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DraftKings Daily Fantasy Football Lineup Picks (Week 16): NFL DFS Advice

RotoBallers, welcome to Week 16 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 16 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 16!

 

DraftKings Quarterbacks - Week 16 DFS Picks

Matthew Stafford - DET @ CIN (DK - $6,200)

Stafford is looking like one of the better options at quarterback this week for a number of reasons. First off, the Lions still have something to play for, so he will be doing all he can to get the win. We know he has multi touchdown upside, as he has done nine times this season. Stafford has put up 17 or more DraftKings points in seven of his last nine games, and has shown to be super consistent. He makes a great play in any format this week, as he is up against the Bengals who have the 18th DVOA against the pass.

Cam Newton - CAR vs TB (DK - $6,800)

Newton has scored 15 or more DraftKings points in six straight games, and is up against one of the worst defenses in the league. He is playing the Buccaneers, who have the 29th DVOA against the pass, and the 21st DVOA against the run. This is a prime spot for him, and he has shown his rushing upside in recent weeks. He has 50 or more rushing yards in five of his last six games, bringing plenty of tournament upside with him.

 

DraftKings Running Backs - Week 16 DFS Picks

Kenyan Drake - MIA @ KC (DK - $7,100)

Drake is up against the Chiefs, who have the 31st DVOA against the run, putting him in a great spot this week. Over the past four week, Drake has 80% of the Dolphins rushing attempts, which means he is their lead back and will be in the game regardless of the situation. The game script isn't saying they will be in this game, as they are a 10 point underdog, but if they want a shot in this game, they will run the ball a lot and slow the game down, putting Drake in a spot to succeed.

Christian McCaffrey - CAR vs TB (DK - $6,400)

McCaffrey brings a dual threat out of the backfield, as he has seen 22 targets over his last four games. He isn't a pure running back and has only gone for a season high of 66 yards this season, but saw double digit rushing attempts last week for the first time since Week 9. This is an encouraging sign, which should benefit him this week, since his opponent has a very bad defense. He is up against the Buccaneers, who have the 21st DOVA against the pass, and the 23rd DVOA against running backs in the passing game. Prime match up for him, and the Panthers are still in a spot where they need to win games, so they won't easy off the gas.

 

DraftKings Wide Receivers - Week 16 DFS Picks

Robert Woods - LAR @ TEN (DK - $6,500)

Woods is back from his injury, and last week he put six receptions 45 yards, and one touchdown. He is good mid range option who has some PPR upside against a Titans team who has the 24th DVOA against the pass. This puts him in a good spot, since the Rams still have something to play for, and will not be resting their starters. Woods has multi touchdown upside, which he has shown in the games before his injury.

Chris Godwin - TB @ CAR (DK - $3,000)

With DeSean Jackson being out of practice yet again on Thursday, Godwin is in a spot to see increased targets, as he did last week, after Jackson left the game early with the injury. Last week he ended with five receptions for 68 yards, for a total of 11.8 DraftKings points. He is also super cheap on DraftKings, so the savings he brings to your lineup will allow you to get up to the higher priced players.

 

DraftKings Tight End - Week 16 DFS Pick

Eric Ebron - DET @ CIN (DK - $3,700)

Everyone and their mother is talking about Antonio Gates this week as a tight end option, since he is so cheap, and will be seeing more targets now that Hunter Henry is done for the year. If you want another option at tight end, look at Ebron. he is up against the Bengals who have the 30th DVOA vs tight ends, and have suffered major losses on their defense. He has 15 receptions over his last two games, and with the Lions needing to win games to stay in the playoff picture, he will see plenty of snaps.

 

DraftKings Defense - Week 16 DFS Pick

Detroit Lions @ Cincinnati Bengals

The Lions are in a spot where they need to win games to try and make the playoffs, so look to their defense to step up against a weak Bengals team. Last week against the Vikings we saw that the Bengals have all but given up on the season, making them a nice target this week. The Lions have seven sacks over their last four games, along with five interceptions in that span. They have turnover potential against this weak Bengals offense.

 

More Weekly DFS Analysis





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Questionable for Game 2
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Ruled Out for Rest of Game 1
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Available for Game 1
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Uncertain for Game 2
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Makes Playoff Debut Sunday
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in Vegas Crease for Playoff Opener
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Begins Fifth Postseason Campaign
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Available for Game 1
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Activated From Injured Reserve
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Sonny Styles One of the Top Targets for Giants at No. 5 in NFL Draft
Renardo Green

49ers Looking to Trade Renardo Green?
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Chargers Not Closing the Door on a Reunion With Keenan Allen
Grayson Allen

is Available for Game 1 on Sunday
A.J. Brown

Eagles Preparing for A.J. Brown's Departure?
Peter Skoronski

Titans to Pick Up Peter Skoronski's Fifth-Year Option
Breece Hall

Dynasty Upside Remains Limited by Offensive Environment in New York
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Dexter Lawrence Signing One-Year Extension With Bengals
Kristaps Porzingis

Unsure About Returning to Golden State
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is Ruled Out for Game 1 on Sunday
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Kenneth Walker III

a Major Dynasty Riser After Offseason Move to Kansas City
Desmond Bane

Considered Probable for Game 1
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Dynasty Value in Question Coming Off Injury?
Tarik Skubal

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Raisel Iglesias

Dealing With Shoulder Issue
Davante Adams

Glaring Opportunity to Sell High on Davante Adams?
Jordan Addison

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Emeka Egbuka

a Trade Target in Some Dynasty Leagues
Kyle Larson

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Denny Hamlin

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Christoper Bell Should Contend for First Win at Kansas
Joel Eriksson Ek

Powers Minnesota Past Dallas in Opening Game
Tyler Reddick

Fastest in Practice and Qualifying for Kansas Race
Ryan Blaney

Could Score another Top-10 Finish at Kansas
Ty Gibbs

Poised to Continue Hot Streak at Kansas
Logan Stankoven

Makes Big Impact in Carolina's Game 1 Victory
Chris Buescher

Always Consistent, Has Speed Heading Into Kansas
William Byron

is A Solid DFS Option for Kansas Lineups
Carson Hocevar

Poised for Career-Best Run at Kansas
Porter Martone

Nets Game-Winning Goal to Defeat Pittsburgh
Frederik Andersen

Shuts Out Ottawa in Game 1
Chase Briscoe

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Chase Elliott

Is A Favorable DFS Option for Kansas Lineups
Matt Boldy

Delivers Huge Game 1 Performance in Win
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Dylan Harper

is Ready for Sunday's Game
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is Questionable for Sunday's Game
Mark Williams

is Questionable for Game 1 on Sunday
Stuart Skinner

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Alexandre Carrier

Back at Practice
Jared McCann

Undergoes Lower-Body Procedure
Andrei Kuzmenko

Activated From Injured Reserve
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Out for Game 1 on Sunday
William Karlsson

Unavailable for Start of First-Round Series
Quinn Hughes

Available Saturday
Miro Heiskanen

Cleared for Game 1
Jhoan Duran

Placed on 15-Day Injured List With Oblique Strain
Kyle Stowers

Will be Activated on Sunday
Jesper Wallstedt

to Start in Goal for Minnesota on Saturday
Logan Stankoven

Presumed Ready for Game 1
Max Muncy

has Another Multi-Homer Game at Coors Field
Lourdes Gurriel Jr.

Expected to Make Season Debut on Saturday
Austin Riley

Hits Two Home Runs in Shutout Win Over Phillies
Daulton Varsho

Removed Early on Friday With Knee Discomfort
Edwin Uceta

Having More Shoulder Issues, "Shut Down for a Few Days"
Josh Hader

Moved to 60-Day Injured List
Willson Contreras

Returns to Red Sox Lineup on Friday
Daniel Palencia

Goes on 15-Day Injured List With Oblique Strain
Juan Soto

Still on Track to Return Next Week
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Nico Hoerner

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Michigan Lands Commitment From Quarterback Kamden Lopati
Sahith Theegala

Brings Strong Form Into Harbour Town
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Needs Putter to Show Up at RBC Heritage
Jacob Bridgeman

Looks to Return to Elite Form at Harbour Town
J.J. Spaun

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Matt Fitzpatrick

Set for Another Strong Showing at RBC Heritage
Jason Day

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Akshay Bhatia

Looking to Rebound at Harbour Town
Cameron Young

Hoping to Secure Second Win of Season at RBC Heritage
Scottie Scheffler

Looks to Win Again at RBC Heritage
Shane Lowry

Has Disappointing Final Round at Masters
Viktor Hovland

Hoping to Build on Final Round at Masters
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Struggling For Consistency Heading to RBC Heritage
Chris Gotterup

Putting Together Outstanding 2026 Season
Justin Thomas

Looks to Defend in Hilton Head
Jordan Spieth

in Search of Improved Putting at RBC Heritage
Marco Penge

May Continue Up-and-Down Ride at the RBC Heritage
Xander Schauffele

Could Get The Job Done at RBC Heritage
Jake Knapp

Keeps Building Strong Results in 2026
Kurt Kitayama

Trying to Regain Form From Florida
Collin Morikawa

Continues to be a Scary DFS Play at RBC Heritage
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF