🖥 TAP TO SAVE 50% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

Midwest Region: March Madness Bracket Predictions

NCAA Tournament - March Madness College Basketball

NCAA Tournament bracket picks and team predictions for the Midwest Region. Read Seth's March Madness picks, sleepers and busts including teams to target and avoid.

March Madness is officially here, so let's fill out some winning brackets! RotoBaller will be bringing you a full breakdown on each tournament region, including some potential sleepers and busts. Today we'll be taking a look at the Midwest Region and my bracket picks.

I'm here to tell you some teams that I believe in to help you make the right tournament bracket decisions. Below I analyze the top four seeds, a potential bust, and a potential final four candidate. Hopefully, my college basketball predictions can help you win your March Madness pools. I really like to use Ken Pomeroy's advanced analytics to help determine a champion. Since 2002, each team to win the title except for one, was ranked top-20 in both offensive and defensive efficiency. I'll be putting those numbers in parentheses after each breakdown of the top-four seeds. Now let's get to it.

Once you're done here, be sure to also check out the rest of our NCAA Tournament articles and analysis including previews, predictions, sleepers, busts and guides on how to fill out your including other predictions for the East, South, and West regions.

Featured Promo: New Novig users get a $25 purchase match (50% discount up to $25) on your first Novig deposit, and 3 free months of RotoBaller's "Big-4" Premium Pass (NBA, NFL, MLB, NHL) which includes exclusive tools for Betting, Props, DFS and more! CLAIM IT NOW

 

Midwest Region Top Four Seeds 

Top four seeds: No. 1 Illinois | N0. 2 Houston | No. 3 West Virginia | No. 4 Oklahoma State

Illinois is the hottest team in the country. They've won seven in a row, including wins over Michigan and Ohio State twice, the second coming in the Big 10 championship. Ayo Donsunmu is a star. They'll make a deep run. (Ken Pom: #7 offense, #5 defense)

Houston will not be a popular play. People don't know much about them but they can score a lot and play really good defense. (Ken Pom: #8 offense, #16 defense)

West Virginia is seeded too high. You'd think a Bob Huggins coached team would play good defense, but they don't. They won't make it out of the first weekend. (Ken Pom: #11 offense, #65 defense)

Oklahoma State will be a very popular pick because of likely number one overall pick Cade Cunningham. But they have a very difficult first-round matchup against Liberty. The Flames have a good cast of upper and lower classmen. They beat Mississippi State as the No. 12 seed in the NCAA Tournament two years ago. Last year they won their conference tournament and were going to do damage. Now, no one is giving them a chance. (Ken Pom: #54 offense, #22 defense)

 

Most Intriguing First Round Matchup

No. 6 San Diego State vs. No. 11 Syracuse

Of course, Syracuse makes the tournament and isn't even a last four in. They're always given the benefit of the doubt by the committee. The Aztecs are favored by two so this will go down to the wire. San Diego State has won 14 in a row. They play a slow methodical physical game. First to 60 wins. And the winner will likely be headed to the Sweet 16.

 

Bust of the Region

Oklahoma State. They'll go as far as Cade Cunningham takes them. If he has a bad game, they'll be out in the First Round. I'm going to take Liberty over the Cowboys in that game.

 

Final Four Pick

Houston. If you want to win your pool, you'll need to take a shot and not go with the popular chalk. Everyone will have Illinois out of this region. Illinois vs. Houston has the potential to be an epic Elite Eight game.

More March Madness Brackets Advice




POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Santi Aldama

Available on Sunday Evening
Ja Morant

Downgraded on Sunday Night
Puka Nacua

Finishes the Regular Season as Top-Scoring Receiver
Atlanta Falcons

Falcons Fire Raheem Morris and Terry Fontenot
David Njoku

Wants to Re-Sign with Browns
Ray Davis

Runs Wild in Final Game of Regular Season
Matthew Stafford

Strengthens MVP Candidacy in Win Over Cardinals
Mitchell Trubisky

Comes Off Bench, Throws for Four Touchdowns
Rhamondre Stevenson

Explodes for Three Touchdowns in Huge Week 18
Giannis Antetokounmpo

Good to Go Against Sacramento
Trae Young

Won't Play on Monday Night
Grayson Allen

Still Out on Sunday Night
Indianapolis Colts

Colts to Bring Back Shane Steichen and Chris Ballard for 2026
Kansas City Royals

Matt Quatraro Signs Three-Year Extension With Royals
Tyrone Tracy Jr.

Catches Eight Passes in Dominant Outing Sunday
Logan Stanley

to Sit Out One Game With Suspension
TOR

Chris Tanev Could Be Done for Rest of Regular Season
Sean Monahan

Expected to Return Tuesday
Alexander Wennberg

Lands Three-Year Extension
Alec Pierce

Makes Several Big Catches Before Ejection
John Beecher

Handed One-Game Suspension
Devon Toews

Unavailable Sunday
Seth Jones

Out Against Avalanche
Josh Allen

Plays One Snap in Week 18
Myles Garrett

Breaks All-Time Single-Season Sack Record
Jaylen Waddle

Officially Sidelined for Season Finale
De'Von Achane

Officially Inactive Against Patriots in Week 18
Dalton Kincaid

Suiting Up Against Jets in Week 18
Kyren Williams

Suiting Up Against Cardinals on Sunday
Davante Adams

Won't Play Against Cardinals in Week 18
J.J. McCarthy

Questionable to Return in Week 18
Jamal Murray

Will Play on Sunday
Amon-Ra St. Brown

Suiting Up for Regular-Season Finale
Christian Braun

Will Play on Sunday
Aaron Gordon

Will Play on Sunday
Ja Morant

Questionable Against the Lakers
Michael Porter Jr.

Off Injury Report, Set to Face Nuggets
Brian Thomas Jr.

Being Evaluated for Concussion in Week 18
Jalen Suggs

Ruled Out for Sunday, No Timetable for Return
Cameron Ward

Done for the Day in Week 18
Caris LeVert

Ruled Out Against Cavaliers
Jarrett Allen

Ruled Out on Sunday Afternoon
CFB

Transfer QB Billy Edwards Commits to North Carolina
CFB

Sam Leavitt Visiting Texas Tech on Saturday
Jamal Murray

Expected to Play Against Nets
Giannis Antetokounmpo

Listed as Probable for Sunday
Tobias Harris

Out at Least Two Weeks with Hip Sprain
Jalen Duren

to Miss at Least One Week with Ankle Injury
Vince Williams Jr.

Misses Eighth Straight Game
Maxime Raynaud

Cleared to Play Sunday After Knee Scare
Isaiah Hartenstein

Remains Out Versus Suns
Nathan MacKinnon

Takes Over Scoring Lead With Four-Point Effort
Herbert Jones

Misses Seventh Straight Game
Nikita Kucherov

Bags Five Points Against Sharks
Darren Raddysh

Celebrates Hat Trick in Big Win
Jordan Binnington

Logs First Shutout of Season
Auston Matthews

Becomes Maple Leafs' All-Time Goals Leader
Jake McCabe

Exits Loss Early
Tom Wilson

Escapes Serious Injury
Joel Kiviranta

Misses Road Trip
Gavin Brindley

Out Saturday
Casey DeSmith

Granted Leave of Absence
Tanner Jeannot

Remains Absent Saturday
Trevor Moore

Won't Play Saturday Night
Shayne Gostisbehere

Set to Return Saturday
William Nylander

Misses Fourth Straight Game
CFB

DJ Lagway Expected To Visit Florida State
Kyle Tucker

Blue Jays "Remain the Favorite" to Sign Kyle Tucker
CFB

Joey Aguilar Undergoes Surgery to Remove Tumor on Friday
CFB

Texas the "Team to Beat" for Transfer Running Back Isaac Brown
CFB

Rocco Becht to Follow Matt Campbell to Penn State?
CFB

Texas Targeting Cam Coleman in Transfer Portal
CFB

Former Texas Running Back CJ Baxter Visiting Kentucky
CFB

Beau Pribula Visiting Virginia Tech, Georgia Tech
Bo Bichette

Yankees Showing Interest in Bo Bichette
Houston Astros

Astros Sign Tatsuya Imai to Three-Year Deal
CFB

Lane Kiffin Interested in Sam Leavitt, Brendan Sorsby at LSU
CFB

Deuce Knight Officially Entering Transfer Portal
CFB

Kewan Lacy Expected to Be Full-Go Against Georgia
CFB

Chip Kelly Named Northwestern Offensive Coordinator

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP