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DraftKings Daily Fantasy Baseball Picks (5/21/18): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on May 21, 2018. Adam Meyer's MLB DFS analysis and sleepers for building optimal DFS rosters.

It's a short nine-game slate on Monday. Two games have an over/under of at least nine total runs. Five teams are heavy favorites (-185): STL, MIN, NYY, LAD, and WSH. However, while you would think pitching would be loaded, the player pool isn't elite.
On a positive note, weather shouldn't be an issue for Monday. The weekend was full of rain and caused headaches for us all.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 5/21/18. The lineup picks will range from some of the elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @CharlieSideHstl.

DraftKings Starting Pitchers

Walker Buehler, LAD (vs. COL) - $9,300

The MLB team with the lowest runs scored in 2018 was able to produce four earned runs against Buehler in his last start (@ MIA). While that news is somewhat alarming, Buehler still managed to strike out seven batters, continuing his streak of at least five Ks per appearance this season. The Rockies are next for Buehler. Colorado has struck out the seventh-most times this season (426). The Rockies are also 27th in team wOBA against right-handed pitchers (.294). From a Vegas point-of-view, the COL/LAD matchup has the lowest over/under on the slate (seven total runs) and the Dodgers are one of the strongest favorites of the ticket (-180). Both odds are in favor of Buehler.

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Jose Berrios, MIN (vs. DET) - $8,500

It’s a mixed bag when it comes to Berrios and his stat lines. He’s been known to strike out 11 batters in a game, or strikeout none. He’s produced three shutouts in 2018, and allowed five earned runs in three starts this year. However, on a slate this small, without strong pitching prospects, I’d roll the dice on Berrios. His opponent, the Tigers, are 26th in team wOBA against righties (.295) and Vegas has given Minnesota the strongest odds to win on Monday (-200).

 

DraftKings Infielders

C - Gary Sanchez, NYY (@ TEX) - $4,800

After an amazing 4-for-5 performance where Sanchez smacked two home runs in Kansas City, he was given the day off. Now, he’ll look to return to action and continue his hot streak. In the past week, Sanchez is 5-for-11 (.455) with two doubles and two home runs. Sanchez is also third on the team in ISO against right-handed pitchers (.262).

1B - Trey Mancini, BAL (@ CWS) - $3,800

I wanted to wait and see who got the nod for some lineups before I locked in my post for Monday. First base can always be a crucial spot to build, when adding power-hitters to your DFS lineup. I tend to lean towards home running hitting options in this position. Mancini is only 2-for-11 (.111) in the past week, but he's homered three times in the last 10 games. Also, his Orioles are projected to score 4.9 runs (fourth-most) against the White Sox.

2B - Brian Dozier, MIN (vs. DET) - $3,900

Here’s another cold bat that you may not be thrilled with, at first. Dozier is 1-for-21 (.048) in the past week, but his proficiency against lefties is still profitable to the DFS community. He leads the team with a .280 ISO against left-handed pitchers (since 2017). When you get a combination of high ISO, with a leadoff hitter (high in the order), and a reasonable price tag you add them to your DK roster.

3B - Anthony Rendon, WSH (vs. SD) - $3,800

Sure, if you add Rendon with the past two selections you get 3-for-44 (.068) in the last seven days. Rendon is 1-for-12 (.083) in the past week. However, all three are solid selections against southpaws. Rendon leads the Nationals with a .320 ISO against left-handed pitchers.

SS - Didi Gregorius, NYY (@ TEX) - $3,900

I swear these are my suggestions for Monday and not an All-Star team of struggling batters. Gregorius is oh-fer in the past week (0-for-7), but again, the ISO doesn't lie. Even with his recent slump, Gregorius still owns a solid ISO against right-handed pitchers since 2017 (.246). Hopefully, this minor rest (hasn't played since Friday) is enough to wake up his bat and return him to his April numbers (.330 AVG, 10 HR, and 30 RBI).

DraftKings Outfielders

Tommy Pham, STL (vs. KC) - $4,600

The Cardinals have the third-highest implied run total for the Monday slate (5.1 runs). Compared to the previously mentioned bats, Pham is phenomenal. He's batting .280 (7-for-25) with one home run and one double in the past week. He's also tallied at least two hits in three of the past five games. Pham has also produced a .306 AVG against right-handed pitchers this season. His .207 ISO against righties also adds to his case.

Aaron Hicks, NYY (@ TEX) - $3,800

Sometimes you need to be creative when adding players from lineups with high implied run totals. While some DFS players will flock to Aaron Judge and Giancarlo Stanton, we need to pivot to cheaper options, like Hicks. His .205 ISO against righties is only seventh-best on New York, but it's in the range we like to use (.200 or better). Hicks is hitting .467 (7-for-15) with one triple and one home run in the past week.

Marcell Ozuna, STL (vs. KC) - $3,300

Ozuna has gone hitless in his last five games, but he still leads the Cardinals with a .226 ISO against right-handed pitchers. As I mentioned in Pham's write-up, St. Louis has the third-highest implied run total on the board. So, gathering as many hitters from the Cardinals is a wise decision. Ozuna's price tag fits the bill for our circumstances.

MLB DFS News and Injury Alerts

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REAL-TIME FANTASY NEWS

Bryce Eldridge

Giants to Promote No. 1-Ranked Prospect Bryce Eldridge to MLB Roster
Jonas Brodin

Out for Games 1 and 2 Against Colorado
Joel Eriksson Ek

Will Miss First Two Games of Colorado Series
Joel Kiviranta

Remains Out of the Lineup Versus Minnesota
Anthony Volpe

Reinstated from Injured List, Optioned to Triple-A
Josh Manson

Out for Game 1 Against Minnesota
Carter Bryant

Iffy for Game 1 Against Timberwolves
Joel Embiid

Considered Probable for Monday
Kyle Anderson

Available for Round 2 Opener
Ayo Dosunmu

Tagged as Questionable on Injury Report
Anthony Edwards

Listed as Questionable for Game 1 Against Spurs
Luka Dončić

Luka Doncic Unavailable for Start of Round 2, Considered Week-to-Week
Brandon Ingram

Won't Play in Game 7 Against Cavaliers
Ranger Suarez

Exits Sunday's Start with Hamstring Tightness
Agustín Ramírez

Marlins Demote Agustin Ramirez to Triple-A
Victor Hedman

Will Not Play Sunday Versus Montreal
Noah Dobson

Will Play Against Tampa Bay on Sunday
Marvin Mims Jr.

Path to Dynasty Relevance May Require a Change in Scenery
Tank Bigsby

Remains a High-End Dynasty Handcuff Running Back in Philadelphia
Ben Rice

Exits Sunday's Contest with Left Hand Contusion
Hunter Henry

Long-Term Future in New England in Question After NFL Draft?
Matthew Golden

a Prime Dynasty Buy-Low Candidate Heading into 2026
Kevin Huerter

is Out for Game 7
Jalen Coker

Carries Breakout Potential into 2026
Dak Prescott

Remains a Dynasty QB1 Heading into 2026
Nikola Vučević

Nikola Vucevic Could be Done in Boston
Christopher Bell

Is Christopher Bell Worth Rostering for Texas Lineups?
Cal Raleigh

Considered Day-to-Day With Soreness in his Side
Brandon Ingram

is Downgraded to Doubtful for Game 7
William Byron

Might have the Speed to Compete for the Win at Texas
Jonathan Isaac

Remains Out for Game 7
Joey Logano

Provides Solid Upside for Texas DFS Lineups
Joe Ryan

Exits Early From Start on Sunday Due to Elbow Soreness
Chase Briscoe

Could Chase Briscoe be A Sneaky Pick for Texas Lineups?
Ty Gibbs

Should DFS Managers Roster Ty Gibbs at Texas?
Daniel Suarez

Is Daniel Suarez Worth Rostering After Career-Best Starting Position at Texas?
Daniel Palencia

Cubs Reinstate Daniel Palencia From the Injured List on Sunday
Kyle Busch

Is a DFS Risk Starting in the Top 10 at Texas
Ronald Acuña Jr.

Braves Place Ronald Acuna Jr. on Injured List With Strained Hamstring
Nick Lodolo

Expected to Make Season Debut on Friday
Tyler Reddick

One of the Favorites to Win Texas
Chase Elliott

Could Contend for Another Win at Texas
Carson Hocevar

on Pole at Texas
NASCAR

Bubba Wallace Wrecks in Practice at Texas
Chris Buescher

Looking to Continue Strong Run at Texas
Austin Dillon

Blows Engine in Practice at Texas
CeeDee Lamb

Is CeeDee Lamb Being Undervalued?
Bijan Robinson

Could Just Be Entering His Dynasty Prime
Derrick White

Delivers All-Around Line in Game 7 Loss
Neemias Queta

Finishes with Double-Double in Playoff Loss
Malik Washington

Emerging as a Low-Cost Dynasty Buy Out of Ambiguous Receiver Room
Jaylen Brown

Posts Strong Line but Celtics Fall Short
Diego Pavia

Ravens Noncommital on Diego Pavia's Future with Team
Tyrese Maxey

Dominates in Series-Clinching Victory
David Njoku

Visiting the Chargers on Monday
VJ Edgecombe

Provides Key Spark in Game 7 Win
Patrick Mahomes

Expected to Participate in OTAs
Joel Embiid

Delivers 34 Points in Series Clincher
Ayo Dosunmu

Considered Day-to-Day Ahead of Game 1
Mike Reilly

Delivers Two Assists in Game 1 Win
Logan Stankoven

Establishes New Franchise Record With Five-Game Goal Streak
Frederik Andersen

Records Second Postseason Shutout
Radko Gudas

Ducks Hope to See Radko Gudas Return During Second Round
Josh Manson

Day-to-Day Ahead of Game 1 Against Wild
Joel Kiviranta

Considered Day-to-Day
Joel Eriksson Ek

Questionable for Game 1 Against Avalanche
Cal Raleigh

Scratched From Lineup, No Reason Given
Ronald Acuña Jr.

