49ers vs. Jagaurs Start 'Em, Sit 'Em - Week 10 Picks for Brock Purdy, Brandon Aiyuk, Deebo Samuel, Calvin Ridley, Evan Engram, more

Fantasy football start 'em, sit 'em, and lineup advice for the 49ers vs. Jaguars matchup in Week 10 (2023). Read the player breakdowns and start/sit picks.

The Week 10 NFL slate isn't loaded with intriguing matchups, but the San Francisco 49ers vs. Jacksonville Jaguars could be the best showdown of the weekend. Both teams are coming off of a bye, and their seasons have been trending in different directions.

The Jaguars have won five straight games, while the Niners have suffered defeat in three consecutive contests. Will Jacksonville continue to roll, or will Kyle Shanahan's squad rebound after the week off?

It is sure to be an interesting one for fantasy football and "real life", and we have you covered with our "start 'em, sit 'em" suggestions for all fantasy-relevant players.

• 2025 fantasy football rankings (redraft)
• Dynasty fantasy football rankings
• 2025 NFL rookie fantasy football rankings
• Best ball fantasy football rankings
• Quarterback fantasy football rankings
• Running back fantasy football rankings
• Wide receiver fantasy football rankings
• Tight end fantasy football rankings

49ers @ Jaguars Matchup Overview

The Jaguars are sitting at 6-2, but they are a home underdog against a reeling 49ers team. The 49ers have been better statistically on offense and defense, but its weakness seems to be in the secondary, where Trevor Lawrence, Christian Kirk, and company could take advantage. Jacksonville has the third-best rushing defense (79.3 YPG), while Christian McCaffrey leads the NFL in rushing. Clearly, something will have to give.

• Betting Lines (DK) Spread: 49ers -3.0
• Betting Lines (DK) Over/Under: 45.0
• Offensive Stats - SF: 376.6 YPG (4th), JAX: 341.4 (14th)
• Defense Stats - SF: 315.0 YPG (10th), JAX: 342.8 (23rd)

49ers Start 'Em, Sit 'Em Picks for Week 10

• Brock Purdy - Start in 12+ Team Leagues
• Christian McCaffrey - Start in All Leagues
• Elijah Mitchell - Avoid in All Leagues
• Deebo Samuel - Start in 12+ Team Leagues
• Brandon Aiyuk - Start in All Leagues
• Jauan Jennings - Avoid in All Leagues
• George Kittle - Start in All Leagues
• Jake Moody - Start in 12+ Team Leagues
• 49ers D/ST - Start in 10+ Team Leagues

Jaguars Start 'Em, Sit 'Em Picks for Week 10

• Trevor Lawrence - Start in 10+ Team Leagues
• Travis Etienne - Start in All Leagues
• Calvin Ridley - Start in 10+ Team Leagues
• Christian Kirk - Start in 10+ Team Leagues
• Evan Engram - Start in All Leagues
• Brandon McManus - Start in 12+ Team Leagues
• Jaguars D/ST - Avoid in All Leagues

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