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DraftKings Daily Fantasy Football Lineup Picks (Week 16): NFL DFS Advice

RotoBallers, welcome to Week 16 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 16 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 16!

 

DraftKings Quarterbacks - Week 16 DFS Picks

Matthew Stafford - DET @ CIN (DK - $6,200)

Stafford is looking like one of the better options at quarterback this week for a number of reasons. First off, the Lions still have something to play for, so he will be doing all he can to get the win. We know he has multi touchdown upside, as he has done nine times this season. Stafford has put up 17 or more DraftKings points in seven of his last nine games, and has shown to be super consistent. He makes a great play in any format this week, as he is up against the Bengals who have the 18th DVOA against the pass.

Cam Newton - CAR vs TB (DK - $6,800)

Newton has scored 15 or more DraftKings points in six straight games, and is up against one of the worst defenses in the league. He is playing the Buccaneers, who have the 29th DVOA against the pass, and the 21st DVOA against the run. This is a prime spot for him, and he has shown his rushing upside in recent weeks. He has 50 or more rushing yards in five of his last six games, bringing plenty of tournament upside with him.

 

DraftKings Running Backs - Week 16 DFS Picks

Kenyan Drake - MIA @ KC (DK - $7,100)

Drake is up against the Chiefs, who have the 31st DVOA against the run, putting him in a great spot this week. Over the past four week, Drake has 80% of the Dolphins rushing attempts, which means he is their lead back and will be in the game regardless of the situation. The game script isn't saying they will be in this game, as they are a 10 point underdog, but if they want a shot in this game, they will run the ball a lot and slow the game down, putting Drake in a spot to succeed.

Christian McCaffrey - CAR vs TB (DK - $6,400)

McCaffrey brings a dual threat out of the backfield, as he has seen 22 targets over his last four games. He isn't a pure running back and has only gone for a season high of 66 yards this season, but saw double digit rushing attempts last week for the first time since Week 9. This is an encouraging sign, which should benefit him this week, since his opponent has a very bad defense. He is up against the Buccaneers, who have the 21st DOVA against the pass, and the 23rd DVOA against running backs in the passing game. Prime match up for him, and the Panthers are still in a spot where they need to win games, so they won't easy off the gas.

 

DraftKings Wide Receivers - Week 16 DFS Picks

Robert Woods - LAR @ TEN (DK - $6,500)

Woods is back from his injury, and last week he put six receptions 45 yards, and one touchdown. He is good mid range option who has some PPR upside against a Titans team who has the 24th DVOA against the pass. This puts him in a good spot, since the Rams still have something to play for, and will not be resting their starters. Woods has multi touchdown upside, which he has shown in the games before his injury.

Chris Godwin - TB @ CAR (DK - $3,000)

With DeSean Jackson being out of practice yet again on Thursday, Godwin is in a spot to see increased targets, as he did last week, after Jackson left the game early with the injury. Last week he ended with five receptions for 68 yards, for a total of 11.8 DraftKings points. He is also super cheap on DraftKings, so the savings he brings to your lineup will allow you to get up to the higher priced players.

 

DraftKings Tight End - Week 16 DFS Pick

Eric Ebron - DET @ CIN (DK - $3,700)

Everyone and their mother is talking about Antonio Gates this week as a tight end option, since he is so cheap, and will be seeing more targets now that Hunter Henry is done for the year. If you want another option at tight end, look at Ebron. he is up against the Bengals who have the 30th DVOA vs tight ends, and have suffered major losses on their defense. He has 15 receptions over his last two games, and with the Lions needing to win games to stay in the playoff picture, he will see plenty of snaps.

 

DraftKings Defense - Week 16 DFS Pick

Detroit Lions @ Cincinnati Bengals

The Lions are in a spot where they need to win games to try and make the playoffs, so look to their defense to step up against a weak Bengals team. Last week against the Vikings we saw that the Bengals have all but given up on the season, making them a nice target this week. The Lions have seven sacks over their last four games, along with five interceptions in that span. They have turnover potential against this weak Bengals offense.

 

More Weekly DFS Analysis





REAL-TIME FANTASY NEWS

Josh Jacobs

"a True Game-Time Decision" for Week 7
Kyler Murray

Expected to Return in Week 9
Brock Bowers

Not Expected to Play on Sunday, "Good Chance" he Returns After Bye
Christian Kirk

Won't Play on Monday Night
Frederick Gaudreau

to Be Sidelined for 4-6 Weeks
Kaiden Guhle

to Miss 4-6 Weeks
Patrick Kane

Ruled Out for Sunday
Noah Hanifin

Not Ready to Return Saturday
Brandon Montour

Takes Leave of Absence
Joel Kiviranta

Out Indefinitely With Lower-Body Injury
Hampus Lindholm

a Game-Time Call Saturday
Rob Dillingham

Timberwolves Exercise Team Option on Rob Dillingham
Scotty Pippen Jr.

to Undergo Surgery, Out at Least 12 Weeks
George Kittle

Activated From Injured Reserve, All Set for Week 7
Jacoby Brissett

Expected to Start for Cardinals in Week 7
Mike Evans

a Game-Time Decision in Week 7
Chris Godwin

Ruled Out for Week 7
Emeka Egbuka

Week 7 Status a "Game-Time Decision"
New York Knicks

Knicks Cut Ties with Garrison Mathews
Dallas Mavericks

Dalano Banton Waived by the Mavericks
Miami Heat

Precious Achiuwa Waived by Miami
Dallas Mavericks

Mavericks Waive Dennis Smith Jr.
Macklin Celebrini

Has Multi-Point Outing Friday
Clayton Keller

Grabs Four Points in Friday's Victory
Nick Schmaltz

Celebrates Second Career Hat Trick Versus Sharks
Dylan Strome

Erupts for Four Points Against Wild
Dylan Larkin

Leads Red Wings to Victory Friday
Zach Bogosian

Hurt on Friday
Nikita Kucherov

Struck by Illness
Jauan Jennings

Good to Go in Week 7
George Kittle

Expected to Play With No Limitations in Week 7
Brendan Donovan

Undergoes Sports Hernia Surgery
George Springer

Exits Game 5 Early After HBP on his Knee
Jackson Chourio

Back in Game 4 Lineup Against Dodgers
Deebo Samuel Sr.

Questionable for Week 7
Kyler Murray

Officially Questionable for Week 7
George Kittle

Likely Playing in Week 7
Alexander Romanov

to Be a Game-Time Call Saturday
Nils Lundkvist

Nursing Lower-Body Injury
Justin Danforth

Expected to Miss More Than One Month
Brock Bowers

Considered Doubtful for Week 7
Jonathan Huberdeau

Set for Season Debut Saturday
Brock Purdy

Ruled Out Again in Week 7
Liam O'Brien

Makes Season Debut Friday
Marvin Harrison Jr.

Clears Concussion Protocol, Will be Active on Sunday
Pierre-Luc Dubois

Out Against Wild
Lucas Raymond

to Remain Out Friday
CeeDee Lamb

Off the Injury Report, Will Return in Week 7
Josh Jacobs

Listed as Questionable For Week 7
Iván Herrera

Ivan Herrera Has Bone Spurs Removed From his Elbow
Carson Wentz

Named Vikings' Starting Quarterback in Week 7
Brendan Allen

Set For UFC Vancouver Main Event
Reinier de Ridder

Reinier De Ridder A Favorite At UFC Vancouver
Mike Malott

Looks For His Third Consecutive Win
Puka Nacua

Rams "Very Optimistic" Puka Nacua Will Return After Week 8 Bye
Kevin Holland

Set For UFC Vancouver Co-Main Event
Aiemann Zahabi

Looks For His Seventh Consecutive Win
Bradley Beal

Set to Make Clippers Debut in Preseason Finale
Marlon Vera

Returns At UFC Vancouver
VJ Edgecombe

Set to Return for Preseason Finale
Jeremy Sochan

Won't Play in Season Opener
Jasmine Jasudavicius

Looks To Extend Her Win Streak
AJ Green

Bucks Agree to Contract Extension
Manon Fiorot

Looks To Bounce Back
Aoriqileng

Aori Aoriqileng Looks To Rebound
Cody Gibson

Looks To Get Back In The Win Column
Jaylen Brown

Considered Day-to-Day with Hamstring Tightness
Kyle Nelson

Set For Lightweight Bout
Matt Frevola

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Jaden Ivey

Will Miss Four Weeks After Knee Surgery
Paul George

Expected to Miss Season Opener
Joel Embiid

Set to Make Preseason Debut on Friday
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Curt Cignetti Signs Eight-Year, $11.6 Million Extension With Indiana
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Carlos Rodon Unlikely to Be Ready for Opening Day After Elbow Surgery
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Removed From ALCS Roster With Back Injury
Jackson Chourio

Aggravates Hamstring, Pulled Early in Game 3 of NLCS
Aaron Judge

Will Not Need Elbow Surgery
Anthony Volpe

Won't be Ready for Start of Next Season
Gerrit Cole

Won't be Ready for Opening Day Next Year
Milwaukee Bucks

Chris Livingston Waived by the Bucks
Keegan Murray

Nique Clifford Shines in Keegan Murray's Absence
Cooper Flagg

Continues to Start at Point Guard
Ron Harper Jr.

Earns a Two-Way Deal with the Celtics
Charlotte Hornets

Spencer Dinwiddie Waived by the Hornets
Tampa Bay Buccaneers

Sterling Shepard's Stock Rising for Buccaneers
CFB

Jermod McCoy Officially Out for Alabama Matchup
CFB

Jam Miller Questionable to Face Tennessee
Jaden Ivey

Considered Day-to-Day
CFB

Arizona State QB Sam Leavitt Probable For Saturday
Anthony Volpe

Undergoes Left-Shoulder Surgery
CFB

Jayden Gibson No Longer with Oklahoma Program
Emmanuel Clase

to be Banished for Life After Gambling Allegations?
Alex Bregman

Plans to Opt Out of Contract With Red Sox
Christopher Bell

Sits Third in Points After Quiet Third-Place Finish
Chase Briscoe

Passes Denny Hamlin at the Start, but Hamlin Gets Him in the End
Joey Logano

Falling Out of Playoff Picture Despite Other Contenders' Crashes
Ryan Blaney

Stage 1 Crash Puts Ryan Blaney in Severe Playoff Trouble
Denny Hamlin

Wins at Las Vegas and Will Compete for the 2025 Cup Series Title
Kyle Larson

Dominates at Las Vegas but Ends Up Second
Chase Elliott

Struggles to Gain A Solid Finish at Las Vegas After Pit-Road Penalty
William Byron

Strong Run Ends In A Wreck at Las Vegas
CFB

Sam Leavitt Viewed as Day-to-Day with Undisclosed Injury
Anthony Santander

Scratched From Game 2 of ALCS With Back Tightness
San Diego Padres

Mike Shildt Retires as a Manager
Mateusz Gamrot

Suffers Second-Round Submission Loss
Charles Oliveira

Gets Back In The Win Column
Montel Jackson

Drops Decision
Deiveson Figueiredo

Gets Split-Decision Victory
Vicente Luque

Outclassed
Vicente Luque

Joel Alvarez Outclasses Vicente Luque
Jhonata Diniz

Suffers Second-Round TKO Loss
Mario Pinto

Remains Undefeated
CFB

Matt Rhule Denying Interest in Penn State Head Coaching Job
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Le'Veon Moss Not Believed to Have Suffered Season-Ending Injury
Ricardo Ramos

Suffers First-Round Submission Loss
CFB

Bill Belichick Says he's Committed to North Carolina
Tiger Woods

Undergoes Back Surgery
CFB

UAB Fires Head Coach Trent Dilfer After 2.5 Seasons In Birmingham
CFB

Penn State Fires Head Coach James Franklin After 10.5 Seasons
CFB

Penn State QB Drew Allar Will Miss The Rest Of 2025 Season With Ankle Injury

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP