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DraftKings Daily Fantasy Football Lineup Picks (Week 16): NFL DFS Advice

RotoBallers, welcome to Week 16 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 16 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 16!

 

DraftKings Quarterbacks - Week 16 DFS Picks

Matthew Stafford - DET @ CIN (DK - $6,200)

Stafford is looking like one of the better options at quarterback this week for a number of reasons. First off, the Lions still have something to play for, so he will be doing all he can to get the win. We know he has multi touchdown upside, as he has done nine times this season. Stafford has put up 17 or more DraftKings points in seven of his last nine games, and has shown to be super consistent. He makes a great play in any format this week, as he is up against the Bengals who have the 18th DVOA against the pass.

Cam Newton - CAR vs TB (DK - $6,800)

Newton has scored 15 or more DraftKings points in six straight games, and is up against one of the worst defenses in the league. He is playing the Buccaneers, who have the 29th DVOA against the pass, and the 21st DVOA against the run. This is a prime spot for him, and he has shown his rushing upside in recent weeks. He has 50 or more rushing yards in five of his last six games, bringing plenty of tournament upside with him.

 

DraftKings Running Backs - Week 16 DFS Picks

Kenyan Drake - MIA @ KC (DK - $7,100)

Drake is up against the Chiefs, who have the 31st DVOA against the run, putting him in a great spot this week. Over the past four week, Drake has 80% of the Dolphins rushing attempts, which means he is their lead back and will be in the game regardless of the situation. The game script isn't saying they will be in this game, as they are a 10 point underdog, but if they want a shot in this game, they will run the ball a lot and slow the game down, putting Drake in a spot to succeed.

Christian McCaffrey - CAR vs TB (DK - $6,400)

McCaffrey brings a dual threat out of the backfield, as he has seen 22 targets over his last four games. He isn't a pure running back and has only gone for a season high of 66 yards this season, but saw double digit rushing attempts last week for the first time since Week 9. This is an encouraging sign, which should benefit him this week, since his opponent has a very bad defense. He is up against the Buccaneers, who have the 21st DOVA against the pass, and the 23rd DVOA against running backs in the passing game. Prime match up for him, and the Panthers are still in a spot where they need to win games, so they won't easy off the gas.

 

DraftKings Wide Receivers - Week 16 DFS Picks

Robert Woods - LAR @ TEN (DK - $6,500)

Woods is back from his injury, and last week he put six receptions 45 yards, and one touchdown. He is good mid range option who has some PPR upside against a Titans team who has the 24th DVOA against the pass. This puts him in a good spot, since the Rams still have something to play for, and will not be resting their starters. Woods has multi touchdown upside, which he has shown in the games before his injury.

Chris Godwin - TB @ CAR (DK - $3,000)

With DeSean Jackson being out of practice yet again on Thursday, Godwin is in a spot to see increased targets, as he did last week, after Jackson left the game early with the injury. Last week he ended with five receptions for 68 yards, for a total of 11.8 DraftKings points. He is also super cheap on DraftKings, so the savings he brings to your lineup will allow you to get up to the higher priced players.

 

DraftKings Tight End - Week 16 DFS Pick

Eric Ebron - DET @ CIN (DK - $3,700)

Everyone and their mother is talking about Antonio Gates this week as a tight end option, since he is so cheap, and will be seeing more targets now that Hunter Henry is done for the year. If you want another option at tight end, look at Ebron. he is up against the Bengals who have the 30th DVOA vs tight ends, and have suffered major losses on their defense. He has 15 receptions over his last two games, and with the Lions needing to win games to stay in the playoff picture, he will see plenty of snaps.

 

DraftKings Defense - Week 16 DFS Pick

Detroit Lions @ Cincinnati Bengals

The Lions are in a spot where they need to win games to try and make the playoffs, so look to their defense to step up against a weak Bengals team. Last week against the Vikings we saw that the Bengals have all but given up on the season, making them a nice target this week. The Lions have seven sacks over their last four games, along with five interceptions in that span. They have turnover potential against this weak Bengals offense.

 

More Weekly DFS Analysis





REAL-TIME FANTASY NEWS

Joel Embiid

is Cleared for Monday's Game 1
Kevin Huerter

is Questionable for Tuesday's Contest
Ayo Dosunmu

is Ruled Out for Game 1 on Monday
Jeremy Sochan

is Available for Game 1 on Monday
Roman Anthony

Pulled Early on Monday After Tweaking his Wrist
Jhoan Duran

to Come Off the Injured List on Tuesday
Owen Tippett

Remains Out Monday
Roope Hintz

Recovering From Hamstring Injury
Tyler Seguin

Expects to Be Ready for Training Camp
Sam Carrick

Could Practice Tuesday
Alexander Nikishin

Won't Play Monday
Jeremy Lauzon

Expected to Miss Round 2
William Karlsson

Rejoins Golden Knights Lineup Monday
Jackson Chourio

Brewers Reinstate Jackson Chourio From the Injured List
Malachi Fields

Could be "Power Forward" at Wide Receiver
Fernando Mendoza

Working on Playing Under Center
Cleveland Browns

Browns Not Naming a Leader in the QB Battle
Anthony Richardson Sr.

Reports for Voluntary Offseason Workouts
Aaron Rodgers

Steelers Losing Patience With Aaron Rodgers?
Skylar Thompson

Ravens Expected to Sign Skylar Thompson
DJ Giddens

Can DJ Giddens Re-Establish His Dynasty Value After Underwhelming Rookie Season?
Desmond Ridder

Packers Sign Tyrod Taylor, Release Desmond Ridder
AJ Barner

a Prime Regression Candidate Entering 2026
Tarik Skubal

to Undergo Elbow Surgery
Cedric Tillman

Losing Dynasty Value in Cleveland Following NFL Draft
Josh Jacobs

Should Dynasty Managers Consider Selling High on Josh Jacobs?
Xavier Legette

Dynasty Stock at an All-Time Low Entering 2026
Chase Elliott

Earns his Second Texas Motor Speedway Victory
Denny Hamlin

Misses Out on Winning at Texas
Alex Bowman

Finishes Third for the Second Week in a Row at Texas
Tyler Reddick

Earns Seventh Top-Five Finish of the Season at Texas
Chris Buescher

Scores his First Career Texas Finish in the Top Five
Rashod Bateman

Droppable in Many Dynasty Leagues
Mark Andrews

Should Dynasty Managers Hold Mark Andrews Until Midseason?
Tyrone Tracy Jr.

Can Maintain Fantasy Relevance When Teammate Returns
Chimere Dike

Trending Down Despite Solid Rookie Season?
Jameson Williams

Needs to Show More Consistency in Clearly Defined Role
CFB

Bryce Underwood in Better Situation Entering Sophomore Season
CFB

Nico Iamaleava Emerging as Leader, Playmaker for UCLA
Raisel Iglesias

to be Activated on Tuesday
Orlando Magic

Jamahl Mosley Out as Magic Head Coach
Chase Brown

Stock Back on the Rise After Surviving Another Offseason
Scottie Barnes

Caps Season with Efficient Game 7 Showing
Donovan Mitchell

Finishes with 22 Points in Deciding Game
J.K. Dobbins

a Depreciating Dynasty Asset
Jarrett Allen

Leads Frontcourt Effort with 19 Rebounds
C.J. Stroud

Can C.J. Stroud End His Dynasty Slide?
Paolo Banchero

Carries Offense in Game 7 Defeat
Jalen Duren

Posts 15-15 Line in Game 7 Win
Parker Washington

Still Undervalued Despite Proven Upside
Tobias Harris

Stays Hot with 30 Points in Win
Cade Cunningham

Shines as Pistons Advance to Semifinals
Jack Della Maddalena

Gets Dominated At UFC Perth
Carlos Prates

Shines At UFC Perth
Jakub Dobes

Backstops Canadiens to Game 7 Victory
Beneil Dariush

Suffers A First-Round TKO Loss
Quillan Salkilld

Remains Unbeaten In The UFC
Quinn Hughes

Takes Over Postseason Scoring Lead With Three-Point Effort
Cale Makar

Shakes Off Injury to Collect Three Points in Game 1
Owen Tippett

a Game-Time Decision Monday
Logan Stanley

Practices Fully Sunday
Sam Carrick

Will Miss Second-Round Matchup
Tim Elliott

Drops Decision At UFC Perth
Noah Ostlund

Expected to Miss Round 2
Steve Erceg

Wins Back-To-Back Fights
Ollie Schmid

Suffers First-Round TKO Loss
Marwan Rahiki

Remains Unbeaten
Bryce Eldridge

Giants to Promote No. 1-Ranked Prospect Bryce Eldridge to MLB Roster
Jonas Brodin

Out for Games 1 and 2 Against Colorado
Joel Eriksson Ek

Will Miss First Two Games of Colorado Series
Joel Kiviranta

Remains Out of the Lineup Versus Minnesota
Anthony Volpe

Reinstated From Injured List, Optioned to Triple-A
Josh Manson

Out for Game 1 Against Minnesota
Carter Bryant

Iffy for Game 1 Against Timberwolves
Joel Embiid

Considered Probable for Monday
Kyle Anderson

Available for Round 2 Opener
Ayo Dosunmu

Tagged as Questionable on Injury Report
Anthony Edwards

Listed as Questionable for Game 1 Against Spurs
Luka Dončić

Luka Doncic Unavailable for Start of Round 2, Considered Week-to-Week
Brandon Ingram

Won't Play in Game 7 Against Cavaliers
Ranger Suarez

Exits Sunday's Start With Hamstring Tightness
Agustín Ramírez

Marlins Demote Agustin Ramirez to Triple-A
Victor Hedman

Will Not Play Sunday Versus Montreal
Noah Dobson

Will Play Against Tampa Bay on Sunday
Ben Rice

Exits Sunday's Contest With Left-Hand Contusion
Kevin Huerter

is Out for Game 7
Nikola Vučević

Nikola Vucevic Could be Done in Boston
Christopher Bell

Is Christopher Bell Worth Rostering for Texas Lineups?
Cal Raleigh

Considered Day-to-Day With Soreness in his Side
William Byron

Might have the Speed to Compete for the Win at Texas
Joey Logano

Provides Solid Upside for Texas DFS Lineups
Joe Ryan

Exits Early From Start on Sunday Due to Elbow Soreness
Chase Briscoe

Could Chase Briscoe be A Sneaky Pick for Texas Lineups?
Ty Gibbs

Should DFS Managers Roster Ty Gibbs at Texas?
Daniel Suarez

Is Daniel Suarez Worth Rostering After Career-Best Starting Position at Texas?
Daniel Palencia

Cubs Reinstate Daniel Palencia From the Injured List on Sunday
Kyle Busch

Is a DFS Risk Starting in the Top 10 at Texas
Ronald Acuña Jr.

Braves Place Ronald Acuna Jr. on Injured List With Strained Hamstring
Nick Lodolo

Expected to Make Season Debut on Friday
Tyler Reddick

One of the Favorites to Win at Texas
Chase Elliott

Could Contend for Another Win at Texas
Carson Hocevar

on Pole at Texas
NASCAR

Bubba Wallace Wrecks in Practice at Texas
Chris Buescher

Looking to Continue Strong Run at Texas
Austin Dillon

Blows Engine in Practice at Texas
Mike Reilly

Delivers Two Assists in Game 1 Win
Cal Raleigh

Scratched From Lineup, No Reason Given
Ronald Acuña Jr.

Ronald Acuna Jr. Exits With Left-Hamstring Tightness
Yandy Díaz

Yandy Diaz Leaves With Side Tightness, Considered Day-to-Day
Jacob Misiorowski

Leaves Start Early on Friday With Hamstring Cramp
Brandon Nimmo

Aggravates Hamstring, Pulled Early on Friday
Ryan Helsley

Placed on Injured List With Elbow Inflammation
Jack Della Maddalena

Returns At UFC Perth
Carlos Prates

Set For UFC Perth Main Event
Quillan Salkilld

Set For Co-Main Event
Beneil Dariush

An Underdog At UFC Perth
Steve Erceg

Looks To Win Back-To-Back Fights
Tim Elliott

Looks For His Third Consecutive Win
Ollie Schmid

Set For His UFC Debut
Marwan Rahiki

Looks To Remain Undefeated
Gary Woodland

Riding Momentum Into Cadillac Championship
Jordan Spieth

Brings Boom-or-Bust Potential to Cadillac Championship
Adam Scott

Looks Poised for Another Strong Finish at Doral
Maverick McNealy

Needs Approach Game to Click at Doral
CFB

Jameson Williams Files Lawsuit Against NCAA, SEC, Big Ten
Harry Hall

Volatility Continues at Cadillac Championship
Tommy Fleetwood

Looks to Rebound at Trump National Doral
Pierceson Coody

a Risky Value Play at Cadillac Championship
Akshay Bhatia

Offers Upside with Risk at Cadillac Championship
Justin Thomas

a Scary Proposition at Cadillac Championship
Scottie Scheffler

The Leading Favorite at Cadillac Championship
Collin Morikawa

Still a Smash Play at Cadillac Championship
Viktor Hovland

Showed at Augusta He Can Finish Well
Sepp Straka

Attempting to Finish Better in Miami
PGA

J.J Spaun Enduring Roller Coaster Start to 2026
Min Woo Lee

Seeks to Make Adjustments at Cadillac Championship
Max Homa

May Struggle at Old Doral This Weekend
Ben Griffin

Rebounds From Rough Stretch as Miami Looms
Shane Lowry

Searching For Answers at Cadillac Championship
Russell Henley

Daunting Test at Doral Likely Not a Place For Russell Henley
Justin Rose

Returns to Action After Finishing Third at Masters Tournament
Hideki Matsuyama

Has The Approach Game to Win at Cadillac Championship
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF