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We're already onto Week 6 of the 2022 NFL season and stashing players for short or long-term upside is important as the fantasy football playoffs will be here before you know it. These fantasy football waiver wire pickup suggestions are for fantasy managers in deep leagues of 14-teams or more or a higher number of bench spots than traditional fantasy leagues. Some players on this list like DeeJay Dallas and Mike Boone are simply wild cards since they're not locked into defined starting roles, but have value in deep leagues as RB handcuffs. Wide receivers like Rondale Moore and Khalil Shakir aren't going to pay off week-to-week but should now be on the fantasy radar after solid performances.
In these kinds of leagues, stashing lotto-ticket plays is paramount for future upside. Even players who are currently buried on the depth chart or have seen minimal work thus far could prove to be valuable pieces at some point in the long NFL season. If we can identify deep league sleepers early, it can help you win your league down the road. With Week 6 marking the beginning of teams on bye weeks, the waiver wire has never been more important this season.
As always, these players are usually cheap to obtain and can be dropped if it's clear they won't have value after a few weeks. With five weeks of data to examine, advanced stats and fantasy statistics carry more weight for the rest of the season. Buckle up, because it's time to do another deep dive of the Week 6 waiver wire.
Be sure to check all of our fantasy football rankings for the 2025 playoffs:- Quarterback fantasy football rankings
- Running back fantasy football rankings
- Wide receiver fantasy football rankings
- Tight end fantasy football rankings
- Kicker fantasy football rankings
- FLEX fantasy football rankings
- Defense (D/ST) fantasy football rankings
- Superflex fantasy football rankings
- IDP fantasy football rankings
- Dynasty fantasy football rankings
Fantasy Football Waiver Wire Targets for Week 6
DeeJay Dallas slots into the RB2 role in the wake of Rashaad Penny's season-ending leg injury. Kenneth Walker is already rostered in deep leagues, but he's the guy to target if he's still out there. If not, Dallas will have some standalone value as his handcuff.
Mike Boone might be a chalky waiver add after his totaled 10 touches for 85 yards on Thursday night against the Indianapolis Colts, but he's worth adding if available. In deeper leagues, Latavius Murray is in play as an injury handcuff to Boone or Melvin Gordon.
Eno Benjamin charted 11 touches and a touchdown with James Conner and Darrell Williams banged up in Week 5. Conner's injury seems to be minor, but Benjamin should be stashed as a handcuff with injury concerns beginning to pop up.
Jerick McKinnon and Isiah Pacheco should continue to be on the fantasy radar, despite Clyde Edwards-Helaire looking like a breakout candidate in 2022. CEH has dealt with injuries throughout his young career, and this backfield is still a committee until further notice.
Caleb Huntley and Avery Williams look to be in a committee backfield with rookie Tyler Allgeier, and in deep leagues, any running back with any size workload has value. If there's another injury to this backfield, Huntley or Williams could see an increased role. It's worth noting Damien Williams (ribs) could be back soon, too.
Boston Scott was inactive in Weeks 4 and 5, but he's just one Miles Sanders or Kenneth Gainwell injury away from a major role in the dominant Eagles' rushing attack, so he's a solid deep league lotto ticket for late-season upside.
Joshua Kelley saw 12 touches for 82 total yards and a touchdown in the win against the Cleveland Browns. He's starting to pull away from Sony Michel as the Chargers' RB2. If Ekeler has to miss any time at some point this season, Kelley's ceiling is sky-high in an explosive offense. Michel is still worth rostering in even deeper leagues.
Tevin Coleman has emerged as the second running back behind Jeff Wilson Jr. for the 49ers. Coleman charted 11 touches for 67 yards and two touchdowns in the win against the Panthers, so he's worth rostering, even if his role drops to a mere handcuff. That said, there might be some competition to acquire him after the big fantasy output.
Jaylen Warren should remain on the fantasy radar even with Najee Harris being the workhorse back in Pittsburgh. Harris has been largely ineffective, so Warren could see more work moving forward. He'd step into a workhorse role in the case of a Harris injury.
Ty Montgomery was injured in his first game with the New England Patriots but could return as the lead third-down back as early as Week 7. With Damien Harris (hamstring) picking up an injury, Montgomery is worth adding on your IR spot on fantasy rosters.
Chuba Hubbard and D'Onta Foreman would likely share touches in the Panthers' offense if Christian McCaffrey, who has already been on the injury report, misses time this season. Their ceilings would be low in an awful offense, but the fantasy RB position is in a rough place right now, so either could have value later on.
Craig Reynolds eclipsed 90 yards against the New England Patriots, and although D'Andre Swift (shoulder, ankle) could return after the Lions' Week 6 bye, Reynolds is a handcuff for both Swift and Jamaal Williams with standalone value.
Samaje Perine is a premier handcuff in a top-tier offense in the NFL, so despite not having standalone value every week, he's a solid bench stash in case of a Joe Mixon injury and has had some decent fantasy production this year.
Skyy Moore is beginning to get involved in the high-powered Kansas City Chiefs offense, so he has sneaky value for fantasy managers in trouble at wide receiver.
Rondale Moore appears to finally be healthy, and he grabbed seven passes for 68 yards against the Philadelphia Eagles. His value will decrease when DeAndre Hopkins (suspension) returns to the offense, but for now, he's worth stashing.
Khalil Shakir took advantage of his increased role, catching three of his five targets for 75 yards and a touchdown against the Pittsburgh Steelers. With Jamison Crowder (ankle) done for the season, he's worth picking up as a "handcuff" to Isaiah McKenzie. Shakir won't have a significant role each week, but Buffalo receivers continue to deal with injuries.
Donovan Peoples-Jones continues to be active in the Cleveland Browns offense. He isn't necessarily worth picking up right now, but keep him on your radar for later in the season when Deshaun Watson makes his season debut.
Josh Reynolds is productive any time he's placed in a significant role and has value in deep leagues until Jameson Williams (knee) comes back and commands snaps. D.J. Chark (ankle) and Amon-Ra St. Brown (ankle) continue to battle injuries. Reynolds is a top wide receiver "handcuff."
Wan'Dale Robinson and Darius Slayton could serve as the Giants' top two wide receivers when everyone gets healthy, and the New York offense led by Daniel Jones looks surprisingly competent.
Treylon Burks is going to fall off some fantasy managers' watchlist after suffering a turf toe injury that placed him on injured reserve, but his injury is minor from a long-term perspective, and he's still worth rostering for the chance of a late-season breakout. It also helps he can be stashed in the injured reserve spot on your fantasy roster.
Kyle Philips and Nick Westbrook-Ikhine are going to see extra snaps and targets while Treylon Burks (foot) has to miss time.
Hayden Hurst now has 20 receptions for 157 yards and two touchdowns on the season, and he's worth picking up after a breakout performance on Sunday Night Football in Week 5.
Tyler Conklin saw at least seven targets in all three of Joe Flacco's starts and caught three-of-five targets for 52 yards in Zach Wilson's season debut. He posted a goose egg in Week 5, but he should remain on the fantasy radar unless he posts another dud performance next week.
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