👉 TAP TO SAVE 30% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

Midwest Region Picks: March Madness Bracket Predictions

NCAA Tournament - March Madness College Basketball

NCAA Tournament bracket picks and team predictions for the Midwest Region. Read Shane's March Madness picks, sleepers and busts including teams to target and avoid.

After nearly two years without March Madness, the NCAA Tournament has returned! That means it's time to complete your brackets and we're here to help. RotoBaller will be bringing you a full breakdown on each tournament region, including some potential sleepers and busts. Today we'll be taking a look at the Midwest Region. 

We'll run through the highly seeded teams in this region, some sleepers, busts to watch out for, and who I like to represent this region in the Final Four.

Once you're done here, be sure to also check out the rest of our NCAA Tournament articles and analysis including previews, predictions, sleepers, busts and guides on how to fill out your brackets.

 

Midwest Region Top Four Seeds 

Top four seeds: No. 1 Illinois, No. 2 Houston, No. 3 West Virginia, No. 4 Oklahoma State

Illinois is one of the hottest teams in college basketball, having lost just once since mid-January. The Illini completed their charge to a top seed by winning the Big Ten Tournament in dramatic fashion on Sunday. The Selection Committee rewarded the Illini with a No. 1 seed, yet the road to the Final Four is far from a cakewalk. This region is loaded with Final Four caliber teams.

That list starts with Houston. The Cougars are 24-3 this season, with all three losses coming in true road games in conference play. Houston ranks in the top 20 in the nation in offensive and defensive efficiency, joining only top seeds Gonzaga, Michigan, and Illinois. Kansas transfer Quentin Grimes has settled in as the go-to-guy in Kelvin Sampson's offense, scoring 18.0 points per game. The most concerning thing about Houston is the Cougars' tendency to commit bail out fouls. Only five teams in college basketball allowed their opponents to score a higher percentage of their points at the free throw line. Over-aggressiveness from Houston got the Cougars in trouble. If the officials call a tight game, Houston is in trouble.

West Virginia slots in as the 3-seed, following a great run in the Big XII this season. Bob Huggins isn't playing his usual "Press Virginia" style. This team is more talented on the offensive end than the past Mountaineer teams that won games with defensive pressure and forced turnovers. Strong shooters dot the perimeter while Deuce McBride creates off the dribble and Derek Culver mans the paint. The Mountaineers love to attack the rim and led their conference in free throw rate.

Lastly, Oklahoma State is likely disappointed with a 4-seed. The Cowboys have looked like one of the nation's most competitive teams of late, racking up 10 Quad 1 wins. Cade Cunningham, a near certainty to be the top pick in this year's NBA Draft, runs the show as a tall, creative point guard. He operates the Cowboy offense, but the role players around him have improved in so many ways this season, preventing teams from overloading their defense toward Cunningham.

 

Most Intriguing First Round Matchup

No. 8 Loyola-Chicago vs No. 9 Georgia Tech

Two teams who just won their conference tournaments, in multi-bid leagues, now squaring off in the first round. The "8 vs. 9" games always fly a little under-the-radar, since they don't have the excitement of a possible upset. That shouldn't be the case here. These are two of the most interesting teams in the field.

Loyola ended the season with the top defensive according to Adjusted defensive efficiency, holding average opponents to just 0.86 points per possession. Offensively, senior center Cameron Krutwig, who contributed to the Ramblers' Final Four run four years ago, runs the show from the high post. His whirling, spinning post moves and brilliant court vision has fans calling him "Jesuit Jokic".

Georgia Tech, meanwhile, is one of the most aggressive defensive teams in the nation. The Yellow Jackets hound opposing ball handlers, reaching for steals whenever possible. Point guard Jose Alvarado is particularly feisty and should make life difficult for Loyola's Braden Norris. This one should stay low scoring, but if the Yellow Jackets are making shots, they should have the upper hand.

 

Bust of the Region

While this region does have a real chance to stay chalk, there are definitely some reasons for pessimism around Oklahoma State. The Cowboys played incredible basketball in February and early March, though it's valid to wonder if they can repeat that level of play.  Over their last 11 games, the Cowboys have won nine times. Three of those wins came in overtime and eight of them came by single digits. Eventually, they won't be able to continue skating by so narrowly.

 

Final Four Pick

Despite the difficult path laid in front of the Illini, it's really hard to pick against Illinois here. Brad Underwood has built a beautiful team in Champagne, centered around Ayo Dosunmu and Kofi Cockburn, both of whom made first-team All-Big Ten. The role players around the Illinois stars have settled in perfectly, making shots when needed and defending their positions. Freshman Andre Curbelo has the chance to be the X-factor who elevates the Illini to the next level. When Dosunmu and Cockburn have tough matchups, foul trouble, or an off-game, Illinois turns to Curbelo, who is a wizard with the ball in his hands. If he can continue to create offense for his teammates, it's hard to see any team in this region topping the Illini.

More March Madness Brackets Advice




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Stephon Gilmore

Announces His Retirement
Hunter Brown

Placed on 15-Day Injured List with Right-Shoulder Strain
Matthew Stafford

Rams to Put Matthew Stafford on Pitch Count Ahead of 2026 Season?
Isaiah Likely

John Harbaugh "Certain" Isaiah Likely Will Break Out
New York Jets

Jets "Leaning Toward" Arvell Reese at No. 2 Overall
Cleveland Browns

Browns Targeting Carnell Tate at No. 6 Overall?
Tennessee Titans

Titans "Love" Their Running Back Room
Jauan Jennings

Asking for Too Much Money?
Brandon Aiyuk

Nothing Imminent With Brandon Aiyuk
Luther Burden III

Bears Want to Continue to Get the Ball to Luther Burden III
Jesús Luzardo

Jesus Luzardo Dominates Rockies on Saturday
Byron Buxton

Back in Sunday's Lineup
Mookie Betts

Heading to the Injured List With Oblique Strain
A.J. Brown

to be Traded to Patriots on June 2?
Cade Horton

Cubs Place Cade Horton on 15-Day Injured List With Forearm Strain
Isaiah Collier

Out Again Sunday
Immanuel Quickley

Still Sidelined Sunday
Nicolas Claxton

Won't Play Sunday
Evan Mobley

Sidelined Sunday
Jarrett Allen

Won't Play Against Indiana
Pascal Siakam

Ruled Out Sunday
Clayton Keller

Collects Four Points Against Canucks
Andrew Nembhard

Ruled Out Vs. Cleveland
Jack Eichel

Records Three Assists in Saturday's Win
Gabe Perreault

Nets First Career Hat Trick
Nicolas Hague

Exits Early Against Sharks
MacKenzie Weegar

Listed as Day-to-Day
Jack McBain

Considered Week-to-Week
Justin Faulk

Questionable Sunday
MarShawn Lloyd

a Dynasty Trade Target with Long-Term Upside?
Emanuel Wilson

a Low-Risk Trade Target in Dynasty Leagues?
Jalen Nailor

Seems Likely to Face Competition
Adrian Kempe

Delivers a Four-Point Performance
Dylan Sampson

a Candidate for Standalone Value in 2026?
Jaylin Noel

Still the Texans' WR4 for 2026?
Evgeni Malkin

Collects Four Points on Saturday
Keenan Allen

Remains a Free Agent in Early April
Mookie Betts

Considered Day-to-Day, Heading for an MRI on Saturday
Juan Soto

Day-to-Day With Minor Groin Strain, No Decision on IL Yet
Anthony Edwards

Questionable for Sunday
Andre Drummond

Kelly Oubre Jr., Andre Drummond Join Starting Lineup Saturday
Marcus Sasser

Upgraded to Available
Atlanta Falcons

Mike Washington Jr. Visits With Falcons
Tobias Harris

Cleared to Play Saturday
Jalen Duren

Available Saturday
Arizona Cardinals

Cardinals "Pushing Hard" for Jeremiyah Love
Paul George

Ready to Rock Saturday
Bruce Brown

Suffers Leg Injury Saturday
Shedeur Sanders

the Favorite to Win Browns QB Job?
Kirk Cousins

Could Make Starts for Raiders in 2026
Austin Reaves

Out for Remainder of Regular Season
Travon Walker

Jaguars Sign Travon Walker to Four-Year Extension
Nick Lardis

Available Against Kraken
Oliver Ekman-Larsson

Won't Play Saturday
MLB

Cubs-Guardians Game Postponed on Saturday
Mookie Betts

Leaves Early With Back Injury
Tyler Kleven

Out Week-to-Week
Mason Marchment

Expected to Return Saturday
Aliaksei Protas

Returns on Saturday
Zach Hyman

Could Miss Two Weeks
Damon Severson

Undergoes Season-Ending Surgery
Jalen Duren

Added to Injury Report Saturday
Paul George

Probable Saturday
Tyler Herro

a Late Scratch Saturday, Simone Fontecchio Starts
Joel Embiid

Will Sit Out Saturday's Game
Justin Champagnie

Active Saturday
Bilal Coulibaly

Tre Johnson Available Against Heat
Alejandro Kirk

Placed on 10-Day Injured List With Thumb Fracture
Juan Soto

Mets Concerned About Juan Soto's Calf Injury
Juan Soto

Removed with Calf Tightness
PHI

Daniel Vladar Defeats the Islanders
Matvei Michkov

Has Three-Point Game on Friday
Byron Buxton

is Day-to-Day with Forearm Contusion
Byron Buxton

Leaves on Friday After Being Hit by a Pitch
Cade Horton

Headed for Injured List Stint
Isaac Paredes

Placed on Bereavement List
Jordan Lawlar

Suffers Fractured Wrist, Set to Miss 6-8 Weeks
Alejandro Kirk

Having X-Rays on his Thumb
Cade Horton

Exits Friday's Start with Forearm Tightness
Chase DeLauter

Returns to Lineup on Friday After Injury Scare
Chris Duncan

Set For UFC Vegas 115 Main Event
Renato Moicano

An Underdog At UFC Vegas 115
Tabatha Ricci

Set For UFC Vegas 115 Co-Main Event
Virna Jandiroba

Looks To Bounce Back
Brendson Ribeiro

In Desperate Need Of Win
Abdul-Rakhman Yakhyaev

Looks To Remain Unbeaten
Ethyn Ewing

Set For His Second UFC Bout
Rafael Estevam

Looks To Remain Undefeated
Patrick Kane

Becomes NHL's Highest-Scoring American
Elias Salomonsson

Lands in Concussion Protocol
Nick Lardis

Injures Left Hand Thursday
Konnor Griffin

Secures $140M Deal; Pittsburgh Building Around Young Star
CFB

Gunner Stockton Looking "Great" After Offseason Injury
CFB

Sam Leavitt Showing "Encouraging Signs" at LSU Practice
J.J. Spaun

Needs the Putter to Cooperate in San Antonio
Thorbjorn Olesen

Trending Up in San Antonio
Denny McCarthy

Carrying Momentum into San Antonio
Chris Kirk

Has Course History on His Side in San Antonio
Billy Horschel

a Volatile Option at the Valero Texas Open
Joe Highsmith

Still Searching for Form in San Antonio
Christiaan Bezuidenhout

Looks to Find Form at the Valero Texas Open
Jordan Spieth

a Horse for Course History at TPC San Antonio
Robert MacIntyre

Has One Flaw to Overcome at Valero Texas Open to be a Must-Play
Maverick McNealy

In Exceptional Form This Season
Michael Thorbjornsen

Playing Well But Still Searching For A Win
Hideki Matsuyama

Playing Well Heading to the Valero Texas Open
Si Woo Kim

Heads to Valero Texas Open For Final Tune-Up Before Masters
Collin Morikawa

Withdraws From Valero Texas Open
PGA

Stephan Jaegar Still Looking For Consistency at Valero Texas Open
Nicolai Hojgaard

is Red-Hot Coming to TPC San Antonio
Tony Finau

a Risky Proposition at Valero Texas Open
Ludvig Aberg

Looks to Shake Off Collapse at Valero Texas Open
Patrick Rodgers

Needs to Make More Birdies in San Antonio
Sepp Straka

Seeks Opportunity in San Antonio This Weekend
Nick Taylor

Could Again Struggle at the Valero Texas Open
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF