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Top 10 NFL Defenses: Weeks 16,17 First Look and Rankings

Buffalo Bills Defense - Fantasy Football DST Rankings, Draft Sleepers

No. 1 Buffalo Bills (vs. New England Patriots, New York Jets)

If the Bills are somehow still available on waivers, make sure to pick them up immediately. This unit will have an extremely favorable matchup in Week 16 against the Patriots and could be used again in Week 17 against the Jets. Buffalo ranks tied for third in takeaways (24) and has forced a turnover in 12 of 13 games this season.

For Week 16, the Bills defense will be a top-5 play at home. In Week 17, Buffalo will have some potential against a Jets offense that has certainly had its struggles throughout the year. Aaron Rodgers has been sacked at least three times in three of the past four games.

Los Angeles Chargers Defense D/ST Streamers, Rankings, Waiver Wire - Khalil Mack Fantasy Football IDP

No. 2 Los Angeles Chargers (vs. Denver Broncos, New England Patriots)

The Chargers will be a top-3 play in the fantasy football championship against the Patriots, so make sure to pick them up ahead of Week 15. Los Angeles ranks fifth in sacks (39) this season, and this defense has totaled at least three sacks in five of the past seven games.

New England has given up 43 sacks (tied for the fourth-most) this season, and Maye has been sacked at least three times in four of the past five games. He has also thrown six interceptions across the last five contests. They are a top play in Week 17 even with a tougher matchup in Week 16 against the Denver Broncos.

No. 3 New Orleans Saints (vs. Green Bay Packers, Las Vegas Raiders)

The Saints defense won’t be a strong fantasy option in Week 16 against the Packers. However, this unit has a ton of potential against the Raiders in the fantasy football championship. New Orleans has totaled multiple sacks in four straight games, and Las Vegas has allowed 43 sacks this season.

While it remains to be seen if Desmond Ridder or Aidan O’Connell (knee) will start in this game, the Saints will have a high enough fantasy floor to be a top-7 play at home in Week 17. The Raiders also rank first in giveaways and 24th in pass-block win rate this season.

Green Bay Packers Defense - Rashan Gary, DST, D/ST, Rankings, Streamers

No. 4 Green Bay Packers (vs. New Orleans Saints, Minnesota Vikings)

Whether you have a first-round bye or just looking for a defense in advance, the Packers should be added in almost all formats right now. That’s because Green Bay will go up against the Saints in Week 16. With Derek Carr recovering from a fractured hand, there’s a strong chance that Jake Haener will draw another start under center for New Orleans.

This unit has a ton of potential in Week 16 against a Saints offense that will likely be missing Carr, Taysom Hill (knee), and Chris Olave (concussion). New Orleans also ranks 31st in pass-block win rate in 2024. In Week 17, they should be avoided facing a tough Minnesota offense.

Indianapolis Colts Defense - DST Rankings, Julian Blackmon, IDP Fantasy Football

No. 5 Indianapolis Colts (vs. Tennessee Titans, New York Giants)

The Colts are one of the few defenses that can be picked up and played in both Week 16 and Week 17. They’ll play the Titans in the second round of the fantasy football playoffs and the Giants in the championship. 

Opposing defenses are averaging 11.2 fantasy points against the Titans offense this season, and Will Levis has been sacked 24 times over the past five weeks. That’s great news for a Colts defense that has totaled at least three sacks in four of the past five games. After that great matchup in Week 16, the Colts can be used again in Week 17 against the Giants. New York will be starting either Drew Lock or Tommy DeVito in the fantasy football championship, and that offensive line has allowed 12 sacks over the past three games. 

No. 6 Seattle Seahawks (vs. Minnesota Vikings, Chicago Bears)

The Seahawks’ defense should be on everyone’s radar heading into the final weeks of the season. While this unit likely shouldn’t be started in Week 16 against the Vikings, it has a fantastic matchup against the Bears in the fantasy football championship.

Chicago has given up the most sacks (56) this season, and Caleb Williams has been taken down 33 times since Week 9. They have totaled multiple sacks in four straight weeks and have forced nine interceptions over the past seven games. 

No. 7 Tampa Bay Buccaneers (vs. Dallas Cowboys, Carolina Panthers)

In Week 16, the Buccaneers will face the Dallas Cowboys who have struggled to find consistency with Cooper Rush under center. Last weekend, they scored 30 points against the Panthers but the week before they scored only 20 and allowed three sacks with an interception against the Bengals. The Panthers have shown some upside at times but similar to Dallas have struggled to deliver on a consistent basis.

Over their past two games, the Buccaneers have allowed less than 20 points in each of them. Over this span they have tallied five sacks and two interceptions making them a viable low-end streaming option.

Titans Defense D/ST Streamers, Rankings, Waiver Wire - Harold Landry Fantasy Football IDP

No. 8 Tennessee Titans (vs. Indianapolis Colts, Jacksonville Jaguars)

Last weekend, Anthony Richardson and the Colts struggled against a tough Denver defense scoring only 13 points and allowed two sacks with two interceptions. The Jaguars offense took a step forward last weekend but remain a top streaming matchup given Mac Jones’ struggles serving as Trevor Lawrence’s replacement.

The Titans have allowed at least 30+ points in three of their past four contests. While this makes them a difficult option to trust, given their two positive matchups, they could be viewed as a last-resort option. They have tallied four interceptions in their past two games and could find similar success facing two inconsistent quarterbacks.

Jessie Bates Atlanta Falcons Defense - Fantasy Football DST, Defense Streamers, Waiver Wire IDP

No. 9 Atlanta Falcons (vs. New York Giants, Washington Commanders)

The Falcons have one of the best matchups in Week 16, with one of the most challenging in Week 17. This weekend, they will face the New York Giants who have scored just 25 combined points in their previous two games. During this span they have been sacked five times and thrown two interceptions. However, they should not be started in Week 17 facing a potent Washington offense.

The Falcons are coming off a strong defensive showing in Week 15 where they held the Raiders to just nine points. In this game they tallied a safety, four sacks, and two interceptions. They should have similar success against the Giants.

Trey Hendrickson Cincinnati Bengals Defense - Fantasy Football DST Streamers, Rankings, Pickups

Fool's Gold Streamer: Cincinnati Bengals (vs. Cleveland Browns, Denver Broncos)

In Jameis Winston‘s six starts this season, he has shown that he can still air it out in the passing game. That has led to the Browns scoring at least 24 points in three of those games. Even though last weekend he struggled, he could have a nice bounce-back performance especially given Cincinnati’s struggles in the secondary.

During the fantasy championships they face the Denver Broncos who have scored at least 29 points in each of their past four games and will likely be in store for another high-scoring affair facing the Bengals.

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REAL-TIME FANTASY NEWS

NFL

Broncos Select Dallen Bentley with 256th Pick
Kevin Durant

Uncertain for Sunday's Action
Austin Reaves

Listed as Questionable for Sunday's Game 4
Aaron Gordon

Active on Saturday
Indianapolis Colts

Colts Select Deion Burks with Pick No. 254
Joel Embiid

Remains Doubtful Ahead of Game 4
New England Patriots

Patriots Select Jam Miller with 245th Pick
Indianapolis Colts

Colts Select Seth McGowan with Pick No. 237
New England Patriots

Patriots Take Quarterback Behren Morton with Pick No. 234
Kansas City Chiefs

Chiefs Draft Garrett Nussmeier With 249th Overall Pick
Cleveland Browns

Browns Draft Carsen Ryan in the Seventh Round
Tennessee Titans

Titans Select Jaren Kanak with Pick No. 225
Washington Commanders

Commanders Take Quarterback Athan Kaliakmanis with Pick No. 223
Houston Texans

Texans Select Lewis Bond with Pick No. 204
Pittsburgh Steelers

Navy's Eli Heidenreich to the Steelers at No. 230 Overall
Jacksonville Jaguars

Jaguars Double Dip at Wide Receiver with C.J. Williams at Pick No. 203
Josh Manson

Not Expected to Play Sunday
Los Angeles Rams

Rams Select CJ Daniels with 197th Pick
Mason Lohrei

Set to Miss Game 4 as Healthy Scratch
Cincinnati Bengals

Bengals Select Jack Endries at No. 221 Overall
Las Vegas Raiders

Raiders Select Malik Benson with 195th Pick
Emil Andrae

Won't Play Saturday
Dallas Cowboys

Cowboys Select Anthony Smith in the Seventh Round
Washington Commanders

Commanders Add Running Back Competition with Kaytron Allen at Pick No. 187
Arturs Silovs

Starting Game 4 Against Flyers
Dan Vladar

Cleared for Game 4
George Kittle

Recovering Well, Could be Ready for Week 1
Mats Zuccarello

Remains Out Saturday
Tampa Bay Buccaneers

Buccaneers Select Bauer Sharp with Pick No. 185
Nikolaj Ehlers

Dealing With Lower-Body Injury
Cleveland Browns

Browns Continue Drafting Quarterbacks with Taylen Green at No. 182
Seattle Seahawks

Seahawks Select Emmanuel Henderson Jr. With 199th Overall Pick
Steven Kwan

Scratched With Neck Stiffness
Trey Yesavage

Returning From Injured List on Tuesday
Eugenio Suárez

Eugenio Suarez Heading to the Injured List With Oblique Strain
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Battles and Scores Two Points in Friday Triumph
Connor McDavid

Delivers Mixed-Bag Performance Friday
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Mikael Granlund

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Giancarlo Stanton

Exits With Leg Tightness on Friday
Isaiah Joe

Likely to Miss Game 3 Against Suns
Peyton Watson

to Remain Sidelined Saturday
Aaron Gordon

Questionable for Saturday's Game 4
Jordan Goodwin

on Track to Return Saturday
Grayson Allen

Listed as Questionable for Saturday
Mark Williams

Won't Play Saturday
Victor Wembanyama

Will Miss Game 3 Against Trail Blazers
Tari Eason

Reed Sheppard Move into Starting Five on Friday
Nickeil Alexander-Walker

Wins Most Improved Player Award
Immanuel Quickley

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Kevin Durant

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Joel Embiid

Officially Ruled Out for Game 3
Eugenio Suárez

Eugenio Suarez Scratched on Friday With Mid-Back Pain
Troy Terry

Available for Game 3 Against Oilers
Radko Gudas

Misses Second Straight Game Friday
Charle-Edouard D'Astous

Unavailable Friday
Dan Vladar

Considered a Game-Time Call for Saturday
Jake Sanderson

Ruled Out for Game 4 Due to Concussion
Yakov Trenin

Won't Play in Game 4 Against Stars
Mats Zuccarello

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Jackson Holliday

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Jeff Hoffman

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Youssef Zalal

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Aljamain Sterling

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Joselyne Edwards

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Norma Dumont

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Rafa Garcia

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Anthony Edwards

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Jordan Kyrou

Recovering From Minor Knee Procedure
Francisco Lindor

Expected to Miss "Significant Time"
Francisco Lindor

Mets Officially Place Francisco Lindor on Injured List With Calf Strain
Michael Harris II

Removed Early With Quad Tightness
Francisco Lindor

Likely Headed to the Injured List
Michael Harris II

Continues to Heat Up With Two-Homer Game on Wednesday
Francisco Lindor

Leaves Wednesday's Game Early With Calf Tightness
JR Ritchie

Earns Promotion, Will Make MLB Debut on Thursday
Wyatt Langford

Expected to Go on Injured List With Flexor Strain
Maikel Garcia

Leaves Early on Wednesday With Elbow Soreness
Roman Anthony

Day-to-Day With Sore Back
Juan Soto

Officially Back in Mets Lineup on Wednesday
J.T. Realmuto

Phillies Place J.T. Realmuto on Injured List With Back Injury
Lucas Giolito

Signs With Padres, Worth a Waiver-Wire Pickup?
CFB

Beau Pribula Leading Virginia Quarterback Competition
Marco Penge

Trending Down Entering Zurich Classic
Sahith Theegala

Eyes Another Strong Week at Zurich Classic
Brooks Koepka

Shane Lowry Teams Up with Brooks Koepka at Zurich Classic
Si Woo Kim

Adds Another Strong Finish at RBC Heritage
Luke Clanton

Hoping to Find Form in New Orleans
Scottie Scheffler

is Starting to Hit His Stride
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Tyler Reddick

Earns His Fifth Win of the 2026 Season at Kansas
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Finishes as the Runner-Up at Kansas
Chase Briscoe

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Denny Hamlin

Leads the Most Laps at Kansas but Misses Out on Victory
Christopher Bell

Falls Out of Contention for Kansas Victory on Final Restart
Mike Malott

Scores Third-Round TKO Win
Gilbert Burns

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Charles Jourdain

Extends Winning Streak
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Drops Decision At UFC Winnipeg
Mandel Nallo

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Scores First-Round TKO Win
Karine Silva

Gets Dominated at UFC Winnipeg
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Dominates Karine Silva
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