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Hopkins is in for all he can handle against Jalen Ramsey and the Los Angeles Rams on Sunday. He is obviously one of the best receivers in the NFL and a must-start option on a weekly basis, but fantasy managers could be in for the second consecutive dud performance from the Arizona Cardinals’ No.1 wideout. Hopkins finished with just three receptions for 21 yards against the weak Jacksonville Jaguars defense in Week 3, but this could have been because he was dealing with a rib injury and was questionable to play the entire week. However, his usage the past two games hasn't been all that inspiring as he has been targeted 10 times total and amassed just 75 receiving yards.
Historically, Hopkins hasn't exactly gotten the better of Ramsey all that often. In nine career matchups, he has averaged six receptions for 66 yards and scored four total touchdowns. A lot of volume could potentially salvage a lack of efficiency in this one, but it is hard to believe quarterback Kyler Murray will be looking for his stud receiver all that often if he is being shadowed by the league’s No. 1 cornerback. Murray has shown he can spread the ball around the field, as we have already seen numerous big fantasy performances from Rondale Moore, Christian Kirk, and A.J. Green to start the season. Once again, unless you play in a very shallow league, you likely can’t afford to sit your WR1.
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