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MLB Betting Picks for Saturday 4/3 - Moneylines, Totals, and Runlines

Jamie Steed recommends betting picks for the MLB slate on 4//2021. He breaks down each team's situation and suggests the top picks on money lines, totals, run lines, and more!

If you're expecting Steve Janik's picks today, then I'm afraid you're in for a disappointment. Steve will be continuing to do the weekdays and I'll be deputizing for the Saturday slates. As well as covering baseball at RotoBaller, I also do the EPL soccer betting pieces so have experience of both aspects and will hopefully help you make some money this season.

Like with my soccer articles, I want to remind you that gambling should be fun. When the fun stops, stop. Never bet more than you're willing to lose. I'm no professional gambler, just a guy who loves the game and likes a bet. But I'll still be giving 100% in my research to make us some money. Everything I put here, I'll be backing myself so we're in this together. I'll also be keeping track of only my picks so I don't drag Steve's numbers down.

We have been really increasing our sports betting content at RotoBaller, and this year will be no different. Tommy Bell will be handling things over in our premium offering, Steve will be carrying the free picks on weekdays throughout the season with some help from yours truly. Early on in the season, our plays will be smaller in volume, as we have very little info on teams and players. As things start to progress, expect to see more action. Let's make some money and have fun. but remember, please gamble responsibly!

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2021 MLB Betting Picks

Moneyline Record: 0-0
O/U Record: 0-0
Runline Record: 0-0
Prop Record: 0-0
2021 Total Record: 0-0

 

San Francisco Giants at Seattle Mariners

O/U: 8.5 | Moneyline: SEA +100, SFG -120

SFG: Logan Webb; SEA: Chris Flexen

The Giants' Opening Day defeat was creative, blowing a five-run lead in the bottom of the eighth inning then three straight walks saw the Mariners walk it off in the tenth. Given their bullpen was decent in 2020 (4.24 ERA), the manner of the defeat is concerning. On the plus side, they managed to score seven runs themselves. Saturday's starter Webb had a 5.36 ERA last year, although his xFIP and SIERA suggest he was a bit better than that. The Giants ranked 11th in OPS versus right-handed pitching last year so their offense has been solid, if not spectacular.

The Mariners are sending Flexen to the mound and despite a 3.01 ERA in the KBO (Korean Baseball Organisation) last year, prior to that he was dreadful in MLB with a career 8.07 ERA. Many scouts believe the KBO is similar to Double-A in regards to their comparative ability, which goes some way to explaining Flexen's success. The Mariners bullpen last year was 5.92 (3rd worst) and their biggest addition to it this offseason was Rafael Montero who blew the save on Opening Day. Their offense does look improved with the addition of Ty France and the return of Mitch Haniger, both of whom should more than offset the loss of Kyle Lewis to the IL.

The Mariners and Giants played each other four times last year, with the Giants winning all four games. Every game had at least ten runs scored in them and Opening Day saw them combine for 15 runs. I prefer the Mariners offense but their pitching makes it hard to back them to win the game. With both starting pitchers having low strikeout numbers, high ERAs and questionable bullpens, we should see plenty of runs in this one.

Pick: Run line over 8.5 (-115) 1 Unit

 

Pittsburgh Pirates at Chicago Cubs

O/U: 11 | Moneyline: CHC -167, PIT +152

PIT: Tyler Anderson; CHC: Jake Arrieta

These next two picks I'm a little more apprehensive about going all-in on but think there is a bit of value to be had, hence only half a unit on each.

The Pirates had a .612 OPS versus right-handed pitching last year which was the worst in the Major League. Meanwhile, the Cubs had a .619 OPS versus left-handed pitching last year, second-worst in the Major League. Opening day saw them combine for eight runs on 11 hits and their 11 games last year combined for 80 runs (average of 7.27 per game). Neither offense fills me with confidence and if any team puts together a big inning, it will likely come once the bullpens get called into action, which is entirely possible given both team's relief pitchers.

Pick: Under 6 runs 1st 5 innings (-110) 0.5 Units

 

Minnesota Twins at Milwaukee Brewers

O/U: 7.5 | Moneyline: MIL -127, MIN +117

MIN: Jose Berrios; MIL: Corbin Burnes

The Twins blew a three-run lead in the bottom of the ninth on Opening Day, with new reliever Alex Colome blowing the save despite all three runs being unearned. Josh Hader then struck out the side in the tenth inning before the Brewers walked it off. Having an off day Friday, the Brewers bullpen aces will be rested and can go again Saturday which gives them an edge.

The Twins will again be without Nelson Cruz in the starting lineup due to there being no DH and they lost Josh Donaldson through injury. The Brewers offense looks the better of the two teams and their bullpen also contains the aforementioned Hader and 2020 NL Rookie of the Year Devin Williams. Both starting pitchers should be pretty evenly matched, so the Brewers look the more likely winner in what should be another close game.

I generally avoid taking the runline when backing the home team to win (especially in a game I expect to be close). In a tied game in the ninth inning or beyond, it's less likely the home team wins by two or more runs, as we saw between these two teams on Opening Day.

Pick: Brewers Moneyline (-127) 0.5 Units




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REAL-TIME FANTASY NEWS

OG Anunoby

is Downgraded to Out for Game 3 on Friday
Mitchell Robinson

is Returning for Game 3
Mats Zuccarello

Expected to Play Saturday
Joel Eriksson Ek

to Be a Game-Time Decision Saturday
Jonas Brodin

Still Out Saturday
Josh Manson

Could Return Saturday
Kaedan Korczak

Scratched for Game 3 Against Ducks
Radko Gudas

Likely to Remain Out Friday
Sam Carrick

Won't Play Friday
Isiah Pacheco

Can Isiah Pacheco Re-Establish His Dynasty Value in Detroit?
Rico Dowdle

Dynasty Ceiling Limited By Backfield Committee in Pittsburgh
Rashid Shaheed

a High-Risk, High-Reward Buy-Low Candidate for Dynasty Managers
Marcus Mariota

Is Marcus Mariota Worth Stashing as an Injury Replacement in Dynasty Leagues?
Jacoby Brissett

a Clear Sell-High Candidate for Dynasty Managers
Blake Snell

to Make Season Debut for Dodgers on Saturday
Najee Harris

Can Najee Harris Re-Establish Some Dynasty Value in 2026?
Cole Ragans

Royals Place Cole Ragans on Injured List With Elbow Impingement
Breece Hall

Jets Sign Breece Hall to Three-Year Extension Worth $45.75 Million
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
Nick Lodolo

Officially Activated, Making Season Debut on Friday
Denver Broncos

Broncos Sign GM George Paton to New Five-Year Deal
Brandon McManus

Packers Release Kicker Brandon McManus
New York Jets

Jets Talking to a "Number of Veteran Quarterbacks"
Travis Etienne Jr.

a Reliable Dynasty Starter Entering First Season With Saints
Kenneth Gainwell

Is Kenneth Gainwell's Dynasty Stock Still Rising After Offseason Change of Scenery?
Mac Jones

a Deep-League Dynasty Stash Candidate
Tez Johnson

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Jared Goff

Remains a High-Floor Dynasty QB2 Heading into 2026
De'Von Achane

Remains a High-End Dynasty RB Despite Uncertain Supporting Cast
Xavier Worthy

Chiefs Limited Xavier Worthy's Usage After Injury Last Year
Rashee Rice

Chiefs Not Ready to Discuss Extension With Rashee Rice?
Cade Otton

Remains a Quality Dynasty Depth Piece
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
Austin Reaves

Scores 31 Points in Game 2 Defeat
T.J. Hockenson

Bounce-Back Chances Stifled by Improved Pass-Catching Depth
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
Chet Holmgren

Anchors Thunder Past Lakers in Game 2
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
Jordan Addison

Facing Competition for No. 2 Role?
Tobias Harris

Stays Hot in Game 2 Victory
Cade Cunningham

Pushes Pistons to 2-0 Series Lead
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
Jarrett Allen

Provides Bright Spot in Cavs' Game 2 Loss to Pistons
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Rasheem Biles an Instant Impact Player for Texas
James Harden

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Donovan Mitchell

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Gradey Dick

Open to Trade Away From Toronto
Michael Porter Jr.

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Charlotte Hornets

Hornets Extend Charles Lee After 25-Win Improvement
Jarred Vanderbilt

Ruled Out for Game 2 Against Thunder
Luke Kennard

Cleared to Play Thursday
Ayo Dosunmu

Considered Questionable for Game 3 Against Spurs
Anthony Edwards

Remains Questionable on Injury Report Ahead of Game 3
Mitchell Robinson

Probable for Friday's Action
Kevin Huerter

Remains Out Thursday
Sam Merrill

Unavailable Thursday
OG Anunoby

Tagged as Questionable for Friday
Joel Embiid

Listed as Questionable for Game 3 Against Knicks
Dan Vladar

Looks to Return to Winning Ways Thursday
Connor Dewar

Penguins Re-Sign Connor Dewar for Two Years
Mikko Rantanen

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Rasmus Dahlin

Ready to Go Friday
Alexander Nikishin

Set to Return Thursday
Christian Dvorak

Available Thursday
Owen Tippett

Remains Out Thursday
Roman Anthony

Heading for the Injured List
CFB

Sam Leavitt Expected to Be Full-Go for Fall Camp
Tarik Skubal

Could Return in 4-6 Weeks After Successful Elbow Surgery
Cole Ragans

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Mark Stone

Nets Late Power-Play Goal in Losing Effort
Leo Carlsson

Pots Game-Winner Wednesday Night
Juraj Slafkovsky

Ends Point Drought in Game 1 Loss
Bowen Byram

Ties Franchise Record With Fourth Postseason Goal
Zach Benson

Posts Second Consecutive Multi-Point Game
Rasmus Dahlin

"Seems Fine" After Early Exit on Wednesday
Emilio Pagán

Emilio Pagan has Grade 2 Hamstring Strain, Expected to Miss 4-8 Weeks
Joe Ryan

Listed as Scheduled Starter for Saturday Against Cleveland
Tyler Glasnow

Not Expected to Land on the Injured List
Framber Valdez

Suspension Reduced to Five Games
Nils Hoglander

Will Miss World Championship Due to Injury
Framber Valdez

Suspended Six Games
Tyler Glasnow

Exits Early on Wednesday With Back Pain
CFB

Brauntae Johnson the Next Star in Notre Dame's Secondary?
CFB

Ethan Barbour a Name to Know in Georgia's Tight End Room
CFB

Payton Pierce Next Up at Linebacker for Ohio State
CFB

Javin Gordon to Play Significant Role for Tennessee?
CFB

Tanook Hines Stepping into WR1 Role for USC
CFB

Rueben Owens II has "Star Potential" in Fourth Campaign
Brandon Woodruff

has Fluid Drained From his Right Shoulder
Brandon Woodruff

to Resume Throwing on Saturday, Return Imminent?
Carlos Correa

to Have Season-Ending Ankle Surgery
Jacob Misiorowski

Listed as Friday's Probable Starter
Logan Webb

Dealing With Knee Discomfort
Carlos Correa

Expected to Miss Significant Time With Ankle Injury
Collin Morikawa

Withdraws From Truist Championship
Xander Schauffele

Carries Elite Form Into Quail Hollow
Hideki Matsuyama

Looks to Bounce Back at Truist Championship
Matt Fitzpatrick

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Patrick Cantlay

Continues Playing Well Heading to Truist Championship
Ludvig Aberg

Returns to Action For Truist Championship
Justin Thomas

Searching for Consistency at Quail Hollow
Jordan Spieth

Looks to Break Through at Quail Hollow
Adam Scott

Brings Strong Form to Quail Hollow
Robert MacIntyre

a Steady Option at Truist Championship
Jason Day

Looks to Overcome Approach Struggles at Quail Hollow
Akshay Bhatia

Looks for Complete Game at Truist Championship
Emilio Pagán

Emilio Pagan Headed for Injured List With Hamstring Injury
Emilio Pagán

Emilio Pagan Carted Off With Apparent Hamstring Injury on Tuesday
Justin Rose

to Continue Mid-Season Club Change at Truist Championship
Si Woo Kim

is Back to Peak Form Ahead of Truist Championship
Sam Burns

to Bounce Back at Truist Championship
Cameron Young

Looks to Carry Dominance to Quail Hollow
Rory McIlroy

Returns to Familiar Stomping Grounds This Week at Quail Hollow
Chris Gotterup

Looking to Bounce Back at Quail Hollow
MLB

Cardinals-Brewers Game Postponed on Tuesday
Tommy Fleetwood

Looking For Better Iron Play at Quail Hollow
CFB

Mario Craver Enters No. 1 Wide Receiver Role for Marcel Reed
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LaNorris Sellers a Strong Rebound Candidate in 2026
CFB

Cam Coleman Poised for Monster Year at Texas?
CFB

Will Hammond Pushing to Be Ready for Week 1
Alex Fitzpatrick

Looking to Keep Up Ball-Striking Output at Quail Hollow
CFB

Notre Dame Leads College Football in Returning Snaps
CFB

Two Ole Miss Football Players Arrested, Charged with DUI
Ben Griffin

Looks Solid on the Surface Heading to Charlotte
Chase Elliott

Earns his Second Texas Motor Speedway Victory
Denny Hamlin

Misses Out on Winning at Texas
Alex Bowman

Finishes Third for the Second Week in a Row at Texas
Tyler Reddick

Earns Seventh Top-Five Finish of the Season at Texas
Chris Buescher

Scores his First Career Texas Finish in the Top Five
CFB

Bryce Underwood in Better Situation Entering Sophomore Season
CFB

Nico Iamaleava Emerging as Leader, Playmaker for UCLA
Jack Della Maddalena

Gets Dominated At UFC Perth
Carlos Prates

Shines At UFC Perth
Beneil Dariush

Suffers A First-Round TKO Loss
Quillan Salkilld

Remains Unbeaten In The UFC
Tim Elliott

Drops Decision At UFC Perth
Steve Erceg

Wins Back-To-Back Fights
Ollie Schmid

Suffers First-Round TKO Loss
Marwan Rahiki

Remains Unbeaten
Christopher Bell

Is Christopher Bell Worth Rostering for Texas Lineups?
William Byron

Might have the Speed to Compete for the Win at Texas
Joey Logano

Provides Solid Upside for Texas DFS Lineups
Chase Briscoe

Could Chase Briscoe be A Sneaky Pick for Texas Lineups?
Ty Gibbs

Should DFS Managers Roster Ty Gibbs at Texas?
Daniel Suarez

Is Daniel Suarez Worth Rostering After Career-Best Starting Position at Texas?
Kyle Busch

Is a DFS Risk Starting in the Top 10 at Texas
Tyler Reddick

One of the Favorites to Win at Texas
Chase Elliott

Could Contend for Another Win at Texas
Carson Hocevar

on Pole at Texas
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Chris Buescher

Looking to Continue Strong Run at Texas
Austin Dillon

Blows Engine in Practice at Texas