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Top MLB Betting Picks for Today's Slate (5/24/19)

Nate Duffett's MLB betting picks for 5/24/19. He analyzes Vegas lines and recommends the top expert bets for today's MLB slate including moneylines and over/unders.

Welcome back RotoBallers! On Friday, May 24th, we see a huge 15 game MLB slate. The day starts with a 2:20 PM game between the Cincinnati Reds and Chicago Cubs, and ends with a 10:15 PM game between the Arizona Diamondbacks and San Francisco Giants.

In this article, we will dive into the numbers and pick out my top recommended betting picks for today's slate. Feel free to hit me up on Twitter @Roto_Nate if you have any questions.

So without any further delay, below are my picks for Friday, May 24th. Good luck!

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San Diego Padres (-120) @ Toronto Blue Jays | O/U: 8.5

Both of these teams are 4-6 in their last ten, but the Padres seem to be breaking out, winning three in a row against the Diamondbacks. The Blue Jays lost three of four to the Red Sox and have been looking terrible despite a breakout offensive game on Tuesday. The Blue Jays haven't looked good at home, only managing an 8-16 record at home while the Padres have gone 12-10 on the road. I'm guessing the odds are lower due to the possible jet lag the Padres will be experiencing after the cross-continent travel, but I feel the talent should outweigh that problem today. If jetlag is a worry for you, by all means, stay away. However, I will be all over the Padres.

My Pick: Padres (-120)

 

Cincinnati Reds @ Chicago Cubs (-155) | O/U: 8.5

This is one of those picks that seems too easy, which is something that scares me, but I will be locking it in regardless. The Cubs are 17-8 at home while the Reds are 10-16 on the road. The Reds are sending Anthony DeSclafani to the mound, who has allowed 11 earned runs over his past three starts. Kyle Hendricks is the counter for the Cubs, allowing one or fewer runs in three of his last four starts, including a start against the Reds 10 days ago when he allowed one earned run over eight innings of work. I'm backing the Cubs to win big at Wrigley today.

My Pick: Cubs -1.5 (+135) 

 

 Boston Red Sox (-146) @ Houston Astros | O/U: 8.5

If last weeks series between these two teams is any indication, a Chris Sale game is the only time when the Astros will be underdogs over this weekend set. I think they are giving Sale too much credit in this matchup, as the Astros are the best team against left-handed pitching in the league with a .382 wOBA. The Astros are also 7-3 over their last ten games and 18-6 at home.

My Pick: Astros (+135)

 

Texas Rangers @ Los Angeles (-158) | O/U: 9

As much as I hate to back a team that has Drew Smyly taking the mound, I will hope that he can give us four or five good innings and then make way for the bullpen. This is a possibility as the Angels are one of the worst teams in the league against left-handed pitching with a .285 wOBA. On the other hand, the Rangers are the second-best team against right-handed pitching with a .355 wOBA so they should be able to get to Griffin Canning tonight. The Rangers are 7-3 in their last 10, while the Angels are 3-7. The odds are too good for me not to take a chance on the red-hot Rangers.

My Pick: Rangers (+148)

 

Chicago White Sox @ Minnesota Twins (-210) | O/U: 9

The Twins have racked up 67 runs over their past seven games, and they face Reynaldo Lopez and his 5.14 ERA today. I think they could cover the over by themselves today, but Jose Berrios has also allowed nine runs over his last two starts, so the White Sox should contribute some runs as well. I can't believe we can get this number at 9 with the way the Twins have been tearing the cover off of the ball and Berrios' recent form. One worry is that Lopez has been doing well recently, but he did that in starts against the Jays and Indians, who are two of the worst hitting teams in the league so far this season.

My Pick: Over 9 

More Fantasy Baseball Analysis




REAL-TIME FANTASY NEWS

Yordan Alvarez

Continues Homer Barrage With Two More Long Balls on Wednesday
Cristopher Sánchez

Cristopher Sanchez Makes History With Seven More Shutout Innings Against Padres
Teoscar Hernández

Teoscar Hernandez Lifted From Wednesday's Game Early With Hamstring Strain
Younghoe Koo

Jets Sign Kicker Younghoe Koo on Wednesday
Quinn Ewers

Looks Good in Wednesday's OTA Practice
Kenley Jansen

Exits Relief Appearance on Wednesday With Groin Injury
Ty Johnson

Taking Part in OTAs
Ja'Tavion Sanders

Cutting Laterally at OTAs
Tre' Harris

has Been a Top-Three Receiver During Offseason Program
Makai Lemon

Already Working With Starters in OTAs
AJ Barner

Undergoes Offseason Procedures, Not Taking Part in OTAs
Zach Charbonnet

Might Not Return Until Midseason
Von Miller

"For Sure" Plans to Play in 2026
Alvin Kamara

Not at OTAs But Preparing for the 2026 Season
Lamar Jackson

"Absolutely" Wants to Stay With Ravens Long-Term
Mason Plumlee

NBA Upgrades Mason Plumlee's Foul to a Flagrant 1
Victor Wembanyama

Receives Warning From NBA
Atlanta Hawks

Hawks Promote Onsi Saleh to President of Basketball Operations
Jalen Williams

Listed as Questionable for Game 6
Ajay Mitchell

Ruled Out for Game 6
Michael Penix Jr.

Not Cleared for 11-on-11 Work
Jacoby Brissett

Still Absent From OTAs This Week
George Kittle

Still Hoping to be Ready for Week 1
Micah Parsons

Expected to Open Training Camp on the PUP List
Tucker Kraft

Packers Hopeful Tucker Kraft Will Participate in Training Camp
Jacory Croskey-Merritt

Held Out of OTAs on Wednesday
Jayden Daniels

Participating in Commanders OTAs
Chris Bell

No Timetable for Chris Bell's Return from Knee Surgery
De'Von Achane

Limited in OTAs Due to Recovery From Shoulder Injury
MarShawn Lloyd

Participating in Packers OTAs
Eury Pérez

Eury Perez Pulled Early on Wednesday With Hamstring Issue
CFB

Drew Mestemaker a Top Big 12 Quarterback Right Away?
PGA

Sungjae Im Remains Boom-or-Bust at Colonial
PGA

Michael Thorbjornsen Trending in Wrong Direction Entering Colonial
De'Aaron Fox

Limited to Nine Points in Game 5 Loss
Russell Henley

a Top Option at Colonial
Harry Hall

Hoping Putter Carries Him at Colonial
Julian Champagnie

Notches 22 Points With Four Triples Tuesday
Stephon Castle

Leads Spurs in Scoring Tuesday Night
Rickie Fowler

Looks to Regain Momentum at Colonial
Victor Wembanyama

Struggles in Game 5 Loss to Thunder
Alex Caruso

a Difference-Maker Again in Game 5
Pierceson Coody

Looking to Stay Hot at Colonial
Jared McCain

Produces 20 Points in First Playoff Start
Shai Gilgeous-Alexander

Scores Game-High 32 Points in Game 5 Win
Martin Necas

Collects an Assist in Game 4 Loss to Golden Knights
Gabriel Landeskog

Scores Only Avalanche Goal in Season-Ending Loss
Carter Hart

Finishes Series-Clincher With 20 Saves
Dylan Coghlan

Continues Unlikely Success Story
Cole Smith

Scores Series-Clincher Tuesday Night
Mark Stone

Nets Another Goal as Golden Knights Finish Off Avalanche
Ludvig Aberg

Looking to Exchange Momentum for a Victory in Fort Worth
Stephan Jaeger

Trending Upward as PGA Heads to Fort Worth
Max Homa

Comes Off Awful Putting Performance at PGA Championship
Tony Finau

Faces Different Test at the Colonial
Robert MacIntyre

Seeks Better Beginning in Fort Worth
Tom Hoge

Ups and Downs Could Continue at Colonial
Brian Harman

Not Having the Best Golf Season in 2026
Austin Eckroat

Struggling Too Often Heading to Charles Schwab Challenge
Zach Bauchou

Tries to Keep Momentum Rolling at Colonial
Keegan Bradley

Looking to Rebound at Colonial
Jared McCain

Moves into Starting Five
Boston Celtics

Joe Mazzulla Wins Coach of the Year
Jalen Williams

is Ruled Out for Game 5 on Tuesday
Zion Williamson

to See More Versatile Role
Cleveland Cavaliers

Kenny Atkinson to Remain Cavaliers Head Coach Next Season
Claude Giroux

Planning to Return for 20th NHL Campaign
Carter Hart

Aiming for Sixth Consecutive Win Tuesday
Evgeni Malkin

Inks New One-Year Deal With Penguins
Mackenzie Blackwood

in Net for Game 4 Against Golden Knights
Valeri Nichushkin

a Game-Time Call Tuesday
Nathan MacKinnon

Will Suit Up Tuesday
Ben Griffin

Looking to Repeat This Week at Colonial
Rasmus Hojgaard

a Player to Avoid at Charles Schwab Challenge
Hideki Matsuyama

Needs Solid Driving Week at Charles Schwab Challenge
Justin Thomas

Trending Well Ahead of Charles Schwab Challenge
Akshay Bhatia

Lacking Driving Prowess Needed at Colonial Country Club
CFB

DJ Lagway Looking to Rebound at Baylor
CFB

Josh Hoover Tasked With Leading Indiana Back to the Playoffs
CFB

Braylon Staley the Next 1,000-Yard Tennessee Receiver?
CFB

Ahmad Hardy's Return Timeline Remains Unclear
Evan Mobley

Finishes Season-Ending Loss With 15 Points
James Harden

Wants to Stay in Cleveland
Donovan Mitchell

Remains Committed to Cavaliers
Mikal Bridges

Cools Off in Game 4 Against Cavaliers
Ivan Demidov

Contributes an Assist in Losing Effort
Lane Hutson

Records Power-Play Goal in Game 3 Loss
Frederik Andersen

Enjoys Another Easy Night at the Office in Game 3
Shayne Gostisbehere

Scores First Postseason Goal
Taylor Hall

Ends Four-Game Goal Drought
Andrei Svechnikov

Scores Game 3 Winner in Overtime
Gage Jump

Athletics to Promote Top Pitching Prospect Gage Jump to Major Leagues
Tatsuya Imai

Two Relievers Combine to No-Hit the Rangers on Monday
Valeri Nichushkin

Nathan MacKinnon, Valeri Nichushkin Uncertain for Game 4
Oliver Kapanen

Sitting as Healthy Scratch Monday
Max Domi

Out Indefinitely Due to Offseason Surgery Complications
Dylan Cease

Heading to Injured List With Hamstring Injury
Daniel Suarez

Wins at Charlotte in Rain-Shortened Coca-Cola 600
Christopher Bell

Finishes as the Runner-Up in the Coca-Cola 600 at Charlotte
Denny Hamlin

Falls Short of Winning and Places Third at Charlotte
Tyler Reddick

Places Fourth After Leading Laps at Charlotte
Kyle Larson

Strong and Consistent Day Ends in Fifth at Charlotte
Dylan Cease

Removed From Sunday's Start With Hamstring Discomfort
Vladimir Guerrero Jr.

Exits Sunday's Game Early with Elbow Contusion
MLB

Reds-Cardinals Game Postponed on Sunday
Edward Cabrera

Cubs Place Edward Cabrera on the 15-Day Injured List
Denny Hamlin

the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
Christopher Bell

Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
William Byron

Could have A Great DFS Performance at Charlotte
Chase Briscoe

Is A Solid Tournament Option for Charlotte DFS Lineups
Ty Gibbs

May not be Worth his Salary for Charlotte DFS Lineups
Chris Buescher

May be a Sneaky Tournament Option for Charlotte Lineups
NASCAR

Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

Is A Strong Addition for DFS Lineups at Charlotte
Austin Dillon

Should Fantasy Managers Roster Austin Dillon for Charlotte DFS Lineups?
Chase Elliott

Should Be Strong at Charlotte
Carson Hocevar

Confident for Coca-Cola 600
Corey Heim

a Chalk DFS Pick at Charlotte
Michael McDowell

Is Michael McDowell A Tournament Option for Charlotte Lineups?
MLB

Orioles-Tigers Game Postponed on Saturday
MLB

Rays-Yankees Postponed on Saturday
Mickey Moniak

Heads to Injured List With Ankle Sprain
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
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