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College Football Betting Expert Picks for Week Twelve (11/21/2020)

Our CFB betting picks, analysis and top recommendations for Week 12. Every week, Nick reviews some of the best bets and wagers for the college football slate.

In Week Eleven, our fortunes continued with the fourth consecutive 3-0 week. Heading into the final weekend of games before Thanksgiving, the recent performance leaves us with much to be thankful for.

In the early noon game this past weekend, Miami managed to hold off the Virginia Tech Hokies as a 2.5-point underdog. At 3:00pm, the UTSA Roadrunners then provided win #2 with an easy rout of their in-state rivals at UTEP. In the late game, Oregon overcame a sluggish start to overcome a young, but impressive Washington State squad. This 12-0 run over the past four weeks improves the season-long record to 22-8.

Week Twelve's list of games should have bettors licking their chops with the amount of action available. Here are some betting picks to follow along with as you enjoy another college football Saturday.

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Clemson at Florida State (+35.5)

O/U: 63

Coach Dabo Swinney's Clemson Tigers will certainly be on a mission to pursue any style points that they can rack up before the anticipated ACC Championship rematch with Notre Dame on December 19. Star quarterback Trevor Lawrence, who should start looking for apartments in New York pretty soon, is returning after a two week absence caused by a positive COVID-19 test. Freshman DJ Uiagalelei stepped in admirably against Notre Dame and Boston College, causing Clemson fans to breathe a sigh of relief for when the time comes that Lawrence departs for the NFL. With Lawrence and Travis Etienne - the ACC's all-time rushing leader - the Clemson offense has hummed to the tune of 40.4 points per game. With a win on Saturday, Trevor Lawrence will tie Rodney Williams, Tajh Boyd, and Deshaun Watson for the record for the most career wins as a starting quarterback at Clemson.

The 2020 season has been an unmitigated disaster for first-year head coach Mike Norvell in Tallahassee, Florida. The team just received word that defensive tackle Marvin Wilson, who is likely a top NFL draft pick in the spring, will miss the remainder of the season with an injury. Additionally, star receiver Tamorrion Terry left the team to begin preparing for the draft, and former starting quarterback James Blackman announced his intention to transfer. 

The talent disparity between these two teams is vast, and expecting Clemson to put up a flurry of points is expected. However, expecting Florida State to be kept off the board is unreasonable with the dual-threat quarterback Jordan Travis leading the way. The Clemson defense has given up 21 points or more in each of its last three games, and if Florida State can get at least 2 touchdowns, it will be difficult for Clemson to cover such a large spread.

Pick: Florida State +35.5

Georgia State at South Alabama (+3.5)

O/U: 58.5

The Georgia State Panthers put quite a scare into the Appalachian State Mountaineers last week in Boone, North Carolina, but were unable to hold onto the close upset opportunity. Entering the game with a mediocre 3-4 record, the Panthers have had a few opportunities slip through their fingers, including the 4-point loss to Appalachian State and a 3-point loss to Louisiana (Lafayette). On offense, freshman quarterback Cornelius Brown IV has had a strong campaign (1,340 passing yards, 13 touchdowns, 5 interceptions) and looks to have a bright future in Atlanta. Brown's top target this year has been Sam Pinckney, aided by junior receiver Cornelious McCoy. The offense averages 33.3 points per game, and should have no problem putting up a flurry of points in Mobile. Surprisingly, Georgia State has never won in any of the 3 matchups against South Alabama on the road, while winning 4 of 5 at home.

The South Alabama Jaguars are chasing their first .500 or better season since 2013. Success is not synonymous with the Jaguars program, something that head coach Steve Campbell is hoping to change. With wins over Southern Miss, Texas State, and Louisiana-Monroe, the team took advantage of the "low-hanging fruit" on the schedule, and was competitive in losses to Tulane and Georgia Southern. Sophomore quarterback Desmond Trotter, when healthy, has paced the team on offense with his ability to pass with efficiency (9 touchdowns to 3 interceptions) and take off and run when nothing is there. Trotter's top target is Jalen Tolbert, who had a major breakout early in the season and has 44 catches and 5 touchdowns. The Jaguars offense has stalled at times, averaging only 20.9 points per game, as result of an anemic rushing attack.

This Sun Belt clash should be an exciting tilt between two teams that are clearly on the rise in the conference. Georgia State has the built-in recruiting advantage in the Atlanta metro area, and in recent years that has shown itself with more consistent on-field play. While the Trotter-to-Tolbert connection does show plenty of promise, there are too many holes throughout the rest of the roster to trust the Jaguars at this point in time.

Pick: Georgia State -3.5

#20 Southern California (USC) at Utah (+3)

O/U: 57.5

USC has opened its season with a pair of closer than expected wins over the Arizona schools, causing some concern. The Trojans' offense has been sharp, spearheaded by sophomore quarterback Kedon Slovis, and his two star receivers Amon-Ra St. Brown and Tyler Vaughns, all of whom will be playing on Sundays. When it comes to night games, USC thrives with an all-time 72.6% winning percentage in games played 5pm or later. In Utah's banner season last year, USC was the only regular season opponent to vanquish the Utes behind their backup quarterback Matt Fink.

The Utah Utes have yet to play this season, with their first two games being postponed due to the Coronavirus. Finally, things look to be trending in the positive (pun intended) direction, as they aim for their opener this weekend. Long-time coach Kyle Whittingham had arguably his most talented team last season, and was probably a win in the Pac-12 championship game away from Utah's first appearance in the College Football Playoff. Gone are quarterback Tyler Huntley, running back Zack Moss, and nine defensive starters (five of whom were drafted in the 2020 NFL draft). The new signal caller will be one of the triumvirate atop the depth chart - former walk-on Drew Lisk, South Carolina graduate transfer Jake Bentley, and highly-touted sophomore Cameron Rising. With an entirely new defense and a new quarterback, there may be an adjustment period in Salt Lake City.

Utah is still scrambling with contact tracing and some lingering positive COVID-19 student-athletes, which might cause nearly 20% of the roster to be unavailable on Saturday. With a few games under their belt so far, USC will have the clear edge and Slovis will try to make his mark early on against a young, new and unproven Utah defense.

Pick: USC -3




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REAL-TIME FANTASY NEWS

Franz Wagner

Expected to Return "Within the Next Week"
T.J. Watt

Cleared to Play in Week 18
Giannis Antetokounmpo

Available Versus Charlotte
Karl-Anthony Towns

Out on Friday Night
Trevor Moore

Likely to Return Saturday
John Klingberg

Doubtful to Play Saturday
Isiah Pacheco

Could be Rested Against Raiders
Radko Gudas

on Track to Return Friday
Amon-Ra St. Brown

Officially Questionable for Week 18
Brayden McNabb

Considered Week-to-Week
De'Von Achane

Doubtful to Face the Patriots
Zach Werenski

Ready to Return Saturday
Ilya Sorokin

Comes Off Injured Reserve
Bo Horvat

Ruled Out for at Least One Week
Stephen Curry

Sidelined with Ankle Sprain on Friday
Jimmy Butler III

Will Not Play Against Thunder
Aaron Jones Sr.

Won't Play in Week 18
Seth Curry

Sidelined on Friday Vs. Thunder
Omarion Hampton

Ruled Out for Week 18
Draymond Green

Getting a Rest Day Against Thunder
Dallas Goedert

Ruled Out With Knee Injury
J.J. McCarthy

Will Start in Week 18
Jerami Grant

Still Watching From Sidelines on Friday
Javonte Williams

Ruled Out for Sunday
Zach Collins

Remains Out on Friday
Michael Porter Jr.

Remains Sidelined on Friday
Cam Thomas

Resting on Friday
Nicolas Claxton

Ruled Out for Friday's Game
Alvin Kamara

Will Remain Out in Week 18
Saddiq Bey

Won't Suit Up on Friday
Davante Adams

Questionable to Play in Week 18
Derik Queen

is Unavailable on Friday
Trae Young

Won't Play on Friday
Kyren Williams

Questionable to Play in Week 18
Kyle Pitts Sr.

Questionable for Sunday
Drake London

Questionable for Season Finale
Harold Fannin Jr.

Ruled Out in Week 18
Harold Fannin Jr.

Unlikely to Play in Week 18
Jaylen Waddle

Questionable to Play in Week 18
Josh Allen

"Good to Go" Vs. Jets
CFB

Joey Aguilar Undergoes Surgery to Remove Tumor on Friday
CFB

Texas the "Team to Beat" for Transfer Running Back Isaac Brown
CFB

Rocco Becht to Follow Matt Campbell to Penn State?
CFB

Texas Targeting Cam Coleman in Transfer Portal
CFB

Former Texas Running Back CJ Baxter Visiting Kentucky
CFB

Beau Pribula Visiting Virginia Tech, Georgia Tech
Derik Queen

Facing First Career Absence Friday
Saddiq Bey

May Sit Out Friday's Game
Grayson Allen

Questionable Friday
Moussa Diabaté

Moussa Diabate Iffy for Friday
Miles Bridges

Likely to Return Friday
De'Andre Hunter

May Miss Second Straight Game Due to Illness
Sebastian Aho

Records Season-High Five Points Thursday
Auston Matthews

Opens 2026 With Four-Point Effort
Dylan Guenther

Posts First Career Hat Trick During Four-Point Night
Josh Anderson

Exits Early After Scoring
Bo Horvat

Sustains Lower-Body Injury Thursday
Noah Laba

Out Week-to-Week
Conor Sheary

Lands on Long-Term Injured Reserve
Bo Bichette

Yankees Showing Interest in Bo Bichette
George Kittle

Listed as Questionable for Week 18
Amon-Ra St. Brown

Trending Towards Playing
Miles Wood

Blue Jackets Place Miles Wood on Injured Reserve
Dak Prescott

May Not Play Full Game in Week 18
Conor Garland

to Miss One Week
Marco Rossi

to Miss at Least One Week
Yegor Chinakhov

Set for Penguins Debut Thursday
Shayne Gostisbehere

Misses Third Consecutive Game Thursday
Auston Matthews

Returns From One-Game Absence
William Nylander

Remains Out Thursday
Houston Astros

Astros Sign Tatsuya Imai to Three-Year Deal
CFB

Lane Kiffin Interested in Sam Leavitt, Brendan Sorsby at LSU
CFB

Deuce Knight Officially Entering Transfer Portal
CFB

Kewan Lacy Expected to Be Full-Go Against Georgia
CFB

Chip Kelly Named Northwestern Offensive Coordinator
CFB

Penn State Working to Hire D'Anton Lynn as Next Defensive Coordinator
CFB

Omar Cooper Expected to be Full-Go for Rose Bowl
CFB

Marcus Freeman Staying with Notre Dame for 2026 Season
CFB

Star Wideout Cam Coleman Entering Transfer Portal
CFB

Jay Hill Expected to be Next Michigan Defensive Coordinator

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