🖥 TAP TO SAVE 50% WITH CODE THANKS
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

Break The Slate: DraftKings NFL DFS Lineup Picks - Week 1

Joe Nicely's DraftKings NFL DFS picks and lineup sleepers for Week 1. His top daily fantasy football recommendations to target for DraftKings DFS contests.

Hi there, RotoBallers, and welcome back to Break The Slate! If you read this article last year then you know what we're about here, but if you are a new reader, let me quickly summarize our goals with this article. We'll spend each week discussing a few NFL DFS plays at each position for the DraftKings main slate. I'll highlight my favorite players and breakdown my reasoning behind them.

I try to update the article on Saturdays to reflect any significant injuries or late-breaking news, as the landscape of the slate can change quickly in the NFL throughout the course of a week, so I hope that you will drop in to check those out before finalizing your lineups. Let me also say that Week 1 specifically is the most unpredictable week of the NFL season and generally serves as something of a "feeling things out" period. That said, thoroughly preparing ourselves will give us a legitimate leg up on a Week 1 slate that is always crammed full of new, casual NFL DFS players.

These DraftKings lineup recommendations are based on matchups, projected ownership, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home-field advantage, and more. There are quite a few great plays available, so read on to find out which players are the best for Week 1. Be sure to also check out our weekly FanDuel DFS lineup picks and lots of other great NFL DFS articles and NFL DFS tools to help you win big! Good luck with your DraftKings DFS lineups, let's Break The Slate together!

Be sure to check all of our fantasy football rankings for 2025:

 

DraftKings DFS Quarterbacks - Week 1 Picks

Kyler Murray - ARI @ TEN ($7,600)

Week 1 is always something of a guessing game, and while we should be willing to embrace volatility in some spots in order to gain GPP leverage, there's nothing wrong with taking a couple of layups where we can find some level of "certainty".

Arizona QB Kyler Murray qualifies. We can expect this offense to once again run completely through Murray - a player that looked like a legitimate MVP contender over the first half of 2020 before struggling with an injury over the latter portion of the year - both this season as a whole and in this Week 1 matchup against a Titans defense that was one of the NFL’s worst last year and finished 29th in Total Defense DVOA. 

Murray’s DFS ceiling and floor are exponentially increased by his ability on the ground, as he racked up an average 51.2 rushing yards per game and totaled 11 TDs on the ground last season. 

Jalen Hurts - PHI @ ATL ($6,400)

If you love the aforementioned Kyler Murray play but are hesitant to pull the trigger on his price tag, Jalen Hurts is a "Kyler Murray Lite" type of option that comes with a noticeable discount. At $6.4k, Hurts brings a tremendous DFS floor to the table thanks to his rushing ability. In his four starts for Philly last year his legs accounted for eye-opening fantasy-point production, as he totaled DK point contributions of 15.4, 6.9, 12.3, & 13.6 just on the ground. That's an average of 12.05 DK points per game without ever throwing a pass! His upside is also intriguing in this matchup against a Falcons defense that - while likely to be improved after an offseason overhaul - ranked dead last in the NFL in both DK points allowed to the QB position and yards allowed per pass last year.

SATURDAY UPDATE: 

This will likely be the lightest version of "Saturday Updates" that we'll have this season, as there are very few injuries of note on the slate and we've had plenty of time to digest the Week 1 salary scale. At the QB spot, KC's Patrick Mahomes wasn't highlighted in this week's write-up, but I feel it goes without saying that Mahomes is always in consideration. The same can be said for Buffalo's Josh Allen. Below Jalen Hurts at $6.4k the volatility at the position increases dramatically, though there are some viable, inexpensive pieces that can be utilized in stacks, such as Joe Burrow, Jameis Winston, and Zach Wilson, while New England's rookie signal-caller Mac Jones stands out as mispriced in cash-game formats.

 

DraftKings DFS Running Backs - Week 1 Picks

Christian McCaffrey - NYJ @ CAR ($9,500)

Volume is a word that you'll see discussed in this article often throughout the season. Put simply, volume is gold in NFL DFS and despite losing the majority of 2020 to an injury, Carolina's Christian McCaffrey is still the volume king. CMC opened the 2020 season priced at $10k for each of the first two games, so while it feels weird to say it, his $9.5k salary for the '21 season opener constitutes something of a discount. The Panthers will not hesitate to feed McCaffrey the ball both on the ground and through the air, and this retooled Jets defense should pose little obstacle to the Stanford alum. Week 1 pricing is notoriously soft and that's once again the case this year. This flexible salary scale offers us a tremendous opportunity to roster McCaffrey on the slate.

James Robinson - JAX @ HOU ($6,400)

This is a really nice "locked-in volume + great matchup" spot for James Robinson. Robinson made a true splash as a rookie in 2020, proving himself to be an effective dual-threat back for the Jags. He was targeted an average of 4.3 times per game last year, while also toting the rock 240 times for 1,070 yards and 7 rushing TDs. It looked as though Robinson's growth would be severely limited when Jacksonville drafted a dynamic back, Travis Etienne, earlier this year, but Etienne's season-ending injury during camp opens the door for Robinson to once again see a large amount of volume in this Jags offense. The matchup is a dreamy one, as the Texans were unquestionably the worst run defense in the league last year and I don't expect the Houston unit to noticeably improve in 2021.

SATURDAY UPDATE: 

There isn't a huge difference between McCaffrey, Dalvin Cook, and Alvin Kamara who are in my opinion, the clear-cut top three RB options on the slate. However, with so much value available throughout the salary scale, these high-priced backs will also be extremely popular, with tons of lineups containing one or two of these guys. So there's something to be said for looking at some mid-priced plays with high-volume expectations such as Steelers rookie Najee Harris and Bengals workhorse Joe Mixon. I'll also toss in Antonio Gibson and Mike Davis as sub-$6k RBs that are certainly worth targeting.

 

DraftKings DFS Wide Receivers - Week 1 Picks

Stefon Diggs - PIT @ BUF ($7,600)

There are several viable spend-up options at the WR position this week, but Buffalo's Stefon Diggs sticks out as my favorite high-priced play at the position. Diggs thrived in his first year in this Bills offense, leading the NFL in both receiving yards (1,846) and receptions (147) last season. He also led the NFL in targets (197) and was targeted an average of 10.4 times per game. We can expect more of the same from this Bills offense in 2021, as OC Brian Daboll somehow didn't get a head coaching job and their core offensive weapons all return. Buffalo threw the ball at a 61.71% clip last season - the 11th-highest rate in the NFL - and I wouldn't be surprised to see that number go even higher this year. As for the matchup, Diggs routinely shreds man coverage, which is what we can expect from this Pittsburgh defense. He lit the Steelers up to the tune of 10 catches for 130 yards and a score when these two teams met last season and his combination of talent, matchup, and volume points toward another big outing for him this go-'round.

Marquez Callaway - GB @ NO  ($3,400) vs Michael Pittman Jr. - SEA @ IND ($4,100) vs Parris Campbell - SEA @ IND ($3,700)

I'm pretty sure that my bosses here at RotoBaller like it when I keep this article fairly straightforward, but I have been known on occasion to howl at the moon. Thankfully, they tolerate me when I sometimes wander off the beaten path because they understand that, sometimes, thinking outside of the box is the key to unlocking big wins in GPP formats. So I hope you'll grant me this little detour and apply the thought process not only to this Week 1 slate, but as a comprehensive mindset going forward this season.

I'm a Knoxville resident and lifelong University of Tennessee Volunteer fan, so I've pretty much had Marquez Callaway circled as a breakout candidate for the past year or so, but a funny thing happened on the way to Week 1, the former Vol has morphed into the uber chalk of the season-opening slate. Don't get me wrong, I love me some Marquez, but an expected-to-be-massively-owned-still-developing-player-in-a-now-Drew Brees-less offense-against-a-tough-Green Bay-secondary is a logical fade candidate in large-field tournament formats.

Because today's NFL DFS players are so sharp, there's already been a steady wave of ownership pivoting to Indy's Michael Pittman, another talented young player with a too-cheap price tag. But what if everyone is moving to the wrong Colt? Parris Campbell has played all of nine career games since 2019, but if there's ever a time to gamble on him being healthy, I suppose it's in Week 1. With TY Hilton currently out of the picture for this Indy offense, Pittman will slide into the alpha role, while Campbell will occupy the slot. Pittman is a nice player and a fine DFS option, but I think it's fair to say that the often-injured Campbell is going extremely overlooked in this spot and represents a really nice 4D-type chess move in a tournament like the Milly Maker.

At the end of the day there are no wrong plays in this trio, but the types of contests you are playing should be a serious consideration when locking one of them in. Marquez in cash and single-entry stuff, Pittman makes sense in smaller tournaments, while Campbell is the type of dart-with-upside option that could help you gain ground against massive GPP fields.

SATURDAY UPDATE: 

A plethora of options that are almost too numerous to list. Strong high-priced and value plays abound at the WR position this week. The most notable high-priced receivers are Davante Adams, Tyreek Hill, and Calvin Ridley for obvious reasons, while value abounds in the form of dirt-cheap options like Rondale Moore, Elijah Moore, and the players highlighted in this week's write-up. There are also numerous stacking combinations with the Vikings, Jags, and Bengals units sticking out.

 

DraftKings DFS Tight Ends - Week 1 Picks

Travis Kelce - CLE @ KC ($8,300)

Ahhh yes...my nemesis position. The TE spot was so rough for me last year that I instituted something called "The Kelce Rule" over the latter portion of the 2020 season. It's pretty simple and goes something like this: If Travis Kelce is on the main slate and healthy, you play him. No matter the price, no matter the matchup...you play him. Now while I plan on relaxing "The Kelce Rule" a bit this year (at least initially), the strategy remains viable because he is such a totally different animal than anyone else we're gonna find at the TE position. Kelce finished second in the NFL in targets - not the tight end position, the entire NFL - last season with 185. He also finished second in the league in both receptions (176) and receiving yards (1,776), while finishing tied for third in receiving TDs with 14. To steal a basketball term, Kelce is a unicorn. As a result, the normal rules don't really apply.

Kyle Pitts - PHI @ ATL ($4,400)

Speaking of unicorns, many believe that Atlanta's rookie TE, Kyle Pitts, is the next one at the position. The Falcons made Pitts the highest-drafted TE in history earlier this year. If his measurables and film from his time at the University of Florida are true indicators, he has the type of slate-breaking upside that we rarely encounter at the TE position. The youngster should be immediately thrown into the fire in this Falcons offense and profiles to be the second option behind Calvin Ridley. He'll square off against an Eagles defense that allowed a MASSIVE 75% catch rate to opposing TEs last season, a mark that was the worst in the NFL.

SATURDAY UPDATE: 

Very little for me to add at the TE spot, as my personal lineups be made up of 100% Pitts or Kelce. I suppose there are ownership reasons to search out other options, but the TE position is so shaky that I'm comfortable limiting my exposure to these two players that I'm confident in.

More Weekly DFS Analysis




POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Josh Jacobs

Intends to Play Against Bears on Saturday
Zach Bogosian

Misses Tuesday's Game
Marcus Johansson

Unavailable Tuesday
Artyom Levshunov

Scratched for Tuesday
Mathew Barzal

a Game-Time Call Tuesday
Joseph Woll

Returns to Action Tuesday
Mike Matheson

Won't Play on Tuesday
Rasmus Ristolainen

Makes Season Debut Tuesday
Bam Knight

Cardinals Place Bam Knight on Injured Reserve
CFB

Kansas State's Jayce Brown Intends to Transfer
CFB

Nation's Leading Passer Drew Mestemaker to Enter Transfer Portal
Justin Crawford

Phillies Planning to Start Justin Crawford in Center Field
CFB

Jayden Maiava Signs New Deal to Return to USC
CFB

Aidan Mizell Won't Return to Florida, Entering Transfer Portal
CFB

East Carolina Targeting Jordan Davis as Next Offensive Coordinator
Patrick Mahomes

Targeting Week 1 Return in 2026
Cutter Gauthier

Scores Twice at MSG
CFB

Michigan QB Jadyn Davis Set to Enter Transfer Portal
CFB

Travis Williams Joining Texas A&M Defensive Staff
Tim Stützle

Tim Stutzle Records Three Assists in Dramatic Win
Filip Forsberg

Nets 11th Career Hat Trick
Sam Reinhart

Pots Two Goals Against Lightning
Darcy Kuemper

Hurt Versus Stars
Gustav Forsling

Injured in Monday's Win
Brandon Hagel

Makes Early Exit Monday
Cooper Flagg

Becomes Youngest 40-Point Scorer in NBA History
Victor Wembanyama

May Come Off the Bench Again Tuesday
Nikola Jović

Nikola Jovic to Undergo MRI Tuesday
Sam Hauser

Tweaks Left Ankle Monday
Peyton Watson

Not Expected to Be Out Long-Term
Ja Morant

Injures Ankle in Monday's Win
Darren Waller

Hauls in Two Touchdowns in Monday Night Loss
Brandon Clarke

Still Out Monday
Rome Odunze

Considered Week-to-Week With Foot Injury
James Harden

Officially Active on Monday Night
Ja Morant

to Remain Under Minutes Restriction Monday
James Harden

a Game-Time Call Monday
John Konchar

to Be Re-Evaluated in Three Weeks
Julian Strawther

Active on Monday
James Harden

Good to Go Monday
Tari Eason

Remains Out Monday
Daniel Gafford

to Be Limited to 17-20 Minutes Monday
Davante Adams

Considered Week-to-Week With Hamstring Injury
Kyle Filipowski

Starting Against Mavericks
Brandon Williams

Out Monday
Tyler Herro

a Late Scratch on Monday
Jaylen Warren

to Play Through Illness on Monday Night
Anthony Davis

Misses Monday's Action, Daniel Gafford Available
Georges Niang

to Be Re-Evaluated in Two Weeks
Jamison Battle

Available Against Heat
Will Smith

Sharks Place Will Smith on Injured Reserve
Andrei Vasilevskiy

Expected to Return Before Christmas
Dylan Holloway

to Miss Six Weeks
Patrick Kane

Expected to Miss at Least Two Games
Quinton Byfield

Ruled Out for Monday
Mika Zibanejad

Won't Play on Monday
Connor Bedard

Out Until 2026
Bhayshul Tuten

to Miss a Few Weeks With Finger Injury
Joe Burrow

Will Start the Rest of the Season
Jayden Daniels

to be Shut Down for Final Three Games
Philip Rivers

Will Start Again in Week 16
Drake London

Falcons "Very Hopeful" Drake London Can Return in Week 16
CFB

Dylan Raiola Entering His Name into Transfer Portal
Micah Parsons

MRI Confirms Torn ACL for Micah Parsons
CFB

Cincinnati's Brendan Sorsby Plans to Transfer When Portal Opens
Adolis García

Adolis Garcia, Phillies Finalizing One-Year Deal on Monday
Jaylen Warren

Questionable for Monday Night Due to Illness
Bam Knight

has "Bad Sprain," Unlikely to Play in Week 16
Brandon Royval

Suffers First-Round TKO Loss
CFB

Baylor, LSU, Miami Among Potential Suitors for DJ Lagway
CFB

Aidan Chiles Will Enter Transfer Portal
Manel Kape

Shines At UFC Vegas 112
New York Jets

Jets Fire Defensive Coordinator Steve Wilks
Kevin Vallejos

Gets Second-Round Knockout Win
Christian Watson

Avoids Long-Term Injury, Status for Week 16 Unclear
Giga Chikadze

Suffers His First Career Knockout Loss
CFB

Quarterback DJ Lagway Entering Transfer Portal
Cesar Almeida

Gets Dominated
Cezary Oleksiejczuk

Wins Sixth Fight In A Row
Teddye Buchanan

Ravens Linebacker Teddye Buchanan Believed to Have Torn ACL
Morgan Charrière

Morgan Charriere Suffers First-Round Knockout Loss
Melquizael Costa

Gets First-Round Knockout Win
Marcus Buchecha

Still Winless In The UFC
Kennedy Nzechukwu

And Marcus Buchecha Fight To Draw
Lance Gibson jr

Lance Gibson Jr. Drops Decision In His UFC Debut
King Green

Gets Back In The Win Column
Dallas Goedert

has Third Two-Touchdown Game on Sunday
Nico Collins

Records First Multi-Touchdown Game of the Season
D'Andre Swift

Falls Just Shy of 100 Rushing Yards, Scores Twice in Week 15
Kenley Jansen

Agrees to One-Year Deal With Tigers
Merrill Kelly

Returns to Diamondbacks on Two-Year Deal
Jorge Polanco

Agrees to Two-Year Deal With Mets
CFB

LaNorris Sellers to Return to South Carolina in 2026
CFB

Washington State Expected to Hire Kirby Moore as Next Head Coach
CFB

Kyle Whittingham Stepping Down as Utah Head Coach
Manel Kape

Set For UFC Vegas 112 Main Event
Brandon Royval

An Underdog At UFC Vegas 112
Kevin Vallejos

Set For His Third UFC Fight
Giga Chikadze

In Dire Need Of Victory
Cesar Almeida

Set To Welcome Cezary Oleksiejczuk To The UFC
Cezary Oleksiejczuk

Set To Make His UFC Debut
Maikel Garcia

Royals Agree on Five-Year Extension
Melquizael Costa

Looks To Extend His Win Streak
Morgan Charrière

Morgan Charriere Looks to Win Second Consecutive Fights
Marcus Buchecha

Looks To Bounce Back
CFB

Sherrone Moore Charged with Home Invasion, Among Other Charges
CFB

Freddie Kitchens Fired from North Carolina Coaching Staff
CFB

Bryce Underwood Could Leave Michigan Without Buyout
Fernando Tatis Jr.

Padres Not Considering Trading Fernando Tatis Jr.
Tarik Skubal

Tigers Engaged in "Serious Talks" Around Trading Tarik Skubal at the Winter Meetings
CFB

Chris Brazzell II Declaring for NFL Draft
CFB

Fernando Mendoza Named AP College Football Player of the Year
Raisel Iglesias

to Remain the Braves Closer
Robert Suarez

Agrees on Three-Year Deal With Braves
CFB

Sherrone Moore Remains in Police Custody
Si Woo Kim

Closes 2025 With Strong Finish Among Putting Woes
Akshay Bhatia

Looks to Rebound in 2026 After Down Year Off the Tee
Brian Harman

2025 Season a Step Back Despite Spring Win
Sam Burns

' Elite Putting Headlines a Solid 2025 Season
Sepp Straka

Ends Stellar 2025 Campaign on a High Note
Robert MacIntyre

Closes Out a Steady 2025 Campaign

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP