene, Central Florida ($6,100)

 

Want some more CFB DFS tools? If you like what you see here, don't forget to sign up for your RotoBaller CFB DFS Premium Pass. Use code MARTENY and receive 10% off your purchase! You'll love the College Football DFS Lineup Optimizer, DFS Cheat Sheets Premium Slack Chatrooms to help you out in real-time.

 

DraftKings CFB DFS Running Backs

Brandon Thomas, Memphis ($6,800)

UCF holding Boise to 20 rushing yards in the opener is a distant memory. They were split wide open by both Navy and Cincinnati, who both gouged them for over 300 yards. This isn't your normal Memphis run game, but Thomas has proven to be a capable runner so far for the Tigers. He has yet to hit triple digits, but he has scored three touchdowns in the last two games. Memphis has proven they will take the air out of the ball if they get a big lead. This feels like the most likely scenario to me here.

David Bailey, Colorado State ($6,000)

The Boston College transfer followed Steve Addazio to Fort Collins and it has been a mostly fruitful trip for him. He piled up two touchdowns against New Mexico last week after a forgettable game against Iowa. With Bailey fully healthy, this is a big spot for him. Utah State has allowed six rushing touchdowns in the last two games, not to mention the 440 yards. The Rams have no issue committing to the run with talented backs like Bailey and A'Jon Vivens. I like both of them here.

Chaton Mobley, Middle Tennessee State ($4,900)

Mobley led the Blue Raiders in rushing against Liberty in Week 6 with eight yards. EIGHT! That highlights how forgettable that game was for the entire offense. The unit will forget tonight against UConn, one of the worst teams on the planet at any level. Mobley ran for 132 yards against Marshall, so he has it in him to put together a strong game. If he's ever going to again, it will be here.

Also consider: Isaiah Bowser, Central Florida ($6,500); Kamari Pleasant, Washington ($5,500); Michael Wiley, Arizona ($4,400); Marquavius Weaver, Memphis ($3,500)

 

DraftKings CFB DFS Wide Receivers

Calvin Austin III, Memphis ($9,200)

Austin was an afterthought in the passing game against Navy, but he still had a 69-yard rushing touchdown on a jet sweep to help salvage his day. Of course, with the price this high, we need more than the bare minimum from him. I do expect more from the Memphis aerial show here against UCF, but don't expect a ceiling game either. I don't see the Knights hanging around.

Deven Thompkins, Utah State ($8,700)

Only Boise State has succeeded in slowing down Thompkins. He still hit double-digit DraftKings points, but Thompkins' low mark aside from that game is 24.8 in the opener against Washington State. He cleared 45 last week against UNLV. The ceiling is much higher on Thompkins here. His target share alone makes him the most likely to break the slate in a GPP, though Austin might be better suited for cash games.

Jarrin Pierce, Middle Tennessee State ($5,800)

The MTSU passing attack is still learning on the fly with a new quarterback installed mid-season, but it has worked out well for Pierce. He has a touchdown in four straight games. The yardage isn't always there, but it's nice to know that Chase Cunningham has a target on Pierce first in the red zone. That makes him less risky than his peers in the receiver room for MTSU.

Keelan Marion, Connecticut ($5,200)

The loss of Tyler Phommanchanh really hurt the UConn passing attack, but Marion has still managed to catch ten passes, including three touchdowns, over the last three games. He's the only UConn player that I would consider despite MTSU's defense being a work in progress. Marion is the only one that I feel I can trust in any capacity. If you're the riverboat gambler type, a couple of UConn pieces could be optimal in a large field GPP.

Also consider: Stanley Berryhill III, Arizona ($6,700); Ryan O'Keefe, Central Florida ($6,100); Sean Dykes, Memphis ($5,600); Rome Odunze, Washington ($4,600)

 

More College Football Analysis

More DFS Lineup Picks

POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

J.T. Realmuto23 mins ago

Alec Bohm Resting On Sunday
D'Angelo Russell24 mins ago

Sidelined On Sunday
Nicolas Claxton32 mins ago

Won't Play Versus Toronto
Jacob Young35 mins ago

Out Again On Sunday
MLB40 mins ago

Braves-Marlins Postponed On Sunday
Josh Jung47 mins ago

To Travel With Rangers To Chicago
Richard Fitts53 mins ago

Hunter Dobbins To Debut On Sunday, Richard Fitts Pushed To Monday
Pascal Siakam56 mins ago

Ruled Out On Sunday
Orlando Arcia58 mins ago

Nick Allen Heads To Bench, Orlando Arcia Back At Shortstop
Nestor Cortes1 hour ago

Placed On 15-Day Injured List
Xavier Edwards1 hour ago

Scratched With Knee Soreness
Luis Torrens1 hour ago

Remains Out With Forearm Injury
Nick Fortes2 hours ago

Remains Sidelined On Sunday
Matt McLain2 hours ago

Not Playing On Sunday
Wilyer Abreu2 hours ago

Sitting For Game 1
Cody Bellinger2 hours ago

Active On Sunday
Chris Bassitt3 hours ago

Strikes Out Nine In No-Decision
Robert Thomas3 hours ago

Totals Four Points As Blues Keep Winning
David Pastrnak3 hours ago

Records Season-High Five Points In Saturday's Win
Ryan McMahon3 hours ago

Hits Home Run No. 1 On Saturday
Jacob Markstrom3 hours ago

Extends Winning Streak With Special Shutout
Shea Theodore3 hours ago

Matches Franchise Record With Big Effort Saturday
Carlos Santana3 hours ago

Homers In Another Multi-Hit Effort
Darcy Kuemper4 hours ago

Collects Fifth Shutout Of The Season
Evgenii Dadonov4 hours ago

Ends Scoring Drought With Hat Trick
Jorge Soler4 hours ago

Hits Two-Run Home Run On Saturday
Sidney Crosby4 hours ago

Bags 14th Career Hat Trick
Mike Trout4 hours ago

Homers In Third Straight Game On Saturday
Matt Mervis4 hours ago

Homers Twice, Collects Three RBI
Denny Hamlin5 hours ago

Starts Third At Darlington, One Of His Top Tracks
Chase Elliott5 hours ago

Will Start 15th At Darlington This Week
Jung Hoo Lee5 hours ago

Hits Two Doubles, Scores Twice
NASCAR5 hours ago

Is Bubba Wallace Worth Rostering For Darlington This Week?
Jesse Winker5 hours ago

Hits Two Triples, Brings In Two Runs
Tyler Reddick5 hours ago

Is One Of The Top Favorites To Win At Darlington
Joey Logano7 hours ago

Increased Speed But Worse Results Make Darlington Outcome Unclear
Chase Briscoe7 hours ago

Likely To Benefit From Toyota Speed At Darlington
Ross Chastain7 hours ago

Is One Of The Best DFS Options
Carson Hocevar7 hours ago

Still A Work In Progress
Chris Buescher7 hours ago

Likely Motivated After Last Year's Darlington Near Miss
Ty Gibbs7 hours ago

Returns To Site Of Best Career Finish
Michael McDowell7 hours ago

Probably Won't Overcome Darlington Mediocrity
Ricky Stenhouse Jr7 hours ago

. Likely Needs Attrition To Earn A Good Darlington Result
Noah Gragson7 hours ago

Looks To See if Xfinity Series Success At Darlington Can Carry Over
AJ Allmendinger7 hours ago

A.J. Allmendinger Has Never Earned A Top-10 Finish At Darlington
Riley Herbst7 hours ago

For Riley Herbst, Rookie Inexperience Likely To Overcome Toyota Speed Advantage
Cody Ware7 hours ago

Seems Worse Than Before His Suspension
JJ Yeley7 hours ago

J.J. Yeley Qualifies Last For Third Time In 2025
Christopher Bell7 hours ago

Should DFS Players Roster Christopher Bell At Darlington?
Alex Bowman8 hours ago

Presents Huge Upside For Darlington DFS Lineups
Ryan Preece8 hours ago

Is An Intriguing Tournament Option For Darlington
Daniel Suarez8 hours ago

Is Daniel Suarez Worth Rostering At Darlington?
New Orleans Saints14 hours ago

Terron Armstead Retires
Giannis Antetokounmpo18 hours ago

Will Play On Saturday Night
Ja Morant18 hours ago

A Late Scratch On Saturday
Tobias Harris18 hours ago

Out Again On Saturday Night
Cade Cunningham18 hours ago

Cleared To Suit Up On Saturday
Jalen Duren18 hours ago

Ruled Out Versus Memphis
Tyler Herro19 hours ago

Ruled Out On Saturday Night
Sam Montembeault19 hours ago

Looks To Extend Winning Streak Against Flyers
Anthony Stolarz19 hours ago

Starts Saturday Night
Jonas Johansson19 hours ago

Takes Over Lightning Crease Saturday
Brady Tkachuk19 hours ago

Ruled Out For Sunday
James van Riemsdyk20 hours ago

Rejoins Blue Jackets Lineup Saturday
Ilya Samsonov20 hours ago

Remains Out On Saturday
Jordan Staal20 hours ago

Out Against Bruins
Mitchell Robinson22 hours ago

Ruled Out Versus The Hawks
Cameron Payne22 hours ago

Back On Saturday
Jalen Brunson22 hours ago

Out On Saturday, Expected To Play On Sunday
Tobias Harris23 hours ago

Questionable Against Memphis
Cade Cunningham23 hours ago

Expected To Play Versus Memphis
Trae Young23 hours ago

Available On Saturday
23 hours ago

Deion Sanders Thinks Shedeur Sanders, Travis Hunter Should Go 1-2 In Draft
Mika Zibanejad1 day ago

Good To Go Against Devils
Cody Glass1 day ago

Expected To Return Against Rangers
Tomas Tatar1 day ago

Available For Saturday's Matinee
Seamus Casey1 day ago

Re-Enters Devils Lineup Saturday
Shakir Mukhamadullin1 day ago

Out On Saturday
Eeli Tolvanen1 day ago

Could Be Ready To Return Saturday
Jaden Schwartz1 day ago

A Game-Time Call Saturday
Denver Broncos2 days ago

Dondrea Tillman Signs Exclusive-Rights Tender
Kansas City Chiefs2 days ago

Janarius Robinson Agrees To Join The Chiefs
New York Jets2 days ago

Tony Adams Signs Tender
Cameron Payne2 days ago

Questionable Versus Atlanta
Miles McBride2 days ago

Still Out On Saturday
Jalen Brunson2 days ago

Might Return To Action On Saturday
Arizona Cardinals2 days ago

Jake Curhan Heading To Arizona
Julio Jones2 days ago

Announces Retirement
Cade Cunningham2 days ago

Out Of Action Friday
Trey Lance2 days ago

Chargers Sign Trey Lance
Brandon Ingram2 days ago

Could Be Cleared For Full Practice Next Week
Gradey Dick2 days ago

Out For Remainder Of Season
Arizona Cardinals2 days ago

Kelvin Beachum Re-Signs One-Year Deal With Cardinals
NFL2 days ago

Travis Hunter To Run Routes At Pro Day On Friday
Josh Emmett2 days ago

An Underdog At UFC Vegas 105
Dallas Cowboys2 days ago

Cowboys Still Searching For Their Lead Running Back
Lerone Murphy2 days ago

A Favorite At UFC Vegas 105
Pat Sabatini2 days ago

Looks To Win Back-To-Back Fights
Joanderson Brito2 days ago

Looks To Get Back In The Win Column
Cortavious Romious2 days ago

Looks For His First UFC Win
ChangHo Lee2 days ago

Looks For His Second UFC Win
Brad Tavares2 days ago

Set For Middleweight Bout
Gerald Meerschaert2 days ago

Set For His 23rd UFC Bout
Luis Gurule2 days ago

Looks To Remain Undefeated
Ode' Osbourne2 days ago

In Dire Need Of Victory
Robert Valentin2 days ago

Set To Open Up UFC Vegas 105 Main Card
Torrez Finney2 days ago

Set For UFC Debut
Miles Boykin3 days ago

Heading To Chicago
Baker Mayfield3 days ago

Tampa Bay Restructures Baker Mayfield's Deal
Case Keenum3 days ago

Chicago Signs Case Keenum To One-Year Deal
Trey McBride3 days ago

Cardinals Making Trey McBride The Highest-Paid Tight End In NFL History
Geno Smith3 days ago

Raiders, Geno Smith Agree To Two-Year Extension
3 days ago

Tyler Shough Could Be Day 2 Pick In NFL Draft
Dallas Cowboys3 days ago

Shemar Stewart Meeting With Cowboys Staff
New York Giants3 days ago

Travis Hunter The Likely Pick For Giants?
Dallas Cowboys3 days ago

DeMarvion Overshown Aiming For Comeback Player Of The Year Award
Washington Commanders3 days ago

Commanders Sign T.J. Maguranyanga
Cameron Young4 days ago

A Player To Avoid At Valero Texas Open
Kurt Kitayama4 days ago

In Search Of Consistency At Valero Texas Open
Si Woo Kim4 days ago

Looking To Bounce Back At Valero Texas Open
Tom Hoge5 days ago

Looking To Build Off Strong Performance At The PLAYERS Championship
Matt Fitzpatrick5 days ago

Looking For Consistency At Valero Texas Open
Corey Conners5 days ago

Continues Strong Form Ahead Of Valero Texas Open
Patrick Cantlay5 days ago

Eyeing Victory At Valero Texas Open
Gary Woodland5 days ago

Showing Great Form Ahead Of Valero Texas Open
Akshay Bhatia5 days ago

Aiming For Repeat At Valero Texas Open
Alejandro Tosti5 days ago

A Volatile Choice At TPC San Antonio
Jordan Spieth5 days ago

Needs To Find Consistency At TPC San Antonio
Jake Knapp5 days ago

Making First Appearance At Valero Texas Open
Michael Kim5 days ago

Looking To Find The Magic Again In San Antonio
Tommy Fleetwood5 days ago

Is Nearly A Must-Play At Valero Texas Open
Tony Finau5 days ago

Hoping For Better Approach Play In San Antonio
Eric Cole5 days ago

Trending In Right Direction Ahead Of Valero
Sam Stevens6 days ago

Enjoys Nice Result In Houston
PGA6 days ago

J.T. Poston Seeks To Contend At Valero Texas Open
Denny McCarthy6 days ago

Keeps Making Cuts But Needs To Make More Putts
Brian Harman6 days ago

Off To A Subpar 2025 So Far
Brandon Moreno6 days ago

Wins Back-To-Back Fights
Steve Erceg6 days ago

Losses Third Consecutive Fight
Drew Dober6 days ago

Gets Knocked Out At UFC Mexico City
Manuel Torres6 days ago

Gets Back In The Win Column
Harry Hall6 days ago

Bounces Back In Houston Last Week
CJ Vergara6 days ago

Gets Submitted
Édgar Cháirez6 days ago

Edgar Chairez Gets Submission Win At UFC Mexico City
Vince Morales6 days ago

Drops Decision At UFC Mexico City
Raul Rosas Jr.6 days ago

Gets Decision Win At UFC Mexico City
Saimon Oliveira6 days ago

Still Winless In The UFC
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF

MORE RECENT ARTICLES

 
Jaxson Dart - College Football Rankings, NCAA CFB DFS Lineup Picks

Fantasy Football Dynasty Rookie Draft: Superflex, 12-Team (2025)

Don't we all love mock drafts? I sure do. The monotony of them can get... monotonous after a while when the vast majority of them just have short, shallow write-ups of each player without giving an emphatic, helpful take on each. I hope to do the opposite. Considering how far consensus can be (and usually […]


Marvin Mims Jr. - Fantasy Football Rankings, Draft Sleepers, NFL DFS Picks

Next Gen Stats Review: 2025 Wide Receiver, Tight End Fantasy Football Outlooks

Last season, we covered Next Gen Stats for receivers and tight ends. It's fun to look at different advanced stats after the previous season's digests. There's no rest because many of us dive into the 2025 prospect class leading to the NFL Draft. We're using a mixture of the publicly available Next Gen Stats and […]


Ja'Marr Chase - Fantasy Football Rankings, NFL Injury News, DFS Lineup Picks

Early 2025 Fantasy Football Mock Draft: 12-Team, Single QB

There's never any reason not to do more fantasy football mock drafts and break down the efficacy of every pick. Or so the saying goes. Sun-Tzu probably said that in The Art of War. I haven't read the whole thing, so I'm not sure. Either way, it's never not interesting to speculate on what the […]


Cam Ward - College Football Rankings, NCAA CFB DFS Lineup Picks, NFL Draft Prospect

NFL Draft Predictions - 2025 First Round Mock Draft (Post-Free Agency)

It seems like the Super Bowl was just yesterday, but in reality, the NFL offseason is chugging right along. We have gone through the Senior Bowl, the first waves of free agency, and the NFL Combine. In just a few short weeks, we will have the NFL Draft. This draft class is unique, with a […]


Top 10 Fantasy Football Busts Of All Time - Le'Veon Bell, Peyton Hillis, LeSean McCoy, and more

Fantasy football managers have the fear of picking busts fresh in their minds every season because every year, players who are thought to be headed for productive seasons, whether due to injury, not reaching overly high expectations, or other reasons, bust hard. Those who drafted San Francisco 49ers running back Christian McCaffrey are well aware […]


Mark Andrews - Fantasy Football Rankings, Draft Sleepers, Waiver Wire Pickups

Every AFC Team's Most Overvalued Dynasty Fantasy Football Player

The 16 teams that comprise the AFC all have players that I don't think are worth, on their own, what you could get for them in trades as compensation. Not all of them are bad players, though. In fact, some of them are quite good. "Most overvalued" is a relative thing. And since there's not […]


Jayden Daniels - Fantasy Football Rankings, NFL Injury News, DFS Lineup Picks

Free Agency Check - Fantasy Football Quarterback ADP Risers and Fallers

This NFL offseason has been incredible. With big-name free agents shuffling around the league, 2025 looks like an exciting season, and we haven’t even had the draft yet! Over the last few offseasons, we have seen a massive increase in quarterbacks switching teams. This season, the list includes Russell Wilson, Sam Darnold, Geno Smith, Justin […]


Kenneth Walker III - Fantasy Football Rankings, Draft Sleepers, Waiver Wire Pickups

Running Back Next Gen Stats Review - Fantasy Football Outlooks For 2025

After the 2023 season, we covered Next Gen Stats for the running back position. We highlighted rush yards over expected per attempt and the percentage of carries with eight defenders in the box. Now, it's time to examine the Next Gen Stats for running backs again, but we'll mix in other advanced metrics. Unsurprisingly, rush […]


Cooper Kupp - Fantasy Football Rankings, NFL Injury News, DFS Lineup Picks

Dynasty Fantasy Football Buy or Sell: DK Metcalf, Cooper Kupp, Davante Adams

Pittsburgh Steelers wide receiver DK Metcalf, Seattle Seahawks wide receiver Cooper Kupp, and Los Angeles Rams wide receiver Davante Adams all landed in new teams ahead of the 2025 season. Formerly of the Seahawks, Rams, and New York Jets, all three of these wideouts' fantasy football values have undergone marked shifts after landing at their […]


UFL DFS PICKS, FANTASY FOOTBALL, DRAFTKINGS, FANDUEL

UFL DFS Lineup Picks: DraftKings Daily Fantasy Fantasy Advice for Week 2

Welcome to Week 2 of the inaugural UFL season, RotoBallers! We already have one week in the books, with the XFL teams off to a hot start at 3-1 while the USFL conference went 1-3. We have Houston squaring off against Arlington in the early game and San Antonio versus St. Louis in the later […]


Michael Florio's Football Show - Podcast RotoBaller Network

Florio's Football Show: NFL Draft QB Scouting Report!

Michael F. Florio gives his scouting report for the 2025 NFL Draft QB class. Do Cam Ward and Shedeur Sanders live up the hype? Should you be excited about Jaxson Dart and Jalen Milroe? Plus, he goes over the deeper options in this class! Be sure to also tune into RotoBaller Radio on SiriusXM (SiriusXM channel […]


UFL RANKINGS, FANTASY FOOTBALL,

UFL Best Bets: Week 2 Picks

Well, the opening week is always full of curveballs, and 2025 was no exception. We actually saw the Birmingham Stallions lose a game, looking bad in the process. Overall, I went 3-3-1 on spreads and over/unders last week, so a bit inconvenient that neither parlay worked out. It is a short season, so the pressure […]


Isaiah Bond - College Football Rankings, NCAA CFB DFS Lineup Picks - NFL Draft

Dynasty Fantasy Football Rookie Sleepers: 5 Undervalued Draft Targets

We all know at this point who the top names are heading into the 2025 NFL Draft. Ashton Jeanty will be the dynasty rookie RB1. Tetairoa McMillan will be the rookie WR1. But fantasy leagues aren't won just by getting a top-2 or three rookie pick and grabbing the best guys. Rookie drafts are also […]