Ronald Acuna Jr. Exits with Left Hamstring Tightness
Anthony Edwards

Remains Week-to-Week
Joel Embiid

Available for Game 7 Against Celtics
Paul George

Cleared to Play Saturday
Owen Tippett

Unlikely to Play Saturday
Jonas Brodin

to Miss Game 1 Against Avalanche
Nikita Zadorov

Played Through Torn MCL in Playoffs
Connor McDavid

Played With Fractured Foot Against Ducks
Alexander Nikishin

a Game-Time Call Saturday
Nikolaj Ehlers

Expected to Play Saturday
Greg Dulcich

Carries Breakout Potential into 2026
Kaelon Black

Well-Positioned for Dynasty Success Following NFL Draft
J'Mari Taylor

Can J'Mari Taylor Break Through Crowded Running Back Depth Chart in Jacksonville?
Eli Raridon

Dynasty Stock Rising Following NFL Draft
Michael Trigg

Facing Uphill Battle for a Roster Spot in Dallas
Matthew Hibner

Is Matthew Hibner the Tight End of the Future in Baltimore?
Seth McGowan

Likely to be RB3 to Begin his Rookie Season
Caleb Douglas

a Low-Upside Dynasty Stash Competing for a Role in Miami
Francis Mauigoa

Giants "Comfortable" With Francis Mauigoa's Back
Yandy Díaz

Yandy Diaz Leaves With Side Tightness, Considered Day-to-Day
Jacob Misiorowski

Leaves Start Early on Friday With Hamstring Cramp
Brandon Nimmo

Aggravates Hamstring, Pulled Early on Friday
Ryan Helsley

Placed on Injured List With Elbow Inflammation
Dylan Holloway

Signs Five-Year Extension With Blues
Barrett Hayton

Jack McBain Iffy for Friday
Ryan Pepiot

to Miss the Rest of the Season, Scheduled for Hip Surgery
Brandon Woodruff

Goes on Injured List With Shoulder Inflammation
Nico Hoerner

Leaves Friday's Game Early With Neck Tightness
Jack Della Maddalena

Returns At UFC Perth
Carlos Prates

Set For UFC Perth Main Event
Quillan Salkilld

Set For Co-Main Event
Beneil Dariush

An Underdog At UFC Perth
Steve Erceg

Looks To Win Back-To-Back Fights
Tim Elliott

Looks For His Third Consecutive Win
Ollie Schmid

Set For His UFC Debut
Marwan Rahiki

Looks To Remain Undefeated
Wyatt Langford

Suffers Setback With Forearm Injury
Brandon Woodruff

to Get Some Time Off
Gary Woodland

Riding Momentum Into Cadillac Championship
Jordan Spieth

Brings Boom-or-Bust Potential to Cadillac Championship
Adam Scott

Looks Poised for Another Strong Finish at Doral
Maverick McNealy

Needs Approach Game to Click at Doral
CFB

Jameson Williams Files Lawsuit Against NCAA, SEC, Big Ten
Harry Hall

Volatility Continues at Cadillac Championship
Tommy Fleetwood

Looks to Rebound at Trump National Doral
Pierceson Coody

a Risky Value Play at Cadillac Championship
Akshay Bhatia

Offers Upside with Risk at Cadillac Championship
Justin Thomas

a Scary Proposition at Cadillac Championship
Scottie Scheffler

The Leading Favorite at Cadillac Championship
Collin Morikawa

Still a Smash Play at Cadillac Championship
Viktor Hovland

Showed at Augusta He Can Finish Well
Sepp Straka

Attempting to Finish Better in Miami
PGA

J.J Spaun Enduring Roller Coaster Start to 2026
Min Woo Lee

Seeks to Make Adjustments at Cadillac Championship
Max Homa

May Struggle at Old Doral This Weekend
Ben Griffin

Rebounds From Rough Stretch as Miami Looms
Shane Lowry

Searching For Answers at Cadillac Championship
Russell Henley

Daunting Test at Doral Likely Not a Place For Russell Henley
Justin Rose

Returns to Action After Finishing Third at Masters Tournament
Hideki Matsuyama

Has The Approach Game to Win at Cadillac Championship
CFB

Brendan Sorsby Facing Potential Permanent Loss of Eligibility
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF