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DraftKings Daily Fantasy Baseball Picks (9/22/21): MLB DFS Lineups

Zack Wheeler - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury nNews

The top daily fantasy baseball lineup picks for DraftKings on 9/22/21. Euan Leith's MLB DFS analysis and sleepers for building optimal DFS rosters.

Happy Wednesday, Rotoballers! With a week and a half of the regular season to go, there are still seven playoff spots up for grabs. The Giants, Dodgers, and Brewers have secured some October baseball, but it's still all up in the air in the NL East and the final Wild Card spot. As for the AL, the Astros and White Sox seem destined for a Divisional Series matchup, while the Rays, Red Sox, Blue Jays, and Yankees fight to the (figurative) death for the remaining three American League spots. That was an incredibly long way of saying: There is a ton left to fight for this year, and I'm looking forward to seeing how the final 10-12 games play out. 

Ten evening games clutter the MLB schedule on Wednesday, with some top-heavy aces and bottom-of-the-barrel bargains. For today, I'm sticking in the top third of the pitching arsenal. It'll cost me on the hitting side, but there are some pleasant values around the diamond to make up for it. One player I am fading is Luis Garcia for the Astros. Recently, he's hit a rough patch, and at $10,000, I'm not sure why you wouldn't go up to Zack Wheeler ($10,400 vs. BAL) or down to the likes of Walker Buehler ($9,800 at COL) or Chris Sale ($9,600 vs. NYM).

This article will provide you with my daily fantasy baseball lineup picks for DraftKings on 9/22/2021. The lineup will range from some of the elite players to mid-priced options and value plays. You can also check out today's FanDuel MLB DFS lineup picks and read more DFS advice and lineup picks for other sports too. It's also important to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away.

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DraftKings DFS Starting Pitchers

Zack Wheeler - P, PHI vs. BAL ($10,400)

Phillies ace Zack Wheeler comes into the slate as the most expensive arm to roster. The right-handed hurler has had his ups and downs since the All-Star break but has still managed to compile a 3.68 ERA, 1.09 WHIP, and a 26.1 percent strikeout rate. In his previous three starts, the 31-year old averaged 27.2 fantasy points per game and has 23 strikeouts in his last 17 2/3 innings. Wheeler will have a chance to match his recent DraftKings output against the Baltimore Orioles today. In September, the O's are slashing a putrid .215/.290/.387 with a 26.8 percent strikeout rate to righties.

Joe Ryan - P, MIN at CHC ($8,200)

I will put Joe Ryan in some of my lineups on Wednesday, but he's a prime candidate for me only checking the boxscore at the end of the night and not watching a single pitch of his outing. The main reason is that he gives up so many flyballs (26 flyball outs in 17 innings), and the second reason is that the Cubs can mash the baseball. However, all hope is not lost with Ryan. In his first three starts, the rookie is 1-1 with a 2.12 ERA, 0.53 WHIP, and 14 strikeouts in 17 innings. A date with the Cubs should fix his lack of strikeouts as they whiff 28.3 percent of the time versus righties in September. As I said, Ryan is a set-it-and-nervously-forget-it option, but I'm not a fan of the arms below him, and I think he will have a low roster percentage on the slate.

Other options: Walker Buehler at COL ($9,800), Chris Sale vs. NYM ($9,600), Ian Anderson at ARI ($8,400)

 

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DraftKings DFS Infielders

Daulton Varsho - C, ARI vs. Ian Anderson ($5,200)

Varsho has been getting the kind of run in the second half of the season most season-long fantasy managers wanted from him all year. Still, the catcher/outfielder is doing his best to make up for lost time with a terrific second half. Since the All-Star break, Varsho has been slashing .294/.357/.588 with 27 runs, 26 RBI, 23 extra-base hits (10 home runs), and four stolen bases. He's doing it all, and while $5,200 isn't a discount, the Diamondbacks do-it-all man is averaging 9.9 FPPG in his last 10 and is one of the safest bets at catcher.

Bobby Dalbec - 1B, BOS vs. Taijuan Walker ($3,300)

Bobby D! His bat has come alive since Kyle Schwarber began challenging for his spot at first base, and it seems to be staving off a what seemed likely bench role in Boston. The young slugger has five home runs and 15 RBI in 15 games to accompany a .404 ISO and .442 weighted on-base average in September. Over his last 10 games, Dalbec has smashed seven extra-base hits and sports a 1.033 OPS. At $3,300, he's one of my favorite values among the 10 games tonight, but I would play him in any contest without any hesitation.

Brendan Rodgers - 2B, COL vs. Walker Buehler ($3,900)

While Walker Buehler brings his talents to the Mile High City on Wednesday, I'm buying what Brendan Rodgers is selling and slamming him in my DFS lineups. He's been nothing short of phenomenal in the second half of the year with a .303/.335/.500 slash line to go along with 31 runs, 27 RBI, and 22 extra-base hits in 50 games. The Rockies infielder isn't even benefitting from the Coors-Field bump yet, as he has a .745 OPS in Colorado and a .864 OPS away from the thin air of Denver. Rodgers is locked in as the two-hole hitter for the Rockies, and I love his price at $3,900.

Nolan Arenado - OF, STL at Brett Anderson ($4,600)

I'm not a Brett Anderson believer, and I'm ready to put my lack of faith to the test with a couple of Cardinals' recommendations. First off, we have Nolan Arenado. The perennial All-Star is predictably having his worst season in a while after leaving Coors Field, but he's been far from a disaster with 33 home runs and 100 RBI in 2021. Recently, he's up to a 1.015 OPS in his last 10 games and has pummeled four baseballs for home runs and driven in 10 RBI. Arenado is hitting in the middle of a Cardinals lineup, making a last-minute September push, and he will push DFS managers into the green on Wednesday.

Elvis Andrus - SS, OAK vs. Chris Flexen ($2,700)

It hasn't been the change-of-scenery narrative some people were hoping for this season with Elvis Andrus after moving from Texas to the Bay Area. However, that's the great thing about DFS: a player can turn it around and be hot for a while and become a terrific addition to our rosters. He came up hitless last night, but he was playing some of his best ball of the season in the previous games. From Sep. 7 - Sep. 20, Andrus registered a hit in 11 of 12 games while batting .472 with four doubles, six RBI, and nine runs. At $2,700, Andrus is a perfect punt play if you need to fit some more significant bats at the other positions.

 

DraftKings DFS Outfielders

Kyle Tucker - OF, HOU at Janson Junk ($4,400)

Homer alert, but, for my money, Kyle Tucker has one of the quietest home run swings in the game.

I want as much of the Houston offense as I can afford right now, and Tucket sitting at $4,400 is too good to pass up. He's up to 27 home runs in 129 games and has a legitimate 40 home run upside if he can stay healthy for an entire season. The lefty bat has heated up over the last week and a half with seven runs, five doubles, three home runs, and seven RBI since Sept. 12. Tucker has seven extra-base hits in his last seven games, and I think he'll make it eight in eight against Jason Junk and the Angels bullpen as the Astros look to inch closer to another AL West title.

Tyler O'Neill - OF, STL at Brett Anderson ($4,300)

I'll be combining Tyler O'Neill with Nolan Arenado for my Cardinals stack and waiting for the fantasy points to flow into my DraftKings lineup. Grabbing the 3-4 St. Louis stack versus Brett Anderson feels like one of the safest plays on the slate. As a team, St. Louis is battering lefties this month to the tune of a .417 wOBA and a 162 wRC+. Like I mentioned earlier, Arenado is hot, and it's making a great team with O'Neill's recent performances. Since Sep. 11, the outfielder is slashing .333/.405/.611 three home runs, 11 RBI, and 13 runs for 12.7 FPPG. There are other combinations of Cardinals to roll out there, but the O'Neill-Arenado pairing is my favorite right now.

Garrett Hampson - OF, COL vs. Walker Buehler ($3,000)

I'm going back to the Coors Field well one more time tonight and grabbing the Rockies leadoff hitter. Garrett Hampson at $3,000 feels like a no-brainer given his price and recent form. The Rockies leadoff hitter is touting a .837 OPS this month, which is his second-highest month behind a .857 mark in June. He did this last season with a big September, and I'm all for rolling the dice and running with it again. Hampson is leading off in Coors Field for $3,000. Sometimes we don't have to think too hard about every matchup and just take the free opportunities to accrue fantasy points with minimal risk. Grab Garrett and spend up at other spots on Wednesday.

 

DraftKings DFS Stacks

  • Houston Astros at Los Angeles Angels (Janson Junk, RHP)
  • St. Louis Cardinals at Milwaukee Brewers (Brett Anderson, LHP)
  • San Francisco Giants at San Diego Padres (Vince Velasquez, RHP)

 



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REAL-TIME FANTASY NEWS

Cade Cunningham

Ready to End Two-Game Absence
Devin Booker

Questionable for Thursday Night
Giannis Antetokounmpo

Probable to Face Spurs
Brandon Williams

Available Wednesday
Max Christie

Out Wednesday
P.J. Washington

Returns to Action Wednesday
Scotty Pippen Jr.

Season Debut Delayed for at Least Four More Weeks
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to Miss 4-6 More Weeks
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Starting Ramp-Up Period, Could Return Soon
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Unavailable Thursday
Julian Phillips

Out Wednesday
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to Be Limited to 28-30 Minutes Wednesday
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Active Against Cavaliers
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Cleared to Play Wednesday
Kelly Oubre Jr.

Available Wednesday
VJ Edgecombe

Active Versus Cavs
Herbert Jones

Misses Wednesday's Action
Christian Braun

Out Wednesday
Sandro Mamukelashvili

Out Versus Pacers on Wednesday
Ivica Zubac

Won't Play Wednesday
Lauri Markkanen

Misses Wednesday's Game Due to Illness
Mackenzie Blackwood

Activated From Injured Reserve
Ben Griffin

Looks To Stay Hot In 2026
Tom Wilson

Cleared for Contact, Could Return Thursday
Neal Pionk

Lands on Injured Reserve, Out Week-to-Week
Jamie Drysdale

Activated From Injured Reserve
Corey Perry

Unavailable Wednesday
Teuvo Teravainen

to Miss at Least One Game
Connor Bedard

Returns to Practice
Alexandre Texier

Canadiens Sign Alexandre Texier to Two-Year Extension
New York Giants

Giants Making "Massive Push" to Hire John Harbaugh on Wednesday
Ranger Suárez

Ranger Suarez Agrees to Five-Year Deal With Red Sox
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Dante Moore Not Entering 2026 NFL Draft, Will Return to Oregon
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FBS Coaches Unanimously Vote to Expand Redshirt Eligibility to Nine Games
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Ohio State Transfer Mylan Graham Signs with Notre Dame
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Caden Durham Withdraws from Transfer Portal, Will Stay at LSU
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Joel Hofer

Controls Hurricanes Tuesday
Jordan Spieth

Perhaps the Most Intriguing Player at Sony Open
Jeremy Swayman

Posts First Shutout of the Season
Zach Werenski

Totals Three Points in Tuesday's Win
Chandler Stephenson

Available Wednesday
Aaron Rai

Looking For Putting Confidence at Waialae Country Club
Jonathan Marchessault

Moved to Injured Reserve
Brayden Point

Labeled Week-to-Week
Collin Morikawa

Isn't The Safe Play He Used to Be Ahead of Sony Open
Kurt Kitayama

Needs His Putting to Turn Around For Success at Year's First Event
Ryan Weathers

Yankees Add Rotation Depth, Acquire Ryan Weathers in Four-Player Deal
Robert Thomas

Out Tuesday
Jake Walman

Available Against Predators
Troy Terry

a Game-Time Decision Tuesday
Justin Sourdif

Won't Play Tuesday
Jakob Chychrun

a Game-Time Call Tuesday
Morgan Geekie

Available Tuesday
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Chargers Fire Offensive Coordinator Greg Roman
Pittsburgh Steelers

Mike Tomlin Stepping Down as Steelers Head Coach
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Georgia Tech the Favorite to Land Justice Haynes?
Nolan Arenado

Cardinals Trade Nolan Arenado to Diamondbacks
Tom Kim

Desperately Needs a Solid Week at Sony Open
Billy Horschel

Hoping For a Fast Start to New Season at Sony Open
Corey Conners

Looks to Have a Return to Form in 2026
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Chris Gotterup a Decent Play at Sony Open
Gary Woodland

Could Prosper at the Sony Open
Keith Mitchell

Unlikely to Contend at Sony Open
Robert MacIntyre

Looking for a Good Performance at the Sony Open
Michael Kim

Hopes to Start Sony Open Better This Week
Tom Hoge

Tries to Erase Poor 2025 Second Half in Hawaii
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Georgia Lands Kentucky Transfer Dante Dowdell
Matthew Stafford

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Sam Leavitt Expected to Sign with LSU
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Packers Expected to Work Out New Deal With Matt LaFleur in the "Coming Days"
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Dylan Raiola Commits to Oregon
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Isaiah Horton Landing with Texas A&M
George Kittle

Suffers Torn Achilles on Sunday
Omarion Hampton

Active for Wild-Card Round Against Patriots
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Ruled Out After Non-Contact Achilles Injury
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Raiders Request Interview With Ejiro Evero
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Mike LaFleur to Interview With Raiders and Cardinals
Aaron Rodgers

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Matthew Stafford

X-Rays Come Back Negative
MacKenzie Gore

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Alex Bregman

Cubs Sign Alex Bregman to Five-Year, $175 Millon Contract
Freddie Freeman

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Max Kepler

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Cam Coleman Visiting Alabama on Friday
Omarion Hampton

Expects to Play Sunday Night
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Eric Singleton Jr. Enters Transfer Portal, Trending to Land at Florida
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NCAA Denies Trinidad Chambliss a Sixth Year of Eligibility
Omarion Hampton

Questionable for Wild-Card Weekend
Kyle Tucker

Mets Remain in Mix for Kyle Tucker
Ketel Marte

Will Remain With Diamondbacks
Rashee Rice

to be Reviewed Under League's Conduct Policy

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