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Welcome RotoBallers to our betting picks for the San Francisco 49ers vs. Arizona Cardinals, another article in our weekly series of free NFL betting picks for every game on the schedule. This free NFL betting breakdown article is for Monday, November 21st, 2022.
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Today's Betting Overview - 49ers @ Cardinals
The 49ers take on the Cardinals on Monday, November 21st at Estadio Azteca, Mexico City. RotoBaller provides free handicapping picks and odds for all NFL games throughout the 2022 season.
- Matchup: San Francisco 49ers (5-4) vs. Arizona Cardinals (4-6)
- Date: Monday, November 21st, 2022
- Time: 8:15 PM ET
- Venue: Estadio Azteca
Today's NFL Sportsbook Odds - 49ers @ Cardinals
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San Francisco 49ers - NFL Betting Analysis
In their last game vs the Los Angeles Chargers, the 49ers won by a score of 22-16. The 6-point win gave the team a non-conference victory. Despite the straight-up win, the 49ers did not cover the spread. They went into the matchup as -8.0 point favorites. The over-under betting total going into the game was 45, which the teams did not surpass. San Francisco pulled out a comeback victory over the Chargers, as they entered the 4th quarter trailing by a score of 16-13. Despite the win, San Francisco was not able to cover the spread. Through 9 games, the 49ers have an ATS record of 4-5. So far, they have an over-under record of 3-6. This week's betting total of 43.5 is right in line with their previous games.
As the 49ers prepare to take on Arizona, they are ranked 18th in points per game at 22.0. Look for the team to put together a strong offensive performance vs a Cardinals defense ranked 31st in points per game. Throughout the game, San Francisco should be able to move the ball through the air, as they are the 10th-ranked team in terms of passing yards. In addition, they are facing off against a defense that has been vulnerable in the secondary. On the ground, San Francisco is averaging 123.67 yards per game, which is 14th in the NFL. Yards could be hard to come by, as Arizona has been stout against the run this season.
Arizona Cardinals - NFL Betting Analysis
Going back to last week, the Cardinals picked up a win in the NFC West, as they defeated the Cardinals by a score of 27-17. Going into last week's matchup, Arizona was a 3.5-point underdog on the spread. With their combined 38 points, the two teams exceeded the betting over-under number of 38. Despite being the 3.5-point underdogs heading into the game, the Cardinals held a 7-point lead heading into the 4th quarter. Through 10 games, the Cardinals have an ATS record of 5-5. So far, they have an over-under record of 5-4-1. This week's betting total of 43.5 is slightly lower than the line in their previous games.
Heading into this week's matchup, the Cardinals' offense is averaging 23.0 points per game, placing them 13th in the NFL. This week, the team is matched up against the league's 3rd ranked defense and could have trouble putting up points. If they are going to have offensive success, it will need to come through the air, as San Francisco is the top defense at defending the run. For the season, Arizona is the 18th-ranked unit in pass yards per game (220.6).
Today's NFL Betting Pick - 49ers vs. Cardinals
Looking back at the recent matchups between San Francisco and Arizona, the Cardinals have taken 3 of the last 5 contests. The two teams have combined to average 42.6 points per game in their last 5 meetings. As Arizona faces off with San Francisco, they are hoping to carry over last year's momentum, as they defeated the 49ers by scores 31-17 and 17-10.
The Arizona Cardinals have gone 3-2-0 vs the spread in these games. On average, the 49ers have averaged 20.6 points per game in the past 5 head-to-head matchups, compared to Arizona at 22.0.
Over their last 3 regular season games, the 49ers have gone 2-1 straight up. Their strong play has also resulted in a ATS mark of 1-2 (last 3).
When looking at their past 3 road matchups, San Francisco has an ATS record of 2-1 while averaging 27.33 per game. The team went 2-1 overall in these games.
Across their previous 3 regular season games, the Cardinals have a straight-up record of just 1-2. Like their straight-up record, Arizona struggled vs the spread, going 1-2. Over these games, they put together an over-under record of 3-0.
Across the Cardinals' last 3 home games, the team averaged 26.67 points per game while allowing 28.33. Their record vs the spread in these contests was 2-1, while going 1-2 straight-up.
Recommended ATS Betting Pick: 49ers -8.0
Recommended OU Betting Pick: Under 43.5
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