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Week 16 Warning Signs: Buffalo Bills vs New England Patriots

Dominick Petrillo takes a close look at whether fantasy GMs can trust any players in the Buffalo Bills vs. New England Patriots game in the championship round of the fantasy playoffs.

Congratulations on making it to the championship week of your fantasy league. Whether you are playing for pride or cash, it is always a great feeling to be among the last teams standing in your league.

There are many great matchups this week. The Broncos will have a field day against the hapless Lions. The Buccaneers and the Texans will have a fantasy bonanza on Saturday. As for us? We are going to take a look at the other end of the spectrum. The biggest game to stay away from. The Josh Allen-led Bills heading to Foxborough to take on the Tom Brady-led Patriots.

This will be a great game for real-life fans. As for fantasy fans? Not as much. In a championship matchup, where points are going to be measured down to the last decimal point, this is a game to stay as far away from as possible. So, let’s take a look at the tale of the tape for this one and find out why exactly you should be staying away.

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Buffalo Bills vs New England Patriots: A matchup made of defense

Both of these teams are having good seasons. In the case of the Bills, you could even call it great. But in the case of both of these teams, this is due directly to the elite play of their defenses and not their offenses.

With both teams in the top three in overall defense and pass defense, there is not much chance either of the quarterbacks in this one will put up points conducive to you wanting to start them. Even in a seemingly great matchup against Cincinnati last week, Brady was able to put up less than 200 yards passing. On the other side of the ball, Josh Allen threw a winning touchdown for the Bills but did not do much else against the Steelers on Sunday night.

With both teams having elite corners in Stephon Gilmore and Tre’Davious White, it will also be hard to find a receiver on either side you want to start. John Brown had a good start to the season. In recent weeks though, he has fallen off as the run game with Devin Singletary taking over. With Cole Beasley being solid but not great and the Patriots linebacker group being great, he also will leave a bitter taste in your mouth if he is started.

For the Patriots, Julian Edelman has always been Mr. Reliable. But playing through a knee and rib injury has taken its toll on the No. 1 target for Brady. This culminated last week with his game of two receptions for nine yards. This is not the production you wanted to see in a plus matchup. Now facing the third-ranked pass defense in the NFL, it could be tough to get anything going. The Absence of Rob Gronkowski has made a huge impact on New England, maybe even more than anyone had anticipated. Not only was he the key to how the offense was run, but his incredible blocking ability led to what success they had in the run game. Success they have not been able to find yet in 2019. Ben Watson is not the answer nor is he reliable at this point in his career. With the tight end position being quite possibly the worst in the NFL, Tom Brady has truly looked like a 42-year old quarterback.

 

Can Anyone Run?

Finally, Sony Michel had a decent game last week but 89 yards on 19 rushes isn’t great. When you compare that to his production season to date, it is a gold mine.

The Bills run defense is not the strength of the defense. That is clearly the pass defense. But they are still good at stopping the run. The fact that Tom Brady of 2019 is not Tom Brady of 2009 is also a key. No longer do teams need to fear the GOAT. Sure, he can still beat you, but not to the level he once could. With multiple weeks of disappointing play this season, including last week where he did not even rank as a top-20 quarterback, the passing game is not what it was. And neither is the run game. While never great, the run game was always a constant in New England. But no longer. With the entire offense taking a step back it has been difficult to find anything on the New England offense to be scared of. With the exception of James White and his PPR potential, this week will be no different in an ugly game.

For the Buffalo Bills, Frank Gore has shown us that longevity will lead you to the pinnacle of the record books. This should not be undermined, but he is not the same runner he once was. At his age, no one could be. Devin Singletary has done a lot to be excited about in his rookie year. His future with Josh Allen looks bright. But the pass rush of the Patriots will smother Allen and Singletary, making it hard to get anything going. Especially on the road in Foxborough, it does not look to be a great day for anyone on the Buffalo roster. The Patriots are coming off their first home loss in over two full seasons against the Chiefs. They are also taking on the first team to truly pose a challenge to them in the division in over a decade. They are not going to be taking this game lightly. Because of this and because both defenses are as good as advertised, this game should be a fantasy desert. Barren and dry.

With a defensive struggle ahead, a repeat of the 16-10 score from the first meeting this season is not only a possibility but also a likely outcome. So, don’t get caught up in the dust storm. Find better players in far better matchups to fill your lineup this week. It may not win you the week, but it will certainly keep you from losing it.

More Fantasy Football Analysis




REAL-TIME FANTASY NEWS

Kevin Huerter

is Cleared to Return for Game 5
Caris LeVert

is Available for Game 5 on Wednesday
Duncan Robinson

is Out for Game 5
Keegan Murray

Undergoes Ankle Procedure
Josh Giddey

Undergoes Ankle Surgery
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Nathan MacKinnon

Chasing History Wednesday
Ryan Poehling

Won't Be an Option for Game 6
Sam Malinski

Set to Miss Second Straight Game
Artturi Lehkonen

Unlikely to Play Wednesday
Matthew Schaefer

Wins Calder Trophy
TOR

Maple Leafs Fire Head Coach Craig Berube
Jalen Hurts

Can Jalen Hurts Bounce Back as a Rusher in 2026?
Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Zach Charbonnet

Dynasty Value in Question Entering 2026
DeVonta Smith

Poised to Reach a New Level of Production in 2026?
Chris Olave

Facing Increased Target Competition in New Orleans Entering 2026
Chris Bell

Dynasty Stock Rising Following NFL Draft
Ted Hurst

Facing Uphill Battle for Playing Time in Tampa Bay
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
Chris Brazzell II

Is Chris Brazzell II the Top Deep Threat in Carolina's Receiver Room?
Kaelon Black

a Threat to Win Backup RB Job in San Fran?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
De'Zhaun Stribling

to be 49ers' New "F" Receiver?
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
Drew Allar

Steelers "Uninstalling" Everything Drew Allar Learned in College
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Ja'Kobi Lane

Is Ja'Kobi Lane the Pass-Catching Answer the Ravens Have Been Seeking?
Zachariah Branch

Does Zachariah Branch Have a Path to Immediate Production?
Max Klare

Can Max Klare Separate Himself in Rams' Tight End Room?
Eli Stowers

the Tight End of the Future in Philadelphia?
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Germie Bernard

Already in a Tough Spot to Hold Dynasty Value
Ayo Dosunmu

Has Busy Night in Game 5
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Jaden McDaniels

Notches 17 Points in Game 5 Loss
Denzel Boston

a Smart Bet to Meet or Exceed Value in Dynasty Rookie Drafts
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Julius Randle

Posts a Double-Double in Losing Effort
Matthew Stafford

a Sell Candidate with Touchdown Regression Likely on its Way
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Anthony Edwards

Held to 20 Points in Game 5 Loss
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Keldon Johnson

Comes Alive in Game 5 Against Timberwolves
Jayden Reed

Dynasty Value Tethered to His Underwhelming Usage
Harris English

Will Need His Putter to Thrive at Aronimink
Stephon Castle

Makes All-Around Impact in Game 5
Kenyon Sadiq

Is Kenyon Sadiq the Next Great Rookie Tight End?
Victor Wembanyama

Leads Spurs to Big Win in Game 5
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Mason McTavish

Delivers Two Assists Tuesday Night
Pavel Dorofeyev

Pots Two Goals in Vital Game 5 Win
Josh Doan

Records Two Assists in Game 4 Victory
Evgeni Malkin

Penguins Want Evgeni Malkin Back
Sidney Crosby

Joins Team Canada for World Championship
Ryan Poehling

Suffers Upper-Body Injury in Game 5 Loss
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Cade Klubnik

Becoming Fan Favorite, in Play to Win Backup QB Job?
Michael Penix Jr.

Throwing During Offseason Program
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Philadelphia 76ers

76ers Part Ways With Daryl Morey
Kevin Huerter

Iffy for Game 5 Against Cavaliers
Dylan Harper

Cleared for Action Tuesday
De'Aaron Fox

Available for Game 5 Against Timberwolves
Caris LeVert

Remains on Injury Report With Heel Issue
Duncan Robinson

Listed as Questionable for Game 5
Memphis Grizzlies

Brandon Clarke Dies at Age 29
Charlie McAvoy

Slapped With Six-Game Suspension
Jonas Brodin

Unavailable for Game 5 Against Avalanche
Joel Eriksson Ek

to Remain Out Wednesday
Sam Malinski

Day-to-Day With Upper-Body Injury
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
Artturi Lehkonen

Considered Day-to-Day
Charlie Coyle

Lands Six-Year Extension
Ukko-Pekka Luukkonen

to Start Game 4 Against Canadiens
Drew Helleson

Unavailable for Game 5
Radko Gudas

Still Out Tuesday
Christian Yelich

Brewers Reinstate Christian Yelich From Injured List
Luka Dončić

Luka Doncic Admits He Wasn't Close to Returning Before Season Ended
CFB

Isaac Brown Has All-American Upside in 2026
LeBron James

Uncertain About Future After Season-Ending Loss
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Henry Bolte

Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Bryce Miller

is Set to Return on Wednesday
Jeff Hoffman

Could Return to Closer Role
Taj Bradley

Hits the Injured List With Pectoral Inflammation
Kyle Bradish

has Nice Bounce-Back Performance With 10 K's
Casey Mize

Throws Bullpen on Friday, Return Not Imminent
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
CFB

Rasheem Biles an Instant Impact Player for Texas
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