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DraftKings Daily Fantasy Football Lineup Picks (Week 16): NFL DFS Advice

RotoBallers, welcome to Week 16 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 16 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 16!

 

DraftKings Quarterbacks - Week 16 DFS Picks

Matthew Stafford - DET @ CIN (DK - $6,200)

Stafford is looking like one of the better options at quarterback this week for a number of reasons. First off, the Lions still have something to play for, so he will be doing all he can to get the win. We know he has multi touchdown upside, as he has done nine times this season. Stafford has put up 17 or more DraftKings points in seven of his last nine games, and has shown to be super consistent. He makes a great play in any format this week, as he is up against the Bengals who have the 18th DVOA against the pass.

Cam Newton - CAR vs TB (DK - $6,800)

Newton has scored 15 or more DraftKings points in six straight games, and is up against one of the worst defenses in the league. He is playing the Buccaneers, who have the 29th DVOA against the pass, and the 21st DVOA against the run. This is a prime spot for him, and he has shown his rushing upside in recent weeks. He has 50 or more rushing yards in five of his last six games, bringing plenty of tournament upside with him.

 

DraftKings Running Backs - Week 16 DFS Picks

Kenyan Drake - MIA @ KC (DK - $7,100)

Drake is up against the Chiefs, who have the 31st DVOA against the run, putting him in a great spot this week. Over the past four week, Drake has 80% of the Dolphins rushing attempts, which means he is their lead back and will be in the game regardless of the situation. The game script isn't saying they will be in this game, as they are a 10 point underdog, but if they want a shot in this game, they will run the ball a lot and slow the game down, putting Drake in a spot to succeed.

Christian McCaffrey - CAR vs TB (DK - $6,400)

McCaffrey brings a dual threat out of the backfield, as he has seen 22 targets over his last four games. He isn't a pure running back and has only gone for a season high of 66 yards this season, but saw double digit rushing attempts last week for the first time since Week 9. This is an encouraging sign, which should benefit him this week, since his opponent has a very bad defense. He is up against the Buccaneers, who have the 21st DOVA against the pass, and the 23rd DVOA against running backs in the passing game. Prime match up for him, and the Panthers are still in a spot where they need to win games, so they won't easy off the gas.

 

DraftKings Wide Receivers - Week 16 DFS Picks

Robert Woods - LAR @ TEN (DK - $6,500)

Woods is back from his injury, and last week he put six receptions 45 yards, and one touchdown. He is good mid range option who has some PPR upside against a Titans team who has the 24th DVOA against the pass. This puts him in a good spot, since the Rams still have something to play for, and will not be resting their starters. Woods has multi touchdown upside, which he has shown in the games before his injury.

Chris Godwin - TB @ CAR (DK - $3,000)

With DeSean Jackson being out of practice yet again on Thursday, Godwin is in a spot to see increased targets, as he did last week, after Jackson left the game early with the injury. Last week he ended with five receptions for 68 yards, for a total of 11.8 DraftKings points. He is also super cheap on DraftKings, so the savings he brings to your lineup will allow you to get up to the higher priced players.

 

DraftKings Tight End - Week 16 DFS Pick

Eric Ebron - DET @ CIN (DK - $3,700)

Everyone and their mother is talking about Antonio Gates this week as a tight end option, since he is so cheap, and will be seeing more targets now that Hunter Henry is done for the year. If you want another option at tight end, look at Ebron. he is up against the Bengals who have the 30th DVOA vs tight ends, and have suffered major losses on their defense. He has 15 receptions over his last two games, and with the Lions needing to win games to stay in the playoff picture, he will see plenty of snaps.

 

DraftKings Defense - Week 16 DFS Pick

Detroit Lions @ Cincinnati Bengals

The Lions are in a spot where they need to win games to try and make the playoffs, so look to their defense to step up against a weak Bengals team. Last week against the Vikings we saw that the Bengals have all but given up on the season, making them a nice target this week. The Lions have seven sacks over their last four games, along with five interceptions in that span. They have turnover potential against this weak Bengals offense.

 

More Weekly DFS Analysis





REAL-TIME FANTASY NEWS

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Found Not Guilty of Assault, Strangulation
Emilio Pagán

Emilio Pagan Carted Off With Apparent Hamstring Injury on Tuesday
Justin Rose

to Continue Mid-Season Club Change at Truist Championship
Si Woo Kim

is Back to Peak Form Ahead of Truist Championship
Sam Merrill

Heads to Locker Room in Game 1
Sam Burns

to Bounce Back at Truist Championship
Cameron Young

Looks to Carry Dominance to Quail Hollow
Anthony Edwards

Iffy for Game 2
Rory McIlroy

Returns to Familiar Stomping Grounds This Week at Quail Hollow
Ayo Dosunmu

Listed as Questionable Wednesday
Kevin Huerter

Remains Out for Series Opener
Carter Bryant

Questionable for Game 2
Chris Gotterup

Looking to Bounce Back at Quail Hollow
MLB

Cardinals-Brewers Game Postponed on Tuesday
Joel Embiid

Expected to Play Wednesday
Roman Anthony

Day-to-Day With Wrist Sprain
Radko Gudas

to Remain Sidelined Wednesday
Sam Carrick

Upgraded to Day-to-Day
Noah Cates

Considered Day-to-Day
Alexander Nikishin

Cleared to Play in Game 3 Against Flyers
Josh Manson

Expected to Remain Out Tuesday
Filip Gustavsson

Starting Game 2 Against Avalanche
Victor Hedman

Reveals Reason for Absence
Travis Kelce

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DJ Moore

a Prime Bounce-Back Candidate Following Offseason Trade
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Ladd McConkey

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Ryan Flournoy

Is Ryan Flournoy a Dynasty Stash Candidate Due to Long-Term Upside in Dallas?
Dante Fowler Jr.

Signing with Seahawks
Jacob Misiorowski

"All Things Look Good" for Jacob Misiorowski to Start on Wednesday
Tommy Fleetwood

Looking For Better Iron Play at Quail Hollow
Micah Parsons

Packers Expect Micah Parsons to be Ready "Early in the Season"
Tucker Kraft

Expected Back "Early in the Season"
Calvin Ridley

Brian Daboll Says it's "Good to Have" Calvin Ridley on Roster
Isaac Guerendo

Buried on Depth Chart, Looking for New Team?
Jalen Nailor

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MLB

Rockies-Mets Game Postponed Due to Inclement Weather
CFB

Mario Craver Enters No. 1 Wide Receiver Role for Marcel Reed
Raisel Iglesias

Braves Officially Reinstate Raisel Iglesias From Injured List on Tuesday
CFB

LaNorris Sellers a Strong Rebound Candidate in 2026
CFB

Cam Coleman Poised for Monster Year at Texas?
Cedric Tillman

on the Trade Block?
CFB

Will Hammond Pushing to Be Ready for Week 1
Alex Fitzpatrick

Looking to Keep Up Ball-Striking Output at Quail Hollow
Emmett Johnson

Andy Reid Compares Emmett Johnson to LeSean McCoy
CFB

Notre Dame Leads College Football in Returning Snaps
Ty Simpson

a Great Fit With the Rams?
CFB

Two Ole Miss Football Players Arrested, Charged with DUI
Alvin Kamara

"Excited" to Share the Backfield With New RB Addition
Carson Beck

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Devaughn Vele

Upside Takes a Hit After the NFL Draft
Brenen Thompson

Compared to Tyreek Hill
Jonathan Taylor

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Jaxon Smith-Njigba

Firmly Entrenched in Top Tier of Dynasty Receivers
Tyrese Maxey

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Joel Embiid

Stays Quiet in Game 1 Against Knicks
Jalen Brunson

Torches 76ers With 35 Points Monday
Dylan Harper

Leads Spurs With 18 Points Monday
Julius Randle

Collects First Double-Double of Postseason
Anthony Edwards

Tallies 18 Points in Comeback Game
Victor Wembanyama

Posts Unique Triple-Double
Jackson LaCombe

Sets New Record With Another Assist
Mikael Granlund

Continues Postseason Success With Third Goal
Mitchell Marner

Notches Two Points in Series-Opening Win
Ben Griffin

Looks Solid on the Surface Heading to Charlotte
Taylor Hall

Makes History With Overtime Winner
Rickie Fowler

Faces a Challenge at Quail Hollow
Nikolaj Ehlers

Collects Two Points in Comeback Win
Cale Makar

Good to Go for Game 2 Against Wild
Gary Woodland

on a Nice Wave Approaching Truist Championship
Ridly Greig

Suspended for Two Games
Sepp Straka

Hoping for More Success at Truist Championship
J.J. Spaun

Approaching Charlotte With Optimism
Alex Smalley

Carries Momentum into Truist Championship
Nicolai Hojgaard

Roller Coaster Heads to Charlotte
Keegan Bradley

Desperate to Bounce Back from Doral Encounter
Dallas Mavericks

Masai Ujiri Hired as Mavericks Team President
Anthony Edwards

to Come Off Bench Monday
Chicago Bulls

Bryson Graham Hired as Bulls Lead Executive
Jalen Williams

Sidelined Tuesday vs Lakers
Carter Bryant

Unavailable for Game 1 Against Minnesota
Anthony Edwards

Set to Return Monday with Restrictions
Joel Embiid

is Cleared for Monday's Game 1
Kevin Huerter

is Questionable for Tuesday's Contest
Roman Anthony

Pulled Early on Monday After Tweaking his Wrist
Jhoan Duran

to Come Off the Injured List on Tuesday
Owen Tippett

Remains Out Monday
Roope Hintz

Recovering From Hamstring Injury
Tyler Seguin

Expects to Be Ready for Training Camp
Sam Carrick

Could Practice Tuesday
Alexander Nikishin

Won't Play Monday
Jeremy Lauzon

Expected to Miss Round 2
William Karlsson

Rejoins Golden Knights Lineup Monday
Jackson Chourio

Brewers Reinstate Jackson Chourio From the Injured List
Tarik Skubal

to Undergo Elbow Surgery
Chase Elliott

Earns his Second Texas Motor Speedway Victory
Denny Hamlin

Misses Out on Winning at Texas
Alex Bowman

Finishes Third for the Second Week in a Row at Texas
Tyler Reddick

Earns Seventh Top-Five Finish of the Season at Texas
Chris Buescher

Scores his First Career Texas Finish in the Top Five
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Bryce Underwood in Better Situation Entering Sophomore Season
CFB

Nico Iamaleava Emerging as Leader, Playmaker for UCLA
Raisel Iglesias

to be Activated on Tuesday
Jack Della Maddalena

Gets Dominated At UFC Perth
Carlos Prates

Shines At UFC Perth
Beneil Dariush

Suffers A First-Round TKO Loss
Quillan Salkilld

Remains Unbeaten In The UFC
Tim Elliott

Drops Decision At UFC Perth
Steve Erceg

Wins Back-To-Back Fights
Ollie Schmid

Suffers First-Round TKO Loss
Marwan Rahiki

Remains Unbeaten
Bryce Eldridge

Giants to Promote No. 1-Ranked Prospect Bryce Eldridge to MLB Roster
Anthony Volpe

Reinstated From Injured List, Optioned to Triple-A
Ranger Suarez

Exits Sunday's Start With Hamstring Tightness
Agustín Ramírez

Marlins Demote Agustin Ramirez to Triple-A
Ben Rice

Exits Sunday's Contest With Left-Hand Contusion
Christopher Bell

Is Christopher Bell Worth Rostering for Texas Lineups?
Cal Raleigh

Considered Day-to-Day With Soreness in his Side
William Byron

Might have the Speed to Compete for the Win at Texas
Joey Logano

Provides Solid Upside for Texas DFS Lineups
Joe Ryan

Exits Early From Start on Sunday Due to Elbow Soreness
Chase Briscoe

Could Chase Briscoe be A Sneaky Pick for Texas Lineups?
Ty Gibbs

Should DFS Managers Roster Ty Gibbs at Texas?
Daniel Suarez

Is Daniel Suarez Worth Rostering After Career-Best Starting Position at Texas?
Daniel Palencia

Cubs Reinstate Daniel Palencia From the Injured List on Sunday
Kyle Busch

Is a DFS Risk Starting in the Top 10 at Texas
Ronald Acuña Jr.

Braves Place Ronald Acuna Jr. on Injured List With Strained Hamstring
Nick Lodolo

Expected to Make Season Debut on Friday
Tyler Reddick

One of the Favorites to Win at Texas
Chase Elliott

Could Contend for Another Win at Texas
Carson Hocevar

on Pole at Texas
NASCAR

Bubba Wallace Wrecks in Practice at Texas
Chris Buescher

Looking to Continue Strong Run at Texas
Austin Dillon

Blows Engine in Practice at Texas
Jack Della Maddalena

Returns At UFC Perth
Carlos Prates

Set For UFC Perth Main Event
Quillan Salkilld

Set For Co-Main Event
Beneil Dariush

An Underdog At UFC Perth
Steve Erceg

Looks To Win Back-To-Back Fights
Tim Elliott

Looks For His Third Consecutive Win
Ollie Schmid

Set For His UFC Debut
Marwan Rahiki

Looks To Remain Undefeated
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF