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DraftKings Daily Fantasy Baseball Picks (5/21/18): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on May 21, 2018. Adam Meyer's MLB DFS analysis and sleepers for building optimal DFS rosters.

It's a short nine-game slate on Monday. Two games have an over/under of at least nine total runs. Five teams are heavy favorites (-185): STL, MIN, NYY, LAD, and WSH. However, while you would think pitching would be loaded, the player pool isn't elite.
On a positive note, weather shouldn't be an issue for Monday. The weekend was full of rain and caused headaches for us all.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 5/21/18. The lineup picks will range from some of the elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @CharlieSideHstl.

DraftKings Starting Pitchers

Walker Buehler, LAD (vs. COL) - $9,300

The MLB team with the lowest runs scored in 2018 was able to produce four earned runs against Buehler in his last start (@ MIA). While that news is somewhat alarming, Buehler still managed to strike out seven batters, continuing his streak of at least five Ks per appearance this season. The Rockies are next for Buehler. Colorado has struck out the seventh-most times this season (426). The Rockies are also 27th in team wOBA against right-handed pitchers (.294). From a Vegas point-of-view, the COL/LAD matchup has the lowest over/under on the slate (seven total runs) and the Dodgers are one of the strongest favorites of the ticket (-180). Both odds are in favor of Buehler.

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Jose Berrios, MIN (vs. DET) - $8,500

It’s a mixed bag when it comes to Berrios and his stat lines. He’s been known to strike out 11 batters in a game, or strikeout none. He’s produced three shutouts in 2018, and allowed five earned runs in three starts this year. However, on a slate this small, without strong pitching prospects, I’d roll the dice on Berrios. His opponent, the Tigers, are 26th in team wOBA against righties (.295) and Vegas has given Minnesota the strongest odds to win on Monday (-200).

 

DraftKings Infielders

C - Gary Sanchez, NYY (@ TEX) - $4,800

After an amazing 4-for-5 performance where Sanchez smacked two home runs in Kansas City, he was given the day off. Now, he’ll look to return to action and continue his hot streak. In the past week, Sanchez is 5-for-11 (.455) with two doubles and two home runs. Sanchez is also third on the team in ISO against right-handed pitchers (.262).

1B - Trey Mancini, BAL (@ CWS) - $3,800

I wanted to wait and see who got the nod for some lineups before I locked in my post for Monday. First base can always be a crucial spot to build, when adding power-hitters to your DFS lineup. I tend to lean towards home running hitting options in this position. Mancini is only 2-for-11 (.111) in the past week, but he's homered three times in the last 10 games. Also, his Orioles are projected to score 4.9 runs (fourth-most) against the White Sox.

2B - Brian Dozier, MIN (vs. DET) - $3,900

Here’s another cold bat that you may not be thrilled with, at first. Dozier is 1-for-21 (.048) in the past week, but his proficiency against lefties is still profitable to the DFS community. He leads the team with a .280 ISO against left-handed pitchers (since 2017). When you get a combination of high ISO, with a leadoff hitter (high in the order), and a reasonable price tag you add them to your DK roster.

3B - Anthony Rendon, WSH (vs. SD) - $3,800

Sure, if you add Rendon with the past two selections you get 3-for-44 (.068) in the last seven days. Rendon is 1-for-12 (.083) in the past week. However, all three are solid selections against southpaws. Rendon leads the Nationals with a .320 ISO against left-handed pitchers.

SS - Didi Gregorius, NYY (@ TEX) - $3,900

I swear these are my suggestions for Monday and not an All-Star team of struggling batters. Gregorius is oh-fer in the past week (0-for-7), but again, the ISO doesn't lie. Even with his recent slump, Gregorius still owns a solid ISO against right-handed pitchers since 2017 (.246). Hopefully, this minor rest (hasn't played since Friday) is enough to wake up his bat and return him to his April numbers (.330 AVG, 10 HR, and 30 RBI).

DraftKings Outfielders

Tommy Pham, STL (vs. KC) - $4,600

The Cardinals have the third-highest implied run total for the Monday slate (5.1 runs). Compared to the previously mentioned bats, Pham is phenomenal. He's batting .280 (7-for-25) with one home run and one double in the past week. He's also tallied at least two hits in three of the past five games. Pham has also produced a .306 AVG against right-handed pitchers this season. His .207 ISO against righties also adds to his case.

Aaron Hicks, NYY (@ TEX) - $3,800

Sometimes you need to be creative when adding players from lineups with high implied run totals. While some DFS players will flock to Aaron Judge and Giancarlo Stanton, we need to pivot to cheaper options, like Hicks. His .205 ISO against righties is only seventh-best on New York, but it's in the range we like to use (.200 or better). Hicks is hitting .467 (7-for-15) with one triple and one home run in the past week.

Marcell Ozuna, STL (vs. KC) - $3,300

Ozuna has gone hitless in his last five games, but he still leads the Cardinals with a .226 ISO against right-handed pitchers. As I mentioned in Pham's write-up, St. Louis has the third-highest implied run total on the board. So, gathering as many hitters from the Cardinals is a wise decision. Ozuna's price tag fits the bill for our circumstances.

MLB DFS News and Injury Alerts

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REAL-TIME FANTASY NEWS

Konnor Griffin

Pirates Expected to Approach Konnor Griffin With Long-Term Extension This Spring
Dejounte Murray

Won't Play on Saturday
Trey Murphy III

is Ruled Out for Saturday's Game
Yordan Alvarez

to Make Some Starts in Left Field
Caleb Martin

is Unavailable on Friday
Klay Thompson

is Resting on Friday
P.J. Washington

to Remain Out on Friday
Josh Jung

Expected to Return on Sunday
Andrew Benintendi

Scratched Due to Side Soreness
Orion Kerkering

to Throw on Saturday
Grae Kessinger

Suffers Knee Injury on Friday
Jake Meyers

Scratched Due to Back Spasms
Harrison Bader

Exits with Thumb Injury
Tyler Seguin

Offically Out for Rest of Season
Zach Benson

Could Be an Option Friday
Tom Wilson

Good to Go Friday
John Carlson

to Miss At Least Two More Games
Connor Hellebuyck

Set to Start Friday Night
Samuel Girard

Evaluated for Lower-Body Injury
Hyeseong Kim

Rebuilt Swing Already Generating Results
Bailey Ober

Focusing on Mechanics in Camp
Devin Williams

Sees Struggles Continue in Spring Debut
Rafael Devers

Scratched With Hamstring Tightness
Marcelo Mayer

Stronger and Faster Entering 2026 Season
Kutter Crawford

Set for Live Batting Practice on Friday
Shane Baz

Strikes Out Four in Spring Debut on Friday
Blake Snell

Making Progress, Will be "Hard" to be Ready for Opening Day
Corey Seager

Scratched Due to Illness
Elly De La Cruz

Feels Fully Healthy This Spring
Stephen Kolek

Being Shut Down With Grade 1 Oblique Strain
Lone'er Kavanagh

Set For UFC Mexico City Main Event
Brandon Moreno

Looks To Bounce Back
Samuel Basallo

Thinks he Can Play This Weekend
David Martinez

Set For UFC Mexico City Co-Main Event
Marlon Vera

In Dire Need Of Victory
King Green

Looks To Win Back-To-Back Fights
Daniel Zellhuber

Aims To Snap Two-Fight Skid
Sergei Bobrovsky

Sharp In Victory
Brad Marchand

Scores Two Goals in Victory
Noah Dobson

Scores Twice in Overtime Loss
Matthew Schaefer

has Two-Goal Game
Felipe Bunes

Looks To Get Back In The Win Column
Édgar Cháirez

Edgar Chairez A Favorite At UFC Mexico City
Konnor Griffin

Back in the Lineup After Injury Scare
George Pickens

Cowboys Not Interested in Trading George Pickens
Cedric Coward

to Miss Sixth Straight Game
Taj Gibson

Agrees to Deal With Grizzlies
Memphis Grizzlies

Kyle Anderson Agrees to Buyout, Plans to Join Timberwolves
Jabari Smith Jr.

Exits with Right Ankle Injury
Norman Powell

Leaves Game with Groin Injury
Alexandre Sarr

Considered Week-to-Week
Lauri Markkanen

to Miss At Least Two Weeks
Matt Boldy

Makes History With Another Four-Point Performance
Jake Guentzel

Sets Up Three Goals Thursday
Leon Draisaitl

Tallies Four Points Against Kings
Joel Kiviranta

Sustains Undisclosed Injury Thursday
Filip Gustavsson

Makes Late Exit Thursday
Joel Armia

Sustains Upper-Body Injury
Drew Doughty

Exits Loss With Lower-Body Injury
Jordan Binnington

on Non-Roster List
Mackenzie Blackwood

Starting in Net Versus Wild
Jaxson Hayes

Good to Go Thursday Night
Robert Williams III

Donovan Clingan Out, Robert Williams III and Yang Hansen Cleared
Patrick Williams

Jalen Smith, Patrick Williams Out At Least One Week
Keldon Johnson

is Active on Thursday
Khris Middleton

Available Thursday Against Sacramento
Daniel Gafford

Ruled Out Thursday vs. Kings
Nikola Jović

Nikola Jovic Remains Out on Thursday
Stephon Castle

Cleared to Play Thursday vs. Nets
Davion Mitchell

is Available on Thursday
Dylan Holloway

Rejoins Blues Lineup Thursday
Simon Edvinsson

Back in Red Wings Lineup Thursday
Ashton Jeanty

Not in Line for Workhorse Role in 2026?
Anthony Richardson Sr.

Colts Give Anthony Richardson Sr. Permission to Seek a Trade
Kyler Murray

Prefers to be Released
Derek Carr

"Strong Belief" That Derek Carr is "Very Serious" About Unretiring
Andy Dalton

Is Andy Dalton Available for a Trade?
Keith Mitchell

Making The Comfortable Return to PGA National
CFB

Chandler Morris Suing NCAA for Seventh Year of Eligibility
Chris Kirk

Searching for a Spark at Cognizant Classic
Brooks Koepka

Making Third PGA Tour Start at Cognizant Classic
Mackenzie Hughes

a Steady Option at Cognizant Classic
Seamus Power

Seeking More Green in Florida
PGA

Haotong Li Back From a Break as Florida Stretch Starts
Stephan Jaeger

Trying to Put Four Rounds Together in Florida
PGA

Nico Echavarria Again Attempting to Make the Weekend
Patrick Fishburn

Looking for a Spark at Cognizant Classic
Blades Brown

Set for Cognizant Classic Debut
Michael Thorbjornsen

Looking to Bounce Back at Cognizant Classic
Maxx Crosby

Raiders Expect Maxx Crosby to Return
Billy Horschel

Looks to Improve Season at Cognizant Classic
Kyle Pitts Sr.

Falcons Place Franchise Tag on Kyle Pitts Sr.
Joe Highsmith

Returns to Defend at Cognizant Classic
Quinshon Judkins

Out of Walking Boot, Will be Ready for Training Camp
Breece Hall

Jets Will Use Franchise Tag on Breece Hall if Extension isn't Reached
Joel Dahmen

Needs Better Consistency Heading Into The Florida Swing
Daniel Berger

Looks to Improve Putting as PGA Tour Begins Its Florida Swing
Kirk Cousins

Falcons Plan to Release Kirk Cousins
Zach Ertz

Plans to Return for 14th Season
Davis Thompson

Struggling to Find Birdies as Florida Looms
Tom Kim

Not Quite Cutting It in 2026
Nicolai Hojgaard

Wants to Build Momentum from Scottsdale
Christiaan Bezuidenhout

Returns After Extended Break for Florida Event
CFB

Gunner Rivers Follows His Father, Commits To North Carolina State
Will Zalatoris

Set to Make Tournament Debut at Cognizant Classic
Rasmus Hojgaard

Trending Up at the Cognizant Classic
Anthony Hernandez

Suffers Third-Round TKO Loss
Sean Strickland

Gets Back In The Win Column
Kyle Pitts Sr.

Falcons Planning to Use Franchise Tag on Kyle Pitts Sr.
Geoff Neal

Suffers Back-To-Back Knockout Losses
Uros Medic

Shines At UFC Houston
Dan Ige

Gets Finished For The First Time In His Career
Melquizael Costa

Extends His Win Streak To Six
NASCAR

Bubba Wallace Falls Short of Victory at EchoPark Speedway
Carson Hocevar

Rallies to Fourth At EchoPark Speedway After Early Struggles
Ross Chastain

Finishes Third At EchoPark Speedway
Chase Briscoe

Scores First Career Top-Five Finish at EchoPark Speedway
Tyler Reddick

Nabs His Second Win of the Season At EchoPark Speedway
Joey Logano

Will Be Popular DFS Pick at EchoPark Speedway
Tyler Reddick

on Pole After Qualifying Rained Out at EchoPark Speedway
Chase Elliott

Could Chase Elliott Be Worth Rostering At EchoPark Speedway?
Ryan Blaney

Is Ryan Blaney Worth Rostering for DFS at EchoPark Speedway?
William Byron

Is William Byron Worth Rostering for DFS at EchoPark Speedway?
Rondale Moore

Passes Away
Denny Hamlin

Is Worth Consideration for EchoPark Speedway DFS Lineups
Brad Keselowski

Is A Tournament Option for DFS At EchoPark Speedway
NASCAR

Is Bubba Wallace Rosterable In DFS At EchoPark Speedway?
Austin Cindric

Should DFS Managers Roster Austin Cindric at EchoPark Speedway?
Ross Chastain

Is Ross Chastain A Sneaky DFS Option for EchoPark Speedway?
Ricky Stenhouse Jr

Is Ricky Stenhouse Jr. Worth Rostering for DFS at EchoPark Speedway?
Alex Bowman

Will Start Towards the Rear At EchoPark Speedway
Javonte Williams

Cowboys Sign Javonte Williams to Three-Year, $24 Million Extension
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF