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DraftKings Daily Fantasy Baseball Picks (5/21/18): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on May 21, 2018. Adam Meyer's MLB DFS analysis and sleepers for building optimal DFS rosters.

It's a short nine-game slate on Monday. Two games have an over/under of at least nine total runs. Five teams are heavy favorites (-185): STL, MIN, NYY, LAD, and WSH. However, while you would think pitching would be loaded, the player pool isn't elite.
On a positive note, weather shouldn't be an issue for Monday. The weekend was full of rain and caused headaches for us all.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 5/21/18. The lineup picks will range from some of the elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @CharlieSideHstl.

DraftKings Starting Pitchers

Walker Buehler, LAD (vs. COL) - $9,300

The MLB team with the lowest runs scored in 2018 was able to produce four earned runs against Buehler in his last start (@ MIA). While that news is somewhat alarming, Buehler still managed to strike out seven batters, continuing his streak of at least five Ks per appearance this season. The Rockies are next for Buehler. Colorado has struck out the seventh-most times this season (426). The Rockies are also 27th in team wOBA against right-handed pitchers (.294). From a Vegas point-of-view, the COL/LAD matchup has the lowest over/under on the slate (seven total runs) and the Dodgers are one of the strongest favorites of the ticket (-180). Both odds are in favor of Buehler.

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Jose Berrios, MIN (vs. DET) - $8,500

It’s a mixed bag when it comes to Berrios and his stat lines. He’s been known to strike out 11 batters in a game, or strikeout none. He’s produced three shutouts in 2018, and allowed five earned runs in three starts this year. However, on a slate this small, without strong pitching prospects, I’d roll the dice on Berrios. His opponent, the Tigers, are 26th in team wOBA against righties (.295) and Vegas has given Minnesota the strongest odds to win on Monday (-200).

 

DraftKings Infielders

C - Gary Sanchez, NYY (@ TEX) - $4,800

After an amazing 4-for-5 performance where Sanchez smacked two home runs in Kansas City, he was given the day off. Now, he’ll look to return to action and continue his hot streak. In the past week, Sanchez is 5-for-11 (.455) with two doubles and two home runs. Sanchez is also third on the team in ISO against right-handed pitchers (.262).

1B - Trey Mancini, BAL (@ CWS) - $3,800

I wanted to wait and see who got the nod for some lineups before I locked in my post for Monday. First base can always be a crucial spot to build, when adding power-hitters to your DFS lineup. I tend to lean towards home running hitting options in this position. Mancini is only 2-for-11 (.111) in the past week, but he's homered three times in the last 10 games. Also, his Orioles are projected to score 4.9 runs (fourth-most) against the White Sox.

2B - Brian Dozier, MIN (vs. DET) - $3,900

Here’s another cold bat that you may not be thrilled with, at first. Dozier is 1-for-21 (.048) in the past week, but his proficiency against lefties is still profitable to the DFS community. He leads the team with a .280 ISO against left-handed pitchers (since 2017). When you get a combination of high ISO, with a leadoff hitter (high in the order), and a reasonable price tag you add them to your DK roster.

3B - Anthony Rendon, WSH (vs. SD) - $3,800

Sure, if you add Rendon with the past two selections you get 3-for-44 (.068) in the last seven days. Rendon is 1-for-12 (.083) in the past week. However, all three are solid selections against southpaws. Rendon leads the Nationals with a .320 ISO against left-handed pitchers.

SS - Didi Gregorius, NYY (@ TEX) - $3,900

I swear these are my suggestions for Monday and not an All-Star team of struggling batters. Gregorius is oh-fer in the past week (0-for-7), but again, the ISO doesn't lie. Even with his recent slump, Gregorius still owns a solid ISO against right-handed pitchers since 2017 (.246). Hopefully, this minor rest (hasn't played since Friday) is enough to wake up his bat and return him to his April numbers (.330 AVG, 10 HR, and 30 RBI).

DraftKings Outfielders

Tommy Pham, STL (vs. KC) - $4,600

The Cardinals have the third-highest implied run total for the Monday slate (5.1 runs). Compared to the previously mentioned bats, Pham is phenomenal. He's batting .280 (7-for-25) with one home run and one double in the past week. He's also tallied at least two hits in three of the past five games. Pham has also produced a .306 AVG against right-handed pitchers this season. His .207 ISO against righties also adds to his case.

Aaron Hicks, NYY (@ TEX) - $3,800

Sometimes you need to be creative when adding players from lineups with high implied run totals. While some DFS players will flock to Aaron Judge and Giancarlo Stanton, we need to pivot to cheaper options, like Hicks. His .205 ISO against righties is only seventh-best on New York, but it's in the range we like to use (.200 or better). Hicks is hitting .467 (7-for-15) with one triple and one home run in the past week.

Marcell Ozuna, STL (vs. KC) - $3,300

Ozuna has gone hitless in his last five games, but he still leads the Cardinals with a .226 ISO against right-handed pitchers. As I mentioned in Pham's write-up, St. Louis has the third-highest implied run total on the board. So, gathering as many hitters from the Cardinals is a wise decision. Ozuna's price tag fits the bill for our circumstances.

MLB DFS News and Injury Alerts

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REAL-TIME FANTASY NEWS

Devin Booker

Injures Ankle on Friday, Requires Assistance Off the Court
RJ Barrett

Starting on Friday
Gunnar Henderson

is Fully Healthy Heading into Spring Training
Herbert Jones

is Returning on Friday
Derrick White

is Resting on Friday
Aaron Gordon

Holds Probable Tag for Friday
Jaylin Williams

is Returning on Friday
Quenton Jackson

Won't Play on Friday
Duncan Robinson

is Available to Play on Friday
Jock Landale

is Cleared to Play for Friday's Game
Ron Holland II

to Play on Friday
Cade Cunningham

is Upgraded to Available on Friday
Neemias Queta

is Available on Friday
Aaron Holiday

Won't Suit Up on Friday
Aaron Wiggins

is Ruled Out for Friday's Game
Bo Horvat

Rejoining Islanders Lineup Saturday
Dylan Holloway

Out Friday
Ross Colton

Won't Play Friday
Filip Chytil

Ready to End Three-Month Absence
Mason McTavish

Misses Second Straight Game Friday
Anthony Stolarz

Returns to Action Friday
Oliver Ekman-Larsson

Available Friday
Tyreek Hill

Dolphins Expected to Release Tyreek Hill
Paddy Pimblett

Set For Interim Lightweight Title Fight
Justin Gaethje

An Underdog At UFC 324
Song Yadong

Looks To Win Back-To-Back Fights
MMA

Sean O'Malley Looks To Get Back In The Win Column
Derrick Lewis

Returns At UFC 324
Waldo Cortes-Acosta

Looks For His Third Consecutive Win
Philip Rivers

Interviewing for Bills Head-Coaching Job
NFL

Fernando Mendoza Officially Declares for NFL Draft
CFB

Arch Manning Undergoes Foot Surgery
Dalton Kincaid

Played Through Torn PCL
CFB

College Football Playoff Expected to Remain a 12-Team Field in 2026
Duncan Robinson

Listed as Probable Friday Against Houston
Ja'Kobe Walter

to Miss Seventh Straight Game
Collin Murray-Boyles

Uncertain Friday Against Portland
RJ Barrett

Could Return Friday vs. Portland
Myles Turner

Expected to Play Friday vs. Nuggets
Sam Merrill

to Miss Fourth Straight Game Friday
Quinn Hughes

Makes History With Three-Assist Effort
Bennedict Mathurin

Remains Sidelined vs. Thunder
Anthony Mantha

Scores Twice Against Oilers
Jet Greaves

Keeps Stars Off Scoreboard With 28 Saves
David Pastrnak

Leads Bruins to Victory With Three-Point Effort
Jonathan Huberdeau

on Track to Return Friday
Darcy Kuemper

Cleared for the Weekend
Zach Benson

Hurt in Thursday's Win
Baltimore Ravens

Ravens Hire Jesse Minter as Their Head Coach
Kris Letang

Questionable Thursday
Andre Burakovsky

Frank Nazar, Andre Burakovsky Available for Blackhawks Thursday
Indianapolis Colts

FBI Investigating the Death of Colts Owner Jim Irsay
Mason Marchment

Available Versus Stars
Alexandre Texier

Misses Second Consecutive Game
Marcus Johansson

Joel Eriksson Ek, Marcus Johansson Could Return Thursday
David Perron

to Miss 5-7 Weeks Due to Hernia Surgery
Mikko Rantanen

Unavailable Thursday
MacKenzie Gore

Rangers Acquire MacKenzie Gore From the Nationals
Brandon Sproat

Dealt to Brewers in Four-Player Trade
Jett Williams

Brewers Acquire Jett Williams From Mets
Freddy Peralta

Mets Acquire Freddy Peralta From Brewers
Kyle Tucker

Expected to Bat Second or Third in Dodgers' Lineup
Brandon Aiyuk

has "Played his Last Snap as a Niner"
Cody Bellinger

Signs Five-Year, $162.5 Million Contract With Yankees
Adam Scott

Looks to Overcome Putting Woes at American Express
Billy Horschel

Looking to Rebound at The American Express
Josh Allen

Might Need Foot Surgery
Russell Henley

Looks to Build on Strong Start at The American Express
Jason Day

Looking to Start 2026 Strong at The American Express
Wyndham Clark

Looking to Regain Form at The American Express
Sam Burns

Looks to Continue Success at The American Express
Akshay Bhatia

Looking to Flip the Script at The American Express
Christiaan Bezuidenhout

Looking to Build on Strong Fall in Season Debut
Kurt Kitayama

Hopes To Continue Strong Start to 2026 Season at American Express
CFB

Princewill Umanmielen Expected to Sign with LSU
Scottie Scheffler

Returns To American Express After Missing Last Year's Edition
Robert MacIntyre

Keeps Momentum Rolling Heading Into American Express
Brian Harman

Can Challenge at American Express if His Putter Stays Hot
Ben Griffin

Outstanding Form Continues Heading Into American Express
Matt Fitzpatrick

Continues Playing Well Following Outstanding Finish to 2025 Season
Patrick Cantlay

Looks to Get a Jump Start on His 2026 Season
Blades Brown

Set to Make First PGA Tour Appearance of 2026
Kevin Roy

Has Some Confidence Heading to Southern California
Min Woo Lee

Poised to Make Bigger Impact in 2026
Max Homa

Needs a Better Start for 2026
Tony Finau

Trying to Reverse Disturbing Trend
Cam Davis

Aims for More Accuracy at American Express
Luisangel Acuña

Luisangel Acuna Sent to White Sox in Trade
Luis Robert Jr.

Mets Acquire Luis Robert Jr. from White Sox
Los Angeles Chargers

Mike McDaniel Expected to Become Chargers Offensive Coordinator
Carlos Beltran

Andruw Jones Elected to Baseball Hall of Fame
CFB

Alberto Mendoza Expected to Land at Georgia Tech
Malik Nabers

Giants Hope Malik Nabers Will be Back for Start of Training Camp
CFB

Duke Suing Quarterback Darian Mensah
Cam Skattebo

Should be Ready by OTAs
George Kittle

Expects to Return "Well Before November"
CFB

Alberto Mendoza Entering Transfer Portal
Mookie Betts

Plans to Retire at the End of his Current Contract
Tennessee Titans

Titans Set to Hire Robert Saleh as Next Head Coach
Miami Dolphins

Dolphins Expected to Hire Jeff Hafley as Next Head Coach
Zach Charbonnet

has Torn ACL
Zach Charbonnet

Needs Knee Surgery, Out for Rest of Playoffs
Tennessee Titans

Mike McCarthy a Finalist for Titans Head-Coaching Job?
Colston Loveland

Suffers Concussion in Divisional Round Loss
Kyren Williams

Scores Two Touchdowns in Divisional Round Win
Buffalo Bills

Bills Fire Head Coach Sean McDermott
Rhamondre Stevenson

Returns in Sunday's AFC Divisional Round Game
Ha-Seong Kim

has Finger Surgery, Out 4-5 Months

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP