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DraftKings Daily Fantasy Football Lineup Picks (Week 16): NFL DFS Advice

RotoBallers, welcome to Week 16 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 16 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 16!

 

DraftKings Quarterbacks - Week 16 DFS Picks

Matthew Stafford - DET @ CIN (DK - $6,200)

Stafford is looking like one of the better options at quarterback this week for a number of reasons. First off, the Lions still have something to play for, so he will be doing all he can to get the win. We know he has multi touchdown upside, as he has done nine times this season. Stafford has put up 17 or more DraftKings points in seven of his last nine games, and has shown to be super consistent. He makes a great play in any format this week, as he is up against the Bengals who have the 18th DVOA against the pass.

Cam Newton - CAR vs TB (DK - $6,800)

Newton has scored 15 or more DraftKings points in six straight games, and is up against one of the worst defenses in the league. He is playing the Buccaneers, who have the 29th DVOA against the pass, and the 21st DVOA against the run. This is a prime spot for him, and he has shown his rushing upside in recent weeks. He has 50 or more rushing yards in five of his last six games, bringing plenty of tournament upside with him.

 

DraftKings Running Backs - Week 16 DFS Picks

Kenyan Drake - MIA @ KC (DK - $7,100)

Drake is up against the Chiefs, who have the 31st DVOA against the run, putting him in a great spot this week. Over the past four week, Drake has 80% of the Dolphins rushing attempts, which means he is their lead back and will be in the game regardless of the situation. The game script isn't saying they will be in this game, as they are a 10 point underdog, but if they want a shot in this game, they will run the ball a lot and slow the game down, putting Drake in a spot to succeed.

Christian McCaffrey - CAR vs TB (DK - $6,400)

McCaffrey brings a dual threat out of the backfield, as he has seen 22 targets over his last four games. He isn't a pure running back and has only gone for a season high of 66 yards this season, but saw double digit rushing attempts last week for the first time since Week 9. This is an encouraging sign, which should benefit him this week, since his opponent has a very bad defense. He is up against the Buccaneers, who have the 21st DOVA against the pass, and the 23rd DVOA against running backs in the passing game. Prime match up for him, and the Panthers are still in a spot where they need to win games, so they won't easy off the gas.

 

DraftKings Wide Receivers - Week 16 DFS Picks

Robert Woods - LAR @ TEN (DK - $6,500)

Woods is back from his injury, and last week he put six receptions 45 yards, and one touchdown. He is good mid range option who has some PPR upside against a Titans team who has the 24th DVOA against the pass. This puts him in a good spot, since the Rams still have something to play for, and will not be resting their starters. Woods has multi touchdown upside, which he has shown in the games before his injury.

Chris Godwin - TB @ CAR (DK - $3,000)

With DeSean Jackson being out of practice yet again on Thursday, Godwin is in a spot to see increased targets, as he did last week, after Jackson left the game early with the injury. Last week he ended with five receptions for 68 yards, for a total of 11.8 DraftKings points. He is also super cheap on DraftKings, so the savings he brings to your lineup will allow you to get up to the higher priced players.

 

DraftKings Tight End - Week 16 DFS Pick

Eric Ebron - DET @ CIN (DK - $3,700)

Everyone and their mother is talking about Antonio Gates this week as a tight end option, since he is so cheap, and will be seeing more targets now that Hunter Henry is done for the year. If you want another option at tight end, look at Ebron. he is up against the Bengals who have the 30th DVOA vs tight ends, and have suffered major losses on their defense. He has 15 receptions over his last two games, and with the Lions needing to win games to stay in the playoff picture, he will see plenty of snaps.

 

DraftKings Defense - Week 16 DFS Pick

Detroit Lions @ Cincinnati Bengals

The Lions are in a spot where they need to win games to try and make the playoffs, so look to their defense to step up against a weak Bengals team. Last week against the Vikings we saw that the Bengals have all but given up on the season, making them a nice target this week. The Lions have seven sacks over their last four games, along with five interceptions in that span. They have turnover potential against this weak Bengals offense.

 

More Weekly DFS Analysis





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is Ruled Out for Friday's Game
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Signs Two-Year Deal With Steelers
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is Unavailable on Friday
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Jeremy Sochan

Won't Suit up on Friday
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Naji Marshall

Cleared to Play Friday
Karl-Anthony Towns

is Ruled Out on Friday
Dallas Goedert

Eagles, Dallas Goedert Push Back Void Date a Second Time to Monday
P.J. Washington

Out Friday Against Cleveland
A.J. Brown

Eagles "Will Not Trade A.J. Brown at This Time"
Wan'Dale Robinson

Poised for Massive Target Volume with New Team in 2026
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Resting Friday Against Cavaliers
Tyler Warren

Profiles as the Clear Lead Target-Earner in Indianapolis
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Takes Full Batting Practice on Friday
Brock Purdy

Has a New No. 1 Wide Receiver to Work With in San Francisco
Jalen McMillan

Has Breakout Potential Heading into 2026
Cam Skattebo

Can Cam Skattebo Take on a Workhorse Role in 2026?
Brandon Woodruff

Still TBD for Opening Day
Tyler Conklin

Signs One-Year Deal With Lions
Rasheed Walker

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Simi Fehoko

Cardinals Re-Sign Receiver Simi Fehoko to One-Year Deal
Van Jefferson

Commanders Signing Van Jefferson on Friday
Dyami Brown

Commanders Bring Back Dyami Brown on One-Year Deal
A.J. Brown

Patriots, Rams Making "Strong Pushes" to Acquire A.J. Brown
Maxx Crosby

Plans to be "200 Percent Ready" by Training Camp
Atlanta Falcons

"No Starters Right Now" for Atlanta's Quarterback Situation
Drew Ogletree

Colts Re-Sign Drew Ogletree to One-Year Deal
L'Jarius Sneed

Titans Releasing L'Jarius Sneed on Friday
Ko Kieft

Buccaneers Re-Sign Ko Kieft for Tight End Depth
Jalen Tolbert

Signing One-Year Deal With Dolphins
Trevor Rogers

to Start on Opening Day for Orioles
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In Dire Need Of Victory
Gillian Robertson

A Favorite At UFC Vegas 114
Amanda Lemos

Set For Co-Main Event
Oumar Sy

Looks To Win Back-To-Back Fights
Ion Cutelaba

Looks To Get Back In The Win Column
Bez Mbeng

Signs 10-Day Contract With Utah
Maxi Kleber

Likely Out Longer with Back Injury
John Konchar

to Miss Second Straight Game
Lauri Markkanen

Not Playing Friday Against Portland
Nathan MacKinnon

Racks Up Four Points in Victory Over Kraken
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Cut Short by Illness Thursday
Alexis Lafrenière

Alexis Lafreniere Stays Hot in Winnipeg
Jonathan Isaac

Exits Early with Knee Issue
Semyon Varlamov

Won't Return This Season
Scotty Pippen Jr.

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Alexander Romanov

Could Return for Playoffs
Declan Carlile

Hurt on Thursday Night
Wyatt Kaiser

Sustains Upper-Body Injury Thursday
Erik Gudbranson

Could Be an Option Saturday
Auston Matthews

Exits Game With Injury
Jimmy Snuggerud

Scores Twice Versus Carolina
Michael Misa

Delivers Multi-Point Performance on Thursday
Keyonte George

to Be Re-Evaluated in Two Weeks
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Around Six Weeks From Being Fully Built Up
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a Game-Time Call Thursday
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Returns to Action Thursday
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to Sit Out Two Weeks
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Ruled Out for Two Weeks
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to Face Hitters in Live Batting Practice on Saturday
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Available Thursday
William Eklund

Questionable to Play Thursday
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Brings Strong Course History to TPC Sawgrass
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to Start the Year on the Injured List
Adam Scott

in Strong Form Ahead of The Players
Kyle Teel

Exits Tuesday's Game With Hamstring Injury
Rickie Fowler

on Quite the Run Heading to TPC Sawgrass
Sepp Straka

Needs to Forget What Happened Sunday at Bay Hill
Jordan Spieth

an Enigma Heading to The Players Championship
Justin Rose

Trying to Pick Up the Pieces in Florida
Maverick McNealy

Bounces Back at Arnold Palmer Invitational
Brooks Koepka

Continues His Florida Swing With Some Momentum
Nicolai Hojgaard

in Strong Form Ahead of The Players
Robert MacIntyre

a Volatile Option at The Players
Matt Fitzpatrick

Looks to Return to Top Form at The Players
Sam Burns

a High-Risk, High-Reward Option at The Players
Keegan Bradley

Hard to Trust at The Players
Xander Schauffele

Rounding into Form Heading to Players Championship
Rory McIlroy

Set to Return at Players Championship to Defend Title
Jake Knapp

Set to Return at Players Championship
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Rasmus Hojgaard

Looking for Bounce-Back at Players Championship
Tommy Fleetwood

Will Need to Find Putter to Compete at Players Championship
Akshay Bhatia

Continues Improving Heading to Players Championship
Merrill Kelly

Set to Make Spring Training Debut on Friday
Francisco Lindor

"100 Percent Optimistic" he Can be Ready for Opening Day
Justin Thomas

Continues Competitive Return at The Players Championship
Corbin Carroll

Set to Play in Cactus League Game on Wednesday
Kyle Stowers

to Make Grapefruit League Debut on Saturday
Hunter Greene

to be Sidelined Through July
Jesús Luzardo

Jesus Luzardo, Phillies Agree on Five-Year Extension
Corbin Carroll

Could Make Spring Debut This Week
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Becomes The New BMF Champion
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Bounces Back
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Reinier De Ridder Loses Back-To-Back Fights
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Gets Dominated
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Extends His Win Streak
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Back in Cactus League Lineup on Monday
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Joey Logano

Crashes out at Phoenix Despite Strong Run
Ryan Blaney

is Always A Top Favorite to Compete for the Win At Phoenix
Denny Hamlin

Is Denny Hamlin Worth Rostering for Phoenix?
Christopher Bell

is Likely to have Another Solid Phoenix Run
Chase Briscoe

has Plenty of Upside for DFS Lineups at Phoenix
Joey Logano

Could Dominate at Phoenix This Weekend
Chase Elliott

has Plenty of Upside for Sunday's Race at Phoenix
Chris Buescher

Is Chris Buescher Worth Rostering For Phoenix DFS Lineups?
Ross Chastain

Has Found Speed Again at Phoenix
Josh Berry

a Solid Sleeper at Phoenix
Brad Keselowski

Skips Qualifying After Practice Crash at Phoenix
Tyler Reddick

Spins in Practice at Phoenix
William Byron

Should Be a Contender at Phoenix
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NASCAR

Could Bubba Wallace Be Playable for Phoenix DFS Lineups?
Anthony Alfredo

Is A Favorable DFS Option In A Substitution Role At Phoenix
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