
Mayfield could be in for another rough outing for fantasy managers against the Los Angeles Chargers pass defense that has given up the fifth-fewest passing yards through the first four weeks of the season. Considering how run-heavy the Cleveland offense is, we will likely be seeing a heavy dose of Nick Chubb and Kareem Hunt to take advantage of the Chargers’ fourth-worst run defense that is allowing 5.3 yards per carry.
Mayfield has struggled to find consistency early on as he has thrown just two touchdown passes through the first four games of the season, and has once again struggled to find chemistry with his WR1 Odell Beckham Jr. . The Chargers have allowed just 6.6 yards per pass attempt, which is not exactly ideal for a quarterback who is likely to be short of volume in this one. This, coupled with the fact they have given up just six passing touchdowns in four games makes the Cleveland quarterback an easy fade in one-QB fantasy leagues. In two-QB and super-flex leagues, he can be valued as a low-end QB2 in this game.
Be sure to check all of our fantasy football rankings for the 2025 playoffs:
- Quarterback fantasy football rankings
- Running back fantasy football rankings
- Wide receiver fantasy football rankings
- Tight end fantasy football rankings
- Kicker fantasy football rankings
- FLEX fantasy football rankings
- Defense (D/ST) fantasy football rankings
- Superflex fantasy football rankings
- IDP fantasy football rankings
- Dynasty fantasy football rankings
More Fantasy Football Analysis

Five Dynasty Fantasy Football Tight End Sleepers to Target Late in Drafts (2025)
Generally, when it comes to tight ends in fantasy football, there are two schools of thought. Take one of the elite options early in your draft or bypass the position and wait until the later rounds to take a few flyers. This is commonly referred to as the “great or late” approach. Unfortunately, for dynasty […]

Dynasty Fantasy Football Rankings - Top 2nd Year Players to Buy and Target in Drafts (2025)
With one full season now in the books for the 2024 NFL Draft class, it's time to look back and re-rank the rookies from that draft for dynasty fantasy football leagues. Several players saw their dynasty value rise following the season, and some players saw their dynasty value plummet. In this article, we will look […]

Dynasty Rookie Fantasy Football Draft Sleepers - Value Pick Targets at Every Position (2025)
Everyone's always looking for sleepers in rookie drafts in Dynasty Fantasy Football. There's a massive payoff waiting for you if you can pick a rookie that far outperforms his expectations. Fantasy managers who selected Brian Thomas Jr. or Bucky Irving in last year's drafts gave their teams massive boosts and players that should produce well […]

NFL Rookie Breakout Trends: Top NFL Draft Prospects to Target in Fantasy Football (2025)
The 2025 NFL Draft has quite a few intriguing prospects, many of whom can be directly compared to players who are already in the league, or at least archetypes that are generally successful. There is a suite of skills at all the offensive skill positions that help players succeed at the next level. They vary […]

Biggest Fantasy Football Breakouts of 2024: TE
Tight ends are becoming increasingly important in NFL offenses. Offensive coordinators are scheming creative ways for their tight ends to get open in an age when the position is as athletic as ever. While tight ends formerly did not tend to experience success until their third season in the league, we have seen recent performers […]
Download Our Free Player News App
Like what you see? You can download our free fantasy football mobile app for iPhone and Android which includes more analysis at every position, 24x7 player news, notifications, injury alerts & daily articles.
Download Our Free News & Alerts Mobile App
Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!
