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DraftKings Daily Fantasy Baseball Picks (5/21/18): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on May 21, 2018. Adam Meyer's MLB DFS analysis and sleepers for building optimal DFS rosters.

It's a short nine-game slate on Monday. Two games have an over/under of at least nine total runs. Five teams are heavy favorites (-185): STL, MIN, NYY, LAD, and WSH. However, while you would think pitching would be loaded, the player pool isn't elite.
On a positive note, weather shouldn't be an issue for Monday. The weekend was full of rain and caused headaches for us all.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 5/21/18. The lineup picks will range from some of the elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @CharlieSideHstl.

DraftKings Starting Pitchers

Walker Buehler, LAD (vs. COL) - $9,300

The MLB team with the lowest runs scored in 2018 was able to produce four earned runs against Buehler in his last start (@ MIA). While that news is somewhat alarming, Buehler still managed to strike out seven batters, continuing his streak of at least five Ks per appearance this season. The Rockies are next for Buehler. Colorado has struck out the seventh-most times this season (426). The Rockies are also 27th in team wOBA against right-handed pitchers (.294). From a Vegas point-of-view, the COL/LAD matchup has the lowest over/under on the slate (seven total runs) and the Dodgers are one of the strongest favorites of the ticket (-180). Both odds are in favor of Buehler.

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Jose Berrios, MIN (vs. DET) - $8,500

It’s a mixed bag when it comes to Berrios and his stat lines. He’s been known to strike out 11 batters in a game, or strikeout none. He’s produced three shutouts in 2018, and allowed five earned runs in three starts this year. However, on a slate this small, without strong pitching prospects, I’d roll the dice on Berrios. His opponent, the Tigers, are 26th in team wOBA against righties (.295) and Vegas has given Minnesota the strongest odds to win on Monday (-200).

 

DraftKings Infielders

C - Gary Sanchez, NYY (@ TEX) - $4,800

After an amazing 4-for-5 performance where Sanchez smacked two home runs in Kansas City, he was given the day off. Now, he’ll look to return to action and continue his hot streak. In the past week, Sanchez is 5-for-11 (.455) with two doubles and two home runs. Sanchez is also third on the team in ISO against right-handed pitchers (.262).

1B - Trey Mancini, BAL (@ CWS) - $3,800

I wanted to wait and see who got the nod for some lineups before I locked in my post for Monday. First base can always be a crucial spot to build, when adding power-hitters to your DFS lineup. I tend to lean towards home running hitting options in this position. Mancini is only 2-for-11 (.111) in the past week, but he's homered three times in the last 10 games. Also, his Orioles are projected to score 4.9 runs (fourth-most) against the White Sox.

2B - Brian Dozier, MIN (vs. DET) - $3,900

Here’s another cold bat that you may not be thrilled with, at first. Dozier is 1-for-21 (.048) in the past week, but his proficiency against lefties is still profitable to the DFS community. He leads the team with a .280 ISO against left-handed pitchers (since 2017). When you get a combination of high ISO, with a leadoff hitter (high in the order), and a reasonable price tag you add them to your DK roster.

3B - Anthony Rendon, WSH (vs. SD) - $3,800

Sure, if you add Rendon with the past two selections you get 3-for-44 (.068) in the last seven days. Rendon is 1-for-12 (.083) in the past week. However, all three are solid selections against southpaws. Rendon leads the Nationals with a .320 ISO against left-handed pitchers.

SS - Didi Gregorius, NYY (@ TEX) - $3,900

I swear these are my suggestions for Monday and not an All-Star team of struggling batters. Gregorius is oh-fer in the past week (0-for-7), but again, the ISO doesn't lie. Even with his recent slump, Gregorius still owns a solid ISO against right-handed pitchers since 2017 (.246). Hopefully, this minor rest (hasn't played since Friday) is enough to wake up his bat and return him to his April numbers (.330 AVG, 10 HR, and 30 RBI).

DraftKings Outfielders

Tommy Pham, STL (vs. KC) - $4,600

The Cardinals have the third-highest implied run total for the Monday slate (5.1 runs). Compared to the previously mentioned bats, Pham is phenomenal. He's batting .280 (7-for-25) with one home run and one double in the past week. He's also tallied at least two hits in three of the past five games. Pham has also produced a .306 AVG against right-handed pitchers this season. His .207 ISO against righties also adds to his case.

Aaron Hicks, NYY (@ TEX) - $3,800

Sometimes you need to be creative when adding players from lineups with high implied run totals. While some DFS players will flock to Aaron Judge and Giancarlo Stanton, we need to pivot to cheaper options, like Hicks. His .205 ISO against righties is only seventh-best on New York, but it's in the range we like to use (.200 or better). Hicks is hitting .467 (7-for-15) with one triple and one home run in the past week.

Marcell Ozuna, STL (vs. KC) - $3,300

Ozuna has gone hitless in his last five games, but he still leads the Cardinals with a .226 ISO against right-handed pitchers. As I mentioned in Pham's write-up, St. Louis has the third-highest implied run total on the board. So, gathering as many hitters from the Cardinals is a wise decision. Ozuna's price tag fits the bill for our circumstances.

MLB DFS News and Injury Alerts

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REAL-TIME FANTASY NEWS

Giancarlo Stanton

Heading to Injured List With Calf Strain
NFL

Mike Vrabel Returns to the Patriots on Monday
Tyree Wilson

Heading into Contract Year With New Team
Calijah Kancey

Buccaneers Pick Up Fifth-Year Option on Calijah Kancey
Jalen Carter

Eagles Exercise Fifth-Year Option on Jalen Carter
Philadelphia Eagles

Eagles Pick Up Nolan Smith's Fifth-Year Option
Keon Coleman

Bills Aren't Giving Up on Keon Coleman
Aaron Rodgers

Former Steelers Coach Thinks Aaron Rodgers Will Return to Pittsburgh
Chris Gotterup

Looks to Continue Big-Game Hunting at Cadillac Championship
George Pickens

hasn't Signed his Franchise Tag With Dallas
Jason Day

Looks to Bring Experience Back to the Blue Monster
Nikola Jović

Nikola Jovic Remains Highly Rated by Heat
Aaron Gordon

Won't Play Monday Night
Tyler Herro

to Undergo "Preemptive Procedure" on Foot
Cameron Young

Returns to Action For Cadillac Championship
Travis Bazzana

Guardians Calling Up Former First Overall Pick Travis Bazzana
Bam Adebayo

Remains Untouchable for Heat
Sam Burns

Looks to Have Big Impact at PGA Tour's Return to Doral
Anthony Edwards

Officially Listed as Week-to-Week
Jordan Goodwin

Still Out Monday
Cooper Flagg

Wins Rookie of the Year Award
Kevin Huerter

is Available to Play in Game 4
Joel Embiid

is Probable for Game 5
Austin Reaves

Could Return for Game 5
Luka Dončić

Luka Doncic Officially Won't Play During First-Round Series
Jonathan Isaac

to Remain Out for Game 4
Will Smith

Back in Action in Series Opener Against Marlins
Josh Naylor

Back in Starting Lineup on Monday
Jason Zucker

Probable for Game 5 Against Bruins
Josh Norris

Could Return to Action Tuesday
Nikita Zadorov

Questionable for Game 5
Viktor Arvidsson

Considered Questionable for Tuesday
Nils Lundkvist

Won't Play Tuesday
Yakov Trenin

Could Be an Option Tuesday
Mats Zuccarello

Questionable for Game 5
Carson Hocevar

Scores his First Career NASCAR Cup Series Victory at Talladega
Chris Buescher

Misses out on Winning at Talladega by Finishing Second
Alex Bowman

Earns First Top-Five Finish at Talladega Since Returning From Injury
Chase Elliott

Scores A Fourth-Place Finish at Talladega
Zane Smith

Nabs First Top-Five Finish of the 2026 Season at Talladega
Marvin Harrison Jr.

Does Marvin Harrison Jr. Still Carry High-End Dynasty Upside?
Marquise Brown

Sliding Down Eagles' Depth Chart Following 2026 Draft
Darnell Mooney

Carries Deep-League Buy-Low Upside into 2026
Christian Kirk

Role in San Francisco in Question Following NFL Draft?
CFB

Texas Tech Quarterback Brendan Sorsby Enters Rehab
Youssef Zalal

Suffers Unanimous-Decision Loss
Brashard Smith

Facing an Uphill Battle for Playing Time in Kansas City
Aljamain Sterling

Wins Back-To-Back Fights
Rashee Rice

Can Rashee Rice Put Together a Full Season of Production in 2026?
Norma Dumont

Drops Decision At UFC Vegas 116
Joselyne Edwards

Scores Upset Win
Alexander Hernandez

Gets Dominated
Alexander Hernandez

Rafa Garcia Dominates Alexander Hernandez
Adrian Luna Martinetti

Unsuccessful In His UFC Debut
Davey Grant

Gets Back In The Win Column
Manny Machado

Clubs Two Homers, Starting to Turn Things Around?
Kyren Williams

Becoming a Better Dynasty Value by the Day
Ben Sinnott

Is it Time to Move on From Ben Sinnott?
Sam Darnold

Still a Reliable Dynasty Hold
Brandon Hagel

Pops Up With Two Goals in Sunday's Win
Justin Fields

Could Dynasty Managers See One More Sell Window for Justin Fields?
Nathan MacKinnon

Records Three Points in Series-Clincher
Dallas Goedert

a Dynasty Bargain After Flurry of Eagles' Moves
Bowen Byram

Extends Goal Streak to Three Games
John Carlson

Delivers Two Assists in Game 4 Victory
Connor McDavid

Bags Pair of Power-Play Assists in 100th Playoff Game
Jason Zucker

Makes Early Exit in Blowout Win
De'Aaron Fox

Notches Game-High 28 Points Sunday
Joel Embiid

Returns With Double-Double
Jayson Tatum

Logs 30-Point Double-Double in Sunday's Win
LeBron James

Quiet in Game 4 Loss to Rockets
Julius Randle

Handed $35K Fine for His Part in Game 4 Altercation
Nikola Jokić

Nikola Jokic Fined $50K for Game 4 Incident
Collin Murray-Boyles

Continues to Shine for Raptors
Deni Avdija

Returns to Form Sunday
Victor Wembanyama

Stuffs Stat Sheet in His Return
Emil Andrae

Expected to Rejoin Flyers Lineup Monday
Matvei Michkov

Set to Be Scratched for Game 5
Radko Gudas

Remains Sidelined Sunday
Jason Dickinson

a Game-Time Decision Sunday
Maxwell Crozier

to Replace Declan Carlile Sunday
Alexander Nikishin

Diagnosed With Concussion
Viktor Arvidsson

Exits Early Sunday
Theo Johnson

a Dynasty Faller After Busy Giants Offseason
Kyle Monangai

Remains a Dynasty Hold
Logan O'Hoppe

Placed on 10-Day Injured List Due to Left-Wrist Fracture
Denny Hamlin

Is Denny Hamlin Worth Rostering for Talladega?
NASCAR

Is Bubba Wallace Playable in Talladega DFS Lineups?
Josh Naylor

Absent on Sunday With Quad Tightness
Ryan Helsley

Returns From Bereavement List on Sunday
Steven Kwan

Back in Sunday's Lineup
Brent Rooker

Activated and Starting on Sunday Against Rangers
Roman Anthony

Returns as DH on Sunday
Tyler Reddick

Stay Away From Tyler Reddick at Talladega
Ryan Blaney

Can Ryan Blaney Shake Off The Bad Luck at Talladega?
Austin Cindric

Could Contend For Another Talladega Win
Kyle Busch

an Easy DFS Pick at Talladega
Ricky Stenhouse Jr

. a High-Risk, High-Reward Pick at Talladega
Todd Gilliland

a Sleeper to Watch at Talladega
Brad Keselowski

Is Brad Keselowski Worth Rostering for Talladega Lineups?
Chase Briscoe

Could Chase Briscoe be A Sneaky Tournament Play for Talladega Lineups?
Christopher Bell

Should DFS Managers Trust Christopher Bell at Talladega?
Ty Gibbs

Is A DFS Risk for Talladega Lineups
Arturs Silovs

Steps in and Saves Pittsburgh on Saturday
Boston Red Sox

Red Sox Fire Manager Alex Cora and Other Coaches
Steven Kwan

Scratched With Neck Stiffness
Trey Yesavage

Returning From Injured List on Tuesday
Eugenio Suárez

Eugenio Suarez Heading to the Injured List With Oblique Strain
MLB

Saturday's Mets-Rockies Game Postponed Due to Weather
Giancarlo Stanton

Exits With Leg Tightness on Friday
Eugenio Suárez

Eugenio Suarez Scratched on Friday With Mid-Back Pain
Jackson Holliday

Receives Positive Test Results, Will be Shut Down for a Week
Jeff Hoffman

Out as Blue Jays Closer
Youssef Zalal

Set For UFC Vegas 116 Main Event
Aljamain Sterling

An Underdog At UFC Vegas 116
Joselyne Edwards

Set For UFC Vegas 116 Co-Main Event
Norma Dumont

Looks To Extend Her Win Streak
Alexander Hernandez

A Favorite At UFC Vegas 116
Rafa Garcia

Looks For His Third Consecutive Win
Adrian Luna Martinetti

Set For His UFC Debut
Davey Grant

Looks To Get Back In The Win Column
Francisco Lindor

Expected to Miss "Significant Time"
CFB

Beau Pribula Leading Virginia Quarterback Competition
Marco Penge

Trending Down Entering Zurich Classic
Sahith Theegala

Eyes Another Strong Week at Zurich Classic
Brooks Koepka

Shane Lowry Teams Up with Brooks Koepka at Zurich Classic
Si Woo Kim

Adds Another Strong Finish at RBC Heritage
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF