👉 TAP TO SAVE 50% WITH CODE SPRING
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

Break The Slate: NFL DFS DraftKings Lineup Picks - Week 16 (Main Slate)

Joe Nicely's DraftKings NFL DFS picks and lineup sleepers for Week 16. His top daily fantasy football recommendations to target for DraftKings DFS contests.

Hi RotoBallers and thanks for joining me for Week 16! With three games on Saturday this week, we'll be dealing with an 11-game main slate. While Week 15 offered us tons of great DFS options - and some ridiculously-high DraftKings scores - the pickings are a bit slimmer this week. That said, we still have some intriguing matchups with players that are in great spots.

These DraftKings lineup recommendations are based on matchups, projected ownership, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home-field advantage, and more. There are some great plays available, so read on to find out which players are the best for Week 16.

Good luck with your DraftKings DFS lineups, let's Break The Slate together!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

DraftKings DFS Quarterbacks - Week 16 Picks

Lamar Jackson - BAL @ CLE ($8,000)

If the Ravens are playing on the main slate, then Lamar Jackson is in consideration for me. It sounds simple, but Jackson has been the "DFS MVP" of this season, showing an unbelievably-consistent combination of floor and ceiling from week to week. The Ravens QB is once again expensive, but there have been very few weeks this year when you would have been disappointed to roster him, as he's averaging almost 30 DK points per game this season. Jackson went over 1,100 rushing yards last week, surpassing Michael Vick for the all-time QB rushing record in a season. He should be able to pad that mark this week against a Browns Defense that has allowed opposing QBs to gain 300 yards on the ground this season and appears to be sleepwalking down the stretch.

Drew Brees - NO @ TEN ($5,900)

Drew Brees heads into Week 16 on a tear. The Saints veteran has posted DK scores of 31.3 and 43.1 over his last two games, and heads to Nashville to face a Titans Defense that is 25th in the NFL in yards allowed per pass. We prefer Brees at home, but we've also seen this Saints offense go on unbelievable high-scoring runs in the past, which makes me content to continue riding the wave in this spot. This matchup carries a projected O/U of 51 with a tight spread and is one of the best games to target on the main slate.

 

DraftKings DFS Running Backs - Week 16 Picks

Joe Mixon - CIN @ MIA ($6,600)

It took 10 weeks, but the Bengals appear to have finally realized what type of player they have in Joe Mixon. Mixon has logged a massive 130 carries since Week 10, which he's converted into 605 rushing yards and three TDs. He brings that hot hand into a beautiful matchup against a Dolphins Defense that has allowed the most rushing yards in the NFL to opposing RBs and is fresh off relinquishing yet another 100-yard game to Saquon Barkley last week. We're getting a quality player in a tremendous matchup at a reasonable price here and I consider Mixon to be one of the top overall plays on this slate.

Deandre Washington - OAK @ LAC ($4,000)

A great opportunity for salary savings here with Oakland's DeAndre Washington. Rookie Josh Jacobs tried to tough it out last week, but won't be active for this matchup against the Chargers, which will throw Washington back into the primary-back role that he served in Jacobs' absence in Week 14. Washington thrived in the role two weeks ago against Tennessee, logging 53 rushing yards and a TD, as well as 43 receiving yards on six catches. We can expect a similar workload for him against a Chargers Defense that's 22nd in the league in DK points allowed to opposing RBs, which makes him a tremendous value option at just $4k.

 

DraftKings DFS Wide Receivers - Week 16 Picks

Michael Thomas - NO @ TEN ($9,300)

No need to get cute here...if you can afford Michael Thomas, roster him. Maybe it sounds like an oversimplification, but like we touched on when discussing Lamar Jackson earlier, if you had rostered Thomas every week this season there would be very few weeks you'd walk away disappointed. The Saints wide receiver has been the most consistent pass catcher in the NFL this season. He leads the league in overall targets at 159 - reeling in an eye popping 133 catches- and is averaging a ridiculous 11.4 targets per game. This Titans secondary has been plagued with injuries and has no one that can challenge Thomas in this matchup, which provides a clear path to another huge outing for the Saints star.

Courtland Sutton - DET @ DEN ($6,200)

Courtland Sutton has ascended to the number-one receiver role for the Denver Broncos over the course of this season thanks to the combination of his explosive play and the departure of Emmanuel Sanders. Sutton has been targeted 107 times this year with a healthy aDOT of 12 yards. It's been a mixed bag for him since Drew Lock stepped into the QB role for the Broncos, as Sutton has snagged 13 of 22 targets for 187 yards and two TDs in Lock's three starts. He draws his best matchup of the "Lock Era" this week against a Lions Defense that has been routinely torched as of late. Detroit ranks 31st in the NFL in receiving yards allowed to opposing WRs and is fresh off a Week 15 game against the Bucs in which they allowed over 100 yards to not one, but TWO Tampa receivers. Sutton is a very explosive player in a prime spot against the Lions...the only concern is the erratic play of his QB.

Mike Williams - OAK @ LAC ($5,000)

I've been banging the Mike Williams drum for several weeks now and DraftKings just refuses to bump his price up enough to make me jump ship. Williams comes in at $5k this week, which is still a pittance to pay for a player with his type of significant downfield role. His aDOT of 18 yards leads the NFL among players with 50 or more targets and his 1,460 total air yards ranks ninth in the league. He gets a gasoline-to-fire matchup against an Oakland Raiders Defense that is allowing an NFL-worst 9.68 yards per target to opposing wide receivers. Williams has had some scary-low volume games this year, but his downfield role against this Raiders secondary makes him an awesome boom-or-bust tournament option this week.

 

DraftKings DFS Tight Ends - Week 16 Picks

Zach Ertz - DAL @ PHI ($6,400)

It's always nice to bargain shop, but one of the main reasons I'm willing to pay up in a DFS roster is "guaranteed" volume. Over Philly's last six games, Zach Ertz has target counts of: 10/13/6/14/11/11. This is the type of usage that I'll gladly spend up for. Dallas has a solid overall defense, but they also funnel targets to opposing tight ends. The Cowboys rank seventh in the league in DK points allowed to the WR position, but just 27th in DK points allowed to TEs. This is a must-win game for the Eagles and their receiving corps has been ridiculously depleted by injuries, which leads me to believe that Eagles QB Carson Wentz will rely on Ertz heavily in this spot.

Austin Hooper - JAX @ ATL ($4,400)

Austin Hooper was in the midst of a career year before being derailed by an injury in Week 10. He's been underwhelming since returning to the Falcons lineup two weeks ago, but this is a great buy-low spot on the talented TE that is priced at just $4.4k, his lowest tag since Week 4. Hooper has been targeted six times in each of his last two games and is set to take on a Jacksonville defense that has flopped in a huge way this year for a Jags organization that appears to be in turmoil. Jacksonville is tied for the fourth-most TDs relinquished to the TE position and most likely just wants this season to be over. He has been dormant recently, but Hooper possesses as much upside as any tight end on this slate.

 

DraftKings DFS Defenses - Week 16 Picks

Denver Broncos Defense - DET @ DEN ($3,500)

Vic Fangio's first year as head coach of the Broncos hasn't exactly been smooth sailing, but the defensive guru has kept Denver playing hard. Despite tons of injuries to this defensive unit, we know that the Broncos are always a capable unit at Mile High Stadium. That is especially true this week against a Lions team that has been spiraling down the drain since Matthew Stafford went down with an injury. The Broncos will get to square off against David Blough, who is 0-3 since taking over the Lions starting job. I look for Denver to force the inexperienced QB into some mistakes this week.

Washington Redskins Defense - NYG @ WAS ($2,800)

It doesn't really matter who ends up starting at QB for the Giants this week, I'll be comfortable saving salary with this Redskins unit in a home matchup. Washington has been competent on the defensive side of the ball...and that's truly all that's needed against this turnover-prone New York squad. The 'Skins have amassed 19 sacks over their last four games and should have no trouble adding to the tally against a Giants O-line that has struggled all season.

More Weekly DFS Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

CJ McCollum

Hawks Plan to Bring Back CJ McCollum
Yandy Díaz

Yandy Diaz Leaves With Side Tightness, Considered Day-to-Day
Jacob Misiorowski

Leaves Start Early on Friday With Hamstring Cramp
Austin Reaves

Starting Friday Night
Brandon Nimmo

Aggravates Hamstring, Pulled Early on Friday
Luke Kennard

Lakers Hope to Retain Luke Kennard in Free Agency
Dillon Brooks

Suns Want to Keep Dillon Brooks Long-Term
Jamal Shead

Joins Starting Lineup Friday
Jayson Tatum

OK for Game 7 Against 76ers
Joel Embiid

Probable for Game 7 Against Celtics
Jonathan Isaac

Downgraded to Out
Kevin Huerter

Misses Second Consecutive Game Friday
Brandon Ingram

Out on Friday
Tobias Harris

Cleared to Play Friday
Kevin Durant

Officially Out for Game 6
Ryan Helsley

Placed on Injured List With Elbow Inflammation
Dylan Holloway

Signs Five-Year Extension With Blues
Barrett Hayton

Jack McBain Iffy for Friday
Logan Stanley

a Game-Time Decision Friday
Viktor Arvidsson

Ruled Out Friday
TB

Nicholas Paul Set to Return Friday
Charle-Edouard D'Astous

Ready for Action Friday
Victor Hedman

to Be an Option "Really Soon"
Ja'Marr Chase

Is Ja'Marr Chase the Obvious Dynasty WR1 Entering 2026?
Javonte Williams

Can Javonte Williams Replicate 2025 Success in 2026?
Terry McLaurin

is Well-Positioned to Rebound in 2026
Justin Herbert

Dynasty Value Rising Following Offseason Overhaul in Los Angeles
Tee Higgins

Is Tee Higgins a Top-24 Dynasty Wide Receiver?
Ryan Pepiot

to Miss the Rest of the Season, Scheduled for Hip Surgery
Kansas City Chiefs

Chiefs Looking to Establish a Running Game in 2026
James Conner

Buried on Cardinals' Depth Chart Heading into 2026
DK Metcalf

Won't be Charged for Incident With Lions Fan
Brandon Woodruff

Goes on Injured List With Shoulder Inflammation
Nico Hoerner

Leaves Friday's Game Early With Neck Tightness
Broderick Jones

Steelers Decline the Fifth-Year Option for Broderick Jones
Russell Wilson

Ready to Hang Up his Cleats for TV Gig?
Chase Claypool

to Try Out for the Packers
Jack Della Maddalena

Returns At UFC Perth
Carlos Prates

Set For UFC Perth Main Event
Quillan Salkilld

Set For Co-Main Event
Beneil Dariush

An Underdog At UFC Perth
Steve Erceg

Looks To Win Back-To-Back Fights
Tim Elliott

Looks For His Third Consecutive Win
Ollie Schmid

Set For His UFC Debut
Marwan Rahiki

Looks To Remain Undefeated
Cam Skattebo

Role Survives the NFL Draft
Malik Nabers

Has Top-Tier Upside When Healthy
Evan Engram

Still Atop Depth Chart After NFL Draft
TreVeyon Henderson

Run-Heavy Apparoach Set to Benefit TreVeyon Henderson?
Wyatt Langford

Suffers Setback With Forearm Injury
Caleb Williams

Continues to Trend Upward in Ben Johnson's System
Anthony Richardson Sr.

Colts Won't Pick Up Anthony Richardson Sr.'s Fifth-Year Option
Cleveland Browns

Browns "Would Love" to Have QB Situation Decided Before Training Camp
Elijah Arroyo

Dynasty Stock Up Slightly After NFL Draft
Tre Tucker

Offers Limited Dynasty Value Despite a Lack of Competition
Jack Bech

has a Clear Path for Growth in Year 2
Terrence Shannon Jr.

Steps Up in Series Clincher
Jaden McDaniels

Leads Timberwolves to Round 2
Nikola Jokić

Nikola Jokic Finishes Strong Despite Series Exit
Mikal Bridges

Breaks Out in Series Clincher
Karl-Anthony Towns

Posts Triple-Double to Close Series
Paul George

Heats Up From Deep in Game 6 Win
Tyrese Maxey

Drops 30 Points to Force Game 7
Devin Booker

Suns Not Interested in Trading Devin Booker
Terrence Shannon Jr.

Starting in Game 6
Brandon Woodruff

to Get Some Time Off
Nikita Chibrikov

Recovering From Core-Muscle Surgery
WPG

Elias Salomonsson Out 5-6 Months After Shoulder Surgery
Radko Gudas

Remains Out Thursday
Tyler Myers

Scratched on Thursday
Michael Bunting

Arttu Hyry Unavailable Thursday, Michael Bunting Makes Postseason Debut
Bobby Brink

to Sit Out Thursday's Game 6
Jonas Brodin

Will Miss Game 6 Against Stars
Michael Harris II

Could be Forced to the Injured List
Luis Robert Jr.

Officially Placed on Injured List
Clayton Keller

Sets Up Two Goals Wednesday Night
Pavel Dorofeyev

Nets Special Hat Trick in Game 5 Win
Dan Vladar

Backstops Flyers to Series-Clinching Win
Leon Draisaitl

Oilers to Use Connor McDavid and Leon Draisaitl on Same Line Thursday
Brady Tkachuk

Remains Committed to Senators
Arttu Hyry

Could Be Available Thursday
Brandon Nimmo

Leaves Wednesday's Game With Hamstring Tightness
MLB

Phillies-Giants Postponed on Wednesday Due to Rain
Nils Lundkvist

to Remain Out Thursday
MLB

Orioles-Astros Game Postponed Due to Inclement Weather on Wednesday
Gary Woodland

Riding Momentum Into Cadillac Championship
Jordan Spieth

Brings Boom-or-Bust Potential to Cadillac Championship
Adam Scott

Looks Poised for Another Strong Finish at Doral
Maverick McNealy

Needs Approach Game to Click at Doral
George Springer

Being Activated From Injured List, Won't Start on Wednesday
Wyatt Langford

Expected to be Activated on Saturday
Garrett Crochet

Goes on Injured List With Shoulder Inflammation
CFB

Jameson Williams Files Lawsuit Against NCAA, SEC, Big Ten
Junior Caminero

Back in Wednesday's Lineup After Injury Scare
Harry Hall

Volatility Continues at Cadillac Championship
Tommy Fleetwood

Looks to Rebound at Trump National Doral
Pierceson Coody

a Risky Value Play at Cadillac Championship
Akshay Bhatia

Offers Upside with Risk at Cadillac Championship
Justin Thomas

a Scary Proposition at Cadillac Championship
Scottie Scheffler

The Leading Favorite at Cadillac Championship
Collin Morikawa

Still a Smash Play at Cadillac Championship
Viktor Hovland

Showed at Augusta He Can Finish Well
Sepp Straka

Attempting to Finish Better in Miami
PGA

J.J Spaun Enduring Roller Coaster Start to 2026
Min Woo Lee

Seeks to Make Adjustments at Cadillac Championship
Max Homa

May Struggle at Old Doral This Weekend
Ben Griffin

Rebounds From Rough Stretch as Miami Looms
Shane Lowry

Searching For Answers at Cadillac Championship
Russell Henley

Daunting Test at Doral Likely Not a Place For Russell Henley
Justin Rose

Returns to Action After Finishing Third at Masters Tournament
Hideki Matsuyama

Has The Approach Game to Win at Cadillac Championship
Junior Caminero

Suffers Jaw Contusion on Tuesday, Considered Day-to-Day
Pete Fairbanks

Going on Injured List With Nerve Irritation
Spencer Strider

to Make Season Debut This Weekend
CFB

Brendan Sorsby Facing Potential Permanent Loss of Eligibility
Carson Hocevar

Scores his First Career NASCAR Cup Series Victory at Talladega
Chris Buescher

Misses out on Winning at Talladega by Finishing Second
Alex Bowman

Earns First Top-Five Finish at Talladega Since Returning From Injury
Chase Elliott

Scores A Fourth-Place Finish at Talladega
Zane Smith

Nabs First Top-Five Finish of the 2026 Season at Talladega
CFB

Texas Tech Quarterback Brendan Sorsby Enters Rehab
Youssef Zalal

Suffers Unanimous-Decision Loss
Aljamain Sterling

Wins Back-To-Back Fights
Norma Dumont

Drops Decision At UFC Vegas 116
Joselyne Edwards

Scores Upset Win
Alexander Hernandez

Gets Dominated
Alexander Hernandez

Rafa Garcia Dominates Alexander Hernandez
Adrian Luna Martinetti

Unsuccessful In His UFC Debut
Davey Grant

Gets Back In The Win Column
Denny Hamlin

Is Denny Hamlin Worth Rostering for Talladega?
NASCAR

Is Bubba Wallace Playable in Talladega DFS Lineups?
Tyler Reddick

Stay Away From Tyler Reddick at Talladega
Ryan Blaney

Can Ryan Blaney Shake Off The Bad Luck at Talladega?
Austin Cindric

Could Contend For Another Talladega Win
Kyle Busch

an Easy DFS Pick at Talladega
Ricky Stenhouse Jr

. a High-Risk, High-Reward Pick at Talladega
Todd Gilliland

a Sleeper to Watch at Talladega
Brad Keselowski

Is Brad Keselowski Worth Rostering for Talladega Lineups?
Chase Briscoe

Could Chase Briscoe be A Sneaky Tournament Play for Talladega Lineups?
Christopher Bell

Should DFS Managers Trust Christopher Bell at Talladega?
Ty Gibbs

Is A DFS Risk for Talladega Lineups
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF