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College Football Betting Expert Picks for Week Twelve (11/21/2020)

Our CFB betting picks, analysis and top recommendations for Week 12. Every week, Nick reviews some of the best bets and wagers for the college football slate.

In Week Eleven, our fortunes continued with the fourth consecutive 3-0 week. Heading into the final weekend of games before Thanksgiving, the recent performance leaves us with much to be thankful for.

In the early noon game this past weekend, Miami managed to hold off the Virginia Tech Hokies as a 2.5-point underdog. At 3:00pm, the UTSA Roadrunners then provided win #2 with an easy rout of their in-state rivals at UTEP. In the late game, Oregon overcame a sluggish start to overcome a young, but impressive Washington State squad. This 12-0 run over the past four weeks improves the season-long record to 22-8.

Week Twelve's list of games should have bettors licking their chops with the amount of action available. Here are some betting picks to follow along with as you enjoy another college football Saturday.

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

Clemson at Florida State (+35.5)

O/U: 63

Coach Dabo Swinney's Clemson Tigers will certainly be on a mission to pursue any style points that they can rack up before the anticipated ACC Championship rematch with Notre Dame on December 19. Star quarterback Trevor Lawrence, who should start looking for apartments in New York pretty soon, is returning after a two week absence caused by a positive COVID-19 test. Freshman DJ Uiagalelei stepped in admirably against Notre Dame and Boston College, causing Clemson fans to breathe a sigh of relief for when the time comes that Lawrence departs for the NFL. With Lawrence and Travis Etienne - the ACC's all-time rushing leader - the Clemson offense has hummed to the tune of 40.4 points per game. With a win on Saturday, Trevor Lawrence will tie Rodney Williams, Tajh Boyd, and Deshaun Watson for the record for the most career wins as a starting quarterback at Clemson.

The 2020 season has been an unmitigated disaster for first-year head coach Mike Norvell in Tallahassee, Florida. The team just received word that defensive tackle Marvin Wilson, who is likely a top NFL draft pick in the spring, will miss the remainder of the season with an injury. Additionally, star receiver Tamorrion Terry left the team to begin preparing for the draft, and former starting quarterback James Blackman announced his intention to transfer. 

The talent disparity between these two teams is vast, and expecting Clemson to put up a flurry of points is expected. However, expecting Florida State to be kept off the board is unreasonable with the dual-threat quarterback Jordan Travis leading the way. The Clemson defense has given up 21 points or more in each of its last three games, and if Florida State can get at least 2 touchdowns, it will be difficult for Clemson to cover such a large spread.

Pick: Florida State +35.5

Georgia State at South Alabama (+3.5)

O/U: 58.5

The Georgia State Panthers put quite a scare into the Appalachian State Mountaineers last week in Boone, North Carolina, but were unable to hold onto the close upset opportunity. Entering the game with a mediocre 3-4 record, the Panthers have had a few opportunities slip through their fingers, including the 4-point loss to Appalachian State and a 3-point loss to Louisiana (Lafayette). On offense, freshman quarterback Cornelius Brown IV has had a strong campaign (1,340 passing yards, 13 touchdowns, 5 interceptions) and looks to have a bright future in Atlanta. Brown's top target this year has been Sam Pinckney, aided by junior receiver Cornelious McCoy. The offense averages 33.3 points per game, and should have no problem putting up a flurry of points in Mobile. Surprisingly, Georgia State has never won in any of the 3 matchups against South Alabama on the road, while winning 4 of 5 at home.

The South Alabama Jaguars are chasing their first .500 or better season since 2013. Success is not synonymous with the Jaguars program, something that head coach Steve Campbell is hoping to change. With wins over Southern Miss, Texas State, and Louisiana-Monroe, the team took advantage of the "low-hanging fruit" on the schedule, and was competitive in losses to Tulane and Georgia Southern. Sophomore quarterback Desmond Trotter, when healthy, has paced the team on offense with his ability to pass with efficiency (9 touchdowns to 3 interceptions) and take off and run when nothing is there. Trotter's top target is Jalen Tolbert, who had a major breakout early in the season and has 44 catches and 5 touchdowns. The Jaguars offense has stalled at times, averaging only 20.9 points per game, as result of an anemic rushing attack.

This Sun Belt clash should be an exciting tilt between two teams that are clearly on the rise in the conference. Georgia State has the built-in recruiting advantage in the Atlanta metro area, and in recent years that has shown itself with more consistent on-field play. While the Trotter-to-Tolbert connection does show plenty of promise, there are too many holes throughout the rest of the roster to trust the Jaguars at this point in time.

Pick: Georgia State -3.5

#20 Southern California (USC) at Utah (+3)

O/U: 57.5

USC has opened its season with a pair of closer than expected wins over the Arizona schools, causing some concern. The Trojans' offense has been sharp, spearheaded by sophomore quarterback Kedon Slovis, and his two star receivers Amon-Ra St. Brown and Tyler Vaughns, all of whom will be playing on Sundays. When it comes to night games, USC thrives with an all-time 72.6% winning percentage in games played 5pm or later. In Utah's banner season last year, USC was the only regular season opponent to vanquish the Utes behind their backup quarterback Matt Fink.

The Utah Utes have yet to play this season, with their first two games being postponed due to the Coronavirus. Finally, things look to be trending in the positive (pun intended) direction, as they aim for their opener this weekend. Long-time coach Kyle Whittingham had arguably his most talented team last season, and was probably a win in the Pac-12 championship game away from Utah's first appearance in the College Football Playoff. Gone are quarterback Tyler Huntley, running back Zack Moss, and nine defensive starters (five of whom were drafted in the 2020 NFL draft). The new signal caller will be one of the triumvirate atop the depth chart - former walk-on Drew Lisk, South Carolina graduate transfer Jake Bentley, and highly-touted sophomore Cameron Rising. With an entirely new defense and a new quarterback, there may be an adjustment period in Salt Lake City.

Utah is still scrambling with contact tracing and some lingering positive COVID-19 student-athletes, which might cause nearly 20% of the roster to be unavailable on Saturday. With a few games under their belt so far, USC will have the clear edge and Slovis will try to make his mark early on against a young, new and unproven Utah defense.

Pick: USC -3




REAL-TIME FANTASY NEWS

Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
Austin Reaves

Could Command $40M Per Year With New Contract
Jalen Duren

Available to Finish Game 6
Yanic Konan Niederhauser

Not Expected to Be Ready for Start of Next Season
Jalen Williams

Declares Himself Healthy for Conference Finals
Terrence Shannon Jr.

Will Play Friday Night
Kevin Huerter

is Available for Game 6
Duncan Robinson

is Returning for Game 6
Caris LeVert

is Cleared for Game 6 on Friday
OG Anunoby

Practices in Full on Friday
Terrence Shannon Jr.

is Tagged as Questionable for Friday
Blake Snell

Scratched From Start on Friday for Undisclosed Reasons
Luther Burden III

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MarShawn Lloyd

Can MarShawn Lloyd Emerge as a Top Dynasty Handcuff Option?
Emanuel Wilson

Can Emanuel Wilson Carve Out a Consistent Role in Seattle?
Max Fried

Heading to Injured List With Elbow Bone Bruise
Jaylin Noel

Playing-Time Outlook in Houston Remains Unclear
Dylan Sampson

Role in Cleveland Looks Secure Heading into 2026
Kirk Cousins

' Dynasty Value Fading Ahead of First Season in Las Vegas
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
George Holani

Dynasty Outlook Remains Cloudy
Jordan Westburg

to Have Season-Ending Elbow Surgery
Kendre Miller

Quickly Fading From Fantasy Relevance
Keon Coleman

Is Keon Coleman a Hopeless Dynasty Asset?
Marvin Harrison Jr.

a Buy-Low Candidate in Dynasty Formats
Hollywood Brown

a Cut Candidate in Dynasty Leagues?
Darnell Mooney

Barely Inside Top-100 WR Dynasty Rankings
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Christian Kirk

Can Christian Kirk Revive his Career in Bay Area?
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
Brashard Smith

Destined to Become Special Teams Player?
MMA

Dohoo Choi Returns At UFC Vegas 117
Ben Sinnott

Dynasty Value Hindered by Free-Agent TE Addition
Juan Diaz

Set To Make His UFC Debut
Sam Darnold

Should Dynasty Managers Continue to Hold Sam Darnold?
Malcolm Wellmaker

Looks To Bounce Back
Justin Fields

Dynasty Managers Getting Ready to Sell High on Justin Fields?
Christian Edwards

Set For His UFC Debut
Dallas Goedert

a Target for Dynasty Managers in Championship Window?
Modestas Bukauskas

Looks To Get Back In The Win Column
Theo Johnson

Not the Primary Option in New System?
Kyle Monangai

Still Time to Buy Low on Kyle Monangai in Dynasty Leagues?
Tarik Skubal

Resumes Playing Catch, Ahead of Schedule?
Amon-Ra St. Brown

an Unheralded Dynasty Cornerstone
Karl-Anthony Towns

Making an Impact as Playmaker in Playoffs
Jalen Duren

Determined to Improve
Kevin Huerter

Tagged as Questionable for Game 6 Against Cavaliers
Caris LeVert

Considered Questionable for Friday
Duncan Robinson

Iffy for Game 6
Lane Hutson

Contributes Two Assists in Game 5 Victory
Nick Suzuki

Amasses Three Points in Crucial Victory Thursday
Juraj Slafkovsky

Dishes Out Three Assists in Game 5 Win
Carter Hart

Stops 31 Pucks in Series-Clinching Win
Pavel Dorofeyev

Enjoys Second Consecutive Multi-Goal Game
Shea Theodore

Records Two Points in Game 6 Win
Mitchell Marner

Scores Special Goal in Series-Clincher
Ryan Johnson

Takes Over as Canucks GM, Sedins Promoted to Co-Presidents
Drew Helleson

Won't Play Thursday
Radko Gudas

Unlikely to Play Thursday
Jeremy Lauzon

Remains Out Thursday
Mark Stone

Misses Third Consecutive Game
EDM

Kris Knoblauch Fired as Oilers Head Coach
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
Byron Buxton

Scratched on Thursday With Hip Soreness
Cal Raleigh

Heading to Injured List With Oblique Strain
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Paul Reed

Makes Big Impact Off the Bench Wednesday
Daniss Jenkins

Contributes 19 Points As Starter
Cade Cunningham

Tallies 39 Points in Losing Effort
Max Strus

Notches 20 Points With Six Triples
Evan Mobley

Close to Triple-Double Wednesday
Jarrett Allen

Records Double-Double in Game 5 Win
Quinn Hughes

Finishes Postseason With 15 Points
Matt Boldy

Posts Two Assists in Season-Ending Loss
Scott Wedgewood

Perfect in Relief Effort
Martin Necas

Records Another Multi-Point Game
Brett Kulak

Sends Avalanche Into Conference Finals
Brayden McNabb

Suspended for One Game
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
Jacob Misiorowski

Pulled Early With Possible Leg Injury
Juan Soto

Exits Wednesday's Game Early with Ankle Injury
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Nathan MacKinnon

Chasing History Wednesday
Ryan Poehling

Won't Be an Option for Game 6
Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
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NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
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ACC, Big 12 Support 24-Team College Football Playoff
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Harris English

Will Need His Putter to Thrive at Aronimink
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
CFB

Isaac Brown Has All-American Upside in 2026
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF