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DraftKings Daily Fantasy Football Lineup Picks (Week 16): NFL DFS Advice

RotoBallers, welcome to Week 16 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 16 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 16!

 

DraftKings Quarterbacks - Week 16 DFS Picks

Matthew Stafford - DET @ CIN (DK - $6,200)

Stafford is looking like one of the better options at quarterback this week for a number of reasons. First off, the Lions still have something to play for, so he will be doing all he can to get the win. We know he has multi touchdown upside, as he has done nine times this season. Stafford has put up 17 or more DraftKings points in seven of his last nine games, and has shown to be super consistent. He makes a great play in any format this week, as he is up against the Bengals who have the 18th DVOA against the pass.

Cam Newton - CAR vs TB (DK - $6,800)

Newton has scored 15 or more DraftKings points in six straight games, and is up against one of the worst defenses in the league. He is playing the Buccaneers, who have the 29th DVOA against the pass, and the 21st DVOA against the run. This is a prime spot for him, and he has shown his rushing upside in recent weeks. He has 50 or more rushing yards in five of his last six games, bringing plenty of tournament upside with him.

 

DraftKings Running Backs - Week 16 DFS Picks

Kenyan Drake - MIA @ KC (DK - $7,100)

Drake is up against the Chiefs, who have the 31st DVOA against the run, putting him in a great spot this week. Over the past four week, Drake has 80% of the Dolphins rushing attempts, which means he is their lead back and will be in the game regardless of the situation. The game script isn't saying they will be in this game, as they are a 10 point underdog, but if they want a shot in this game, they will run the ball a lot and slow the game down, putting Drake in a spot to succeed.

Christian McCaffrey - CAR vs TB (DK - $6,400)

McCaffrey brings a dual threat out of the backfield, as he has seen 22 targets over his last four games. He isn't a pure running back and has only gone for a season high of 66 yards this season, but saw double digit rushing attempts last week for the first time since Week 9. This is an encouraging sign, which should benefit him this week, since his opponent has a very bad defense. He is up against the Buccaneers, who have the 21st DOVA against the pass, and the 23rd DVOA against running backs in the passing game. Prime match up for him, and the Panthers are still in a spot where they need to win games, so they won't easy off the gas.

 

DraftKings Wide Receivers - Week 16 DFS Picks

Robert Woods - LAR @ TEN (DK - $6,500)

Woods is back from his injury, and last week he put six receptions 45 yards, and one touchdown. He is good mid range option who has some PPR upside against a Titans team who has the 24th DVOA against the pass. This puts him in a good spot, since the Rams still have something to play for, and will not be resting their starters. Woods has multi touchdown upside, which he has shown in the games before his injury.

Chris Godwin - TB @ CAR (DK - $3,000)

With DeSean Jackson being out of practice yet again on Thursday, Godwin is in a spot to see increased targets, as he did last week, after Jackson left the game early with the injury. Last week he ended with five receptions for 68 yards, for a total of 11.8 DraftKings points. He is also super cheap on DraftKings, so the savings he brings to your lineup will allow you to get up to the higher priced players.

 

DraftKings Tight End - Week 16 DFS Pick

Eric Ebron - DET @ CIN (DK - $3,700)

Everyone and their mother is talking about Antonio Gates this week as a tight end option, since he is so cheap, and will be seeing more targets now that Hunter Henry is done for the year. If you want another option at tight end, look at Ebron. he is up against the Bengals who have the 30th DVOA vs tight ends, and have suffered major losses on their defense. He has 15 receptions over his last two games, and with the Lions needing to win games to stay in the playoff picture, he will see plenty of snaps.

 

DraftKings Defense - Week 16 DFS Pick

Detroit Lions @ Cincinnati Bengals

The Lions are in a spot where they need to win games to try and make the playoffs, so look to their defense to step up against a weak Bengals team. Last week against the Vikings we saw that the Bengals have all but given up on the season, making them a nice target this week. The Lions have seven sacks over their last four games, along with five interceptions in that span. They have turnover potential against this weak Bengals offense.

 

More Weekly DFS Analysis





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REAL-TIME FANTASY NEWS

Shane Bieber

Staying in Toronto for 2026
Salvador Perez

Agrees to Two-Year Extension With Royals
Gustav Nyquist

Jets Move Gustav Nyquist to Injured Reserve
Noah Hanifin

Expected to Return From 10-Game Absence Tuesday
William Eklund

to Remain Out Wednesday
TB

Max Crozier Available Tuesday
Tristan Jarry

Lands on Injured Reserve
Jason Zucker

Placed on Injured Reserve
Trevor Story

Opts in for Remaining Two Years on his Contract
Pyotr Kochetkov

Starts on Tuesday
Luguentz Dort

Available on Tuesday
Yu Darvish

to Miss All of 2026 Following Flexor-Tendon Surgery
Jacoby Brissett

to Start Again in Week 10
Kyler Murray

Given 4-8 Week Timetable for Foot Injury
Anthony Edwards

Considered Questionable For Wednesday
Yves Missi

Out Tuesday
Zion Williamson

Expected to Miss at Least One Week
Bradley Beal

Sidelined on Tuesday
Kawhi Leonard

Out Versus Thunder on Tuesday
A.J. Brown

Won't be Traded at Deadline
Garrett Wilson

"Untouchable" in Trade Talks
Jakob Poeltl

Questionable Vs. the Bucks on Tuesday
Kawhi Leonard

Uncertain for Tuesday
Precious Achiuwa

Has Agreed to Sign With the Kings
Darius Garland

Could Make Season Debut As Early As Wednesday
Shota Imanaga

Becomes a Free Agent
Jimmy Butler III

Downgraded to Questionable Against the Suns
Luis Robert Jr.

White Sox Pick Up 2026 Option on Luis Robert Jr.
LaMelo Ball

Will Not Play Tuesday
CFB

LJ Martin Expected to Play in Top-10 Matchup Against Texas Tech
PGA

LIV Golf Expanding To 72-Hole Format In 2026
Rashid Shaheed

Being Shipped to the Seahawks
Sauce Gardner

Colts Acquiring Sauce Gardner From the Jets
Travis Hunter

Not Expected to be Out Long-Term
Brian Thomas Jr.

has Low-Grade Ankle Sprain, has Chance to Play in Week 10
Jakobi Meyers

Jaguars Acquiring Jakobi Meyers
Al Horford

Sits Out Tuesday's Game
Chet Holmgren

Back in Thunder Lineup Tuesday
LaMelo Ball

May Remain Out Tuesday
Zion Williamson

Considered Questionable for Tuesday
Jared McCain

on Track to Make Season Debut Tuesday
Joel Embiid

Available Tuesday
Filip Forsberg

Has Multi-Point Outing Monday
Brock Boeser

Notches Three Points in Overtime Victory
Joey Daccord

Continues Home Success Monday
Connor McDavid

Surpasses 1,100 Career Points
Auston Matthews

Sparks Maple Leafs Comeback
Noel Acciari

Sustains Upper-Body Injury
Kyler Murray

Still the Starting QB When Healthy
Atlanta Braves

Braves Hire Walt Weiss as Their Next Manager
Kris Bubic

Cleared to Begin a Throwing Program
Brandon Woodruff

Declines Mutual Option for 2026
Freddy Peralta

Brewers Exercise 2026 Option on Freddy Peralta
Lucas Giolito

Declines his 2026 Player Option
Daniel Gafford

to be Limited on Monday
Jabari Smith Jr.

Sidelined on Monday Night
Josh Hart

Available to Play on Monday
Kyler Murray

Officially Inactive on Monday Night
J.J. Spaun

Finishes Sixth at Procore Championship
PGA

Matti Schmid Finishes Tied for 46th at Baycurrent Classic
Keith Mitchell

Finishes Tied for 10th at Baycurrent Classic
Si Woo Kim

Finishes Tied for 21st at Genesis Championship
Mackenzie Hughes

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Max Greyserman

Finishes Second at Baycurrent Classic
Austin Eckroat

Finishes Tied for 56th at Baycurrent Classic
Luke Clanton

Finishes Tied for 56th at Bank of Utah Championship
Morgan Barron

Out Week-to-Week
Terry McLaurin

Commanders Don't Think Terry McLaurin Will Play in Week 10
Jayden Daniels

to be "Out for a While" With Dislocated Elbow
Adam Lowry

Ready for Season Debut Tuesday
Pierre-Luc Dubois

to Miss "Extended Period of Time"
Omarion Hampton

Not Expected to Return to Practice Until After Week 12 Bye
Robert Thomas

Set to Return Monday
Quinn Hughes

Available Monday
Justin Brazeau

Remains Out Monday
William Nylander

Rejoins Maple Leafs Lineup Monday
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Alex Bregman

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Edwin Díaz

Edwin Diaz on the Open Market This Winter
Cody Bellinger

Becomes Free Agent After Opting Out
Robert Suarez

Opts Out, Becomes Free Agent
Kyle Larson

Wins His Second NASCAR Cup Series Championship at Phoenix
Ryan Blaney

Concludes the 2025 Season with A Win at Phoenix
William Byron

Strong Championship Effort Ends With Late-Race Flat-Tire Crash
Quinshon Judkins

Browns Optimistic Quinshon Judkins Can Play in Week 10
Tucker Kraft

Done for the Year With Torn ACL
Denny Hamlin

Overtime Four-Tire Call Costs Denny Hamlin the Championship
Chase Briscoe

Championship Bid Never Really Started After Two Tire Failures
Brad Keselowski

Nearly Steals Phoenix Race
David Onama

Suffers First-Round TKO Loss
Steve Garcia

Scores First-Round TKO Win
Ante Delija

Suffers His First UFC Loss
CFB

Dylan Raiola Suffers Season-Ending Injury
Waldo Cortes-Acosta

Gets Knockout Win
Themba Gorimbo

Drops Decision At UFC Vegas 110
Jayden Daniels

Suffers Dislocated Elbow on Sunday Night
Jeremiah Wells

Gets Back In The Win Column
Yadier del Valle

Remains Undefeated
Jayden Daniels

X-Rays Come Back Negative on Jayden Daniels' Left Arm, MRI to Come
Jaelan Phillips

Gets Dealt to Eagles for a Third-Round Pick
Isaac Dulgarian

Cut By UFC Following Submission Loss
Daniel Frunza

Still Winless In The UFC
Charles Radtke

Dominates Daniel Frunza
Allan Nascimento

Gets Submission Win
Philipp Kurashev

Stays Hot on Sunday
Cody Durden

Suffers Second-Round Submission Loss
Jaylen Warren

Records First Career Two-Touchdown Game in Week 9 Win Over Colts
Michael Pittman Jr.

Leads Colts With Nine Catches in Week 9 Loss at Pittsburgh
Max Scherzer

Doesn't Plan on Retiring
Michael King

Becomes Free Agent After Declining Mutual Option
Austin Cindric

is A Driver to Avoid for Phoenix DFS Lineups
Yoshinobu Yamamoto

Named World Series MVP
Alex Bowman

Could Alex Bowman be A Sneaky Tournament Play for Phoenix?
Noah Gragson

Should DFS Players Roster Noah Gragson At Phoenix?
Erik Jones

Is Erik Jones Worth Rostering for DFS at Phoenix?
Michael McDowell

an Easy Recommendation for DFS at Phoenix
Chase Briscoe

Probably Won't Win the Title
Joey Logano

Could Play Spoiler in Championship Battle at Phoenix
Tyler Reddick

Seeking to End Winless Drought, but Probably Won't Have the Speed
NASCAR

Bubba Wallace Looks to Protect Top-10 Points Finish at Phoenix
Brad Keselowski

Hasn't Been Fast at Phoenix With RFK Racing
Daniel Suarez

With Nothing at Stake, Expect Little From Daniel Suarez
Kyle Busch

Qualifies Well, but Will Probably Finish Worse Than he Starts
Chris Buescher

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Austin Dillon

Looks to Avoid Finishing Last in NASCAR Playoffs
AJ Allmendinger

A.J. Allmendinger Might be a Worthy DFS Option
Shohei Ohtani

to Start Game 7 of World Series
Alejandro Kirk

X-Rays Come Back Negative on Alejandro Kirk's Hand
David Onama

Set For UFC Vegas 110 Main Event
Steve Garcia

Returns At UFC Vegas 110
Waldo Cortes-Acosta

Set For Co-Main Event
Ante Delija

In Search For His Second UFC Win
Themba Gorimbo

A Favorite At UFC Vegas 110
Jeremiah Wells

Looks To Return To The Win Column
Yadier del Valle

Looks To Remain Undefeated
CFB

Arizona State Quarterback Sam Leavitt Out for the Season
Isaac Dulgarian

Looks To Win Back-To-Back Fights
Daniel Frunza

Looks For His First UFC Win
CFB

Arch Manning Listed as Questionable for Vanderbilt Matchup
CFB

Arion Carter Listed as Questionable Ahead of Oklahoma Matchup

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