X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 50% Now
Import Your Leagues
Props Tool
Compare Any Players
Compare Any Players
24x7 News and Alerts

DraftKings Daily Fantasy Baseball Picks (9/22/21): MLB DFS Lineups

Zack Wheeler - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury nNews

The top daily fantasy baseball lineup picks for DraftKings on 9/22/21. Euan Leith's MLB DFS analysis and sleepers for building optimal DFS rosters.

Happy Wednesday, Rotoballers! With a week and a half of the regular season to go, there are still seven playoff spots up for grabs. The Giants, Dodgers, and Brewers have secured some October baseball, but it's still all up in the air in the NL East and the final Wild Card spot. As for the AL, the Astros and White Sox seem destined for a Divisional Series matchup, while the Rays, Red Sox, Blue Jays, and Yankees fight to the (figurative) death for the remaining three American League spots. That was an incredibly long way of saying: There is a ton left to fight for this year, and I'm looking forward to seeing how the final 10-12 games play out. 

Ten evening games clutter the MLB schedule on Wednesday, with some top-heavy aces and bottom-of-the-barrel bargains. For today, I'm sticking in the top third of the pitching arsenal. It'll cost me on the hitting side, but there are some pleasant values around the diamond to make up for it. One player I am fading is Luis Garcia for the Astros. Recently, he's hit a rough patch, and at $10,000, I'm not sure why you wouldn't go up to Zack Wheeler ($10,400 vs. BAL) or down to the likes of Walker Buehler ($9,800 at COL) or Chris Sale ($9,600 vs. NYM).

This article will provide you with my daily fantasy baseball lineup picks for DraftKings on 9/22/2021. The lineup will range from some of the elite players to mid-priced options and value plays. You can also check out today's FanDuel MLB DFS lineup picks and read more DFS advice and lineup picks for other sports too. It's also important to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away.

Featured Promo! Save 50% on any PGA Premium Pass using discount code MASTERS, this week only! Win more with our DFS and Betting Packages, get expert tools and advice from proven winners including the Lineup Optimizer, Research Station, betting/props cheat sheet and more. GAIN FULL ACCESS HERE

 

DraftKings DFS Starting Pitchers

Zack Wheeler - P, PHI vs. BAL ($10,400)

Phillies ace Zack Wheeler comes into the slate as the most expensive arm to roster. The right-handed hurler has had his ups and downs since the All-Star break but has still managed to compile a 3.68 ERA, 1.09 WHIP, and a 26.1 percent strikeout rate. In his previous three starts, the 31-year old averaged 27.2 fantasy points per game and has 23 strikeouts in his last 17 2/3 innings. Wheeler will have a chance to match his recent DraftKings output against the Baltimore Orioles today. In September, the O's are slashing a putrid .215/.290/.387 with a 26.8 percent strikeout rate to righties.

Joe Ryan - P, MIN at CHC ($8,200)

I will put Joe Ryan in some of my lineups on Wednesday, but he's a prime candidate for me only checking the boxscore at the end of the night and not watching a single pitch of his outing. The main reason is that he gives up so many flyballs (26 flyball outs in 17 innings), and the second reason is that the Cubs can mash the baseball. However, all hope is not lost with Ryan. In his first three starts, the rookie is 1-1 with a 2.12 ERA, 0.53 WHIP, and 14 strikeouts in 17 innings. A date with the Cubs should fix his lack of strikeouts as they whiff 28.3 percent of the time versus righties in September. As I said, Ryan is a set-it-and-nervously-forget-it option, but I'm not a fan of the arms below him, and I think he will have a low roster percentage on the slate.

Other options: Walker Buehler at COL ($9,800), Chris Sale vs. NYM ($9,600), Ian Anderson at ARI ($8,400)

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

DraftKings DFS Infielders

Daulton Varsho - C, ARI vs. Ian Anderson ($5,200)

Varsho has been getting the kind of run in the second half of the season most season-long fantasy managers wanted from him all year. Still, the catcher/outfielder is doing his best to make up for lost time with a terrific second half. Since the All-Star break, Varsho has been slashing .294/.357/.588 with 27 runs, 26 RBI, 23 extra-base hits (10 home runs), and four stolen bases. He's doing it all, and while $5,200 isn't a discount, the Diamondbacks do-it-all man is averaging 9.9 FPPG in his last 10 and is one of the safest bets at catcher.

Bobby Dalbec - 1B, BOS vs. Taijuan Walker ($3,300)

Bobby D! His bat has come alive since Kyle Schwarber began challenging for his spot at first base, and it seems to be staving off a what seemed likely bench role in Boston. The young slugger has five home runs and 15 RBI in 15 games to accompany a .404 ISO and .442 weighted on-base average in September. Over his last 10 games, Dalbec has smashed seven extra-base hits and sports a 1.033 OPS. At $3,300, he's one of my favorite values among the 10 games tonight, but I would play him in any contest without any hesitation.

Brendan Rodgers - 2B, COL vs. Walker Buehler ($3,900)

While Walker Buehler brings his talents to the Mile High City on Wednesday, I'm buying what Brendan Rodgers is selling and slamming him in my DFS lineups. He's been nothing short of phenomenal in the second half of the year with a .303/.335/.500 slash line to go along with 31 runs, 27 RBI, and 22 extra-base hits in 50 games. The Rockies infielder isn't even benefitting from the Coors-Field bump yet, as he has a .745 OPS in Colorado and a .864 OPS away from the thin air of Denver. Rodgers is locked in as the two-hole hitter for the Rockies, and I love his price at $3,900.

Nolan Arenado - OF, STL at Brett Anderson ($4,600)

I'm not a Brett Anderson believer, and I'm ready to put my lack of faith to the test with a couple of Cardinals' recommendations. First off, we have Nolan Arenado. The perennial All-Star is predictably having his worst season in a while after leaving Coors Field, but he's been far from a disaster with 33 home runs and 100 RBI in 2021. Recently, he's up to a 1.015 OPS in his last 10 games and has pummeled four baseballs for home runs and driven in 10 RBI. Arenado is hitting in the middle of a Cardinals lineup, making a last-minute September push, and he will push DFS managers into the green on Wednesday.

Elvis Andrus - SS, OAK vs. Chris Flexen ($2,700)

It hasn't been the change-of-scenery narrative some people were hoping for this season with Elvis Andrus after moving from Texas to the Bay Area. However, that's the great thing about DFS: a player can turn it around and be hot for a while and become a terrific addition to our rosters. He came up hitless last night, but he was playing some of his best ball of the season in the previous games. From Sep. 7 - Sep. 20, Andrus registered a hit in 11 of 12 games while batting .472 with four doubles, six RBI, and nine runs. At $2,700, Andrus is a perfect punt play if you need to fit some more significant bats at the other positions.

 

DraftKings DFS Outfielders

Kyle Tucker - OF, HOU at Janson Junk ($4,400)

Homer alert, but, for my money, Kyle Tucker has one of the quietest home run swings in the game.

I want as much of the Houston offense as I can afford right now, and Tucket sitting at $4,400 is too good to pass up. He's up to 27 home runs in 129 games and has a legitimate 40 home run upside if he can stay healthy for an entire season. The lefty bat has heated up over the last week and a half with seven runs, five doubles, three home runs, and seven RBI since Sept. 12. Tucker has seven extra-base hits in his last seven games, and I think he'll make it eight in eight against Jason Junk and the Angels bullpen as the Astros look to inch closer to another AL West title.

Tyler O'Neill - OF, STL at Brett Anderson ($4,300)

I'll be combining Tyler O'Neill with Nolan Arenado for my Cardinals stack and waiting for the fantasy points to flow into my DraftKings lineup. Grabbing the 3-4 St. Louis stack versus Brett Anderson feels like one of the safest plays on the slate. As a team, St. Louis is battering lefties this month to the tune of a .417 wOBA and a 162 wRC+. Like I mentioned earlier, Arenado is hot, and it's making a great team with O'Neill's recent performances. Since Sep. 11, the outfielder is slashing .333/.405/.611 three home runs, 11 RBI, and 13 runs for 12.7 FPPG. There are other combinations of Cardinals to roll out there, but the O'Neill-Arenado pairing is my favorite right now.

Garrett Hampson - OF, COL vs. Walker Buehler ($3,000)

I'm going back to the Coors Field well one more time tonight and grabbing the Rockies leadoff hitter. Garrett Hampson at $3,000 feels like a no-brainer given his price and recent form. The Rockies leadoff hitter is touting a .837 OPS this month, which is his second-highest month behind a .857 mark in June. He did this last season with a big September, and I'm all for rolling the dice and running with it again. Hampson is leading off in Coors Field for $3,000. Sometimes we don't have to think too hard about every matchup and just take the free opportunities to accrue fantasy points with minimal risk. Grab Garrett and spend up at other spots on Wednesday.

 

DraftKings DFS Stacks

  • Houston Astros at Los Angeles Angels (Janson Junk, RHP)
  • St. Louis Cardinals at Milwaukee Brewers (Brett Anderson, LHP)
  • San Francisco Giants at San Diego Padres (Vince Velasquez, RHP)

 



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 50% Now
Import Your Leagues
Props Tool
Compare Any Players
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Jonathan Isaac

Unlikely to Play in Game 2
Mark Williams

Could Sit Again in Game 2
Grayson Allen

Questionable for Game 2
Jordan Goodwin

Iffy for Game 2
Chicago Bulls

Billy Donovan Exiting as Bulls Head Coach
Ron Harper Jr.

Available for Game 2 Against 76ers
Zack Wheeler

to Make Season Debut on Saturday
Jonathan Toews

Undecided on NHL Future
Jonathan Huberdeau

Expects to Be Ready for Training Camp
DAL

Nathan Bastian Not Expected to Play Before Round 2
Roope Hintz

Doubtful for Game 4
Adam Henrique

Won't Play in Game 2 Against Ducks
Victor Hedman

Doubtful to Play in Round 1
Charle-Edouard D'Astous

Unavailable Tuesday
Dalton Kincaid

Sell Window in Dynasty Formats May Be Closing Ahead of NFL Draft
Alvin Kamara

Remains a Top Dynasty Sell Candidate Ahead of NFL Draft
Jordan James

Offers Sneaky Buy-Low Potential Ahead of NFL Draft
Jaylen Waddle

a Top Buy-Low Candidate Heading into First Season in Denver
Josh Downs

a Top Buy-Low Candidate Ahead of NFL Draft
Mike Evans

a Sneaky Dynasty Buy Candidate Ahead of NFL Draft?
Tyler Bass

Close to Full Health, Ready to Return to Fantasy Relevance?
Ronald Acuña Jr.

Ronald Acuna Jr. Back in Leadoff Spot on Tuesday After Injury Scare
New England Patriots

Patriots Targeting Eli Stowers in the NFL Draft?
CFB

Ashton Daniels Named Florida State's Starting Quarterback
Aaron Rodgers

Mike McCarthy has Confidence in Aaron Rodgers if he Re-Signs
Daniel Jones

is Dropping Back and Passing in his Rehab
Juan Soto

Expected to Return on Wednesday
NFL

Jermod McCoy Could Fall in Draft Due to Long-Term Knee Concerns
NFL

Ty Simpson Could Fall Out of the First Round
Washington Commanders

Jeremiyah Love Could Unlock Commanders Offense
Royce Lewis

Twins Reinstate Royce Lewis From Injured List on Tuesday
Adley Rutschman

Activated From Injured List on Tuesday
Nnamdi Madubuike

Doctors Think Nnamdi Madubuike Can Resume his Playing Career
Kayshon Boutte

Not Present for Voluntary Workouts
Tetairoa McMillan

Working on "Power" and Weight/Muscle Gain
Ashton Jeanty

a Top Dynasty Buy Ahead of the NFL Draft?
Tyler Shough

Poised to Get a Wide Receiver Upgrade in the NFL Draft?
Mason Taylor

a Sneaky Buy in Dynasty Leagues as NFL Draft Approaches?
Devin Neal

a Sneaky Buy Ahead of the NFL Draft
Dylan Cease

Continues Strong Start With 12-Strikeout Performance
Ricky Pearsall

Not Yet Ready to Make the WR1 Leap
Raisel Iglesias

Placed on 15-Day Injured List with Shoulder Inflammation
Jake Sanderson

Records Two Assists in Losing Effort
Brock Faber

Bags Two Goals in Monday's Defeat
Wyatt Johnston

Notches Two Goals in Game 2 Win
Troy Terry

Has Special Playoffs Debut
Dan Vladar

Leads Flyers to Victory With 27-Save Shutout
Yakov Trenin

Suffers Upper-Body Injury in Game 2
Rasmus Sandin

to Miss Start of 2026-27
CJ McCollum

Shines at MSG in Game 2
Donovan Mitchell

Extends 30-Point Streak
Jakob Poeltl

Gets Benched in Second Half
Brandon Ingram

Continues to Struggle
Al Horford

Undecided on Future
Brandin Podziemski

Wants to Stay With Warriors Long-Term
Max Muncy

With Another Two-Homer Game, Becoming Must-Add Off Waiver Wire
Jordan McLaughlin

Ruled Out for Game 2
Ron Harper Jr.

Probable for Game 2
Austin Reaves

to Remain Out Tuesday
Luka Dončić

Luka Doncic Still Out Tuesday
Anthony Edwards

Active on Monday Night
Kevin Durant

a Game-Time Decision on Tuesday
Ronald Acuña Jr.

Ronald Acuna Jr. Day-to-Day After Being Hit on the Hand on Monday
Mick Abel

Injury Described as "Not Too Serious"
Brendan Donovan

Mariners Place Brendan Donovan on Injured List With Groin Strain
Joel Embiid

is Officially Ruled Out for Game 2
Sonny Gray

Heading to the Injured List With Hamstring Injury
Victor Wembanyama

Wins Defensive Player of the Year
OG Anunoby

is Available to Play for Monday's Game 2
Edwin Díaz

Edwin Diaz Expected to Miss Around Three Months
Edwin Uceta

Shut Down for 2-3 Weeks; Is he Still Stash-Worthy?
Charle-Edouard D'Astous

Doubtful for Game 2
Brad Keller

Will "Probably" Earn First Save Situation in Modified Phillies Bullpen
Roope Hintz

to Miss at Least Two More Games
Edwin Díaz

Edwin Diaz Placed on 15-Day Injured List with Elbow Injury
Ross Johnston

Won't Play in Game 1 Against Oilers
Artem Zub

Considered a Game-Time Decision Monday
Tyler Kleven

Remains Out Monday
Jason Dickinson

a Game-Time Call Monday
Leon Draisaitl

Expected to Return Monday
Tyler Reddick

Earns His Fifth Win of the 2026 Season at Kansas
Kyle Larson

Finishes as the Runner-Up at Kansas
Chase Briscoe

Rallies for A New Career-Best Finish at Kansas
Denny Hamlin

Leads the Most Laps at Kansas but Misses Out on Victory
Christopher Bell

Falls Out of Contention for Kansas Victory on Final Restart
Mike Malott

Scores Third-Round TKO Win
Sonny Gray

Leaves Monday's Start Early With Hamstring Tightness
Gilbert Burns

Retires After UFC Winnipeg Loss
Charles Jourdain

Extends Winning Streak
Mick Abel

Twins Placing Mick Abel on Injured List With Elbow Inflammation
Kyler Phillips

Drops Decision At UFC Winnipeg
Mandel Nallo

Suffers First-Round TKO Loss In His UFC Debut
Jai Herbert

Scores First-Round TKO Win
Karine Silva

Gets Dominated at UFC Winnipeg
Jasmine Jasudavicius

Dominates Karine Silva
Corbin Carroll

Expected Back Tuesday; Injury Concern Appears Minor
Juan Soto

is on Track to Return Next Homestand
Corbin Carroll

Exits Sunday's Game with Back Tightness
Kyle Larson

Should not be Underestimated for the Win at Kansas
Denny Hamlin

Can Denny Hamlin Dominate at Kansas Again?
NASCAR

Christoper Bell Should Contend for First Win at Kansas
Tyler Reddick

Fastest in Practice and Qualifying for Kansas Race
Ryan Blaney

Could Score another Top-10 Finish at Kansas
Ty Gibbs

Poised to Continue Hot Streak at Kansas
Chris Buescher

Always Consistent, Has Speed Heading Into Kansas
William Byron

is A Solid DFS Option for Kansas Lineups
Carson Hocevar

Poised for Career-Best Run at Kansas
Chase Briscoe

Is Chase Briscoe Worth Rostering for DFS at Kansas?
Chase Elliott

Is A Favorable DFS Option for Kansas Lineups
Joey Logano

Could Joey Logano be Considered Playable In DFS This Week at Kansas?
NASCAR

Bubba Wallace is A Favorable Driver to Consider for Kansas Lineups
Ross Chastain

Is Ross Chastain A Worthy DFS Option for Kansas?
Brad Keselowski

Could Brad Keselowski be A Sneaky DFS Option for Kansas?
Daniel Suarez

Should DFS Managers Roster Daniel Suarez at Kansas?
Mike Malott

A Favorite At UFC Winnipeg
Gilbert Burns

Set For UFC Winnipeg Main Event
Kyler Phillips

Set UFC Winnipeg Co-Main Event
Charles Jourdain

Looks To Extend His Win Streak
Jai Herbert

An Underdog At UFC Winnipeg
Mandel Nallo

Set For His UFC Debut
Karine Silva

Looks To Get Back In The Win Column
Jasmine Jasudavicius

Looks To Bounce Back
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF