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DraftKings Daily Fantasy Baseball Picks (5/21/18): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on May 21, 2018. Adam Meyer's MLB DFS analysis and sleepers for building optimal DFS rosters.

It's a short nine-game slate on Monday. Two games have an over/under of at least nine total runs. Five teams are heavy favorites (-185): STL, MIN, NYY, LAD, and WSH. However, while you would think pitching would be loaded, the player pool isn't elite.
On a positive note, weather shouldn't be an issue for Monday. The weekend was full of rain and caused headaches for us all.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 5/21/18. The lineup picks will range from some of the elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @CharlieSideHstl.

DraftKings Starting Pitchers

Walker Buehler, LAD (vs. COL) - $9,300

The MLB team with the lowest runs scored in 2018 was able to produce four earned runs against Buehler in his last start (@ MIA). While that news is somewhat alarming, Buehler still managed to strike out seven batters, continuing his streak of at least five Ks per appearance this season. The Rockies are next for Buehler. Colorado has struck out the seventh-most times this season (426). The Rockies are also 27th in team wOBA against right-handed pitchers (.294). From a Vegas point-of-view, the COL/LAD matchup has the lowest over/under on the slate (seven total runs) and the Dodgers are one of the strongest favorites of the ticket (-180). Both odds are in favor of Buehler.

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Jose Berrios, MIN (vs. DET) - $8,500

It’s a mixed bag when it comes to Berrios and his stat lines. He’s been known to strike out 11 batters in a game, or strikeout none. He’s produced three shutouts in 2018, and allowed five earned runs in three starts this year. However, on a slate this small, without strong pitching prospects, I’d roll the dice on Berrios. His opponent, the Tigers, are 26th in team wOBA against righties (.295) and Vegas has given Minnesota the strongest odds to win on Monday (-200).

 

DraftKings Infielders

C - Gary Sanchez, NYY (@ TEX) - $4,800

After an amazing 4-for-5 performance where Sanchez smacked two home runs in Kansas City, he was given the day off. Now, he’ll look to return to action and continue his hot streak. In the past week, Sanchez is 5-for-11 (.455) with two doubles and two home runs. Sanchez is also third on the team in ISO against right-handed pitchers (.262).

1B - Trey Mancini, BAL (@ CWS) - $3,800

I wanted to wait and see who got the nod for some lineups before I locked in my post for Monday. First base can always be a crucial spot to build, when adding power-hitters to your DFS lineup. I tend to lean towards home running hitting options in this position. Mancini is only 2-for-11 (.111) in the past week, but he's homered three times in the last 10 games. Also, his Orioles are projected to score 4.9 runs (fourth-most) against the White Sox.

2B - Brian Dozier, MIN (vs. DET) - $3,900

Here’s another cold bat that you may not be thrilled with, at first. Dozier is 1-for-21 (.048) in the past week, but his proficiency against lefties is still profitable to the DFS community. He leads the team with a .280 ISO against left-handed pitchers (since 2017). When you get a combination of high ISO, with a leadoff hitter (high in the order), and a reasonable price tag you add them to your DK roster.

3B - Anthony Rendon, WSH (vs. SD) - $3,800

Sure, if you add Rendon with the past two selections you get 3-for-44 (.068) in the last seven days. Rendon is 1-for-12 (.083) in the past week. However, all three are solid selections against southpaws. Rendon leads the Nationals with a .320 ISO against left-handed pitchers.

SS - Didi Gregorius, NYY (@ TEX) - $3,900

I swear these are my suggestions for Monday and not an All-Star team of struggling batters. Gregorius is oh-fer in the past week (0-for-7), but again, the ISO doesn't lie. Even with his recent slump, Gregorius still owns a solid ISO against right-handed pitchers since 2017 (.246). Hopefully, this minor rest (hasn't played since Friday) is enough to wake up his bat and return him to his April numbers (.330 AVG, 10 HR, and 30 RBI).

DraftKings Outfielders

Tommy Pham, STL (vs. KC) - $4,600

The Cardinals have the third-highest implied run total for the Monday slate (5.1 runs). Compared to the previously mentioned bats, Pham is phenomenal. He's batting .280 (7-for-25) with one home run and one double in the past week. He's also tallied at least two hits in three of the past five games. Pham has also produced a .306 AVG against right-handed pitchers this season. His .207 ISO against righties also adds to his case.

Aaron Hicks, NYY (@ TEX) - $3,800

Sometimes you need to be creative when adding players from lineups with high implied run totals. While some DFS players will flock to Aaron Judge and Giancarlo Stanton, we need to pivot to cheaper options, like Hicks. His .205 ISO against righties is only seventh-best on New York, but it's in the range we like to use (.200 or better). Hicks is hitting .467 (7-for-15) with one triple and one home run in the past week.

Marcell Ozuna, STL (vs. KC) - $3,300

Ozuna has gone hitless in his last five games, but he still leads the Cardinals with a .226 ISO against right-handed pitchers. As I mentioned in Pham's write-up, St. Louis has the third-highest implied run total on the board. So, gathering as many hitters from the Cardinals is a wise decision. Ozuna's price tag fits the bill for our circumstances.

MLB DFS News and Injury Alerts

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REAL-TIME FANTASY NEWS

Collin Morikawa

Isn't The Safe Play He Used to Be Ahead of Sony Open
Luka Dončić

Luka Doncic Available Tuesday Night
Kurt Kitayama

Needs His Putting to Turn Around For Success at Year's First Event
Max Christie

Could Miss Wednesday's Game Due to Illness
LeBron James

Cleared to Play Tuesday
P.J. Washington

Listed as Questionable for Wednesday
Egor Demin

Back in Action Wednesday
Cam Thomas

Available Wednesday
Jakob Poeltl

Unavailable Versus Pacers
RJ Barrett

to Miss Third Straight Game Wednesday
Trae Young

Won't Play Wednesday
Rui Hachimura

to Be Limited to 18 Minutes Tuesday
Ivica Zubac

Iffy for Wednesday
Kawhi Leonard

Questionable for Wednesday
Jerami Grant

Ruled Out Tuesday
VJ Edgecombe

Considered Probable for Wednesday
Paul George

Listed as Probable for Wednesday
Joel Embiid

Expected to Suit Up Wednesday
Anthony Davis

Won't Have Surgery, Out for Six Weeks
Ryan Weathers

Yankees Add Rotation Depth, Acquire Ryan Weathers in Four-Player Deal
Norman Powell

Good to Go on Tuesday
Robert Thomas

Out Tuesday
Luguentz Dort

Ruled Out For Tuesday's Matchup With Spurs
Jake Walman

Available Against Predators
Troy Terry

a Game-Time Decision Tuesday
Justin Sourdif

Won't Play Tuesday
Jaxson Hayes

Unavailable Against Hawks
Jakob Chychrun

a Game-Time Call Tuesday
Morgan Geekie

Available Tuesday
Luke Kennard

Sidelined Tuesday
Bryan Rust

Returns to Action Tuesday
Erik Karlsson

Penguins Place Erik Karlsson on Injured Reserve
Los Angeles Chargers

Chargers Fire Offensive Coordinator Greg Roman
Pittsburgh Steelers

Mike Tomlin Stepping Down as Steelers Head Coach
CFB

Georgia Tech the Favorite to Land Justice Haynes?
Nolan Arenado

Cardinals Trade Nolan Arenado to Diamondbacks
Tom Kim

Desperately Needs a Solid Week at Sony Open
Billy Horschel

Hoping For a Fast Start to New Season at Sony Open
Corey Conners

Looks to Have a Return to Form in 2026
PGA

Chris Gotterup a Decent Play at Sony Open
Philip Broberg

Likely Out Tuesday
Jacob Trouba

on Track to Return Tuesday
Gary Woodland

Could Prosper at the Sony Open
Will Smith

Upgraded to Day-to-Day
Connor McDavid

Stretches Point Streak to 19 Games
Keith Mitchell

Unlikely to Contend at Sony Open
Teuvo Teravainen

Makes Early Exit Monday
Robert MacIntyre

Looking for a Good Performance at the Sony Open
Nicholas Robertson

Hurt Versus Avalanche
Brayden Point

Injured in Monday's Win
Michael Kim

Hopes to Start Sony Open Better This Week
Tom Hoge

Tries to Erase Poor 2025 Second Half in Hawaii
Brian Harman

Seeks Fresh Start in Hawaii
Eric Cole

Looks to Last Year for Success at Sony Open
Daniel Berger

Starts Off 2026 at Sony Open
Nico Collins

Suffers Concussion Against Steelers
Nico Collins

Carted to Locker Room for Concussion Evaluation
Kyle Tucker

Mets Meet With Kyle Tucker
Dalton Kincaid

"Should be Fine" for Divisional Round
Conor Garland

Returns From Five-Game Absence
Kiefer Sherwood

Out Monday, Could Miss Several Weeks
Marco Rossi

to Miss 2-3 More Weeks
Louis Crevier

Back for Blackhawks Monday
Jordan Eberle

Available Against Rangers
Joel Eriksson Ek

Out Monday
Brooks Koepka

Officially Returning To PGA Tour
Tucker Kraft

Hopes to be Ready for Week 1 of Next Season
CFB

Georgia Lands Kentucky Transfer Dante Dowdell
Matthew Stafford

has "Little Sprain," Should be "Good to Go"
CFB

Sam Leavitt Expected to Sign with LSU
Green Bay Packers

Packers Expected to Work Out New Deal With Matt LaFleur in the "Coming Days"
CFB

Dylan Raiola Commits to Oregon
CFB

Isaiah Horton Landing with Texas A&M
George Kittle

Suffers Torn Achilles on Sunday
Omarion Hampton

Active for Wild-Card Round Against Patriots
George Kittle

Ruled Out After Non-Contact Achilles Injury
Las Vegas Raiders

Raiders Request Interview With Ejiro Evero
Los Angeles Rams

Mike LaFleur to Interview With Raiders and Cardinals
Aaron Rodgers

Steelers Open to Re-Signing Aaron Rodgers?
Matthew Stafford

X-Rays Come Back Negative
MacKenzie Gore

Yankees Pursuing Trade for MacKenzie Gore
Alex Bregman

Cubs Sign Alex Bregman to Five-Year, $175 Millon Contract
Freddie Freeman

Withdraws from World Baseball Classic
Max Kepler

Receives 80-Game PED Suspension
CFB

Cam Coleman Visiting Alabama on Friday
Omarion Hampton

Expects to Play Sunday Night
CFB

Eric Singleton Jr. Enters Transfer Portal, Trending to Land at Florida
CFB

NCAA Denies Trinidad Chambliss a Sixth Year of Eligibility
Omarion Hampton

Questionable for Wild-Card Weekend
Kyle Tucker

Mets Remain in Mix for Kyle Tucker
Ketel Marte

Will Remain With Diamondbacks
Rashee Rice

to be Reviewed Under League's Conduct Policy
Daniel Jones

Colts Plan to Re-Sign Daniel Jones
Davante Adams

Off the Injury Report, Will Play Against Carolina
Bo Bichette

Phillies to Meet With Bo Bichette
Rome Odunze

Will Return for Wild-Card Game on Saturday
CFB

DJ Lagway Commits to Baylor

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP