👉 TAP TO SAVE 30% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

Midwest Region Picks: March Madness Bracket Predictions

NCAA Tournament - March Madness College Basketball

NCAA Tournament bracket picks and team predictions for the Midwest Region. Read Shane's March Madness picks, sleepers and busts including teams to target and avoid.

After nearly two years without March Madness, the NCAA Tournament has returned! That means it's time to complete your brackets and we're here to help. RotoBaller will be bringing you a full breakdown on each tournament region, including some potential sleepers and busts. Today we'll be taking a look at the Midwest Region. 

We'll run through the highly seeded teams in this region, some sleepers, busts to watch out for, and who I like to represent this region in the Final Four.

Once you're done here, be sure to also check out the rest of our NCAA Tournament articles and analysis including previews, predictions, sleepers, busts and guides on how to fill out your brackets.

Featured Promo! Save 30% on any Premium Pass using discount code NEW. Win more with our DFS, Betting and Season-Long Pass, get expert tools and advice from proven winners! GAIN ACCESS

 

Midwest Region Top Four Seeds 

Top four seeds: No. 1 Illinois, No. 2 Houston, No. 3 West Virginia, No. 4 Oklahoma State

Illinois is one of the hottest teams in college basketball, having lost just once since mid-January. The Illini completed their charge to a top seed by winning the Big Ten Tournament in dramatic fashion on Sunday. The Selection Committee rewarded the Illini with a No. 1 seed, yet the road to the Final Four is far from a cakewalk. This region is loaded with Final Four caliber teams.

That list starts with Houston. The Cougars are 24-3 this season, with all three losses coming in true road games in conference play. Houston ranks in the top 20 in the nation in offensive and defensive efficiency, joining only top seeds Gonzaga, Michigan, and Illinois. Kansas transfer Quentin Grimes has settled in as the go-to-guy in Kelvin Sampson's offense, scoring 18.0 points per game. The most concerning thing about Houston is the Cougars' tendency to commit bail out fouls. Only five teams in college basketball allowed their opponents to score a higher percentage of their points at the free throw line. Over-aggressiveness from Houston got the Cougars in trouble. If the officials call a tight game, Houston is in trouble.

West Virginia slots in as the 3-seed, following a great run in the Big XII this season. Bob Huggins isn't playing his usual "Press Virginia" style. This team is more talented on the offensive end than the past Mountaineer teams that won games with defensive pressure and forced turnovers. Strong shooters dot the perimeter while Deuce McBride creates off the dribble and Derek Culver mans the paint. The Mountaineers love to attack the rim and led their conference in free throw rate.

Lastly, Oklahoma State is likely disappointed with a 4-seed. The Cowboys have looked like one of the nation's most competitive teams of late, racking up 10 Quad 1 wins. Cade Cunningham, a near certainty to be the top pick in this year's NBA Draft, runs the show as a tall, creative point guard. He operates the Cowboy offense, but the role players around him have improved in so many ways this season, preventing teams from overloading their defense toward Cunningham.

 

Most Intriguing First Round Matchup

No. 8 Loyola-Chicago vs No. 9 Georgia Tech

Two teams who just won their conference tournaments, in multi-bid leagues, now squaring off in the first round. The "8 vs. 9" games always fly a little under-the-radar, since they don't have the excitement of a possible upset. That shouldn't be the case here. These are two of the most interesting teams in the field.

Loyola ended the season with the top defensive according to Adjusted defensive efficiency, holding average opponents to just 0.86 points per possession. Offensively, senior center Cameron Krutwig, who contributed to the Ramblers' Final Four run four years ago, runs the show from the high post. His whirling, spinning post moves and brilliant court vision has fans calling him "Jesuit Jokic".

Georgia Tech, meanwhile, is one of the most aggressive defensive teams in the nation. The Yellow Jackets hound opposing ball handlers, reaching for steals whenever possible. Point guard Jose Alvarado is particularly feisty and should make life difficult for Loyola's Braden Norris. This one should stay low scoring, but if the Yellow Jackets are making shots, they should have the upper hand.

 

Bust of the Region

While this region does have a real chance to stay chalk, there are definitely some reasons for pessimism around Oklahoma State. The Cowboys played incredible basketball in February and early March, though it's valid to wonder if they can repeat that level of play.  Over their last 11 games, the Cowboys have won nine times. Three of those wins came in overtime and eight of them came by single digits. Eventually, they won't be able to continue skating by so narrowly.

 

Final Four Pick

Despite the difficult path laid in front of the Illini, it's really hard to pick against Illinois here. Brad Underwood has built a beautiful team in Champagne, centered around Ayo Dosunmu and Kofi Cockburn, both of whom made first-team All-Big Ten. The role players around the Illinois stars have settled in perfectly, making shots when needed and defending their positions. Freshman Andre Curbelo has the chance to be the X-factor who elevates the Illini to the next level. When Dosunmu and Cockburn have tough matchups, foul trouble, or an off-game, Illinois turns to Curbelo, who is a wizard with the ball in his hands. If he can continue to create offense for his teammates, it's hard to see any team in this region topping the Illini.

More March Madness Brackets Advice




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Jake Allen

has Excellent Performance in Defeat
Logan Thompson

Nearly Perfect In Victory
Pascal Siakam

Uncertain for Saturday Against Spurs
Stephon Castle

Questionable for Saturday Versus Pacers
Donovan Mitchell

Questionable as Cavaliers Visit New Orleans
Kevin Porter Jr.

Listed as Questionable Against Phoenix
Isaiah Collier

to Miss Second Straight Game
Joel Embiid

Out Saturday Against Utah
Tanner Bibee

to Take the Ball on Opening Day
Logan Webb

to Start on Opening Day for Giants
Christian Wilkins

"Fully Intends" to Play in 2026
Jake Bobo

Jaguars Sign Receiver Jake Bobo to an Offer Sheet
Trent Williams

49ers Decline to Pick Up Trent Williams' $10 Million Option Bonus
Jaxon Smith-Njigba

Seahawks Exercise Jaxon Smith-Njigba's Fifth-Year Option
Cristopher Sánchez

Cristopher Sanchez to Start on Opening Day for Phillies
Chris Sale

Braves Name Chris Sale as Their Opening Day Starter
Kyle Stowers

Leaves Friday's Game With Hamstring Tightness
DJ Chark

Hangs Up his Cleats
Naz Reid

Ruled Out Friday Against Portland
Jasson Domínguez

Jasson Dominguez Optioned to Triple-A
GG Jackson II

Out Friday Against Boston
Austin Reaves

Added to Injury Report Saturday
Kawhi Leonard

Questionable Against Dallas
Trae Young

Still Sidelined Saturday
Terance Mann

is Unavailable on Friday
Tyler Toffoli

Won't Play Saturday
Andrew Wiggins

Remains Out Saturday
Marcus Sasser

to Sit Out on Friday
Cedric Coward

a Late Scratch Friday
Joel Armia

Ready to Return From Back Injury
Quinten Post

is Ruled Out for Friday's Game
Joel Eriksson Ek

Kirill Kaprizov, Joel Eriksson Ek to Remain Out Saturday
Karl-Anthony Towns

Set to Suit Up Against Brooklyn
Ziaire Williams

to Play on Friday
Ross Colton

Still Out Friday
Ben Saraf

is Available on Friday
Yan Kuznetsov

Remains Sidelined Friday
Ivica Zubac

to Miss Rest of the Season
Shayne Gostisbehere

Misses Seventh Straight Contest
Jacob Misiorowski

Named Opening Day Starter
Morgan Rielly

Cleared to Play Friday
Mike Trout

X-Rays Come Back Negative on Mike Trout's Hand
Ja'Tavion Sanders

Panthers Expect Ja'Tavion Sanders to be Ready for Offseason Program
Dylan Crews

Optioned to Triple-A Rochester
Quinshon Judkins

Does Quinshon Judkins Have RB1 Upside in Dynasty Formats?
Jayden Reed

Is Jayden Reed a Buy-Low Candidate After Injury-Marred 2025 Campaign?
Lerone Murphy

Set For UFC London Main Event
Chris Olave

Rehabs his Dynasty Value With Resurgent 2025 Performance
Movsar Evloev

Looks To Remain Unbeaten
Tyrone Tracy Jr.

Facing Uphill Battle for Playing Time in New York
Michael Aswell

Jr. An Underdog At UFC London
Luke Riley

Set For UFC London Co-Main Event
Chimere Dike

Could See a Diminished Role in 2026
Joe Ryan

Named Opening Day Starter for Twins
Chase Brown

Profiles as a High-End Dynasty Running Back Heading into 2026
Sam Patterson

Looks To Extend His Win Streak
Michael Page

Set For Welterweight Bout
Austen Lane

In Dire Need Of Victory
Iwo Baraniewski

A Favorite At UFC London
C.J. Stroud

Will C.J. Stroud Ever Rediscover his Rookie-Season Magic?
Bijan Robinson

Finally Has the Falcons' Backfield All to Himself
Najee Harris

Remains on the Open Market
George Kittle

Injury Complicates Price Tag
Jameson Williams

Flashes WR1 Upside Ahead of 2026
Parker Washington

a Solidified Fantasy Option Despite Crowded Offense?
Nico Collins

Has Yet to Reach His Full Potential
Collin Murray-Boyles

Unlikely to Play Friday
Sergei Bobrovsky

Shuts Out Oilers with 21 Saves
Trent Frederic

Exits Early Against Panthers
Mason Appleton

Hurt Thursday Night
Tyler Toffoli

Suffers Lower-Body Injury in Thursday's Loss
Victor Hedman

Makes Early Exit Due to Illness
Juuse Saros

Dealing with Upper-Body Injury
Rome Odunze

Steps Into a Larger Role for 2026
Baker Mayfield

Loses Top Receiver After Subpar Season
Spencer Knight

Shuts Down the Wild on Thursday
Adam Fantilli

Scores Two Goals in Victory
Francisco Alvarez

Pulled Early Thursday With Back Tightness
Auston Matthews

Ruled Out for 12 Weeks
Yaroslav Askarov

Still Out Thursday
Luis Severino

to Start for A's on Opening Day
Kirill Kaprizov

Won't Play Against Blackhawks
Alex Tuch

Expected to Return Thursday
Logan Gilbert

Named Mariners Opening Day Starter
José Ramírez

Jose Ramirez Back in Cactus League Lineup on Thursday
Hayden Birdsong

to Have Tommy John Surgery, Miss Entire 2026 Season
Zack Wheeler

to Pitch in Minor-League Game on Monday
Paul Skenes

Pirates Officially Name Paul Skenes Their Opening Day Starter
Jurickson Profar

Officially Suspended for Entire 2026 Season
Carson Williams

"Likely" to Be Rays Opening Day Starting Shortstop
Trey Yesavage

Will Open 2026 on the Injured List Due to Shoulder Impingement
Max Fried

to Start on Opening Day for Yankees
Akshay Bhatia

Withdraws From Valspar Championship
CFB

Alberto Mendoza Drawing Positive Reviews at Georgia Tech
CFB

Anthony Colandrea Impressing in Nebraska's Spring Practices
J.J. Spaun

Offers Upside Despite Poor Course History at Innisbrook
Aaron Rai

Looks to Bounce Back at Valspar Championship
Johnny Keefer

Brings Ball-Striking Upside to Valspar Championship
Billy Horschel

a Volatile Play at Valspar Championship
Ben Griffin

Looks to Rebound at the Valspar Championship
Corey Conners

Brings Elite Ball-Striking to Valspar Championship
Xander Schauffele

Trending In The Right Direction For Valspar Championship
Sahith Theegala

Has Shot to Challenge at Valspar Championship
Mackenzie Hughes

Looking to Bounce Back at Valspar Championship
Nicolai Hojgaard

Finding Rhythm For Valspar Championship
Matt Fitzpatrick

Continues Hot Start to 2026 Heading to Valspar Championship
Pierceson Coody

Heads to Valspar Championship Following Two Missed Cuts
Wyndham Clark

Searching for Momentum at Valspar Championship
Justin Thomas

Is Justin Thomas Back Ahead of This Week's Valspar Championship?
Jordan Spieth

to Bounce Back at Favored Valspar Championship?
Brooks Koepka

is Starting to Find His Groove Again Ahead of Valspar Championship
Viktor Hovland

is One of The Best DFS Plays at Innesbrook
Rasmus Hojgaard

to Get Back on Track at Valspar Championship
Tony Finau

is Again a Scary Option at Valspar Championship
Blades Brown

Continues PGA Tour Run at Valspar Championship
Josh Emmett

Suffers First-Round TKO Loss
Kevin Vallejos

Scores First-Round TKO
Amanda Lemos

Drops Back-To-Back Fights
Gillian Robertson

Extends Her Win Streak
Andre Fili

Drops Decision on Saturday
Denny Hamlin

Dominates and Gets His Third Career Las Vegas Win
Chase Elliott

Earns Runner-Up Finish at Las Vegas
William Byron

Wins A Stage and Finishes Third at Las Vegas
Christopher Bell

Finishes Fourth at Las Vegas After Strong Run
Kyle Larson

Fades to Seventh Despite Leading Laps Early at Las Vegas
Andre Fili

Jose Delgado Edges Andre Fili in Split-Decision Win
Oumar Sy

Suffers First-Round Submission Loss
Ion Cutelaba

Returns To The Win Column
CFB

CJ Carr Enters Sophomore Season as Heisman Favorite
CFB

Aaron Philo Not a Lock to be Florida's Starting QB?
CFB

George MacIntyre the Favorite to Win Tennessee Quarterback Battle?
CFB

Keelon Russell, Austin Mack Battling for Alabama QB1 Duties
Christopher Bell

Looking for Redemption, Wins Pole at Las Vegas
Denny Hamlin

Should Contend for Another Vegas Win
Chase Briscoe

Qualifies 18th Despite Toyota Dominating at Las Vegas
Chase Elliott

May Fly Under the Radar at Las Vegas
NASCAR

Ross Chastian Has Been As Solid As They Come at Las Vegas
Ty Gibbs

Could Ty Gibbs Finally Break Through With a Win at Las Vegas?
Brad Keselowski

a Solid DFS Pick at Las Vegas
Kyle Larson

Should Kyle Larson be Considered A Favorite for Las Vegas?
William Byron

Could Compete for a Top-Five Finish at Las Vegas
Ryan Blaney

Is Ryan Blaney Worth Rostering in Tournament DFS Lineups for Las Vegas?
Tyler Reddick

Could Continue his Top-10 Streak at Las Vegas
Joey Logano

Should DFS Managers Underestimate Joey Logano for Las Vegas?
Chris Buescher

Is Chris Buescher Worth Rostering For Las Vegas DFS Lineups?
NASCAR

Bubba Wallace is A Risky DFS Option Who Could Pay Off at Las Vegas
Josh Berry

Has Plenty of Upside for Las Vegas DFS Lineups
Ryan Preece

Scores his First Las Vegas Top-10 Starting Spot in Qualifying
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF