🖥 TAP TO SAVE 50% WITH CODE THANKS
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

FanDuel NFL DFS Lineup Picks for Week 10 - Daily Fantasy Football

Dennis Clausen highlights the top FanDuel NFL DFS lineup picks for Week 10 of the 2021 season, and some value sleepers for your daily fantasy football rosters.

What a wild Week 9 it was. With so many players not only failing to meet projections but also falling well below, the scores throughout the DFS community weren't the prettiest by any means. Yet, it was likely a good day for those who turned to James Conner, Jonathan Taylor, Nick Chubb, or Joe Mixon as their preferred options. Additionally, we can't forget about Lamar Jackson or Justin Herbert's contributions, either, while also acknowledging the performance of the returning George Kittle, who had six receptions for 101 yards and a touchdown in his first game since suffering a calf injury back in Week 4. We also saw some wideouts come out of nowhere to make some noise, with Elijah Moore and Olamide Zaccheaus crushing their respective values.

Of course, things have certainly changed since the conclusion of Week 9, with the top story heading toward Sunday being the unfortunate incident involving Dalvin Cook, who is in danger of possibly missing time. Although that may not happen as early as the Vikings meeting against the Los Angeles Chargers, it's certainly a situation fantasy managers want to keep an eye on, mainly if Cook gets suspended. If that's the case, Alexander Mattison will automatically assume the role as the team's top back, and we all know what the 23-year-old is capable of when given a chance.

In this article, I will be providing you with my Week 10 daily fantasy football lineup picks for FanDuel’s “Main Slate.” These lineups can vary from higher-priced players and elite options to lower-priced players and value picks on FanDuel. Be sure to also check out our weekly DraftKings DFS lineup picks and lots of other great NFL DFS articles and NFL DFS tools to help you win big! Feel free to give me a follow on Twitter @DennisMClausen.

Be sure to check all of our fantasy football rankings for 2025:

 

FanDuel Quarterbacks - Week 10 DFS Lineup Picks

Josh Allen, QB - vs. NYJ ($8,700)

We shouldn't be ready to give up on Allen, who surprisingly performed terribly during the improbable loss to the Jaguars. After he got off to a slow start against the Dolphins in Week 7, many had assumed that the bye would do him some good. However, that's not how things played out, as the former Wyoming Cowboy had one of the worst performances of his career against Jacksonville.

Nonetheless, Allen can help lessen the sting by turning things around against the Jets. Fortunately, he has a good chance, actually an excellent chance, of doing just that against a New York team that has struggled defensively, allowing 130 points combined against the Patriots, Bengals, and Colts over the last three weeks.

Dak Prescott, QB - vs. ATL ($8,100)

Prescott returned last Sunday against the Broncos after dealing with a calf injury that forced him to miss some time. Despite the possibility of being rusty, the veteran was still expected to have his way with the Denver defense. Yet, that didn't happen, and just like in Josh Allen's case, his output was a colossal disappointment. Still, he's allowed a free pass, primarily since he likely wasn't 100 percent, so we can put that disastrous outing behind him and move on to Atlanta.

Prescott stated that he has been working on his footwork during practice throughout the week, which was an issue against the Broncos. With that, he should regain some confidence, especially regarding planting his foot during throws, something he had a problem doing during the loss. To make things even more enticing, Vegas has the Cowboys as one of the top-scoring teams on the slate, so it's more likely than not he will bounce back against the Falcons.

Also Consider: Patrick Mahomes ($8,400), Justin Herbert ($8,000)

 

FanDuel Running Backs - Week 10 DFS Lineup Picks

James Conner, RB - vs. CAR ($7,000)

Kyler Murray and DeAndre Hopkins didn't suit up for the Week 9 showdown against the 49ers, and it was seemingly a foregone conclusion that the Cardinals would get smoked. Let's face it, Colt McCoy hasn't been the most reliable signal-caller through the years, and while Christian Kirk and Rondale Moore have had their moments of efficiency, not having an MVP candidate or a stud receiver in the lineup isn't ideal.

Yet, Arizona has arguably the best one-two punch out of the backfield in Conner and Chase Edmonds, so naturally, they were expected to serve as a crutch for McCoy when things got rough. Yet, things got even worse for the birds after Edmonds went down with a high-ankle sprain and didn't finish the game as a result. Luckily, Conner, who most believed was well past his prime, turned on the burners and carried the team on his back to a win.

The former Steeler was already playing well leading up to bout versus San Francisco, scoring at least once in five of his eight showings on the year. Yet, he surpassed expectations by finding the end zone three times in total while racking up nearly 100 rushing yards. He also caught all five of his targets for 77 yards. With Edmonds now out for the foreseeable future, Conner should get plenty of opportunities to produce against a shoddy Panthers defense, even if Murray and Hopkins can make it back.

D'Ernest Johnson, RB - @ NE ($5,400)

When we thought we'd seen the last of Johnson, here he is again, ready to occupy space in an abundance of DFS lineups. Yes, we'd love to believe we can get away with other options to go against the crowd. However, when considering his potential points total in relation to his value, we may not have any other choice than to keep him under consideration against New England.

Kareem Hunt remains out with a calf issue, and Nick Chubb has, you guessed it, COVID-19, so Johnson should be in line to handle the bulk of the work in Week 10. The 22-year-old was a menace against Denver during his only start of the season by racking up 146 yards and a touchdown off 22 carries. He also had a pair of receptions for 22 yards. It isn't unreasonable to believe he may see that same workload against the Patriots. Yet, even if he doesn't produce the way he did against the Broncos, the bargain opportunity certainly makes rolling with Johnson worth the risk.

Also Consider: Jonathan Taylor ($9,400), Austin Ekeler ($8,600), Dalvin Cook ($8,500), Darrel Williams ($6,000), Mark Ingram II ($5,500)

 

FanDuel Wide Receivers - Week 10 DFS Lineup Picks

Davante Adams, WR - vs. SEA ($8,700)

Adams wasn't available for Thursday Night Football versus Arizona in Week 8 after he was placed on the reserve/COVID-19 list. Yet, he made his return last Sunday against Kansas City, albeit he didn't have Aaron Rodgers throwing him the ball. With Rodgers out against the Chiefs because of a positive COVID-19 diagnosis, Jordan Love got the first start of his career.

Without a doubt, the absence of the reigning MVP signal-caller didn't do Adams any favors. He would finish with only 42 receiving yards, catching just six of his 14 looks from Love throughout the game. Fortunately, Rodgers is on track to play against the Seahawks. Still, even if Rodgers doesn't, Adams has plenty of room to produce against Seattle.

Tyreek Hill, WR - @ LV ($8,400)

Hill began the year by nearly compiling 200 yards against the Cleveland Browns. However, he hasn't been as consistent as most fantasy managers had expected him to be since then. Sure, he's had some good outings. Yet, he's had some bad ones as well.

Nonetheless, now is a good time for DFS enthusiasts to start believing in the 27-year-old. His rostering cost is super low. Also, Hill has played well versus the Raiders throughout his career by hauling in 43 catches for 635 yards and six total touchdowns. Although historical trends don't necessarily result in similar outcomes, everyone should be willing to take a chance on this one.

Also Consider: Cooper Kupp ($9,500), Justin Jefferson ($7,500), Diontae Johnson ($7,400), Keenan Allen ($7,200)

 

FanDuel Tight Ends - Week 10 DFS Lineup Picks

Darren Waller, TE - vs. KC ($7,000)

Las Vegas has had its share of ups and downs this year. While the team is playing better than most had anticipated, it's even more impressive that the Raiders have a winning record when you consider the organization parted ways with its head coach, Jon Gruden, and leading wideout, Henry Ruggs III.

Without Ruggs, it was expected that others would step up, and that's just what happened against the Giants. However, Waller remained the most involved by providing a source of comfort for Derek Carr. Overall, Waller received 11 looks from Carr, with the 29-year-old bringing in seven catches for a game-high 92 yards. It will be a battle of arguably the best tight ends in the league, as Waller and Travis Kelce will square off in an AFC West showdown. Fortunately for the former Georgia Tech Yellow Jacket, the Chiefs haven't played well on the defensive end all year. It's also expected that Waller will continue to get more than enough attention from Carr not only in Week 10 but for the remainder of the year.

Also Consider: Travis Kelce ($7,500)



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Weekly DFS Analysis




POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Haydn Fleury

Cleared to Play
Simon Nemec

to Miss "Some Time"
Jake Evans

Back for Canadiens Saturday
Ilya Lyubushkin

Returns to Stars Lineup Saturday
Roope Hintz

Good to Go Saturday
Charlie Lindgren

Activated From Injured Reserve
Oliver Ekman-Larsson

Available Against Oilers
William Nylander

a Game-Time Decision Saturday
Christian McCaffrey

Questionable for Sunday With Back Injury
Brandon Aiyuk

49ers' "Optimism Has Run Out" on Brandon Aiyuk
Philip Rivers

Will Start on Sunday Against the Seahawks
Jorge Polanco

Agrees to Two-Year Deal With Mets
De'Von Achane

Expected to Play Monday Night
Rome Odunze

Bears Optimistic Rome Odunze Will Play in Week 15
CFB

LaNorris Sellers to Return to South Carolina in 2026
Cason Wallace

Off Injury Report Saturday
Keyonte George

Erupts for Career-High 39 Points Against Memphis
Bones Hyland

Exits Early With Knee Contusion
Isaiah Joe

To Miss Fourth Straight Game
Isaiah Hartenstein

Removed From Injury Report
Austin Reaves

To Be Re-Evaluated In One Week With Calf Strain
Logan O'Connor

Still Not Ready for Season Debut
Lukas Dostal

Activated From Injured Reserve
NJ

Arseni Gritsyuk Ruled Out for Weekend's Action
Connor Bedard

Ruled Out for Saturday
Zeev Buium

Canucks Acquire Zeev Buium From Wild
Marco Rossi

Moves to Vancouver
Quinn Hughes

Traded to WIld
Joel Embiid

Available Against Indiana
Ja Morant

Back on Friday Night
Rickard Rakell

Available Saturday
Tre Jones

is Returning on Friday
Coby White

Cleared for Action Versus Hornets
Jake Ferguson

Listed as Questionable for Week 15
Bo Horvat

Ruled Out for Saturday
Tre Johnson

to be Limited in Return on Friday
Andrei Vasilevskiy

Could Return Monday
Geno Smith

Officially Ruled Out for Week 15
Victor Hedman

to Be Out Until February
Kenny Pickett

to Start in Week 15 Against Eagles
Moussa Diabaté

Moussa Diabate Available on Friday
Jared McCann

to Miss Three Weeks With Lower-Body Injury
Tyrese Maxey

Under the Weather on Friday
Josh Jacobs

Officially Questionable to Face the Broncos
Victor Wembanyama

Expected to Return on Saturday
Stuart Skinner

Shipped to Pittsburgh
Anthony Edwards

Sidelined on Friday Evening
Deebo Samuel Sr.

Questionable for Week 15
CFB

Washington State Expected to Hire Kirby Moore as Next Head Coach
CFB

Kyle Whittingham Stepping Down as Utah Head Coach
T.J. Watt

Officially Ruled Out for Monday Night
Manel Kape

Set For UFC Vegas 112 Main Event
Davante Adams

to be Questionable, Expected to Play on Sunday
Brandon Royval

An Underdog At UFC Vegas 112
Rome Odunze

Questionable for Sunday
Kevin Vallejos

Set For His Third UFC Fight
Alvin Kamara

Ruled Out for Sunday
Giga Chikadze

In Dire Need Of Victory
Cesar Almeida

Set To Welcome Cezary Oleksiejczuk To The UFC
Cezary Oleksiejczuk

Set To Make His UFC Debut
Jayden Daniels

Not Cleared for Contact
T.J. Watt

Undergoes Surgery for Collapsed Lung
Maikel Garcia

Royals Agree on Five-Year Extension
Melquizael Costa

Looks To Extend His Win Streak
Morgan Charrière

Morgan Charriere Looks to Win Second Consecutive Fights
Marcus Buchecha

Looks To Bounce Back
Kennedy Nzechukwu

A Favorite At UFC Vegas 112
King Green

Returns At UFC Vegas 112
Lance Gibson jr

Lance Gibson Jr. Set To Open Up UFC Vegas 112 Main Card
Jake Ferguson

on Track to Play in Week 15
CFB

Sherrone Moore Charged with Home Invasion, Among Other Charges
Jayden Daniels

Cleared for Contact
Tee Higgins

Ruled Out Against Ravens
Marvin Harrison Jr.

Ruled Out for Week 15, Expected Back This Year
Josh Jacobs

"Feeling Pretty Good," Will Practice on Friday
Daniel Gafford

Still Unlikely to Play Friday
Khris Middleton

Misses Second Straight Game
Collin Sexton

Sidelined Again Versus Bulls
Coby White

On Track To Suit Up Versus Charlotte
Tre Jones

Expected To Play Friday Vs. Hornets
Ayo Dosunmu

to Miss Friday's Game Vs. Hornets
CFB

Freddie Kitchens Fired from North Carolina Coaching Staff
CFB

Bryce Underwood Could Leave Michigan Without Buyout
Fernando Tatis Jr.

Padres Not Considering Trading Fernando Tatis Jr.
Tarik Skubal

Tigers Engaged in "Serious Talks" Around Trading Tarik Skubal at the Winter Meetings
CFB

Chris Brazzell II Declaring for NFL Draft
CFB

Fernando Mendoza Named AP College Football Player of the Year
Raisel Iglesias

to Remain the Braves Closer
Robert Suarez

Agrees on Three-Year Deal With Braves
CFB

Sherrone Moore Remains in Police Custody
CFB

Joe Klanderman Joining Baylor Coaching Staff
CFB

Kentucky Hiring Jay Bateman as Next Defensive Coordinator
Si Woo Kim

Closes 2025 With Strong Finish Among Putting Woes
Akshay Bhatia

Looks to Rebound in 2026 After Down Year Off the Tee
Brian Harman

2025 Season a Step Back Despite Spring Win
Sam Burns

' Elite Putting Headlines a Solid 2025 Season
Sepp Straka

Ends Stellar 2025 Campaign on a High Note
Robert MacIntyre

Closes Out a Steady 2025 Campaign
CFB

Chip Kelly Interviews for Georgia Tech Offensive Coordinator Job
CFB

Louisville Receiver Chris Bell has a Torn ACL
Min Woo Lee

Breaks Through to Win in Texas This Year
PGA

Alex Noren Wins Twice on European Tour This Year
Wyndham Clark

has Up-and-Down 2025 Golf Season
CFB

Michigan Fires Head Coach Sherrone Moore
Corey Conners

Comes Close to Winning Again in Very Good 2025
Justin Rose

Turns Back the Clock in 2025
CFB

Jim Knowles Expected to be Hired as Tennessee's Defensive Coordinator
Harris English

Enjoys Solid Finish at Hero World Challenge
CFB

Defensive Coordinator Jim Knowles Not Being Retained at Penn State
CFB

Indiana's Stephen Daley Done for Season After Post-Game Injury
Pete Alonso

Orioles Finalizing Five-Year Deal
Kyle Finnegan

Tigers, Kyle Finnegan Agree on Two-Year Deal
Bo Bichette

Red Sox Out on Bo Bichette For Now
Philadelphia Phillies

Phillies Extend Manager Rob Thomson Through 2027 Season
Michael King

the Mets' Top Rotation Target?
Ronald Acuña Jr.

Ronald Acuna Jr. Could Move Back to Leadoff Spot
CFB

Florida, Wisconsin Among Suitors for QB Transfer Kenny Minchey
CFB

Bryan Harsin, Justin Wilcox Candidates for Washington State Head Coach Job?
Edwin Díaz

Edwin Diaz Agrees to Deal With the Dodgers
Kyle Schwarber

Returning to Phillies on Five-Year Deal
CFB

Ole Miss Hiring John David Baker as Offensive Coordinator
CFB

Ty Howle the Top Target for Virginia Tech Offensive Coordinator Job
Shohei Ohtani

to be Used More as Traditional Starting Pitcher Next Year
Yordan Alvarez

to Become Full-Time DH in 2026?
Mason Miller

Padres Plan to Keep Mason Miller in the Bullpen
Ranger Suárez

Orioles Interested in Signing Ranger Suarez
Anthony Volpe

Yankees Don't Expect Anthony Volpe to be Ready in April
Gerrit Cole

Targeting a Return in May/June
Rory McIlroy

Ends 2025 as the Year's Most Unburdened Player
Aaron Rai

Needs to Figure Out Putting Woes This Offseason
Jordan Spieth

Plays Better on Paper in 2025 Than Results Show
PGA

Chris Gotterup Needs to Find Better Touch and Consistency This Offseason
Hideki Matsuyama

Ends 2025 Season With a Bookend Victory
Scottie Scheffler

Comes Up Just Shy of Hero World Challenge Victory
Merab Dvalishvili

Drops A Decision At UFC 323
Petr Yan

Reclaims Bantamweight Title
Alexandre Pantoja

Era Ends With Gruesome Injury
Joshua Van

Becomes Second-Youngest UFC Champion
Brandon Moreno

Suffers His First TKO Loss
Brandon Moreno

Tatsuro Taira Becomes First Fighter To Finish Brandon Moreno
Henry Cejudo

Payton Talbott Retires Henry Cejudo
Henry Cejudo

Retires After UFC 323 Loss
Jan Blachowicz

Bogdan Guskov Vs. Jan Blachowicz Ends In A Majority Draw
San Francisco Giants

Jeff Kent Elected to Baseball Hall of Fame

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP