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DraftKings Daily Fantasy Football Lineup Picks (Week 16): NFL DFS Advice

RotoBallers, welcome to Week 16 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 16 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 16!

 

DraftKings Quarterbacks - Week 16 DFS Picks

Matthew Stafford - DET @ CIN (DK - $6,200)

Stafford is looking like one of the better options at quarterback this week for a number of reasons. First off, the Lions still have something to play for, so he will be doing all he can to get the win. We know he has multi touchdown upside, as he has done nine times this season. Stafford has put up 17 or more DraftKings points in seven of his last nine games, and has shown to be super consistent. He makes a great play in any format this week, as he is up against the Bengals who have the 18th DVOA against the pass.

Cam Newton - CAR vs TB (DK - $6,800)

Newton has scored 15 or more DraftKings points in six straight games, and is up against one of the worst defenses in the league. He is playing the Buccaneers, who have the 29th DVOA against the pass, and the 21st DVOA against the run. This is a prime spot for him, and he has shown his rushing upside in recent weeks. He has 50 or more rushing yards in five of his last six games, bringing plenty of tournament upside with him.

 

DraftKings Running Backs - Week 16 DFS Picks

Kenyan Drake - MIA @ KC (DK - $7,100)

Drake is up against the Chiefs, who have the 31st DVOA against the run, putting him in a great spot this week. Over the past four week, Drake has 80% of the Dolphins rushing attempts, which means he is their lead back and will be in the game regardless of the situation. The game script isn't saying they will be in this game, as they are a 10 point underdog, but if they want a shot in this game, they will run the ball a lot and slow the game down, putting Drake in a spot to succeed.

Christian McCaffrey - CAR vs TB (DK - $6,400)

McCaffrey brings a dual threat out of the backfield, as he has seen 22 targets over his last four games. He isn't a pure running back and has only gone for a season high of 66 yards this season, but saw double digit rushing attempts last week for the first time since Week 9. This is an encouraging sign, which should benefit him this week, since his opponent has a very bad defense. He is up against the Buccaneers, who have the 21st DOVA against the pass, and the 23rd DVOA against running backs in the passing game. Prime match up for him, and the Panthers are still in a spot where they need to win games, so they won't easy off the gas.

 

DraftKings Wide Receivers - Week 16 DFS Picks

Robert Woods - LAR @ TEN (DK - $6,500)

Woods is back from his injury, and last week he put six receptions 45 yards, and one touchdown. He is good mid range option who has some PPR upside against a Titans team who has the 24th DVOA against the pass. This puts him in a good spot, since the Rams still have something to play for, and will not be resting their starters. Woods has multi touchdown upside, which he has shown in the games before his injury.

Chris Godwin - TB @ CAR (DK - $3,000)

With DeSean Jackson being out of practice yet again on Thursday, Godwin is in a spot to see increased targets, as he did last week, after Jackson left the game early with the injury. Last week he ended with five receptions for 68 yards, for a total of 11.8 DraftKings points. He is also super cheap on DraftKings, so the savings he brings to your lineup will allow you to get up to the higher priced players.

 

DraftKings Tight End - Week 16 DFS Pick

Eric Ebron - DET @ CIN (DK - $3,700)

Everyone and their mother is talking about Antonio Gates this week as a tight end option, since he is so cheap, and will be seeing more targets now that Hunter Henry is done for the year. If you want another option at tight end, look at Ebron. he is up against the Bengals who have the 30th DVOA vs tight ends, and have suffered major losses on their defense. He has 15 receptions over his last two games, and with the Lions needing to win games to stay in the playoff picture, he will see plenty of snaps.

 

DraftKings Defense - Week 16 DFS Pick

Detroit Lions @ Cincinnati Bengals

The Lions are in a spot where they need to win games to try and make the playoffs, so look to their defense to step up against a weak Bengals team. Last week against the Vikings we saw that the Bengals have all but given up on the season, making them a nice target this week. The Lions have seven sacks over their last four games, along with five interceptions in that span. They have turnover potential against this weak Bengals offense.

 

More Weekly DFS Analysis





REAL-TIME FANTASY NEWS

LeBron James

Available Versus Sacramento
Zion Williamson

Ruled Out Versus Clippers
Shelby Miller

Officially Placed on 60-Day Injured List
Kevin Love

Resting Monday Against Nuggets
Jacob deGrom

is Nearing Spring Debut
Tristan Vukcevic

Could Miss Game Vs. Houston
José Soriano

Jose Soriano has Start Pushed Back
John Collins

Cleared to Play Sunday
Bobby Miller

Being Viewed as Reliever
Brandon Clarke

to be Re-Evaluated in Two Weeks
Walker Jenkins

is Diagnosed with Hamstring Strain
Caleb Martin

Returns Against Thunder
P.J. Washington

Naji Marshall Ruled Out Sunday
Kyshawn George

Could Miss Game Against Houston
Baylor Scheierman

Cleared to Play Sunday
Rui Hachimura

Set to Return Against Kings
LeBron James

Questionable Against Kings
Jonathan Drouin

Unavailable Sunday
Darcy Kuemper

Won't Play Monday Due to Illness
Andrew Mangiapane

Oilers Place Andrew Mangiapane on Waivers
Jabari Smith Jr.

Still Out on Monday
Uvis Balinskis

Out Sunday
Jalen Johnson

Back on Sunday Night
Dmitry Kulikov

Comes Off Injured Reserve
Mark Stone

Exits With Injury Sunday
Deni Avdija

Remains Out on Sunday
Zach Edey

to Undergo Another Ankle Surgery
Merrill Kelly

"Optimistic" About Being Ready by Opening Day
Gabriel Moreno

Can Gabriel Moreno Put Together a Fully Healthy Season in 2026?
Mark Vientos

May Be Limited to Part-Time Role in New York
Kyler Murray

Likely to be Released
Noah Cameron

Can Noah Cameron Repeat His Breakout 2025 Season?
Justin Steele

"Full-Go" on Throwing, Still Eyeing May or June Return
Travis Etienne Jr.

Not Expected to be Franchise-Tagged
Aaron Jones Sr.

Vikings Planning to Release Aaron Jones Sr.?
Samuel Basallo

is Returning on Sunday
St. Louis Cardinals

Cardinals Sign Oliver Marmol to Two-Year Extension
Thomas White

is Diagnosed with Oblique Strain
Carmen Mlodzinski

to Compete for Starting Rotation Spot
Tyler Reddick

Could Make History at COTA
Shane Van Gisbergen

Shane van Gisbergen Still the Favorite at COTA
Christopher Bell

Will Be Tough to Beat at COTA
Jacob Melton

is Returning on Sunday
AJ Allmendinger

Could Contend at COTA
Connor Zilisch

Carries Plenty of Upside for DFS at COTA
Chase Elliott

May be A Strong Contender Again at COTA
Chris Buescher

Is Nothing But Consistent at Road Courses
Ross Chastain

May Be An Underrated Competitor for the Win at COTA
William Byron

Is William Byron a Viable DFS Option for COTA?
Carson Hocevar

Needs Clean Race at COTA
Nick Suzuki

Enjoys Three-Point Night Against Capitals
Rasmus Dahlin

Collects Three Points Saturday
Kyle Larson

Could be A Decent DFS Option for COTA Lineups
Joel Kiviranta

in Concussion Protocol
Joel Eriksson Ek

Available Sunday
Ryan Blaney

Could Ryan Blaney be A Sleeper DFS Option for All Formats for COTA?
Mark Scheifele

Expected to Play Sunday
Chase Briscoe

Should DFS Players Roster Chase Briscoe at COTA?
Adam Wilsby

Exits Early Versus Stars
Gage Goncalves

Hurt in Saturday's Loss
Russell Westbrook

Off Injury Report Sunday
Kawhi Leonard

Set to Play Against Pelicans
NASCAR

Bubba Wallace Is A Favorable Value Option for COTA DFS Lineups
Ty Gibbs

Could Ty Gibbs Be A Rosterable DFS Play for COTA?
Michael McDowell

Is Michael McDowell A Favorable DFS Option for COTA?
Donovan Mitchell

to Miss Third Straight Game
Joel Embiid

Sidelined Three Games with Oblique Injury
Cooper Flagg

Remains Sidelined Sunday
Cale Makar

Scores Twice Versus Chicago
Connor McDavid

has a Three-Assist Game
Keston Hiura

Exits After Getting Hit by Pitch
Leo De Vries

Exits Early on Saturday
Kyle Stowers

is Dealing with Minor Hamstring Strain
Cody Bellinger

Dealing With Back Injury
Corbin Carroll

Likely to be Ready for Opening Day
Vladislav Namestnikov

Out Week-to-Week
Nino Niederreiter

Recovering From Surgery
Colton Parayko

Doubtful for Sunday
Zach Benson

Activated From Injured Reserve
Anthony Cirelli

a Game-Time Decision Saturday
Roope Hintz

Remains Out Saturday
Starling Marte

Royals Agree With Starling Marte
A.J. Brown

Patriots "Have Explored Trade Talks" Involving A.J. Brown
Lone'er Kavanagh

Set For UFC Mexico City Main Event
Brandon Moreno

Looks To Bounce Back
David Martinez

Set For UFC Mexico City Co-Main Event
Marlon Vera

In Dire Need Of Victory
King Green

Looks To Win Back-To-Back Fights
Daniel Zellhuber

Aims To Snap Two-Fight Skid
Felipe Bunes

Looks To Get Back In The Win Column
Édgar Cháirez

Edgar Chairez A Favorite At UFC Mexico City
George Pickens

Cowboys Not Interested in Trading George Pickens
Ashton Jeanty

Not in Line for Workhorse Role in 2026?
Anthony Richardson Sr.

Colts Give Anthony Richardson Sr. Permission to Seek a Trade
Kyler Murray

Prefers to be Released
Derek Carr

"Strong Belief" That Derek Carr is "Very Serious" About Unretiring
Andy Dalton

Is Andy Dalton Available for a Trade?
Keith Mitchell

Making The Comfortable Return to PGA National
CFB

Chandler Morris Suing NCAA for Seventh Year of Eligibility
Chris Kirk

Searching for a Spark at Cognizant Classic
Brooks Koepka

Making Third PGA Tour Start at Cognizant Classic
Mackenzie Hughes

a Steady Option at Cognizant Classic
Seamus Power

Seeking More Green in Florida
PGA

Haotong Li Back From a Break as Florida Stretch Starts
Stephan Jaeger

Trying to Put Four Rounds Together in Florida
PGA

Nico Echavarria Again Attempting to Make the Weekend
Patrick Fishburn

Looking for a Spark at Cognizant Classic
Blades Brown

Set for Cognizant Classic Debut
Michael Thorbjornsen

Looking to Bounce Back at Cognizant Classic
Maxx Crosby

Raiders Expect Maxx Crosby to Return
Billy Horschel

Looks to Improve Season at Cognizant Classic
Kyle Pitts Sr.

Falcons Place Franchise Tag on Kyle Pitts Sr.
Joe Highsmith

Returns to Defend at Cognizant Classic
Quinshon Judkins

Out of Walking Boot, Will be Ready for Training Camp
Breece Hall

Jets Will Use Franchise Tag on Breece Hall if Extension isn't Reached
Joel Dahmen

Needs Better Consistency Heading Into The Florida Swing
Daniel Berger

Looks to Improve Putting as PGA Tour Begins Its Florida Swing
Kirk Cousins

Falcons Plan to Release Kirk Cousins
Zach Ertz

Plans to Return for 14th Season
Davis Thompson

Struggling to Find Birdies as Florida Looms
Tom Kim

Not Quite Cutting It in 2026
Nicolai Hojgaard

Wants to Build Momentum from Scottsdale
Christiaan Bezuidenhout

Returns After Extended Break for Florida Event
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF