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QB vs Pass Rush Matchups To Watch - Week 16

Gage Bridgford (@GbridgfordNFL) identifies quarterbacks to watch in Week 16 based on the opposing pass rush defense. These QBs could be players to fade and avoid or to start and stream in fantasy football leagues.

Week 16 is here, and fantasy championships are on the line. Some teams head into the fantasy finals as big favorites but others are scrapping to pull off a big win as underdogs. Real teams start at quarterback, and the position is pretty important for fantasy as well.

Quarterbacks have changed the game for fantasy football this year with guys like Lamar Jackson and Josh Allen taking full advantage of their running ability to stress defenses. It gives you more viable options on a week-to-week basis.

Right now, these are the weeks that we've spent months preparing and competing for. There's no room for an error, and it's not time to get cute. We have to set our best lineups to win because we aren't coming back next week if we don't.

Be sure to check all of our fantasy football rankings for 2025:

 

Look Away Before It Gets Ugly

Jared Goff @ San Francisco 49ers

You're telling me that Los Angeles Rams quarterback Jared Goff has to go on the road in a do-or-die game against one of the best teams in the conference. I don't like his odds. His offensive line has struggled to generate time for their quarterback despite only giving up 21 sacks this season. In the previous matchup between these two teams, Goff was taken down four times. So, one-fifth of his sacks came in one game, and that was at home.

One issue for the San Francisco 49ers Defense is that they're dealing with several injuries to their pass rush. However, they're still trotting out one of the most fearsome fronts in football from Nick Bosa to Arik Armstead and everyone in between. They have 47 sacks on the year, and, with two games remaining, they would have finished as a top-10 team in sacks last season. This group gets after the quarterback, and, in their fight for playoff seeding, they'll be wanting to make a statement on Saturday night.

 

Sam Darnold vs Pittsburgh Steelers

This Pittsburgh Steelers team is not the best in football, but, with the collection of players that they've been trotting out, they're playing far better than anyone would have expected. It's been largely on the back of their defense. They've gotten an NFL best 49 sacks thus far, and they'll likely be adding to that total in Week 16. They control their playoff destiny if they're able to win in each of the final two weeks. Week 17 isn't guaranteed against a hot Baltimore Ravens team, but they can make life a lot easier with a win this week.

New York Jets quarterback Sam Darnold has been hit a lot this year, as the team has given up 48 sacks on the season. He's also been extremely inconsistent. After seeing ghosts against the New England Patriots, he had a hot few games, but they've also lost to two winless teams (at the time) in the Miami Dolphins and Cincinnati Bengals. They're eliminated from playoff contention, and they have nothing to play for other than draft positioning. Additionally, the dynamic between him and head coach Adam Gase will be interesting to watch after their sideline blowup last week.

 

Daniel Jones @ Washington Redskins

First things first, why are the New York Giants playing Daniel Jones (ankle) despite his high ankle sprain? You just spent a first-round pick on the guy, and you're bringing him back literally two weeks after an injury that typically takes multiple weeks to recover from. This offensive line has allowed 38 sacks this season, and his mobility will likely be limited by the injury. New York just lost tight end Evan Engram (foot) for the remainder of the season, and these final two weeks will not be an amazing swan song.

The Washington Redskins have shown life in recent weeks with quarterback Dwayne Haskins under center, and their defense has also shown some improvement. They're fifth in the NFL with 42 sacks, and they want to see what they have in this rookie with the year nearly over. This is an audition for their next head coach whether that is Urban Meyer or someone else. In a battle of two terrible teams in lost seasons, I think Washington gets after Jones early and often.

 

That's More Like It

Gardner Minshew @ Atlanta Falcons

I would like Jaguars quarterback Gardner Minshew a lot more if this were a home game, but, I still like him this week. No longer under the reign of the almighty Tom Coughlin, this Jaguars team is going to come out and make a statement, and a lot of that is going to be by running the ball and throwing against an overmatched Falcons Defense. The Jaguars are in the top half of the NFL in sacks allowed. Additionally, both of his starting wide receivers are expected to be healthy for this dome contest with D.J. Chark apparently over an ankle injury that cost him the previous game.

The Falcons are led by a defensive-minded head coach, but they've been a lot more bark than bite for a few years. This season, they have just 24 sacks through 14 games. The strength of their pass rush is on the inside with stud defensive tackle Grady Jarrett, but the strength of the Jaguars offensive line is on the interior. The matchups aren't in their favor, and, in a sneaky shootout, the odds favor the Jaguars in this one.

 

Kyler Murray @ Seattle Seahawks

Arizona Cardinals quarterback Kyler Murray has performed about as well as one could have hoped entering the year. He has used his running ability to keep his fantasy floor high, and, despite playing behind a struggling offensive line, he gets the ball out to his receivers. The team is averaging about 22 points per game, and they're going to be forced to score a lot against one of the NFL's top-10 offenses.

Thankfully for Murray and Arizona, the Seahawks don't have the fierce pass rush that they had earlier in the decade. They have just 24 sacks this season, and they're giving up over 24 points per game. This defense allows points, and the offense is often tasked with bailing them out. Murray will find his opportunities to score despite his offensive line's struggles.

 

Drew Lock vs Detroit Lions

Fading the Detroit Lions Defense has been a good strategy for most of the year. They don't have any form of a pass rush, and their secondary, outside of veteran cornerback Darius Slay, can't cover anyone. Drew Lock came back to earth last week against a sneaky good Kansas City Chiefs Defense, but he has the matchup to rebound this week. His offensive line has only allowed three sacks in the three games he has played, and the Lions aren't the type of group that could drastically increase that total.

The Lions have 27 sacks this season with 14.0 of those sacks coming from two players in the forms of Trey Flowers and Devon Kennard. Outside of those two, the next-highest player on the team has just two. If Denver can slow down those two, it's going to be next to impossible for Detroit to generate any pressure. Lock isn't an ideal play, but he's far from the worst on this week's slate.

More Weekly Lineup Prep




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REAL-TIME FANTASY NEWS

Denny McCarthy

Looking For Another Solid Finish at RSM Classic
Si Woo Kim

Looking To Use Current Momentum to Flip Script at RSM Classic
Zion Williamson

Considered Questionable for Wednesday
Bam Adebayo

Could Return to Action Wednesday
Mackenzie Hughes

a Good Bounce-Back Candidate at RSM Classic
Jalen Brunson

Questionable for Wednesday
Jerami Grant

Picks Up Late Questionable Tag
Kyle Anderson

Cleared for Action Against the Lakers
Harris English

Making 14th Start at This Week's RSM Classic
Jrue Holiday

Ruled Out Tuesday
Taylor Hendricks

Returning on Tuesday
Kyle Filipowski

Won't Suit Up Versus the Lakers
LeBron James

Will Play on Tuesday Night
Luke Clanton

Looking For a Solid Finish in Year's Final Event
Daniel Berger

Making Start in Season Finale at This Week's RSM Classic
Konnor Griffin

Could Compete for Starting Shortstop Job in 2026
Keegan Murray

Expected to Make Season Debut Thursday
Gleyber Torres

Accepts Tigers Qualifying Offer
Alexandre Sarr

Uncertain for Wednesday's Game in Minnesota
Ausar Thompson

Returning Versus Atlanta
Cade Cunningham

Active on Tuesday Night
Jabari Smith Jr.

Questionable with Knee Issue Ahead of Meeting Versus Cleveland
Domantas Sabonis

to Miss Wednesday's Game
Paul George

Won't Play Wednesday Night
Onyeka Okongwu

Available on Tuesday
Joel Embiid

Listed as Doubtful for Wednesday
Jalen Suggs

Available Tuesday
Zaccharie Risacher

Ruled Out With Hip Contusion vs. Pistons
Odell Beckham Jr.

Officially Reinstated by NFL Commissioner
Kristaps Porzingis

Ruled Out on Tuesday Night
Matt Murray

to Miss Six Weeks With Lower-Body Injury
Ilya Lyubushkin

Out on Tuesday
Jamie Benn

Makes Season Debut Tuesday
Evgenii Dadonov

on Track to Return Tuesday
Dougie Hamilton

a Game-Time Call Tuesday
Anthony Cirelli

Expected to Return Against Devils
Victor Hedman

Questionable for Tuesday
Auston Matthews

to Miss at Least Two More Games
C.J. Stroud

Expected to Return in Week 13 Against Colts
C.J. Stroud

to Miss Another Game
Joe Mixon

Uncertainty Remains Around Joe Mixon's Return Timeline
Jaylen Warren

Mike Tomlin Optimistic About Jaylen Warren's Availability for Week 12
C.J. Stroud

Not Expected to Play on Thursday Night
Aaron Rodgers

Won't Need Surgery on Fractured Wrist, Could Play in Week 12?
Davis Mills

Prepping for Third Straight Start in Week 12?
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Sam Leavitt Set to Enter Transfer Portal?
Mason Rudolph

Could Make His First Start of 2025 in Week 12
Brock Wright

Sets Career-High in Targets; Lined Up for More Work?
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Struggles Again and Faces Role Uncertainty After Bye
Dak Prescott

in Full Command Monday Night With Four Touchdown Passes
Quentin Johnston

Posts Zero Catches During Offensive Collapse
George Pickens

Erupts for 144 Yards, Touchdown in Monday Night Win
CeeDee Lamb

George Pickens Benched for First Drive
Jose Altuve

Undergoes Foot Surgery
Alex Singleton

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Doubtful Again in Week 12
Shedeur Sanders

Expected to Make First Career Start in Week 12
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Dealing With Knee Contusion
Mikael Granlund

Unavailable Monday
Alex Bregman

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Conor Garland

Misses Monday's Game
Eetu Luostarinen

Out on Monday
Drake London

Considered "Week-to-Week"
Drew Doughty

Listed as Week-to-Week
Ja'Marr Chase

Being Suspended for One Game for Unsportsmanlike Conduct
John Carlson

a Game-Time Call Monday
Viktor Arvidsson

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Charlie McAvoy

Out Against Hurricanes
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James Franklin to be Virginia Tech's Next Head Coach
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Beau Pribula Has Chance to Face Oklahoma on Saturday
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Establishes Vegas Record Sunday
Mats Zuccarello

Logs Two Assists in Overtime Victory
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Leads Red Wings to Victory at MSG
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Delivers Four Assists in Sunday's Win
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Limited to Handful of Minutes Sunday
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Gets Dominated
Islam Makhachev

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Gets Outclassed
Valentina Shevchenko

Wins Unanimous Decision At UFC 322
Sean Brady

Suffers First-Round TKO Loss
Michael Morales

Remains Unbeaten
Leon Edwards

Suffers Second-Round Knockout Loss
Leon Edwards

Carlos Prates Becomes The First Man To Knock Out Leon Edwards
Beneil Dariush

Suffers Brutal First-Round Knockout Loss
Beneil Dariush

Benoit Saint Denis Knocks Out Beneil Dariush In 16 Seconds
Josh Naylor

Mariners Finalizing Five-Year Contract
CFB

Jeremiah Smith, Carnell Tate Not Dealing With Long-Term Injuries
CFB

Virginia Tech Close To Naming James Franklin As Head Coach
CFB

Garrett Nussmeier Doubtful vs. Arkansas On Saturday
Edwin Díaz

Blue Jays Interested in Signing Edwin Diaz?
Jacob deGrom

Named AL Comeback Player of the Year
Ronald Acuña Jr.

Ronald Acuna Jr. Wins NL Comeback Player of the Year Award
Aroldis Chapman

Named AL Reliever of the Year
Edwin Díaz

Edwin Diaz Named NL Reliever of the Year
Justin Thomas

Will Miss Start Of 2026 After Undergoing Back Surgery
Islam Makhachev

Set For UFC 322 Main Event
Jack Della Maddalena

Set For His First Title Defense
Zhang Weili

Can Become The New Women's Flyweight Champion
Valentina Shevchenko

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Michael Morales

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Mario Craver a Game-Time Decision for Week 12
Sean Brady

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Carlos Prates

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Leon Edwards

Looks To Get Back In The Win Column
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Beneil Dariush

Looks To Win Back-To-Back Fights
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Virginia's Chandler Morris Trending Toward Facing Duke on Saturday
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Wins his Fourth MVP Award
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