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Top 10 NFL Defenses: Weeks 16,17 First Look and Rankings

Buffalo Bills Defense - Fantasy Football DST Rankings, Draft Sleepers

No. 1 Buffalo Bills (vs. New England Patriots, New York Jets)

If the Bills are somehow still available on waivers, make sure to pick them up immediately. This unit will have an extremely favorable matchup in Week 16 against the Patriots and could be used again in Week 17 against the Jets. Buffalo ranks tied for third in takeaways (24) and has forced a turnover in 12 of 13 games this season.

For Week 16, the Bills defense will be a top-5 play at home. In Week 17, Buffalo will have some potential against a Jets offense that has certainly had its struggles throughout the year. Aaron Rodgers has been sacked at least three times in three of the past four games.

Los Angeles Chargers Defense D/ST Streamers, Rankings, Waiver Wire - Khalil Mack Fantasy Football IDP

No. 2 Los Angeles Chargers (vs. Denver Broncos, New England Patriots)

The Chargers will be a top-3 play in the fantasy football championship against the Patriots, so make sure to pick them up ahead of Week 15. Los Angeles ranks fifth in sacks (39) this season, and this defense has totaled at least three sacks in five of the past seven games.

New England has given up 43 sacks (tied for the fourth-most) this season, and Maye has been sacked at least three times in four of the past five games. He has also thrown six interceptions across the last five contests. They are a top play in Week 17 even with a tougher matchup in Week 16 against the Denver Broncos.

No. 3 New Orleans Saints (vs. Green Bay Packers, Las Vegas Raiders)

The Saints defense won’t be a strong fantasy option in Week 16 against the Packers. However, this unit has a ton of potential against the Raiders in the fantasy football championship. New Orleans has totaled multiple sacks in four straight games, and Las Vegas has allowed 43 sacks this season.

While it remains to be seen if Desmond Ridder or Aidan O’Connell (knee) will start in this game, the Saints will have a high enough fantasy floor to be a top-7 play at home in Week 17. The Raiders also rank first in giveaways and 24th in pass-block win rate this season.

Green Bay Packers Defense - Rashan Gary, DST, D/ST, Rankings, Streamers

No. 4 Green Bay Packers (vs. New Orleans Saints, Minnesota Vikings)

Whether you have a first-round bye or just looking for a defense in advance, the Packers should be added in almost all formats right now. That’s because Green Bay will go up against the Saints in Week 16. With Derek Carr recovering from a fractured hand, there’s a strong chance that Jake Haener will draw another start under center for New Orleans.

This unit has a ton of potential in Week 16 against a Saints offense that will likely be missing Carr, Taysom Hill (knee), and Chris Olave (concussion). New Orleans also ranks 31st in pass-block win rate in 2024. In Week 17, they should be avoided facing a tough Minnesota offense.

Indianapolis Colts Defense - DST Rankings, Julian Blackmon, IDP Fantasy Football

No. 5 Indianapolis Colts (vs. Tennessee Titans, New York Giants)

The Colts are one of the few defenses that can be picked up and played in both Week 16 and Week 17. They’ll play the Titans in the second round of the fantasy football playoffs and the Giants in the championship. 

Opposing defenses are averaging 11.2 fantasy points against the Titans offense this season, and Will Levis has been sacked 24 times over the past five weeks. That’s great news for a Colts defense that has totaled at least three sacks in four of the past five games. After that great matchup in Week 16, the Colts can be used again in Week 17 against the Giants. New York will be starting either Drew Lock or Tommy DeVito in the fantasy football championship, and that offensive line has allowed 12 sacks over the past three games. 

No. 6 Seattle Seahawks (vs. Minnesota Vikings, Chicago Bears)

The Seahawks’ defense should be on everyone’s radar heading into the final weeks of the season. While this unit likely shouldn’t be started in Week 16 against the Vikings, it has a fantastic matchup against the Bears in the fantasy football championship.

Chicago has given up the most sacks (56) this season, and Caleb Williams has been taken down 33 times since Week 9. They have totaled multiple sacks in four straight weeks and have forced nine interceptions over the past seven games. 

No. 7 Tampa Bay Buccaneers (vs. Dallas Cowboys, Carolina Panthers)

In Week 16, the Buccaneers will face the Dallas Cowboys who have struggled to find consistency with Cooper Rush under center. Last weekend, they scored 30 points against the Panthers but the week before they scored only 20 and allowed three sacks with an interception against the Bengals. The Panthers have shown some upside at times but similar to Dallas have struggled to deliver on a consistent basis.

Over their past two games, the Buccaneers have allowed less than 20 points in each of them. Over this span they have tallied five sacks and two interceptions making them a viable low-end streaming option.

Titans Defense D/ST Streamers, Rankings, Waiver Wire - Harold Landry Fantasy Football IDP

No. 8 Tennessee Titans (vs. Indianapolis Colts, Jacksonville Jaguars)

Last weekend, Anthony Richardson and the Colts struggled against a tough Denver defense scoring only 13 points and allowed two sacks with two interceptions. The Jaguars offense took a step forward last weekend but remain a top streaming matchup given Mac Jones’ struggles serving as Trevor Lawrence’s replacement.

The Titans have allowed at least 30+ points in three of their past four contests. While this makes them a difficult option to trust, given their two positive matchups, they could be viewed as a last-resort option. They have tallied four interceptions in their past two games and could find similar success facing two inconsistent quarterbacks.

Jessie Bates Atlanta Falcons Defense - Fantasy Football DST, Defense Streamers, Waiver Wire IDP

No. 9 Atlanta Falcons (vs. New York Giants, Washington Commanders)

The Falcons have one of the best matchups in Week 16, with one of the most challenging in Week 17. This weekend, they will face the New York Giants who have scored just 25 combined points in their previous two games. During this span they have been sacked five times and thrown two interceptions. However, they should not be started in Week 17 facing a potent Washington offense.

The Falcons are coming off a strong defensive showing in Week 15 where they held the Raiders to just nine points. In this game they tallied a safety, four sacks, and two interceptions. They should have similar success against the Giants.

Trey Hendrickson Cincinnati Bengals Defense - Fantasy Football DST Streamers, Rankings, Pickups

Fool's Gold Streamer: Cincinnati Bengals (vs. Cleveland Browns, Denver Broncos)

In Jameis Winston‘s six starts this season, he has shown that he can still air it out in the passing game. That has led to the Browns scoring at least 24 points in three of those games. Even though last weekend he struggled, he could have a nice bounce-back performance especially given Cincinnati’s struggles in the secondary.

During the fantasy championships they face the Denver Broncos who have scored at least 29 points in each of their past four games and will likely be in store for another high-scoring affair facing the Bengals.

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REAL-TIME FANTASY NEWS

Las Vegas Raiders

Raiders to Host Fernando Mendoza for a Top-30 Visit in Two Weeks
Tua Tagovailoa

Open to Being a QB Mentor in Atlanta
Zay Flowers

Ravens Want to Extend Zay Flowers Soon
Jeremy Peña

Jeremy Pena on the Astros Opening Day Roster
Blake Snell

Dodgers Place Blake Snell on 15-Day Injured List
John Carlson

Sets Up Three Goals Tuesday Night
Joel Hofer

Picks Up Sixth Shutout of the Season
John Tavares

Records Three Assists in Tuesday's Win
NJ

Arseni Gritsyuk Scheduled for Imaging Wednesday
Jordan Mason

Could Benefit from Quarterback Change
Tony DeAngelo

Suffers Lower-Body Injury Tuesday
Aaron Rodgers

Mike McCarthy Would Welcome an Aaron Rodgers Reunion
Emmitt Finnie

Enters Concussion Protocol
Ryan Fox

a High-Upside Value in Houston
Barrett Hayton

Sustains Upper-Body Injury Tuesday
Dak Prescott

Remains Egregiously Undervalued
Marco Penge

a Boom-or-Bust Option in Houston
Cedric Coward

Returns From Three-Game Absence
CeeDee Lamb

Cowboys' Offensive Cohesion Could Lead to Another Big Year from CeeDee Lamb
Jaylen Wells

Won't Play Against Spurs
NFL

Jeremiyah Love Does Not Participate at Notre Dame Pro Day
Ty Jerome

Unavailable Wednesday
Brice Sensabaugh

Resting on Wednesday
Kyle Filipowski

Dealing With Illness, Unlikely to Play Wednesday
Jakob Poeltl

Could Miss Another Game Wednesday
Immanuel Quickley

Questionable Wednesday
Puka Nacua

Accused of Biting a Woman, Making Antisemitic Remarks
Aaron Rai

Looks to Bounce Back in Houston
Luther Burden III

Ascending Into Major Role on Offense?
Jason Day

a Volatile Option at the Texas Children's Houston Open
Joe Mixon

Remains a Free Agent as April Approaches
Kirby Yates

Angels Place Kirby Yates on 15-Day Injured List
Elijah Moore

Eagles Sign Elijah Moore to a One-Year Deal
Harris English

Eyes a Bounce-Back at the Texas Children's Houston Open
Ben Griffin

Looks for Turnaround at the Texas Children's Houston Open
Kirk Cousins

an Option as Backup Quarterback in Green Bay?
Zach Wilson

Saints Sign Zach Wilson to a One-Year Deal
Rickie Fowler

Brings Strong Form Into Texas Children's Houston Open
Brandon Clarke

to Miss Rest of Season
Ja Morant

Done for the Season
Brady Tkachuk

Collects Two More Points on Tuesday
Royce O'Neale

Available Tuesday Night
Grayson Allen

Cleared for Action Tuesday
Martin Necas

Scores Twice Against Penguins
Brandon Ingram

Questionable for Wednesday's Game
Ryan Dunn

Won't Play Against Nuggets
Paul George

Officially Available Wednesday
Nick Lodolo

Will Open 2026 on the Injured List Due to Finger Ailment
Pete Crow-Armstrong

Agrees to Six-Year, $115 Million Extension With the Cubs
John Collins

is Returning on Wednesday
Jordan Miller

is Questionable for Wednesday's Game
Bennedict Mathurin

is Returning on Wednesday
Kawhi Leonard

is Uncertain for Wednesday's Game
Kyle Kuzma

Carries Questionable Tag for Wednesday
Bobby Portis

is Tagged as Questionable for Wednesday
Kevin Porter Jr.

to Miss Fourth Straight Game
Igor Chernyshov

Returns to Sharks Lineup
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Good to Go Tuesday
Ross Colton

Logan O'Connor, Ross Colton Available Tuesday
Morgan Rielly

Back in Action Tuesday
Joel Eriksson Ek

Kirill Kaprizov, Joel Eriksson Ek Returning Tuesday
Thomas Chabot

to Be "Out a While"
Evgeni Malkin

Out Against Avalanche Tuesday
Joe Flacco

Reaches Agreement to Return to Bengals
Marvin Mims Jr.

Now a Trade Candidate in Denver?
Francisco Lindor

Likely to be Ready for Opening Day
Ryan Gerard

Can Continue Rolling at Texas Children's Houston Open
Pierceson Coody

Bounces Back at Valspar Championship
Rasmus Hojgaard

Trying to Get Back on Track at Texas Children's Houston Open
Michael Thorbjornsen

Playing Well Heading to Texas Children's Houston Open
Harry Hall

Looking for Consistency at Texas Children's Houston Open
Brooks Koepka

Continues Building Momentum
Odell Beckham Jr.

Plans to Play in 2026
RJ Harvey

Ready for a Year 2 Jump?
Baker Mayfield

Buccaneers Expected to Discuss Extension With Baker Mayfield This Offseason
Brian Robinson Jr.

Falcons to Sign Brian Robinson Jr.
Joey Bosa

a Good Fit for the 49ers?
Roki Sasaki

to Stick in Rotation Despite Spring Struggles
Kevin McGonigle

Makes Tigers Opening Day Roster
Scottie Scheffler

Withdraws From Texas Children's Houston Open
James Reimer

Picks Up Victory Against Rangers
Ryan Pepiot

Placed on Injured List to Open the Season
J.J. Wetherholt

JJ Wetherholt Likely to Hit Leadoff on Opening Day
Connelly Early

to Make First Start on Sunday
Luke Clanton

Might Have a Problem in Houston
Sam Stevens

Happy to See Houston This Week
Keith Mitchell

Tries to Rebound After The Players Championship
Will Zalatoris

Returning This Week at Houston
Wyndham Clark

Trending in the Wrong Direction Heading to Houston
Shane Lowry

Seeking Better Luck in Houston This Weekend
Kurt Kitayama

Poised to Bounce Back at the Houston Open
Pete Crow-Armstrong

Cubs, Pete Crow-Armstrong Finalizing Long-Term Extension
Shane Pinto

Opens Scoring Versus Rangers
Blake Snell

Targeting a May Return
Hunter Greene

Reds Place Hunter Greene on 60-Day Injured List
J.J. Wetherholt

JJ Wetherholt Makes Cardinals Opening Day Roster
Nick Pivetta

to Start on Opening Day for Padres
Brandon Woodruff

Makes Brewers Opening Day Rotation
Zack Wheeler

to Start Rehab Assignment on Saturday
Carson Benge

Makes Mets Opening Day Roster
Seiya Suzuki

to Start the Season on the Injured List
Lerone Murphy

Suffers His First Loss
Dennis Santana

Won't be Pirates' Primary Closer
Movsar Evloev

Edges Out Lerone Murphy
CFB

Notre Dame Ranks No. 1 in Returning Production for 2026
Michael Aswell

Jr. Drops Decision At UFC London
Michael Aswell

Luke Riley Outclasses Michael Aswell Jr.
Sam Patterson

Suffers Unanimous-Decision Loss
Michael Page

Wins Lackluster Decision
Austen Lane

Suffers First-Round TKO Loss
Iwo Baraniewski

Delivers 28-Second TKO
Lawson Crouse

Picks Up Three Points in Overtime Win
Filip Forsberg

Takes Predators Past Blackhawks
Alex Ovechkin

Scores 1,000th Career Goal
Tyler Reddick

Overcomes Adversity for Fourth Victory of the Season At Darlington
Brad Keselowski

Falls Short of Darlington Victory Despite Domination
Ryan Blaney

Recovers From Pit-Road Struggles to Score Career-Best Darlington Finish
Carson Hocevar

Rallies to Finish Fourth at Darlington
Kyle Larson

Decent Performance Ends with Technical Issues At Darlington
Tyler Reddick

the Clear Favorite at Darlington
Kyle Larson

a High-Risk, High-Reward Driver at Darlington
Ryan Blaney

Is Getting Better at Darlington
NASCAR

Bubba Wallace Not Slowing Down at Darlington
Chris Buescher

Should be a Top-10 Contender at Darlington
Austin Cindric

a Sleeper at Darlington
Erik Jones

Quickest in Practice at Darlington
Denny Hamlin

Qualifies Ninth for this Week's Cup Race at Darlington
Chase Briscoe

Is One of the Top DFS Options of the Week for Darlington
William Byron

Is William Byron A Playable DFS Option for Darlington Lineups?
Christopher Bell

Could Christopher Bell be Considered A Decent DFS Option for Darlington?
Chase Elliott

Is Chase Elliott Worth Rostering At Darlington This Week For DFS?
Joey Logano

May Not Have the Speed to Warrant A Darlington DFS Lineup Spot
Ross Chastain

Should DFS Players Trust Ross Chastain at Darlington?
Kyle Busch

Could Kyle Busch Be A Worthy DFS Option for Darlington?
Brad Keselowski

May be A Contriarian DFS Tournament Option At Darlington
Lerone Murphy

Set For UFC London Main Event
Movsar Evloev

Looks To Remain Unbeaten
Michael Aswell

Jr. An Underdog At UFC London
Luke Riley

Set For UFC London Co-Main Event
Sam Patterson

Looks To Extend His Win Streak
Michael Page

Set For Welterweight Bout
Austen Lane

In Dire Need Of Victory
Iwo Baraniewski

A Favorite At UFC London
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