X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Value Picks
Compare Any Players
News and Alerts

Titans vs 49ers Start 'Em, Sit 'Em: A.J. Brown, Brandon Aiyuk, Jeff Wilson, D'Onta Foreman

Deebo Samuel - Fantasy Football Rankings, NFL Injury News, DFS Lineup Picks

Fantasy football start em, sit em and lineups advice for the Titans vs 49ers Thursday game in Week 16 (2021). Ellis Johnson analyzes the TNF matchups with a detailed breakdown.

We are officially in the fantasy playoffs for all leagues. For those of you who made it, congratulations. To those of you joining us after a bye week, I hope you didn’t get too comfortable. Lastly, to those of us that missed playoffs, let’s focus on the holiday season and enjoy the NFL playoff push.

Last week was wildly mediocre for fantasy. In what was most fantasy manager’s worst nightmare, we had one of the lowest scoring Week 15’s of all time. This included star fantasy players such as Ja'Marr Chase, Alvin Kamara, Najee Harris, and many others, posting season-low fantasy weeks. On top of this, we had a few monster games from the usual suspects (Travis Kelce and Mark Andrews for example) as well as Tyler Huntley and Duke Johnson Jr. 

Going into Week 16, we can only hope for a better fantasy output. To start the week off we have two teams that are both on the verge of making the postseason. The revitalized 49ers are traveling to Nashville to take on a hobbled Titans team. As always, my name is Ellis Johnson, and this is your RotoBaller Thursday Night Preview.

Be sure to check all of our fantasy football rankings for 2025:

 

San Fransisco 49ers @ Tennessee Titans - 8:20 pm ET 

Notable Injuries

 

Must-Starts for Fantasy Football Lineups

A.J. Brown (WR, TEN): He’s back baby. Well, hopefully he is back. After being activated from the Injured Reserve earlier this week, all signs are pointing in the right direction. The young superstar has been very disappointing for fantasy this season. Not only has he missed a significant portion of the season due to injuries, but he also had five of his nine games under 10 fantasy points. Thankfully we have seen stretches this season that showcase the upside of Brown, with two consecutive weeks with 130+ receiving yards and a score. The Titans are taking on a 49ers team that ranks 11th in fantasy points allowed to the position. The Titans offense has been struggling, and Brown just might be the spark they need to get back on track. I would start AJB as a solid WR1 this week.

UPDATE: A.J. Brown has officially been activated from IR and will return this week.

Deebo Samuel (WR, SF): Speaking of WR1’s, holy smokes is Deebo Samuel having a year. Whether he is a receiver or running back, Samuel has become the best in the league at yards after the catch. He is currently the WR2 on the season and has the second most touchdowns at the position. In both of the categories, he is only trailing Cooper Kupp and of his 12 touchdowns, seven are rushing touchdowns. With the 49ers backfield being a revolving door, Samuel has become not only their leading receiver but the team's lead back when necessary. Samuel is one of the most versatile players in the league and should continue to carry your fantasy team this week against the team that allows the second-most fantasy points to the WR position. 

George Kittle (TE, SF): Here we transition from one yards after the catch monster to another. Ironically on the same team, Kittle has put his athletic abilities on full display these last few weeks. Since returning from injury, Kittle has been on a tear. Over this seven-week period, he only has one week below ten fantasy points, averaging 89 receiving yards and 0.86 touchdowns. Oh, and also he is the TE-one over the last seven weeks. Unless you are against Andrews or Kelce, Kittle is a massive fantasy advantage at the position. I would look for him to continue his dominance in this good matchup. 

 

Solid Options for Fantasy Football Lineups

D'Onta Foreman (RB, TEN): From the depths of the fantasy underworld, Foreman has resurfaced himself and taken over one of the league’s most prolific rushing offenses. For those of you who believe his resurgence has come out of nowhere, here is a little history. The 2016 Doak Walker Award Winner (given to the best college running back) entered the league with a lot of buzz. After being drafted to the Texans in 2017 in the third round, he found himself sitting behind the veteran Lamar Miller. In his limited work, he displayed explosiveness and promise. Unfortunately with an Achilles tear in 2018, he found himself being picked up by the Colts off of waivers in 2019. He then had to leave after tearing his bicep in the preseason and tried out for the Titans in 2020. Flash forward to now, and we have ourselves the RB10 over the last two weeks. All of that was to say that this kid had promise and has had to overcome devastating injuries. Over his last three games, he has 100 yards rushing twice and found the endzone in the third game. If you managed to pick him up from your waivers you are most likely playing him out of necessity, however, he is a solid play against a mild-tier 49er run defense. 

Jimmy Garoppolo (QB, SF): Since Week 12, Jimmy G has quietly snuck his way into the QB-one category. Over these last three games, he is the QB11 and is the QB18 on the season. In the last four games, he has torched teams for 230+ yards in each game, including two games narrowly missing the 300-yard mark. When you have weapons like Samuel and Kittle, managers have been relieved to see the veteran QB start airing out the ball. Tennessee's defense is in the top half in most points allowed to the QB position this season. If you are desperate for a playoff QB or need a solid QB-two this week, Jimmy Garoppolo is a solid play this Thursday.

 

Flex Considerations for Fantasy Football Lineups

Ryan Tannehill (QB, TEN): Unfortunately, Tannehill just hasn’t been cutting it for fantasy teams. It’s hard to blame the veteran after losing key players in Derrick Henry, A.J. Brown, and Julio Jones for most of the year. It came as no surprise that losing Henry slowed the entire fantasy offense, but ironically, the loss of the star running back has impacted Tannehill the most. Failing to score 10 fantasy points in three of his last four games, it’s hard to trust Tannehill this week. Thankfully, he possesses upside with his legs, as he has scored twice on the ground over the last two weeks. Plus, the return of A.J. Brown does spark some optimism. However, he is no more than a high-upside/low-floor play this week against a very solid 49ers defense.

Brandon Aiyuk (WR, SF): If there was an award for the scariest player to start in fantasy, Aiyuk would have to be in the running. After being praised all offseason, he literally disappeared at the start of the season. Then, seemingly out of the blue, he started seeing starter snap counts and six or more targets in six of the last eight games. Then, once you finally feel comfortable playing him, he catches one of two targets for 36 yards against a poor Falcons secondary last week. Thankfully he gets the chance to redeem himself against another exploitable opponent. The Titans are allowing the second-most fantasy points to the position and could provide some life for the young receiver. However, because we saw a good matchup last week and it did not translate for Aiyuk’s fantasy success, he is hard to trust as more than a high-upside flex play this week.

 

Consider Sitting for Fantasy Football Lineups

Jeff Wilson Jr. (RB, SF): Yes, Elijah Mitchell has been ruled out. Yes, Wilson Jr. is coming off a monster game. No, I don’t think you should play him if you have other alternative options. Well, at least I think you should be careful if you do decide to start him. This “sit” is a result of Tennessee being the best fantasy defense against running backs on the season. They have managed to shut down the run all season, and that continued last week as they stiffed Najee Harris. Wilson Jr. finally had the game managers had been waiting for, however, I don’t want to rely on one good performance in the fantasy playoffs, especially against a very tough opponent. I would look elsewhere this week if possible.

Other Titans pass-catchers: Whether you are holding onto Julio Jones or are taking a shot at Anthony Firkser, Nick Westbrook-Ikhine, or Chester Rogers, I don’t think you can play any of them this week. Not only have the 49ers been very solid on defense these last few weeks, but these players also have not been reliable for fantasy. Although it is tough to sit Julio Jones if he is active, I would not want to risk the possibility of reinjury this week. My favorite player of this group has to be Westbrook-Ikhine as he has seen six or more targets in three of the last four games, but I would try to find the higher upside in another flyer this week.

 

As soon as we were heating up, we cooled right down. Thanks to a massive fourth quarter and an overtime touchdown, we missed on both of our picks last week. Nevertheless, we go into this week with fresh eyes. The Titans have been playing miserable football recently, while the 49ers could be argued to be one of the hottest teams in the league right now. Additionally, with the Titan's lack of passing defense and desperation to turn their season around at home, this could be a fun game to start Week 16. I wish you all the best of luck this week and happy holidays! 

Ellis’ Picks: 49ers -3.0 (12-5), Over 44.0 (11-6)

Career record: Spread (21-14), Over/Under (20-15)



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Fantasy Football Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Value Picks
Compare Any Players
News and Alerts

REAL-TIME FANTASY NEWS

Kameron Misner15 mins ago

Collects Three Hits, Homers Twice Monday
Shane Baz23 mins ago

Fans 11 In Dominant Win Monday
Framber Valdez31 mins ago

Allows 10 Hits In Monday Loss
Nolan Arenado37 mins ago

Collects Two Doubles, Homers Monday
Austin Riley47 mins ago

Homers Twice, Plates Five Monday
Endy Rodríguez3 hours ago

Endy Rodriguez Removed Early On Monday
Brenton Doyle3 hours ago

To Miss Another Game
Kris Bryant4 hours ago

Heading To Injured List
Teoscar Hernández4 hours ago

Teoscar Hernandez Absent From Monday's Lineup
Carson Kelly4 hours ago

Sitting Out On Monday
Seiya Suzuki4 hours ago

Remains Out On Monday
Cory Joseph4 hours ago

Available For Play-In Game
Franz Wagner5 hours ago

Expected To Return Tuesday
Paolo Banchero5 hours ago

On Track To Return Tuesday
Georges Niang5 hours ago

Off The Injury Report
Caris LeVert5 hours ago

Available Tuesday
Onyeka Okongwu5 hours ago

Ready To Face Magic Tuesday
Dyson Daniels5 hours ago

Good To Go Tuesday
Clint Capela5 hours ago

To Remain Out Tuesday
Trae Young5 hours ago

Probable For Tuesday's Play-In Game
Luis González6 hours ago

Luis Gonzalez Designated For Assignment
Brady Tkachuk6 hours ago

To Be Ready For Start Of Playoffs
Joe Boyle6 hours ago

Eric Orze Promoted, Joe Boyle Optioned
Drew Doughty6 hours ago

Available Against Oilers
Zebby Matthews6 hours ago

Not Expected To Join Rotation This Week
Mason Marchment6 hours ago

Won't Play Against Red Wings
Jesus Made6 hours ago

Returns From Ankle Injury
Esa Lindell6 hours ago

Misses Another Game Monday
Jack Leiter7 hours ago

Could Make Rehab Start This Week
Thomas Harley7 hours ago

Sits Out Second Consecutive Game
Quinn Mathews7 hours ago

Placed On Triple-A Injured List
Ivan Demidov7 hours ago

To Make His NHL Debut Monday
Dmitry Kulikov7 hours ago

Set To End 12-Game Absence
Sam Reinhart7 hours ago

Back For Panthers Monday
Christian Yelich7 hours ago

Out Against Tough Lefty
Sam Bennett7 hours ago

Available Against Rangers
George Springer7 hours ago

Out Monday With Wrist Inflammation
Aleksander Barkov7 hours ago

Returns To Panthers Lineup Monday
Marcell Ozuna7 hours ago

Out With Minor Leg Injury
Paul Cotter7 hours ago

Suspended For Two Games
Hunter Renfroe7 hours ago

Resting On Monday
Mattias Ekholm8 hours ago

To Miss First Round Of Playoffs
Ryan Nugent-Hopkins8 hours ago

Ready To Return Against Kings
Connor McDavid8 hours ago

Won't Play Monday
Brandon Miller8 hours ago

Unsure When He'll Return To Full Basketball Activities
Kyle Lowry8 hours ago

Wants To Play One More Season
Guerschon Yabusele8 hours ago

Daryl Morey, 76ers Want To Bring Back Guerschon Yabusele
De'Aaron Fox8 hours ago

Hopes To Sign An Extension With San Antonio
New England Patriots9 hours ago

Abdul Carter Visiting With New England
9 hours ago

Cam Skattebo Lined Up For Final Two Top-30 Visits
Dallas Cowboys9 hours ago

Micah Parsons In Dallas For Voluntary Workouts
Chicago Bears10 hours ago

Bears Extend Kyler Gordon
Donovan Mitchell11 hours ago

Will Be "Full-On" During Practice This Week
Jaylen Brown11 hours ago

Expected To Be Ready For Game 1
Kelly Oubre Jr.11 hours ago

Says There's Unfinished Business In Philadelphia
Andre Drummond12 hours ago

Plans To Return To Philadelphia
Phoenix Suns13 hours ago

Suns Fire Head Coach Mike Budenholzer
Josh Giddey13 hours ago

Bulls Are "Optimistic" That Josh Giddey Will Play Wednesday
Austin Dillon14 hours ago

Nabs His First Top-10 Finish Of The 2025 Season At Bristol
Ryan Blaney14 hours ago

Bold Strategies Fall Flat, Still Musters A Top-Five Finish At Bristol
Christopher Bell14 hours ago

Finishes In The Top 10 After Falling Back Midway At Bristol
Ty Gibbs14 hours ago

Earns His First Top-Five Finish Of The 2025 Season At Bristol
Chase Briscoe14 hours ago

Quietly Scores First Career Top-Five Finish At Bristol
Dustin Wolf18 hours ago

Stands Tall On Sunday
Corey Perry18 hours ago

Scores Goal, Adds Assist On Sunday
Adam Fantilli18 hours ago

Scores Twice In Victory
Nikita Kucherov18 hours ago

Tallies Three Points On Sunday
Morgan Geekie18 hours ago

Scores In Fifth Straight Contest
Ilya Sorokin18 hours ago

Stops 25 Shots In Victory
William Byron20 hours ago

Denny Hamlin Cuts Into William Byron's Points Lead
William Byron20 hours ago

Makes Best Of His Mediocre Qualifying Run With Sixth-Place Finish
Alex Bowman20 hours ago

Despite Engine Failure, Alex Bowman's Improved Speed Looks Promising
NASCAR20 hours ago

A.J. Allmendinger Enters Playoff Picture With Surprise Bristol Top-10 Finish
Jared McCain1 day ago

Doing "A Little Jumping" Without Pain
Quentin Grimes1 day ago

"Comfortable" In Philadelphia
Mattias Ekholm1 day ago

May Miss Rest Of The Year
Evan Engram1 day ago

Touts Bo Nix As A "True Weapon"
Arizona Cardinals1 day ago

Calais Campbell Still Feeling "Dominant" At Age 38
Detroit Lions1 day ago

Aidan Hutchinson Nearing End Of Rehab
Kenny Pickett1 day ago

Intends To Start For Browns
Seattle Seahawks1 day ago

Seahawks Likely Looking To Upgrade Offensive Line In The Draft
Cincinnati Bengals1 day ago

Bengals Expected To Focus On Defense In NFL Draft
1 day ago

Kyren Lacy Passes Away
1 day ago

Tetairoa McMillan Has Visits Lined Up
Tennessee Titans1 day ago

All Signs Point To Titans Taking Cam Ward At No. 1 Overall
Kyle Larson2 days ago

Will Compete For The Win At Bristol
Chase Elliott2 days ago

Is One Of The More Favorable DFS Options Available For Bristol
William Byron2 days ago

Is A Solid DFS Option For Bristol Lineups
Tyler Reddick2 days ago

Could Tyler Reddick Be A Sneaky DFS Option For Bristol?
NASCAR2 days ago

Is Bubba Wallace Worth Rostering For Bristol This Week?
Ross Chastain2 days ago

Could Ross Chastain Be A Worthy DFS Choice For Bristol?
Carson Hocevar2 days ago

Is Carson Hocevar Worth Rostering For Bristol DFS Lineups?
NASCAR2 days ago

Should Fantasy Managers Avoid Rostering A.J. Allmendinger In DFS For Bristol?
Ryan Preece2 days ago

Is Ryan Preece Worth Rostering For Bristol Lineups?
Austin Dillon2 days ago

May Be One Of The Top Value Options For Bristol DFS This Week
Noah Gragson2 days ago

Should DFS Players Consider Noah Gragson For Bristol Lineups?
Riley Herbst2 days ago

Is In Play For Bristol DFS Lineups
Arizona Cardinals2 days ago

Cardinals Could Be Targeting A Receiver In NFL Draft
Atlanta Falcons2 days ago

Falcons Expected To Prioritize Defense In Upcoming Draft
Atlanta Falcons2 days ago

Falcons Re-Sign Kevin King
Miami Dolphins2 days ago

Kader Kohou Signs Tender To Return To Dolphins
Dak Prescott2 days ago

Doing Well In Recovery From Hamstring Injury
Arizona Cardinals3 days ago

Patrick Peterson Retiring
3 days ago

Tyler Shough Visits With Saints On Friday
Derek Carr3 days ago

Could Miss Start Of Season With Shoulder Injury
Diego Lopes3 days ago

Can Become New UFC Featherweight Champion
Alexander Volkanovski3 days ago

Looks To Reclaim Featherweight Title
Paddy Pimblett3 days ago

Looks To Remain Undefeated In The UFC
Michael Chandler3 days ago

Set For Co-Main Event
MMA3 days ago

Patricio Freire Set For His UFC Debut
Yair Rodriguez3 days ago

Looks To Get Back In The Win Column
Jean Silva3 days ago

A Favorite At UFC 314
Bryce Mitchell3 days ago

Looks To Win Back-To-Back Fights
Dominick Reyes3 days ago

Set To Open Up UFC 314 Main Card
Nikita Krylov3 days ago

Looks For His Fourth Win In A Row
Maverick McNealy5 days ago

Looking For Success At Masters Debut
Tony Finau6 days ago

Looks To Stay Consistent At Augusta
Thomas Detry6 days ago

A Shaky Play At Augusta
Sam Burns6 days ago

Not In Good Form Ahead Of Masters
Will Zalatoris6 days ago

Looks To Continue Great History At Augusta
Rory McIlroy6 days ago

2025 Is The Best Chance For Rory McIlroy To Complete Career Grand Slam
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF