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DraftKings Daily Fantasy Baseball Picks (5/21/18): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on May 21, 2018. Adam Meyer's MLB DFS analysis and sleepers for building optimal DFS rosters.

It's a short nine-game slate on Monday. Two games have an over/under of at least nine total runs. Five teams are heavy favorites (-185): STL, MIN, NYY, LAD, and WSH. However, while you would think pitching would be loaded, the player pool isn't elite.
On a positive note, weather shouldn't be an issue for Monday. The weekend was full of rain and caused headaches for us all.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 5/21/18. The lineup picks will range from some of the elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @CharlieSideHstl.

DraftKings Starting Pitchers

Walker Buehler, LAD (vs. COL) - $9,300

The MLB team with the lowest runs scored in 2018 was able to produce four earned runs against Buehler in his last start (@ MIA). While that news is somewhat alarming, Buehler still managed to strike out seven batters, continuing his streak of at least five Ks per appearance this season. The Rockies are next for Buehler. Colorado has struck out the seventh-most times this season (426). The Rockies are also 27th in team wOBA against right-handed pitchers (.294). From a Vegas point-of-view, the COL/LAD matchup has the lowest over/under on the slate (seven total runs) and the Dodgers are one of the strongest favorites of the ticket (-180). Both odds are in favor of Buehler.

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Jose Berrios, MIN (vs. DET) - $8,500

It’s a mixed bag when it comes to Berrios and his stat lines. He’s been known to strike out 11 batters in a game, or strikeout none. He’s produced three shutouts in 2018, and allowed five earned runs in three starts this year. However, on a slate this small, without strong pitching prospects, I’d roll the dice on Berrios. His opponent, the Tigers, are 26th in team wOBA against righties (.295) and Vegas has given Minnesota the strongest odds to win on Monday (-200).

 

DraftKings Infielders

C - Gary Sanchez, NYY (@ TEX) - $4,800

After an amazing 4-for-5 performance where Sanchez smacked two home runs in Kansas City, he was given the day off. Now, he’ll look to return to action and continue his hot streak. In the past week, Sanchez is 5-for-11 (.455) with two doubles and two home runs. Sanchez is also third on the team in ISO against right-handed pitchers (.262).

1B - Trey Mancini, BAL (@ CWS) - $3,800

I wanted to wait and see who got the nod for some lineups before I locked in my post for Monday. First base can always be a crucial spot to build, when adding power-hitters to your DFS lineup. I tend to lean towards home running hitting options in this position. Mancini is only 2-for-11 (.111) in the past week, but he's homered three times in the last 10 games. Also, his Orioles are projected to score 4.9 runs (fourth-most) against the White Sox.

2B - Brian Dozier, MIN (vs. DET) - $3,900

Here’s another cold bat that you may not be thrilled with, at first. Dozier is 1-for-21 (.048) in the past week, but his proficiency against lefties is still profitable to the DFS community. He leads the team with a .280 ISO against left-handed pitchers (since 2017). When you get a combination of high ISO, with a leadoff hitter (high in the order), and a reasonable price tag you add them to your DK roster.

3B - Anthony Rendon, WSH (vs. SD) - $3,800

Sure, if you add Rendon with the past two selections you get 3-for-44 (.068) in the last seven days. Rendon is 1-for-12 (.083) in the past week. However, all three are solid selections against southpaws. Rendon leads the Nationals with a .320 ISO against left-handed pitchers.

SS - Didi Gregorius, NYY (@ TEX) - $3,900

I swear these are my suggestions for Monday and not an All-Star team of struggling batters. Gregorius is oh-fer in the past week (0-for-7), but again, the ISO doesn't lie. Even with his recent slump, Gregorius still owns a solid ISO against right-handed pitchers since 2017 (.246). Hopefully, this minor rest (hasn't played since Friday) is enough to wake up his bat and return him to his April numbers (.330 AVG, 10 HR, and 30 RBI).

DraftKings Outfielders

Tommy Pham, STL (vs. KC) - $4,600

The Cardinals have the third-highest implied run total for the Monday slate (5.1 runs). Compared to the previously mentioned bats, Pham is phenomenal. He's batting .280 (7-for-25) with one home run and one double in the past week. He's also tallied at least two hits in three of the past five games. Pham has also produced a .306 AVG against right-handed pitchers this season. His .207 ISO against righties also adds to his case.

Aaron Hicks, NYY (@ TEX) - $3,800

Sometimes you need to be creative when adding players from lineups with high implied run totals. While some DFS players will flock to Aaron Judge and Giancarlo Stanton, we need to pivot to cheaper options, like Hicks. His .205 ISO against righties is only seventh-best on New York, but it's in the range we like to use (.200 or better). Hicks is hitting .467 (7-for-15) with one triple and one home run in the past week.

Marcell Ozuna, STL (vs. KC) - $3,300

Ozuna has gone hitless in his last five games, but he still leads the Cardinals with a .226 ISO against right-handed pitchers. As I mentioned in Pham's write-up, St. Louis has the third-highest implied run total on the board. So, gathering as many hitters from the Cardinals is a wise decision. Ozuna's price tag fits the bill for our circumstances.

MLB DFS News and Injury Alerts

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REAL-TIME FANTASY NEWS

Jaxson Hayes

Sidelined on Tuesday
Al Horford

De'Anthony Melton Will Play Against the Pelicans, Al Horford Ruled Out
Naz Reid

Listed as Available to Play Tuesday
Jalen Smith

Will Not Play Tuesday Against the Hornets
Coby White

Available To Make His Hornets' Debut Tuesday
Davion Mitchell

Upgraded to Probable for Tuesday
Jaylen Brown

Will Not Play Tuesday
Breece Hall

Jets Will Use Franchise Tag on Breece Hall if Extension isn't Reached
Trey Yesavage

to be on Strict Inning Limit This Season
Joel Dahmen

Needs Better Consistency Heading Into The Florida Swing
Blaine Crim

Suffers Oblique Strain
Matt Waldron

"Week-to-Week" After Undergoing Surgery
Daniel Berger

Looks to Improve Putting as PGA Tour Begins Its Florida Swing
Oneil Cruz

Looking to Improve Against Left-Handed Pitchers
Sebastian Walcott

has Internal-Brace Surgery, Out 5-6 Months
Ricky Tiedemann

to Back Off for a Week Due to Elbow Soreness
Kirk Cousins

Falcons Plan to Release Kirk Cousins
Zach Ertz

Plans to Return for 14th Season
Jameson Taillon

Can Be a Sneaky Late-Round Value
Matt Wallner

Ready for a Breakout Season?
Jaxson Hayes

Unlikely to Play Tuesday
Jonathan Kuminga

Questionable Against Wizards
Andrés Giménez

Andres Gimenez Looking for Healthy 2026
Jae'Sean Tate

to Be Re-Evaluated in Two Weeks
Ernie Clement

Expected to Play a Major Role in Toronto
Ryan Kalkbrenner

Listed as Probable Against Bulls
Tristan Vukcevic

Could Miss Second Straight Game
Chris Sale

Signs Extension With Braves
De'Anthony Melton

Could Miss Game Vs. New Orleans
Vince Williams Jr.

Feared to Have Significant Knee Injury
Grayson Allen

Questionable to Face Celtics
Jalen Suggs

Could Miss Third Straight Game
Draymond Green

Iffy for Tuesday's Matchup
Davis Thompson

Struggling to Find Birdies as Florida Looms
Kristaps Porzingis

to Miss Two More Games
Naz Reid

in Danger of Missing Another Contest
Tom Kim

Not Quite Cutting It in 2026
Deni Avdija

Won't Play Tuesday
Andrew Nembhard

Questionable Tuesday
Nicolai Hojgaard

Wants to Build Momentum from Scottsdale
Christiaan Bezuidenhout

Returns After Extended Break for Florida Event
Carson Fulmer

Signs Minor-League Deal With Pirates
Brent Honeywell

Signs Minor-League Contract With Giants
Graham Pauley

Undergoes Imaging for Forearm Tightness
Trevor Story

a Strong Candidate to Hit Second in 2026
Bryan Abreu

Could Begin Season as the Closer
Justin Foscue

Exits Grapefruit League Game With Hamstring Tightness
Trevor Megill

had Offseason PRP Injections
Merrill Kelly

is Awaiting MRI Results
José Berríos

Jose Berrios Feels Fully Healthy Now
CFB

Gunner Rivers Follows His Father, Commits To North Carolina State
Will Zalatoris

Set to Make Tournament Debut at Cognizant Classic
Linus Ullmark

Available for Senators
Rasmus Hojgaard

Trending Up at the Cognizant Classic
Ryan Reaves

Sharks Activate Ryan Reaves From Injured Reserve
Charlie Lindgren

Activated From Injured Reserve Monday
Josh Norris

Cleared to Return Wednesday
Max McGreevy

Will Need to Improve on the Greens to Compete
Rico Hoey

Returns to Cognizant Classic
Austin Eckroat

Looks to Bounce Back at Cognizant Classic
Aaron Rai

Bounces Back After Rough Start to 2026 Season
Shane Lowry

Continues Playing Well Heading to Cognizant Classic
Max Homa

Has Opportunity to Continue Building Momentum at the Cognizant Classic
Ryan Gerard

Strong Approach Play Behind his Hot Start in 2026
Luke Clanton

Making Fourth Start of 2026 at Cognizant Classic
Kevin Lankinen

Unlikely to Play Wednesday
Josh Morrissey

to Miss Start of Road Trip
Mikko Rantanen

Expected to Miss Time
Jared Jones

Aiming to be Ready in Late May
Andrew Putnam

Looks to Jumpstart His Season at Cognizant Classic
Adam Scott

Looks For Continued Success at PGA National
Anthony Hernandez

Suffers Third-Round TKO Loss
Sean Strickland

Gets Back In The Win Column
Kyle Pitts Sr.

Falcons Planning to Use Franchise Tag on Kyle Pitts Sr.
Geoff Neal

Suffers Back-To-Back Knockout Losses
Uros Medic

Shines At UFC Houston
Dan Ige

Gets Finished For The First Time In His Career
Melquizael Costa

Extends His Win Streak To Six
NASCAR

Bubba Wallace Falls Short of Victory at EchoPark Speedway
Carson Hocevar

Rallies to Fourth At EchoPark Speedway After Early Struggles
Ross Chastain

Finishes Third At EchoPark Speedway
Chase Briscoe

Scores First Career Top-Five Finish at EchoPark Speedway
Tyler Reddick

Nabs His Second Win of the Season At EchoPark Speedway
Joey Logano

Will Be Popular DFS Pick at EchoPark Speedway
Tyler Reddick

on Pole After Qualifying Rained Out at EchoPark Speedway
Chase Elliott

Could Chase Elliott Be Worth Rostering At EchoPark Speedway?
Ryan Blaney

Is Ryan Blaney Worth Rostering for DFS at EchoPark Speedway?
William Byron

Is William Byron Worth Rostering for DFS at EchoPark Speedway?
Rondale Moore

Passes Away
Denny Hamlin

Is Worth Consideration for EchoPark Speedway DFS Lineups
Brad Keselowski

Is A Tournament Option for DFS At EchoPark Speedway
NASCAR

Is Bubba Wallace Rosterable In DFS At EchoPark Speedway?
Austin Cindric

Should DFS Managers Roster Austin Cindric at EchoPark Speedway?
Ross Chastain

Is Ross Chastain A Sneaky DFS Option for EchoPark Speedway?
Ricky Stenhouse Jr

Is Ricky Stenhouse Jr. Worth Rostering for DFS at EchoPark Speedway?
Alex Bowman

Will Start Towards the Rear At EchoPark Speedway
Javonte Williams

Cowboys Sign Javonte Williams to Three-Year, $24 Million Extension
Joel Armia

Wraps Up Olympics With Three-Point Performance
Daniil Tarasov

Available for Panthers
Evan Rodrigues

Set to Return Next Week
Aaron Ekblad

Expected to Play Thursday
Pavel Zacha

Cleared for Action
VAN

Jonathan Lekkerimaki Needs Season-Ending Shoulder Surgery
Mikko Rantanen

Misses Bronze-Medal Game With Lower-Body Injury
Blake Coleman

Activated From Injured Reserve
Matt Rempe

Heading to Injured Reserve After Second Thumb Procedure
Sidney Crosby

a Game-Time Call for Olympic Final
Josh Morrissey

Won't Play Sunday
Filip Chytil

Out Indefinitely With Facial Fracture
Connor McDavid

Makes History With Another Multi-Point Outing
Tage Thompson

Expected to Play in Olympic Final
Travis Etienne Jr.

has "Legitimate Interest" in Joining Chiefs
Zach Charbonnet

Undergoes Knee Surgery on Friday
CFB

Curt Cignetti Agrees to New Deal With Indiana, Will Earn $13.2 Million Per Year
Anthony Hernandez

Set For UFC Houston Main Event
Sean Strickland

Looks To Get Back In The Win Column
Uros Medic

Set For UFC Houston Co-Main Event
Geoff Neal

Looks To Get Back In The Win Column
Melquizael Costa

A Favorite At UFC Houston
Dan Ige

An Underdog At UFC Houston
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF