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Top 10 NFL Defenses: Weeks 16,17 First Look and Rankings

Buffalo Bills Defense - Fantasy Football DST Rankings, Draft Sleepers

No. 1 Buffalo Bills (vs. New England Patriots, New York Jets)

If the Bills are somehow still available on waivers, make sure to pick them up immediately. This unit will have an extremely favorable matchup in Week 16 against the Patriots and could be used again in Week 17 against the Jets. Buffalo ranks tied for third in takeaways (24) and has forced a turnover in 12 of 13 games this season.

For Week 16, the Bills defense will be a top-5 play at home. In Week 17, Buffalo will have some potential against a Jets offense that has certainly had its struggles throughout the year. Aaron Rodgers has been sacked at least three times in three of the past four games.

Los Angeles Chargers Defense D/ST Streamers, Rankings, Waiver Wire - Khalil Mack Fantasy Football IDP

No. 2 Los Angeles Chargers (vs. Denver Broncos, New England Patriots)

The Chargers will be a top-3 play in the fantasy football championship against the Patriots, so make sure to pick them up ahead of Week 15. Los Angeles ranks fifth in sacks (39) this season, and this defense has totaled at least three sacks in five of the past seven games.

New England has given up 43 sacks (tied for the fourth-most) this season, and Maye has been sacked at least three times in four of the past five games. He has also thrown six interceptions across the last five contests. They are a top play in Week 17 even with a tougher matchup in Week 16 against the Denver Broncos.

No. 3 New Orleans Saints (vs. Green Bay Packers, Las Vegas Raiders)

The Saints defense won’t be a strong fantasy option in Week 16 against the Packers. However, this unit has a ton of potential against the Raiders in the fantasy football championship. New Orleans has totaled multiple sacks in four straight games, and Las Vegas has allowed 43 sacks this season.

While it remains to be seen if Desmond Ridder or Aidan O’Connell (knee) will start in this game, the Saints will have a high enough fantasy floor to be a top-7 play at home in Week 17. The Raiders also rank first in giveaways and 24th in pass-block win rate this season.

Green Bay Packers Defense - Rashan Gary, DST, D/ST, Rankings, Streamers

No. 4 Green Bay Packers (vs. New Orleans Saints, Minnesota Vikings)

Whether you have a first-round bye or just looking for a defense in advance, the Packers should be added in almost all formats right now. That’s because Green Bay will go up against the Saints in Week 16. With Derek Carr recovering from a fractured hand, there’s a strong chance that Jake Haener will draw another start under center for New Orleans.

This unit has a ton of potential in Week 16 against a Saints offense that will likely be missing Carr, Taysom Hill (knee), and Chris Olave (concussion). New Orleans also ranks 31st in pass-block win rate in 2024. In Week 17, they should be avoided facing a tough Minnesota offense.

Indianapolis Colts Defense - DST Rankings, Julian Blackmon, IDP Fantasy Football

No. 5 Indianapolis Colts (vs. Tennessee Titans, New York Giants)

The Colts are one of the few defenses that can be picked up and played in both Week 16 and Week 17. They’ll play the Titans in the second round of the fantasy football playoffs and the Giants in the championship. 

Opposing defenses are averaging 11.2 fantasy points against the Titans offense this season, and Will Levis has been sacked 24 times over the past five weeks. That’s great news for a Colts defense that has totaled at least three sacks in four of the past five games. After that great matchup in Week 16, the Colts can be used again in Week 17 against the Giants. New York will be starting either Drew Lock or Tommy DeVito in the fantasy football championship, and that offensive line has allowed 12 sacks over the past three games. 

No. 6 Seattle Seahawks (vs. Minnesota Vikings, Chicago Bears)

The Seahawks’ defense should be on everyone’s radar heading into the final weeks of the season. While this unit likely shouldn’t be started in Week 16 against the Vikings, it has a fantastic matchup against the Bears in the fantasy football championship.

Chicago has given up the most sacks (56) this season, and Caleb Williams has been taken down 33 times since Week 9. They have totaled multiple sacks in four straight weeks and have forced nine interceptions over the past seven games. 

No. 7 Tampa Bay Buccaneers (vs. Dallas Cowboys, Carolina Panthers)

In Week 16, the Buccaneers will face the Dallas Cowboys who have struggled to find consistency with Cooper Rush under center. Last weekend, they scored 30 points against the Panthers but the week before they scored only 20 and allowed three sacks with an interception against the Bengals. The Panthers have shown some upside at times but similar to Dallas have struggled to deliver on a consistent basis.

Over their past two games, the Buccaneers have allowed less than 20 points in each of them. Over this span they have tallied five sacks and two interceptions making them a viable low-end streaming option.

Titans Defense D/ST Streamers, Rankings, Waiver Wire - Harold Landry Fantasy Football IDP

No. 8 Tennessee Titans (vs. Indianapolis Colts, Jacksonville Jaguars)

Last weekend, Anthony Richardson and the Colts struggled against a tough Denver defense scoring only 13 points and allowed two sacks with two interceptions. The Jaguars offense took a step forward last weekend but remain a top streaming matchup given Mac Jones’ struggles serving as Trevor Lawrence’s replacement.

The Titans have allowed at least 30+ points in three of their past four contests. While this makes them a difficult option to trust, given their two positive matchups, they could be viewed as a last-resort option. They have tallied four interceptions in their past two games and could find similar success facing two inconsistent quarterbacks.

Jessie Bates Atlanta Falcons Defense - Fantasy Football DST, Defense Streamers, Waiver Wire IDP

No. 9 Atlanta Falcons (vs. New York Giants, Washington Commanders)

The Falcons have one of the best matchups in Week 16, with one of the most challenging in Week 17. This weekend, they will face the New York Giants who have scored just 25 combined points in their previous two games. During this span they have been sacked five times and thrown two interceptions. However, they should not be started in Week 17 facing a potent Washington offense.

The Falcons are coming off a strong defensive showing in Week 15 where they held the Raiders to just nine points. In this game they tallied a safety, four sacks, and two interceptions. They should have similar success against the Giants.

Trey Hendrickson Cincinnati Bengals Defense - Fantasy Football DST Streamers, Rankings, Pickups

Fool's Gold Streamer: Cincinnati Bengals (vs. Cleveland Browns, Denver Broncos)

In Jameis Winston‘s six starts this season, he has shown that he can still air it out in the passing game. That has led to the Browns scoring at least 24 points in three of those games. Even though last weekend he struggled, he could have a nice bounce-back performance especially given Cincinnati’s struggles in the secondary.

During the fantasy championships they face the Denver Broncos who have scored at least 29 points in each of their past four games and will likely be in store for another high-scoring affair facing the Bengals.

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REAL-TIME FANTASY NEWS

Jonathan Kuminga

Remains Out Tuesday
Keegan Murray

Could Make his Season Debut This Week
Caris LeVert

Liston as Out on Tuesday
Tobias Harris

Could Return Thursday
Ausar Thompson

Questionable Again on Tuesday
Joe Mixon

Uncertainty Remains Around Joe Mixon's Return Timeline
Cade Cunningham

is Questionable Tuesday in Atlanta
Jaylen Warren

Mike Tomlin Optimistic About Jaylen Warren's Availability for Week 12
C.J. Stroud

Not Expected to Play on Thursday Night
Aaron Rodgers

Won't Need Surgery on Fractured Wrist, Could Play in Week 12?
Davis Mills

Prepping for Third Straight Start in Week 12?
CFB

Sam Leavitt Set to Enter Transfer Portal?
Mason Rudolph

Could Make His First Start of 2025 in Week 12
Brock Wright

Sets Career-High in Targets; Lined Up for More Work?
Stephon Castle

Out Against Grizzlies
Kimani Vidal

Struggles Again and Faces Role Uncertainty After Bye
Dak Prescott

in Full Command Monday Night With Four Touchdown Passes
Quentin Johnston

Posts Zero Catches During Offensive Collapse
George Pickens

Erupts for 144 Yards, Touchdown in Monday Night Win
Jrue Holiday

Unlikely to Play Tuesday
CeeDee Lamb

George Pickens Benched for First Drive
LeBron James

Officially Listed as Questionable for Tuesday
Jose Altuve

Undergoes Foot Surgery
Giannis Antetokounmpo

Exits Monday's Game With Groin Injury
Julian Strawther

Out on Monday
Cameron Johnson

Cleared for Action Monday
Nikola Jokić

Nikola Jokic Available Against Bulls
Zaccharie Risacher

Considered Questionable for Tuesday's Game
Onyeka Okongwu

Iffy for Tuesday
Kristaps Porzingis

May Miss Another Game Tuesday
Jalen Suggs

Listed as Questionable for Tuesday
Paolo Banchero

to Remain Out Tuesday
Ayo Dosunmu

Playing on Minutes Restriction Monday
Tre Jones

Still Out Monday
Saddiq Bey

Won't Play Against OKC
Alex Singleton

Broncos Optimistic Patrick Surtain, Alex Singleton Will Return After the Bye
Trey Hendrickson

Doubtful Again in Week 12
Shedeur Sanders

Expected to Make First Career Start in Week 12
Josh Jacobs

Dealing With Knee Contusion
Mikael Granlund

Unavailable Monday
Alex Bregman

Red Sox Going for Either Alex Bregman or Pete Alonso?
Conor Garland

Misses Monday's Game
Eetu Luostarinen

Out on Monday
Drake London

Considered "Week-to-Week"
Drew Doughty

Listed as Week-to-Week
Ja'Marr Chase

Being Suspended for One Game for Unsportsmanlike Conduct
John Carlson

a Game-Time Call Monday
Viktor Arvidsson

Out Week-to-Week
Charlie McAvoy

Out Against Hurricanes
CFB

James Franklin to be Virginia Tech's Next Head Coach
Brandon Aiyuk

49ers Won't Open Brandon Aiyuk's Practice Window This Week
Joe Burrow

Could Do 11-on-11 Work This Week in Practice
Michael Penix Jr.

Heads to Injured Reserve, Could Need Full Knee Reconstruction
CFB

Fernando Mendoza the Clear Heisman Trophy Favorite?
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Beau Pribula Has Chance to Face Oklahoma on Saturday
Mitchell Marner

Establishes Vegas Record Sunday
Mats Zuccarello

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Lucas Raymond

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Quinn Hughes

Delivers Four Assists in Sunday's Win
Conor Garland

Limited to Handful of Minutes Sunday
Ryan Hartman

Suffers Lower-Body Injury
Adrian Kempe

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Jack Della Maddalena

Gets Dominated
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Zhang Weili

Gets Outclassed
Valentina Shevchenko

Wins Unanimous Decision At UFC 322
Sean Brady

Suffers First-Round TKO Loss
Michael Morales

Remains Unbeaten
Leon Edwards

Suffers Second-Round Knockout Loss
Leon Edwards

Carlos Prates Becomes The First Man To Knock Out Leon Edwards
Beneil Dariush

Suffers Brutal First-Round Knockout Loss
Beneil Dariush

Benoit Saint Denis Knocks Out Beneil Dariush In 16 Seconds
Josh Naylor

Mariners Finalizing Five-Year Contract
Scott Mayfield

Available Sunday
NYI

Max Shabanov Returns From 12-Game Absence Sunday
Samuel Honzek

Out Week-to-Week
Kirby Dach

Sidelined for 4-6 Weeks
Thatcher Demko

Considered Week-to-Week
Filip Hronek

Good to Go Sunday
Quinn Hughes

Back in Action Sunday
CFB

Jeremiah Smith, Carnell Tate Not Dealing With Long-Term Injuries
CFB

Virginia Tech Close To Naming James Franklin As Head Coach
CFB

Garrett Nussmeier Doubtful vs. Arkansas On Saturday
Edwin Díaz

Blue Jays Interested in Signing Edwin Diaz?
Jacob deGrom

Named AL Comeback Player of the Year
Ronald Acuña Jr.

Ronald Acuna Jr. Wins NL Comeback Player of the Year Award
Aroldis Chapman

Named AL Reliever of the Year
Edwin Díaz

Edwin Diaz Named NL Reliever of the Year
Justin Thomas

Will Miss Start Of 2026 After Undergoing Back Surgery
Islam Makhachev

Set For UFC 322 Main Event
Jack Della Maddalena

Set For His First Title Defense
Zhang Weili

Can Become The New Women's Flyweight Champion
Valentina Shevchenko

Set For UFC 322 Co-Main Event
Michael Morales

Looks To Remain Undefeated
CFB

Mario Craver a Game-Time Decision for Week 12
Sean Brady

Set For Title Eliminator Bout
Carlos Prates

A Favorite At UFC 322
Leon Edwards

Looks To Get Back In The Win Column
Benoît Saint Denis

Benoit Saint Denis Set To Open Up UFC 322 Main Card
Beneil Dariush

Looks To Win Back-To-Back Fights
CFB

Virginia's Chandler Morris Trending Toward Facing Duke on Saturday
Edwin Díaz

Edwin Diaz Says There's a "50-50" Chance he Returns to Mets
Shohei Ohtani

Wins his Fourth MVP Award
Aaron Judge

Wins AL MVP Award Again
Raisel Iglesias

Dodgers Interested in Signing Raisel Iglesias
Pete Alonso

Orioles Could be in the Mix to Sign Pete Alonso
Félix Bautista

Felix Bautista Could Return in Second Half in 2026
Kodai Senga

Attracting Trade Interest, Will the Mets Move him?
Yordan Alvarez

Expected to be Ready for Spring Training
Byron Buxton

Could Waive his No-Trade Clause
Paul Skenes

the Unanimous NL Cy Young Winner
Tarik Skubal

Wins AL Cy Young for Second Straight Year

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