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4 years agoSan Francisco 49ers wide receiver Deebo Samuel (hamstring) and running back Tevin Coleman (knee) are officially out for Week 10 against the Saints. With the team's bye coming in Week 11, both Samuel and Coleman could be back on the field in Week 12 against the division-rival Rams. It will be Samuel's third straight absence and sixth missed game in total in 2020. Rookie Brandon Aiyuk, Kendrick Bourne and Richie James Jr. should operate in three-receiver sets. Aiyuk has the most upside and could see a healthy amount of targets. He's a WR3 with upside after the catch. With Coleman and Raheem Mostert (ankle) both missing another game, Jerick McKinnon and JaMycal Hasty will split the backfield work yet again. McKinnon is riding the hot hand and is on the RB2/3 borderline in a tough matchup.--Keith Hernandez - RotoBaller
Source: NFL.com

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