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Top MLB Betting Picks for Today's Slate (5/24/19)

Nate Duffett's MLB betting picks for 5/24/19. He analyzes Vegas lines and recommends the top expert bets for today's MLB slate including moneylines and over/unders.

Welcome back RotoBallers! On Friday, May 24th, we see a huge 15 game MLB slate. The day starts with a 2:20 PM game between the Cincinnati Reds and Chicago Cubs, and ends with a 10:15 PM game between the Arizona Diamondbacks and San Francisco Giants.

In this article, we will dive into the numbers and pick out my top recommended betting picks for today's slate. Feel free to hit me up on Twitter @Roto_Nate if you have any questions.

So without any further delay, below are my picks for Friday, May 24th. Good luck!

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San Diego Padres (-120) @ Toronto Blue Jays | O/U: 8.5

Both of these teams are 4-6 in their last ten, but the Padres seem to be breaking out, winning three in a row against the Diamondbacks. The Blue Jays lost three of four to the Red Sox and have been looking terrible despite a breakout offensive game on Tuesday. The Blue Jays haven't looked good at home, only managing an 8-16 record at home while the Padres have gone 12-10 on the road. I'm guessing the odds are lower due to the possible jet lag the Padres will be experiencing after the cross-continent travel, but I feel the talent should outweigh that problem today. If jetlag is a worry for you, by all means, stay away. However, I will be all over the Padres.

My Pick: Padres (-120)

 

Cincinnati Reds @ Chicago Cubs (-155) | O/U: 8.5

This is one of those picks that seems too easy, which is something that scares me, but I will be locking it in regardless. The Cubs are 17-8 at home while the Reds are 10-16 on the road. The Reds are sending Anthony DeSclafani to the mound, who has allowed 11 earned runs over his past three starts. Kyle Hendricks is the counter for the Cubs, allowing one or fewer runs in three of his last four starts, including a start against the Reds 10 days ago when he allowed one earned run over eight innings of work. I'm backing the Cubs to win big at Wrigley today.

My Pick: Cubs -1.5 (+135) 

 

 Boston Red Sox (-146) @ Houston Astros | O/U: 8.5

If last weeks series between these two teams is any indication, a Chris Sale game is the only time when the Astros will be underdogs over this weekend set. I think they are giving Sale too much credit in this matchup, as the Astros are the best team against left-handed pitching in the league with a .382 wOBA. The Astros are also 7-3 over their last ten games and 18-6 at home.

My Pick: Astros (+135)

 

Texas Rangers @ Los Angeles (-158) | O/U: 9

As much as I hate to back a team that has Drew Smyly taking the mound, I will hope that he can give us four or five good innings and then make way for the bullpen. This is a possibility as the Angels are one of the worst teams in the league against left-handed pitching with a .285 wOBA. On the other hand, the Rangers are the second-best team against right-handed pitching with a .355 wOBA so they should be able to get to Griffin Canning tonight. The Rangers are 7-3 in their last 10, while the Angels are 3-7. The odds are too good for me not to take a chance on the red-hot Rangers.

My Pick: Rangers (+148)

 

Chicago White Sox @ Minnesota Twins (-210) | O/U: 9

The Twins have racked up 67 runs over their past seven games, and they face Reynaldo Lopez and his 5.14 ERA today. I think they could cover the over by themselves today, but Jose Berrios has also allowed nine runs over his last two starts, so the White Sox should contribute some runs as well. I can't believe we can get this number at 9 with the way the Twins have been tearing the cover off of the ball and Berrios' recent form. One worry is that Lopez has been doing well recently, but he did that in starts against the Jays and Indians, who are two of the worst hitting teams in the league so far this season.

My Pick: Over 9 

More Fantasy Baseball Analysis




REAL-TIME FANTASY NEWS

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Kayshon Boutte

to Compete for Snaps in Three-Receiver Sets
Alvin Kamara

Attends OTAs on Wednesday
Andrei Iosivas

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Tyjae Spears

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Jaylen Wright

the Dynasty Handcuff Running Back to Own in Miami?
Colby Parkinson

Facing Likely Regression After Career Year in 2025
Omarion Hampton

Remains a High-End Dynasty RB1 Despite Injury History
Rickie Fowler

Looks To Continue Resurgent Season At Memorial
Ollie Gordon II

Is Ollie Gordon II Still Worthy of a Dynasty Roster Spot?
Justin Herbert

Overhauling his Footwork This Offseason
De'Von Achane

Doing Individual Drills at Minicamp
Ashton Jeanty

Raiders Emphasizing Ashton Jeanty's Progress as Their Lead Back
Marvin Harrison Jr.

Still on the Mend From 2025 Injuries
Brandon Aiyuk

Warrant Issued for Brandon Aiyuk's Arrest in California
Blake Corum

Remains an Elite Handcuff in Dynasty Leagues
Chris Godwin Jr.

Consistency the Key for Chris Godwin Jr. in Dynasty Leagues
David Montgomery

Can Managers Look to Sell High on David Montgomery This Year?
Malik Willis

a Low-Cost Dynasty Target in Miami?
Terrance Ferguson

Can Terrance Ferguson Still be the Tight End to Roster in Los Angeles?
CFB

Can Eric Singleton Jr. Fully Break Out at Third School?
CFB

Katin Houser Steps into QB1 Role for Illinois
CFB

Savion Hiter an Immediate Impact Freshman for Michigan
CFB

Isaiah Horton Set to Take Over KC Concepcion's Role
CFB

UCLA Transfer Karson Gordon Signs with Austin Peay
CFB

Will Muschamp Bringing New Intensity to Texas Practices
Gary Woodland

Brings Boom-or-Bust Potential to Memorial
Jordan Spieth

Still Searching for a Breakthrough
Ted Hurst

Can Ted Hurst Find Consistent Fantasy Success in a Crowded Receiver Room?
Alex Smalley

Brings Elite Form to Memorial Tournament
Jayden Reed

Still an Unproven Dynasty Asset
Justin Rose

Looks to Recapture Memorial Tournament Success
Cameron Young

Looks to Get Back to His Contending Ways at Murifield Village
Chris Gotterup

Needs to Find Fairways at Muirfield Village
Si Woo Kim

Looks to Stay Hot at Memorial Tournament
Matt Fitzpatrick

Positioned for Success at Muirfield Village
Jalen Chatfield

Records Two Assists in Tuesday's Loss
Keegan Bradley

Looking for Another Strong Finish at Muirfield
Nikolaj Ehlers

Nets Two Goals in Game 1 Loss to Golden Knights
Shea Theodore

Notches Three Points in Game 1 Win
Brayden McNabb

Sets Up Three Goals in Game 1 Win Over Hurricanes
Justin Thomas

is an Exciting Play This Week in Ohio
Brett Howden

Starts Finals With Multi-Point Effort
Scottie Scheffler

Looks to Win Memorial Tournament for Third Consecutive Year
Tomas Hertl

Scores Game-Winner in Finals Opener
Rory McIlroy

Looking for Better Performance at Muirfield Village
Drake Baldwin

Could Return During Braves Next Homestand
Garrett Crochet

Diagnosed With Low-Grade Lat Strain
Russell Henley

Coming to Ohio on the Heels of Latest Victory
Tommy Fleetwood

Looking for Better Iron Play at Memorial Tournament
Patrick Cantlay

Looks to Continue Dominance at Muirfield Village
Ludvig Aberg

a Great Fit for Muirfield Village
Isaiah Hartenstein

Hopeful to Stay with Oklahoma City
Luguentz Dort

Wants to Remain with Thunder
Mitchell Robinson

is Questionable for Game 1
Moussa Diabaté

Moussa Diabate Has Contract Guaranteed for 2026-2027 Season
Oso Ighodaro

Gets Guaranteed Contract for Next Season
NAS

Chris MacFarland Joins Predators as President and General Manager
VAN

Canucks Name Manny Malhotra as New Head Coach
Brendan Gallagher

to Leave Canadiens This Offseason
Patrik Laine

Looking Forward to Free Agency
Jeremy Lauzon

Returns to Action Tuesday
Zach Werenski

Wins 2025-26 Norris Trophy
Aaron Judge

Out on Tuesday With Rib/Shoulder Injury
Josh Hader

Set to Return from Injured List on Tuesday
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SEC Coach Calls Buster Faulkner a "Home-Run Hire"
CFB

Auburn a Sleeper in the SEC Under Alex Golesh?
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Noah Fifita Primed for Strong 2026 Campaign
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Oregon Assistant Coach Charged with DUII, Reckless Driving
CFB

Tight End Nick Pollack Commits to Clemson
Akshay Bhatia

Needs the Driver to be True in Ohio
Aaron Rai

Primed to take on the Memorial Tournament
J.J. Spaun

Rebounded at Charles Schwab Challenge
Xander Schauffele

One to Watch This Week in Ohio
Elly De La Cruz

to Miss 2-4 Weeks of Action
Chase Burns

is Scratched Due to Illness
Deiveson Figueiredo

Suffers Second-Round Submission Loss
Song Yadong

Gets Second-Round Submission Win
Zhang Mingyang

Suffers Back-To-Back Losses
Alonzo Menifield

Gets Back In The Win Column
Tallison Teixeira

Suffers First-Round Knockout Loss
Sergei Pavlovich

Scores First-Round Knockout Win
Cameron Smotherman

Suffers Third Loss In A Row
Edwin Arroyo

Reds Promote Top Infield Prospect Edwin Arroyo, Viewed as Priority Pick Up Ahead of MLB Debut
Kai Asakura

Earns His First UFC Win
Elly De La Cruz

Placed on IL with Right Hamstring Tightness
Denny Hamlin

Earns the first Nashville Cup Series Victory of his Career on Sunday
Christopher Bell

Finishes as the Runner-Up at Nashville
Chase Briscoe

Earns First Career Podium Finish at Nashville
Ryan Blaney

Scores A Solid Top-10 Finish at Nashville
Kyle Larson

Top-10 Streak at Nashville Ends after Late Flat Tire Spin
Elly De La Cruz

Exits with Hamstring Tightness
Tyler Reddick

Is One of the Top Favorites to Win at Nashville
Kyle Larson

May Continue his Top-10 Consistency at Nashville this week
Christopher Bell

Is One of the Top Competitors for the Win at Nashville
Chase Briscoe

Is A Must Start for Nashville DFS Lineups
Chase Elliott

has Plenty of Upside for Nashville DFS Lineups
William Byron

Is William Byron A Playable DFS Option for Nashville Lineups?
Carson Hocevar

Is Likely to have Another Solid Result at Nashville
NASCAR

Should Fantasy Players Roster Bubba Wallace at Nashville?
Chris Buescher

Is A Decent All-Around DFS Option for Nashville Lineups
Daniel Suarez

is Likely to Drop Positions during the Cracker Barrel 400
Garrett Crochet

Suffers Setback, Likely to Undergo MRI for Lat Tightness
Denny Hamlin

Could Denny Hamlin Dominate at Nashville?
Ryan Blaney

Is a DFS Tournament Option at Nashville
Ty Gibbs

Don't Overlook Ty Gibbs at Nashville
Joey Logano

Could Show Life at Nashville
Ross Chastain

Needs a Good Run at Nashville
Chet Holmgren

Fails to Step Up in the Season Finale
Cason Wallace

Ends Postseason with Strong Showing
Shai Gilgeous-Alexander

Caps MVP Season with Game 7 Exit
Stephon Castle

Continues Postseason Run with 16 Points
Julian Champagnie

Shines in Series-Clinching Win
De'Aaron Fox

Provides Secondary Punch in Game 7 Triumph
Victor Wembanyama

Earns Conference Finals MVP in Spurs' Game 7 Win
NBA

Warriors Prioritize Depth Around Returning Steve Kerr
Donovan Mitchell

Remains Cleveland's Top Priority
Adou Thiero

Remains a Lakers Development Project
NBA

76ers Hire Mike Gansey as President of Basketball Operations
NBA

Chicago Bulls Explore Kevin Young as Coaching Candidate
Kyrie Irving

Reports He's Nearing Full Strength in ACL Recovery
Lane Hutson

Posts a Power-Play Assist in Game 5 Loss
Cole Caufield

Nets a Power-Play Goal in Season-Ending Loss
Seth Jarvis

Closes Out East Finals With Multi-Point Game
Logan Stankoven

Notches Three Points in Big Game 5 Win
Taylor Hall

Racks Up Three Points in Series-Clinching Win
Frederik Andersen

Remains Stellar as Hurricanes Clinch Finals Berth
Jacob Gonzalez

is Heading to the Big Leagues
Munetaka Murakami

Exits with Hamstring Tightness
Mitchell Robinson

Plans to Play in Game 1 After Finger Surgery
Ajay Mitchell

Ruled Out for Game 7
Jalen Williams

Unavailable in Decisive Game 7
Eury Pérez

Eury Perez is Placed on 15-Day Injured List
Deiveson Figueiredo

Set For UFC Macau Main Event
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Yadong Song Returns At UFC Macau
Alonzo Menifield

An Underdog At UFC Macau
Zhang Mingyang

Set For UFC Macau Co-Main Event
Tallison Teixeira

Looks To Win Back-To-Back Fights
Sergei Pavlovich

A Favorite At UFC Macau
Cameron Smotherman

Looks To Bounce Back
Kai Asakura

Looks To Get Back In The Win Column
CFB

Faizon Brandon In Position to Start Week 1
CFB

Dane Weber Commits to Cal
CFB

Joey McGuire Attempts to Add Texas to Schedule
CFB

Mike Leach on 2027 College Football Hall of Fame Ballot
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Maryland, Baylor Schedule Home-and-Home
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Taron Dickens Decommits From North Carolina
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF