January 5, 2025
Per head coach Kyle Shanahan, San Francisco 49ers running back
Isaac Guerendo (knee, ankle) has likely picked up an MCL sprain but will undergo more testing on Monday to confirm the severity of the injury. Matt Barrows of The Athletic reported the news. That'd be a best-case scenario for the rookie, who was carted off in the first quarter of his team's 47-24 loss to the Arizona Cardinals. Guerendo was bent up awkwardly not even two minutes into the contest and quickly ruled out afterward. San Francisco has been unable to keep a running back healthy this season, as they've had four suffer serious injuries. It's been a disappointing year for the 49ers -- a team with Super Bowl aspirations that won't make a playoff appearance in 2024 after a campaign riddled with injuries. They'll hope for better in 2025.
--Alex CiullaSource: Matt Barrows
January 5, 2025
San Francisco 49ers running back
Isaac Guerendo (knee, ankle) exited during the first quarter of Sunday's Week 18 game against the Arizona Cardinals. He has been ruled out for the remainder of the contest. It was an ugly scene in Arizona as Guerendo's leg bent awkwardly while he was being tackled. He was in noticeable pain while being carted off the field, and the 49ers ruled him out with both knee and ankle injuries very quickly. He finishes Sunday's contest with two carries for five yards. All in all, he registered 420 rushing yards, 152 receiving yards, and four total touchdowns while splitting time as a depth option and starter this season.
Patrick Taylor Jr. will lead the 49ers' backfield for the remainder of Sunday's contest.
--Andersen Pickard - RotoBallerSource: Matt Barrows
January 3, 2025
San Francisco 49ers rookie running back
Isaac Guerendo (foot, hamstring) is off the injury report and ready to roll for a Week 18 matchup with the Cardinals in Arizona. Last week at home versus Detroit, Guerendo took just nine carries for 34 yards but snagged all four targets in the passing game for 65 yards. Arizona's defense represents a favorable opportunity for Guerendo to finish his first NFL campaign on a high note -- they have allowed the 10th-most half-PPR points per game (21.9). Last week, they allowed 14.7 points to
Kyren Williams of the Los Angeles Rams. With the 49ers having been eliminated from playoff contention weeks ago and playing their final game of 2024, head coach Kyle Shanahan should give Guerendo his classic heavy lead-back usage while assessing Guerendo's role in 2025. This could be especially true with the 49ers injury issues -- backup
Joshua Dobbs is starting for an injured
Brock Purdy (right elbow), wideout
Deebo Samuel Sr. (rib, wrist) is out, and tight end
George Kittle (ankle, hamstring) is questionable. Guerendo is a back-end RB1 in Week 18.
--Brad Beltz - RotoBallerSource: Pro Football Reference
December 28, 2024
San Francisco 49ers rookie running back
Isaac Guerendo (foot, hamstring) will return from a one-week absence when the team hosts the Detroit Lions on Monday night. Before missing last week's contest against Miami, Guerendo took 16 carries for 57 yards and caught four of four targets for 18 yards versus the Rams. The week before that, the fourth-rounder out of Louisville popped off for 25.8 half-PPR points against Chicago. Detroit has a quality rush defense, having allowed the fourth-fewest points per game to opposing running backs this season. Most recently, they held the Bears to 59 yards and no touchdowns on the ground. It's worth noting that San Francisco is down to their third-string left tackle and could be missing starting right tackle Colton McKivitz (knee), who is questionable. Consider Guerendo a back-end RB2 in Week 17.
--Brad Beltz - RotoBallerSource: Pro Football Reference
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