X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

DraftKings Daily Fantasy Baseball Picks (9/22/21): MLB DFS Lineups

Zack Wheeler - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury nNews

The top daily fantasy baseball lineup picks for DraftKings on 9/22/21. Euan Leith's MLB DFS analysis and sleepers for building optimal DFS rosters.

Happy Wednesday, Rotoballers! With a week and a half of the regular season to go, there are still seven playoff spots up for grabs. The Giants, Dodgers, and Brewers have secured some October baseball, but it's still all up in the air in the NL East and the final Wild Card spot. As for the AL, the Astros and White Sox seem destined for a Divisional Series matchup, while the Rays, Red Sox, Blue Jays, and Yankees fight to the (figurative) death for the remaining three American League spots. That was an incredibly long way of saying: There is a ton left to fight for this year, and I'm looking forward to seeing how the final 10-12 games play out. 

Ten evening games clutter the MLB schedule on Wednesday, with some top-heavy aces and bottom-of-the-barrel bargains. For today, I'm sticking in the top third of the pitching arsenal. It'll cost me on the hitting side, but there are some pleasant values around the diamond to make up for it. One player I am fading is Luis Garcia for the Astros. Recently, he's hit a rough patch, and at $10,000, I'm not sure why you wouldn't go up to Zack Wheeler ($10,400 vs. BAL) or down to the likes of Walker Buehler ($9,800 at COL) or Chris Sale ($9,600 vs. NYM).

This article will provide you with my daily fantasy baseball lineup picks for DraftKings on 9/22/2021. The lineup will range from some of the elite players to mid-priced options and value plays. You can also check out today's FanDuel MLB DFS lineup picks and read more DFS advice and lineup picks for other sports too. It's also important to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away.

Featured Promo! Save 30% on any Premium Pass using discount code NEW. Win more with our DFS, Betting and Season-Long Pass, get expert tools and advice from proven winners! GAIN ACCESS

 

DraftKings DFS Starting Pitchers

Zack Wheeler - P, PHI vs. BAL ($10,400)

Phillies ace Zack Wheeler comes into the slate as the most expensive arm to roster. The right-handed hurler has had his ups and downs since the All-Star break but has still managed to compile a 3.68 ERA, 1.09 WHIP, and a 26.1 percent strikeout rate. In his previous three starts, the 31-year old averaged 27.2 fantasy points per game and has 23 strikeouts in his last 17 2/3 innings. Wheeler will have a chance to match his recent DraftKings output against the Baltimore Orioles today. In September, the O's are slashing a putrid .215/.290/.387 with a 26.8 percent strikeout rate to righties.

Joe Ryan - P, MIN at CHC ($8,200)

I will put Joe Ryan in some of my lineups on Wednesday, but he's a prime candidate for me only checking the boxscore at the end of the night and not watching a single pitch of his outing. The main reason is that he gives up so many flyballs (26 flyball outs in 17 innings), and the second reason is that the Cubs can mash the baseball. However, all hope is not lost with Ryan. In his first three starts, the rookie is 1-1 with a 2.12 ERA, 0.53 WHIP, and 14 strikeouts in 17 innings. A date with the Cubs should fix his lack of strikeouts as they whiff 28.3 percent of the time versus righties in September. As I said, Ryan is a set-it-and-nervously-forget-it option, but I'm not a fan of the arms below him, and I think he will have a low roster percentage on the slate.

Other options: Walker Buehler at COL ($9,800), Chris Sale vs. NYM ($9,600), Ian Anderson at ARI ($8,400)

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

DraftKings DFS Infielders

Daulton Varsho - C, ARI vs. Ian Anderson ($5,200)

Varsho has been getting the kind of run in the second half of the season most season-long fantasy managers wanted from him all year. Still, the catcher/outfielder is doing his best to make up for lost time with a terrific second half. Since the All-Star break, Varsho has been slashing .294/.357/.588 with 27 runs, 26 RBI, 23 extra-base hits (10 home runs), and four stolen bases. He's doing it all, and while $5,200 isn't a discount, the Diamondbacks do-it-all man is averaging 9.9 FPPG in his last 10 and is one of the safest bets at catcher.

Bobby Dalbec - 1B, BOS vs. Taijuan Walker ($3,300)

Bobby D! His bat has come alive since Kyle Schwarber began challenging for his spot at first base, and it seems to be staving off a what seemed likely bench role in Boston. The young slugger has five home runs and 15 RBI in 15 games to accompany a .404 ISO and .442 weighted on-base average in September. Over his last 10 games, Dalbec has smashed seven extra-base hits and sports a 1.033 OPS. At $3,300, he's one of my favorite values among the 10 games tonight, but I would play him in any contest without any hesitation.

Brendan Rodgers - 2B, COL vs. Walker Buehler ($3,900)

While Walker Buehler brings his talents to the Mile High City on Wednesday, I'm buying what Brendan Rodgers is selling and slamming him in my DFS lineups. He's been nothing short of phenomenal in the second half of the year with a .303/.335/.500 slash line to go along with 31 runs, 27 RBI, and 22 extra-base hits in 50 games. The Rockies infielder isn't even benefitting from the Coors-Field bump yet, as he has a .745 OPS in Colorado and a .864 OPS away from the thin air of Denver. Rodgers is locked in as the two-hole hitter for the Rockies, and I love his price at $3,900.

Nolan Arenado - OF, STL at Brett Anderson ($4,600)

I'm not a Brett Anderson believer, and I'm ready to put my lack of faith to the test with a couple of Cardinals' recommendations. First off, we have Nolan Arenado. The perennial All-Star is predictably having his worst season in a while after leaving Coors Field, but he's been far from a disaster with 33 home runs and 100 RBI in 2021. Recently, he's up to a 1.015 OPS in his last 10 games and has pummeled four baseballs for home runs and driven in 10 RBI. Arenado is hitting in the middle of a Cardinals lineup, making a last-minute September push, and he will push DFS managers into the green on Wednesday.

Elvis Andrus - SS, OAK vs. Chris Flexen ($2,700)

It hasn't been the change-of-scenery narrative some people were hoping for this season with Elvis Andrus after moving from Texas to the Bay Area. However, that's the great thing about DFS: a player can turn it around and be hot for a while and become a terrific addition to our rosters. He came up hitless last night, but he was playing some of his best ball of the season in the previous games. From Sep. 7 - Sep. 20, Andrus registered a hit in 11 of 12 games while batting .472 with four doubles, six RBI, and nine runs. At $2,700, Andrus is a perfect punt play if you need to fit some more significant bats at the other positions.

 

DraftKings DFS Outfielders

Kyle Tucker - OF, HOU at Janson Junk ($4,400)

Homer alert, but, for my money, Kyle Tucker has one of the quietest home run swings in the game.

I want as much of the Houston offense as I can afford right now, and Tucket sitting at $4,400 is too good to pass up. He's up to 27 home runs in 129 games and has a legitimate 40 home run upside if he can stay healthy for an entire season. The lefty bat has heated up over the last week and a half with seven runs, five doubles, three home runs, and seven RBI since Sept. 12. Tucker has seven extra-base hits in his last seven games, and I think he'll make it eight in eight against Jason Junk and the Angels bullpen as the Astros look to inch closer to another AL West title.

Tyler O'Neill - OF, STL at Brett Anderson ($4,300)

I'll be combining Tyler O'Neill with Nolan Arenado for my Cardinals stack and waiting for the fantasy points to flow into my DraftKings lineup. Grabbing the 3-4 St. Louis stack versus Brett Anderson feels like one of the safest plays on the slate. As a team, St. Louis is battering lefties this month to the tune of a .417 wOBA and a 162 wRC+. Like I mentioned earlier, Arenado is hot, and it's making a great team with O'Neill's recent performances. Since Sep. 11, the outfielder is slashing .333/.405/.611 three home runs, 11 RBI, and 13 runs for 12.7 FPPG. There are other combinations of Cardinals to roll out there, but the O'Neill-Arenado pairing is my favorite right now.

Garrett Hampson - OF, COL vs. Walker Buehler ($3,000)

I'm going back to the Coors Field well one more time tonight and grabbing the Rockies leadoff hitter. Garrett Hampson at $3,000 feels like a no-brainer given his price and recent form. The Rockies leadoff hitter is touting a .837 OPS this month, which is his second-highest month behind a .857 mark in June. He did this last season with a big September, and I'm all for rolling the dice and running with it again. Hampson is leading off in Coors Field for $3,000. Sometimes we don't have to think too hard about every matchup and just take the free opportunities to accrue fantasy points with minimal risk. Grab Garrett and spend up at other spots on Wednesday.

 

DraftKings DFS Stacks

  • Houston Astros at Los Angeles Angels (Janson Junk, RHP)
  • St. Louis Cardinals at Milwaukee Brewers (Brett Anderson, LHP)
  • San Francisco Giants at San Diego Padres (Vince Velasquez, RHP)

 



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Trevor Siemian

Signing With the Falcons
J.J. Wetherholt

JJ Wetherholt Likely to Hit Leadoff on Opening Day
Tucker Kraft

a Post-Injury Buy-Low Candidate
Jakobi Meyers

Vying for Top Spot in Jacksonville Receiver Room
Jayden Higgins

Faces Obstacles in Second Season
Sam LaPorta

New Offensive Philosophy Could Help Sam LaPorta Get Back into Top Tier
Jaylon Tyson

Unavailable Against Magic
Noah Gray

Remains Buried on Kansas City Depth Chart
Jarrett Allen

Still Out Tuesday
Anthony Black

Remains Out Tuesday
Jalen Suggs

to Miss Second Consecutive Game
Kon Knueppel

Probable Tuesday
Nique Clifford

Kings Plan to Re-Evaluate Nique Clifford in One Week
Moses Moody

Stretchered Off With Knee Injury
Luke Clanton

Might Have a Problem in Houston
Sam Stevens

Happy to See Houston This Week
Keith Mitchell

Tries to Rebound After The Players Championship
Will Zalatoris

Returning This Week at Houston
Wyndham Clark

Trending in the Wrong Direction Heading to Houston
Shane Lowry

Seeking Better Luck in Houston This Weekend
Kurt Kitayama

Poised to Bounce Back at the Houston Open
Jake Knapp

More Suited for a Course Like the Houston Open
Tony Finau

Continues Playing Well Heading to Texas Children's Houston Open
Scottie Scheffler

Returns to Action for Texas Children's Houston Open
Sam Burns

Looks to Carry Momentum Into Houston
Pete Crow-Armstrong

Cubs, Pete Crow-Armstrong Finalizing Long-Term Extension
Cam Thomas

Bucks Waive Cam Thomas
Kyle Kuzma

Won't Play Against Clippers
John Collins

Misses Monday's Action
Kawhi Leonard

Available Monday Night
Caleb Martin

Brandon Williams Remain Out Monday
Brandon Ingram

a Late Scratch Versus Jazz
Sahith Theegala

to Rebound at Texas Children's Houston Open
De'Anthony Melton

Moses Moody, De'Anthony Melton Available Monday
Kristaps Porzingis

Ready to Rock Monday
Cody Williams

Ruled Out Monday
Immanuel Quickley

Jamal Shead Starting With Immanuel Quickley Out
Stephan Jaeger

Hopes to Jumpstart Season at Texas Children's Houston Open
Collin Murray-Boyles

Rejoins Raptors Lineup
Adam Scott

Hopes to Get Back on Track in Houston
Drake Powell

Slated to Miss Monday's Matchup With Portland
Peyton Watson

Ruled Out Tuesday
Blake Snell

Targeting a May Return
Obi Toppin

Cleared to Play Against Magic
PGA

Sungjae Im Looks to Carry Hot Play to Houston
Nicolai Hojgaard

to Get Back on Track in Houston
Hunter Greene

Reds Place Hunter Greene on 60-Day Injured List
Chris Gotterup

to be a Popular Choice at Texas Children's Houston Open
Blake Whiteheart

Returns to the Browns
Min Woo Lee

Looks to Keep Strong Season Going in Title Defense in Houston
J.J. Wetherholt

JJ Wetherholt Makes Cardinals Opening Day Roster
NFL

Ty Simpson Expected to be a First-Round Pick
Jake Bobo

Seahawks Match Offer Sheet for Jake Bobo
Tommy DeVito

Becomes QB2 in New England
Quentin Johnston

Chargers Unlikely to Trade Quentin Johnston?
Nick Pivetta

to Start on Opening Day for Padres
Brandon Woodruff

Makes Brewers Opening Day Rotation
Zack Wheeler

to Start Rehab Assignment on Saturday
Carson Benge

Makes Mets Opening Day Roster
D'Andre Swift

Facing Playing-Time Questions Heading into 2026
Travis Kelce

Officially Signs New Contract With the Chiefs
NFL

Can Denzel Boston Overcome Speed and Athleticism Concerns at the NFL Level?
NFL

Jadarian Price's Dynasty Stock is Rising as the 2026 Draft Approaches
NFL

Can Chris Bell Make an Immediate Impact in the NFL?
Seiya Suzuki

to Start the Season on the Injured List
Travis Homer

Signs With Steelers as RB Depth
Lerone Murphy

Suffers His First Loss
Dennis Santana

Won't be Pirates' Primary Closer
Movsar Evloev

Edges Out Lerone Murphy
CFB

Notre Dame Ranks No. 1 in Returning Production for 2026
Michael Aswell

Jr. Drops Decision At UFC London
Michael Aswell

Luke Riley Outclasses Michael Aswell Jr.
DeVonta Smith

Wide Range of Possible Outcomes for DeVonta Smith in 2026
Woody Marks

to Serve as Backup in Sophomore Season?
Puka Nacua

Extension for Puka Nacua isn't Expected Soon
Sam Patterson

Suffers Unanimous-Decision Loss
Michael Page

Wins Lackluster Decision
Austen Lane

Suffers First-Round TKO Loss
Joshua Dobbs

Patriots Planning to Release Joshua Dobbs
Spencer Strider

to Start the Season on Injured List
Iwo Baraniewski

Delivers 28-Second TKO
Lawson Crouse

Picks Up Three Points in Overtime Win
Filip Forsberg

Takes Predators Past Blackhawks
Alex Ovechkin

Scores 1,000th Career Goal
Nate Schmidt

Exits Early Due to Illness
Matt Grzelcyk

to Miss Four-Game Road Trip
Mikko Rantanen

to Return to Full Practice
A.J. Greer

Handed a Three-Game Suspension
Troy Terry

Wins it for Anahiem
Tyler Reddick

Overcomes Adversity for Fourth Victory of the Season At Darlington
Brad Keselowski

Falls Short of Darlington Victory Despite Domination
Ryan Blaney

Recovers From Pit-Road Struggles to Score Career-Best Darlington Finish
Carson Hocevar

Rallies to Finish Fourth at Darlington
Kyle Larson

Decent Performance Ends with Technical Issues At Darlington
Ilya Sorokin

Earns Shutout Over Columbus
Ethen Frank

Sustains Lower-Body Injury Sunday
Grayson Rodriguez

to Open Season on Injured List
Brett Pesce

Questionable to Return This Season
Stefan Noesen

Done for the Season
Yan Kuznetsov

Misses Fourth Consecutive Game Sunday
Connor Zary

Out Sunday
Mike Trout

Returns on Sunday
Anthony Duclair

Misses Sunday's Game
Ryan Pulock

Unavailable Sunday
Nick Lodolo

Exits Early With a Blister
Jeremy Peña

Astros Not Ruling Out Jeremy Pena for Opening Day
Cristopher Sánchez

Phillies Sign Cristopher Sanchez to a Six-Year Extension
Tyler Reddick

the Clear Favorite at Darlington
Kyle Stowers

Placed on Injured List with Hamstring Strain
Kyle Larson

a High-Risk, High-Reward Driver at Darlington
Ryan Blaney

Is Getting Better at Darlington
NASCAR

Bubba Wallace Not Slowing Down at Darlington
Chris Buescher

Should be a Top-10 Contender at Darlington
Austin Cindric

a Sleeper at Darlington
Erik Jones

Quickest in Practice at Darlington
Morgan Geekie

Records Three Assists Against Red Wings
Steven Stamkos

Notches Three Points in Win Over Golden Knights
Cole Caufield

Records Career-High Five Points in Saturday's Win
Denny Hamlin

Qualifies Ninth for this Week's Cup Race at Darlington
Chase Briscoe

Is One of the Top DFS Options of the Week for Darlington
Nikita Kucherov

Takes Over Scoring Lead With Four-Point Effort
Tyler Tucker

Out Week-to-Week
William Byron

Is William Byron A Playable DFS Option for Darlington Lineups?
Christopher Bell

Could Christopher Bell be Considered A Decent DFS Option for Darlington?
Chase Elliott

Is Chase Elliott Worth Rostering At Darlington This Week For DFS?
Joey Logano

May Not Have the Speed to Warrant A Darlington DFS Lineup Spot
Ross Chastain

Should DFS Players Trust Ross Chastain at Darlington?
Kyle Busch

Could Kyle Busch Be A Worthy DFS Option for Darlington?
Brad Keselowski

May be A Contriarian DFS Tournament Option At Darlington
Seiya Suzuki

Won't be Ready for Opening Day
Gleyber Torres

Clear to Return on Monday
Konnor Griffin

Assigned to Minor-League Camp
Lerone Murphy

Set For UFC London Main Event
Movsar Evloev

Looks To Remain Unbeaten
Michael Aswell

Jr. An Underdog At UFC London
Luke Riley

Set For UFC London Co-Main Event
Sam Patterson

Looks To Extend His Win Streak
Michael Page

Set For Welterweight Bout
Austen Lane

In Dire Need Of Victory
Iwo Baraniewski

A Favorite At UFC London
Akshay Bhatia

Withdraws From Valspar Championship
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF